Seeking Alpha • Jul 08

Compass Pathways: 'Strong Buy' COMP360 Trial Wins And Q4 NDA Full Submission

Summary Compass Pathways plc is upgraded from Hold to Strong Buy following robust phase 3 data for COMP360 in treatment-resistant depression [TRD]. The company's COMP360 met primary endpoints in both the COMP005 and COMP006 studies, demonstrating rapid and durable efficacy out to 26 weeks with infrequent dosing. The FDA granted a rolling NDA review and a Commissioner's National Priority Voucher, potentially shortening the review to 1–2 months; NDA submission completion is expected Q4 2026. The company is well-capitalized with $466M in cash, sufficient to fund operations into 2028, and is also advancing COMP360 for PTSD in late-stage development. Read the full article on Seeking Alpha

Analysis Article • Dec 08

Is COMPASS Pathways (NASDAQ:CMPS) Weighed On By Its Debt Load?

Some say volatility, rather than debt, is the best way to think about risk as an investor, but Warren Buffett famously...

Analysis Article • Aug 07

Is COMPASS Pathways (NASDAQ:CMPS) Using Debt Sensibly?

NasdaqGS:CMPS 1 Year Share Price vs Fair Value Explore COMPASS Pathways's Fair Values from the Community and select...

Seeking Alpha • Feb 28

Compass Pathways: Betting On The Future Of Psilocybin Therapy

Summary Compass Pathways is positioned to leverage regulatory tailwinds and compelling clinical data, despite broader skepticism and high cash burn in the psychedelic biotech sector. The company has a financial cushion with cash reserves of $165.1 million, providing 4-6 quarters of runway before needing additional capital. COMP360 shows promise in treating treatment-resistant depression and PTSD, with significant clinical trial results and potential long-term economic benefits. Regulatory hurdles and scientific doubts remain, but if Compass achieves FDA approval, its current market valuation could be deeply discounted relative to its long-term potential. Read the full article on Seeking Alpha

Analysis Article • Jan 04

Does COMPASS Pathways (NASDAQ:CMPS) Have A Healthy Balance Sheet?

Some say volatility, rather than debt, is the best way to think about risk as an investor, but Warren Buffett famously...

Seeking Alpha • Nov 01

Compass Pathways: Minor Delay Of COMP360 Data Brings About Buy Opportunity

Summary Compass Pathways plc obtained positive results from phase 2b study using COMP360 for treatment resistant depression patients; Primary endpoint met with statistically significant p-value of p<0.001. Top-line results from the phase 3 COMP005 study, using COMP360 for treatment-resistant depression patients, expected in Q2 of 2025. The global treatment-resistant depression treatment market size is projected to grow to $4 billion by 2033. Other indications being explored using COMP360 as a synthetic psilocybin are anorexia nervosa and post-traumatic stress disorder. Read the full article on Seeking Alpha

Seeking Alpha • Aug 19

Compass Pathways: Sector-Wide Reality Check Needed Post FDA Lykos MDMA Decision

Summary The psychedelics sector has suffered a big blow, with the US FDA knocking back a New Drug Application for MDMA-assisted therapy. The potential for a negative FDA decision had been well-flagged by an advisory committee report in June, so the market may have already priced in the downside. Arguments that the negative FDA decision on MDMA may actually be good news for Compass Pathways plc and peers are not persuasive. The FDA decision is not the end of the road for the psychedelics sector, but Compass Pathways and peers face serious challenges regarding regulatory approval, access to capital and commercialization. The group took action to strengthen its balance sheet in 2023, but my cash burn analysis indicates that further capital injections will be needed before the end of 2025. Read the full article on Seeking Alpha

Seeking Alpha • Jul 08

Compass Pathways: Buy It For Its Promising Psychedelic Mental Health Therapies

Summary COMPASS Pathways' lead drug, COMP360, is a synthetic psilocybin in Phase 3 trials for TRD and Phase 2 for PTSD and AN. The company addresses unmet mental health needs through psychedelic therapies. COMP360 showed promising results in Phase 2 trials for PTSD, with significant improvements in depression symptoms. Industry-wide regulatory uncertainties persist, highlighted by the FDA's recent decision against MDMA for PTSD. I believe CMPS is undervalued. Its substantial aggregate TAM and strategic collaborations bode well for potential FDA approval and commercialization. Read the full article on Seeking Alpha

Seeking Alpha • May 23

Psychedelics Closer To Commercialization; Compass Far And Away The Leader

Summary Regulatory risk in the psychedelic industry is decreasing, which is a positive sign for investors. Institutional investors are becoming more willing to invest in leading psychedelic companies through private placements. Analyst Alex Carchidi discusses Compass, Cybin, Atai, and MindMed seeing improvements in their balance sheets and clinical trial data. Read the full article on Seeking Alpha

Seeking Alpha • Apr 25

COMPASS Pathways: Will MDMA-Assisted Therapy Pave The Way Or Slam The Door Shut?

