Stock Analysis

Board Member’s $1.2 Million Share Buy Might Change the Case for Investing in Exelixis (EXEL)

  • Earlier this week, Exelixis board member David Johnson purchased 27,500 shares for approximately US$1.2 million, reinforcing interest in the company’s future direction.
  • This substantial insider investment stands out as a meaningful show of confidence by a key leader, particularly given Exelixis’s focus on advancing cancer therapies.
  • With this significant board member share purchase as a backdrop, we’ll look at how insider confidence shapes Exelixis’s broader investment narrative.

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Exelixis Investment Narrative Recap

To be a shareholder of Exelixis, you need to share the belief that its leadership in cancer therapies and innovative pipeline can offset risks tied to its reliance on CABOMETYX, its main revenue contributor. While David Johnson’s recent US$1.2 million insider share purchase indicates board-level confidence, it does not materially impact the near-term catalyst of pipeline progress, nor does it shift the most significant risk: future revenue vulnerability once CABOMETYX faces generic competition.

Among recent announcements, the promising results from the STELLAR-303 trial, where zanzalintinib showed a 20% reduction in risk of death for colorectal cancer, resonates strongly. This development is closely linked to the company's main catalyst, as further clinical trial wins and new drug approvals could diversify Exelixis’s revenue base and mitigate risks from heavy reliance on a single product.

By contrast, investors should be mindful that rising 340B sales mean a higher share of Exelixis’s business is exposed to price …

Read the full narrative on Exelixis (it's free!)

Exelixis' outlook anticipates $3.1 billion in revenue and $1.1 billion in earnings by 2028. This projection relies on an annual revenue growth rate of 11.7% and an earnings increase of $497.7 million from the current $602.3 million.

Uncover how Exelixis' forecasts yield a $44.61 fair value, in line with its current price.

Exploring Other Perspectives

EXEL Community Fair Values as at Nov 2025
EXEL Community Fair Values as at Nov 2025

Twelve individual perspectives from the Simply Wall St Community put Exelixis’s estimated fair value as low as US$36 and as high as US$185,847 a share. With Exelixis’s dependence on CABOMETYX so pronounced, you may want to explore how shifts in pricing or patent exclusivity could shape future outcomes.

Explore 12 other fair value estimates on Exelixis - why the stock might be worth over 4x more than the current price!

Build Your Own Exelixis Narrative

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Valuation is complex, but we're here to simplify it.

Discover if Exelixis might be undervalued or overvalued with our detailed analysis, featuring fair value estimates, potential risks, dividends, insider trades, and its financial condition.

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About NasdaqGS:EXEL

Exelixis

An oncology company, focuses on the discovery, development, and commercialization of new medicines for difficult-to-treat cancers in the United States.

Flawless balance sheet and undervalued.

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