Cyclerion Therapeutics, Inc.

NasdaqCM:CYCN Stock Report

Market Cap: US$12.7m

Cyclerion Therapeutics Past Earnings Performance

Past criteria checks 0/6

Cyclerion Therapeutics has been growing earnings at an average annual rate of 60.3%, while the Biotechs industry saw earnings growing at 36.2% annually. Revenues have been declining at an average rate of 13.1% per year.

Key information

60.28%

Earnings growth rate

66.85%

EPS growth rate

Biotechs Industry Growth17.04%
Revenue growth rate-13.09%
Return on equity-77.69%
Net Margin-264.73%
Last Earnings Update31 Mar 2026

Recent past performance updates

Recent updates

Seeking Alpha Oct 06

Cyclerion stock tanks 32% on workforce reduction, clinical development refocus

Cyclerion Therapeutics (NASDAQ:CYCN) on Thursday said it would reduce its workforce by about 45% as part of a strategic prioritization to focus its resources on the development of its therapy CY6463 for the treatment of mitochondrial diseases. Shares of the micro-cap clinical-stage biopharma slumped 32% to $0.64 in morning trading. CYCN said it expects to take a one-time charge related to the workforce reduction of about $1.9M that would be incurred primarily in Q4 2022. The company will first concentrate its development of CY6463 for MELAS, which is a mitochondrial disease that primarily affects the nervous system and muscles. CYCN plans to meet with the U.S. FDA in Q4 to discuss the MELAS development program. The company also said it intends to leverage its other clinical assets through licensing agreements and partnership.
Analysis Article Aug 09

We're Keeping An Eye On Cyclerion Therapeutics' (NASDAQ:CYCN) Cash Burn Rate

We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...
Analysis Article Mar 03

We're Keeping An Eye On Cyclerion Therapeutics' (NASDAQ:CYCN) Cash Burn Rate

We can readily understand why investors are attracted to unprofitable companies. For example, although...
Seeking Alpha Oct 26

Cyclerion Therapeutics: Distressed Spinoff Developing New Medicines For CNS Disorders

Cyclerion is a spinoff from Ironwood Pharmaceuticals that has had 2 clinical failures but has a unique lead asset in neurodegeneration. Cyclerion has upcoming phase 2 data coming out in H12022 that will be a major inflection point to potentially open up new opportunities for the distressed company. As a result, the company is one to monitor over the next few months and wait to potentially buy the stock after new clinical data is reported.
Seeking Alpha Jun 21

Cyclerion Therapeutics: Insiders Buying With No Clinical Data Due Until YE 2021

After two candidate failures over the past two years, Cyclerion Therapeutics, Inc. is pinning its hopes on CNS therapy CY6463. The soluble guanylate cyclase modulator is currently undergoing mid-stage evaluation for one CNS indication and should enter a Phase 2 study for another in 2021. With a small market cap and no clinical data due until YE21, yet significant insider buying from the CEO, this busted IPO merited a deeper dive. A full investment analysis is provided in the paragraphs below.
Analysis Article Mar 09

Who Has Been Buying Cyclerion Therapeutics, Inc. (NASDAQ:CYCN) Shares?

It is not uncommon to see companies perform well in the years after insiders buy shares. On the other hand, we'd be...
Analysis Article Jan 28

What Kind Of Shareholders Hold The Majority In Cyclerion Therapeutics, Inc.'s (NASDAQ:CYCN) Shares?

A look at the shareholders of Cyclerion Therapeutics, Inc. ( NASDAQ:CYCN ) can tell us which group is most powerful...
Analysis Article Dec 20

Can You Imagine How Cyclerion Therapeutics' (NASDAQ:CYCN) Shareholders Feel About The 40% Share Price Increase?

The last three months have been tough on Cyclerion Therapeutics, Inc. ( NASDAQ:CYCN ) shareholders, who have seen the...

Revenue & Expenses Breakdown

How Cyclerion Therapeutics makes and spends money. Based on latest reported earnings, on an LTM basis.


Earnings and Revenue History

NasdaqCM:CYCN Revenue, expenses and earnings (USD Millions)
DateRevenueEarningsG+A ExpensesR&D Expenses
31 Mar 262-570
31 Dec 252-460
30 Sep 253-260
30 Jun 252-260
31 Mar 252-350
31 Dec 242-350
30 Sep 240-560
30 Jun 240-1070
31 Mar 240-1170
31 Dec 230-1380
30 Sep 230-15100
30 Jun 23-13100
31 Mar 230-8120
31 Dec 220-18130
30 Sep 221-25140
30 Jun 222-48160
31 Mar 225-51190
31 Dec 214-52210
30 Sep 214-60230
30 Jun 214-68270
31 Mar 211-71270
31 Dec 202-78290
30 Sep 204-85320
30 Jun 205-93280
31 Mar 206-106340
31 Dec 195-123340
30 Sep 193-128320
30 Jun 192-130360
31 Mar 190-12731-22
31 Dec 180-115280
30 Sep 180-1122224
30 Jun 180-1081945
31 Mar 180-991584
31 Dec 170-941579

Quality Earnings: CYCN is currently unprofitable.

Growing Profit Margin: CYCN is currently unprofitable.


Free Cash Flow vs Earnings Analysis


Past Earnings Growth Analysis

Earnings Trend: CYCN is unprofitable, but has reduced losses over the past 5 years at a rate of 60.3% per year.

Accelerating Growth: Unable to compare CYCN's earnings growth over the past year to its 5-year average as it is currently unprofitable

Earnings vs Industry: CYCN is unprofitable, making it difficult to compare its past year earnings growth to the Biotechs industry (54.5%).


Return on Equity

High ROE: CYCN has a negative Return on Equity (-77.69%), as it is currently unprofitable.


Return on Assets


Return on Capital Employed


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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/06/10 23:05
End of Day Share Price 2026/06/10 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Cyclerion Therapeutics, Inc. is covered by 3 analysts. 1 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Pete StavropoulosCantor Fitzgerald & Co.
Joon So LeeTruist Securities
David BautzZacks Small-Cap Research