Summary The US FDA is due to make a decision regarding MDMA-assisted therapy in August 2024 – this will be a critical event for the future of COMPASS Pathways. COMPASS Pathways’ share price has exhibited extreme volatility over the last year, highlighting the speculative nature of investing in the psychedelics sector. COMPASS Pathways has experienced delays with its COMP 005 clinical trial, but is confident that its COMP360 New Drug Application timeline remains unchanged. The departure of the company’s co-founders came as a surprise, and follows on from the sudden exit of the group’s CFO in late 2023. Read the full article on Seeking Alpha

Seeking Alpha • Feb 08

Compass Pathways: Psilocybin Developer A Potentially Intriguing, Contrarian Play

Summary Compass Pathways plc, a biotech company based in London, is developing a psilocybin-based therapy for CNS disorders. The company's shares declined by over 80% in 2022 due to safety concerns and regulatory hurdles. Psilocybin is classified as a Schedule I substance in the U.S., posing challenges for commercial marketing in the country. Compass' COMP-360 therapy involves sessions with therapists and digital support, and has met efficacy endpoints in a Phase 2 study. There are multiple reasons to doubt the therapy can be approved, and Compass has a high cash burn, but Phase 3 data due this year may support an approval push, if positive. An interesting contrarian play, for those with a higher appetite for risk. Read the full article on Seeking Alpha

Analysis Article • Dec 06

Companies Like COMPASS Pathways (NASDAQ:CMPS) Are In A Position To Invest In Growth

Just because a business does not make any money, does not mean that the stock will go down. For example, although...

Seeking Alpha • Oct 19

Booker again pushes for easier access to psychedelics for terminally ill patients

Sen. Cory Booker (D-N.J.) is again pushing for easier access to psychedelic drugs, including psilocybin, the active psychedelic compound in "magic mushrooms," and MDMA, for terminally ill patients. In July, Booker and Sen. Rand Paul (R-Ky.) introduced legislation to clarify that the Right to Try Act allows for access to some psychedelics and cannabis. Companion legislation was also filed in the House. In a video posted to Twitter, Booker said that psilocybin and MDMA particularly "are showing incredible results for helping people with PTSD, with trauma, even with anxiety and depression." Several companies are examining psychedelics for mental health disorders, including COMPASS Pathways (NASDAQ:CMPS), Cybin (NYSE:CYBN), atai Life Sciences (NASDAQ:ATAI), and MindMed (NASDAQ:MNMD). Check out why Seeking Alpha contributor Stephen Tobin is bullish on atai Life Sciences (ATAI).

Analysis Article • Aug 13

Here's Why We're Not Too Worried About COMPASS Pathways' (NASDAQ:CMPS) Cash Burn Situation

Just because a business does not make any money, does not mean that the stock will go down. For example, although...

