Ionis Pharmaceuticals, Inc.

NasdaqGS:IONS Stock Report

Market Cap: US$13.2b

Ionis Pharmaceuticals Balance Sheet Health

Financial Health criteria checks 4/6

Ionis Pharmaceuticals has a total shareholder equity of $618.0M and total debt of $1.8B, which brings its debt-to-equity ratio to 290.8%. Its total assets and total liabilities are $3.0B and $2.4B respectively.

Key information

290.76%

Debt to equity ratio

US$1.80b

Debt

Interest coverage ration/a
CashUS$2.24b
EquityUS$617.97m
Total liabilitiesUS$2.42b
Total assetsUS$3.03b

Recent financial health updates

Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Too Much Debt?

Jul 30
Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Too Much Debt?

Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Debt In A Risky Way?

Apr 20
Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Debt In A Risky Way?

Recent updates

Ionis: Expected 2026 Launch Of Olezarsen In SHTG To Spur Leap In Revenue Growth

Jan 20

Earnings Update: Here's Why Analysts Just Lifted Their Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Price Target To US$81.91

Nov 01
Earnings Update: Here's Why Analysts Just Lifted Their Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Price Target To US$81.91

Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) 34% Share Price Surge Not Quite Adding Up

Sep 03
Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) 34% Share Price Surge Not Quite Adding Up

Analysts Just Published A Bright New Outlook For Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS)

Aug 01
Analysts Just Published A Bright New Outlook For Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS)

Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Too Much Debt?

Jul 30
Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Too Much Debt?

Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) Shares Climb 28% But Its Business Is Yet to Catch Up

Jul 03
Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) Shares Climb 28% But Its Business Is Yet to Catch Up

We Discuss Why Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) CEO Compensation May Be Closely Reviewed

May 30
We Discuss Why Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) CEO Compensation May Be Closely Reviewed

Analysts Just Shipped A Substantial Upgrade To Their Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Estimates

May 02
Analysts Just Shipped A Substantial Upgrade To Their Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Estimates

Ionis: Potentially A Great Time To Buy Ahead Of Q1 Earnings (Upgrade)

Apr 22

Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Debt In A Risky Way?

Apr 20
Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Debt In A Risky Way?

Lacklustre Performance Is Driving Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) Low P/S

Mar 24
Lacklustre Performance Is Driving Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) Low P/S
User avatar

Anticipated Drug Launches Will Shift Biotech Company To Commercial Stage

Ionis is set to boost revenue through first-mover advantage with TRYNGOLZA and other product launches targeting unmet medical needs.

Ionis Pharmaceuticals: Promising Growth From Tryngolza Approval

Dec 23

Ionis Pharmaceuticals: Catalysts Due In 2025/2026 Are Extremely Compelling

Oct 23

Ionis Pharmaceuticals: Harnessing RNA-Targeted Therapies For Long-Term Shareholder Value

Aug 11

Ionis: Tough Run For Share Price Belies Multiple Reasons For Optimism

May 28

Financial Position Analysis

Short Term Liabilities: IONS's short term assets ($2.5B) exceed its short term liabilities ($903.5M).

Long Term Liabilities: IONS's short term assets ($2.5B) exceed its long term liabilities ($1.5B).

Debt to Equity History and Analysis

Debt Level: IONS has more cash than its total debt.

Reducing Debt: IONS's debt to equity ratio has increased from 49.7% to 290.8% over the past 5 years.

Balance Sheet

Cash Runway Analysis

For companies that have on average been loss-making in the past, we assess whether they have at least 1 year of cash runway.

Stable Cash Runway: IONS has sufficient cash runway for more than 3 years based on its current free cash flow.

Forecast Cash Runway: Insufficient data to determine if IONS has enough cash runway if its free cash flow continues to grow or shrink based on historical rates.

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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/02/13 22:33
End of Day Share Price 2026/02/13 00:00
Earnings2025/09/30
Annual Earnings2024/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Ionis Pharmaceuticals, Inc. is covered by 45 analysts. 20 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
James BirchenoughBarclays
Eliana MerleBarclays
Huidong WangBarclays