Seeking Alpha • Aug 11

COMPASS Pathways And The Trillion Dollar Opportunity

COMPASS Pathways is developing a psychedelic drug to treat many mental illnesses. The drug appears to be safe and effective for a wide range of mental health problems. If the drug gets authorized and approved, it will be the only available pharmacological treatment for millions and has a chance of generating trillions of dollars in revenue. There is some evidence that the US administration is preparing to authorize and approve the drug within two years. The most challenging-to-treat mental health disorders, including PTSD, major depressive disorders, addictions to alcohol and drugs, anxiety, and eating disorders, lead to the deaths of thousands of people each year and to untold suffering for the patients and their families. Many patients do not respond to current treatments, and no pharmacological therapy is available for many serious mental illnesses. COMPASS Pathways plc (CMPS) is a UK-based company trying to use the Psychedelic drug Psilocybin to treat some of the most challenging mental illnesses. I will present my view that: 1. The drug has an unusually high chance of passing its upcoming phase III trial. 2. The regulatory infrastructure in the U.S. is likely to approve the drug within two years. 3. If approved, the drug will be the first entrant into a multi-trillion dollar total addressable market ("TAM"). Getting Approved To be approved, a drug must be safe to use and effective. That is the purpose of a medical trial. Psychedelic compounds have been used by humans for many years (in some cases, centuries), sometimes as part of religious ceremonies but often for their hallucinogenic properties. Psilocybin is the active ingredient in Magic Mushrooms, extensively used in the past. As a result of this usage we already know two important facts: They are well tolerated by Humans. They affect the way the brain works. Many companies are trying to develop treatments using a variety of psychedelic compounds. I will be working through them and writing about them in the coming months, looking for more to invest in and for those to avoid. In this article, I will be concentrating on COMPASS Pathways. I started my research by examining what medical trials are taking place now and built the following table. Ongoing trials in the field (Author generated) The table is not exhaustive; however, it contains the companies I could find currently running a trial and the drug tested. (Trials of psychedelics in other areas, e.g., severe pain, are also ongoing put not on the table.) The compound with the most trials in place is Psilocybin 9 phase two trials looking at six different mental illnesses. Those six various illnesses represent more than a 350 million patient population. CMPS is running three of these trials. Having decided to look at CMPS, I investigated evidence around its candidate drug COMP360, a proprietary Psilocybin compound. Does Psilocybin Work? A search of the National Library of Medicine delivered 22 hits for Meta-Analysis Psilocybin. (meta-analysis is a research article looking at multiple trials) The latest was from February 2022 and looked at single or multi-dose trials of Psilocybin. It looked at ten studies and reported:- The present study demonstrates that single- or two-dose psilocybin administration has rapid and sustained antidepressant effects for up to 6 months, with favorable cardiovascular safety and acceptability. Of the 22 Meta-Analysis, nine covered depression (three included anxiety), two looked at addiction, one behavioral disorder, five were general reports, and the rest looked at side effects. All 22 studies were positive for Psilocybin, showing very few significant side effects and sustained and significant improvement in all patient populations. One general analysis considered 13 trials between 1969 and 2020, concluding that the different psychedelic drugs have different neuropsychological consequences. It also said Psychedelic compounds have shown the ability to increase neuroplasticity. They offer a chance to alter brain activity, reduce the suffering of victims, and perhaps ultimately a cure to many mental illnesses for a large percentage of sufferers. My study of published meta-analysis suggests that Psilocybin has a pronounced and durable effect on many mental illnesses and has few severe side effects. The problem is that the available studies are not of the standard that the FDA will need to authorize these compounds for use. CMPS Psilocybin drug trials. Last month, COMPASS Pathways released the results of the highly anticipated phase II trial of its Psilocybin assisted therapy. The FDA granted COMPASS Pathways Breakthrough Therapy Designation ((BTD)) in October 2018. It was an important step and means the FDA has been working with CMPS to accelerate the drug's approval process. The BTD followed the 2015 Phase I study when compass dosed 19 patients with its Psilcoybin compound and found promising signals in treatment-resistant depression. A fuller explanation is in this article quoted below The FDA designates a drug as a Breakthrough Therapy if preliminary clinical evidence shows that it may demonstrate substantial improvement over available therapy. Breakthrough Therapies are supported by the FDA throughout the clinical development programme to ensure as efficient a process as possible. In the Phase 2 trial, designed to work out the correct dosage for larger stage 3 trials, CMPS tested its psilocybin formula COMP360 for patients with treatment-resistant depression ((TRD)). TRD patients have tried at least two other forms of treatment without benefit and are considered the hardest subset of major depressive illness patients to treat. Market reaction to Phase II results The market did not receive the trial results well, and the stock price fell. It is my view that the market completely misinterpreted these results. Given that the patient group had already tried two forms of treatment, 25% of them meeting the primary endpoint of a sustained response on the ((MADRS)) scale at 12 weeks is a very positive outcome. It did mean that 75% of patients did not respond, which shows the drug will not be a panacea for eliminating depression, and we do not have data on the durability beyond 12 weeks from this study. However, the results are better than any other treatment for this group of patients. Safety, this again was misinterpreted in my view; five patients reported suicidal ideation or behavior and self-injury. Compass CEO said the five patients were in the non-responder group; The Pollan effect may be the case here. Bearing in mind the nature of the group, this may well explain this negative impact, and COMP360 may not be a cause at all. Patients in the study may have raised their hopes so much that they may have become desperate when the drug did not help them. In April this year, a further study was presented; twelve patients who had previously tried at least five anti-depressant treatments were given a single 25mg dose with therapy support. 58% of patients showed the required MADRS response at 12 weeks and reported no adverse events or suicidal tendencies. CMPS expects to begin the phase III trial in Q3 2022; the protocols have been submitted to the FDA before launching this large-scale multi-center international trial. The results will be pivotal for CMPS, the FDA will approve the drug, or not, when they receive the results. Anorexia Nervosa The preoccupation with weight and shape is one of the most challenging disorders to treat and currently has no pharmacological treatment. In April, COMPASS presented the results of an investigator lead study into Anorexia Nervosa. This serious mental illness carries the highest mortality rate of psychiatric disorders, with up to 40% of deaths coming from suicide. In the trial, 40% of patients experienced clinically significant reductions in eating disorder psychopathology at the 3-month follow-up, and 50% demonstrated statistically significant decreases in eating concerns. 90% of patients thought the treatment had helped them, and no adverse reactions were recorded. COMPASS announced in July 2022 that they would be pressing on with a double-blind, randomized controlled phase II trial of COMP360 in anorexia nervosa. The trial will be of FDA standard and take place in the UK and the US with 60 patients. COMPASS has also initiated a Phase II trial looking at COMP360 with patients who have PTSD. How can one drug be expected to treat all of these different mental disorders? The brain's capacity to change, its neuroplasticity, makes a cure possible. This video explains that Psilocybin affects the serotonin system in the brain, a widespread complex system of receptors of which one, Serotonin 2A, involved in regulating mood, sleep, and thinking process, is affected by Psilocybin. The compound increases the brain's neuroplasticity, allowing different brain regions to connect in new ways; connections causing unhealthy states such as depression and addiction can be reset healthily. The drug allows the brain to reset unhealthy patterns and, as a result, may work on all unhealthy patterns. Which explains the positive effects found in every study in every area investigated.

Seeking Alpha • Aug 03

COMPASS Pathways ADS Q2 2022 Earnings Preview

COMPASS Pathways ADS (NASDAQ:CMPS) is scheduled to announce Q2 earnings results on Wednesday, August 3rd, after market close. The consensus EPS Estimate is -$0.60 (-36.4% Y/Y) and the consensus Revenue Estimate is $0M Over the last 3 months, EPS estimates have seen 5 upward revisions and 0 downward.

Snowflake Score
Valuation	3/6
Future Growth	2/6
Past Performance	0/6
Financial Health	4/6
Dividends	0/6

Historical stock prices
Current Share Price	US$13.64
52 Week High	US$15.40
52 Week Low	US$3.45
Beta	2.49
1 Month Change	23.66%
3 Month Change	146.65%
1 Year Change	271.16%
3 Year Change	50.14%
5 Year Change	-61.05%
Change since IPO	-52.97%

	CMPS	US Biotechs	US Market
7D	0.1%	-2.4%	0.7%
1Y	271.2%	35.9%	20.6%

CMPS volatility
CMPS Average Weekly Movement	16.5%
Biotechs Industry Average Movement	10.4%
Market Average Movement	7.3%
10% most volatile stocks in US Market	16.6%
10% least volatile stocks in US Market	3.2%

CMPS fundamental statistics
Market cap	US$1.84b
Earnings (TTM)	-US$192.36m
Revenue (TTM)	n/a

CMPS income statement (TTM)
Revenue	US$0
Cost of Revenue	US$0
Gross Profit	US$0
Other Expenses	US$192.36m
Earnings	-US$192.36m

Earnings per share (EPS)	-1.43
Gross Margin	0.00%
Net Profit Margin	0.00%
Debt/Equity Ratio	15.5%

Data	Last Updated (UTC time)
Company Analysis	2026/07/10 08:46
End of Day Share Price	2026/07/10 00:00
Earnings	2026/03/31
Annual Earnings	2025/12/31

Package	Data	Timeframe	Example US Source ^*
Company Financials	10 years	Income statement Cash flow statement Balance sheet	SEC Form 10-K SEC Form 10-Q
Analyst Consensus Estimates	+3 years	Forecast financials Analyst price targets	Analyst Research Reports Blue Matrix
Market Prices	30 years	Stock prices Dividends, Splits and Actions	ICE Market Data SEC Form S-1
Ownership	10 years	Top shareholders Insider trading	SEC Form 4 SEC Form 13D
Management	10 years	Leadership team Board of directors	SEC Form 10-K SEC Form DEF 14A
Key Developments	10 years	Company announcements	SEC Form 8-K

Analyst	Institution
Madison Wynne El-Saadi	B. Riley Securities, Inc.
Thomas Shrader	BTIG
Sumant Satchidanand Kulkarni	Canaccord Genuity

COMPASS Pathways (CMPS) Stock Overview

Rewards

Risk Analysis

Analyst Price Targets

Phase III Completion And PTSD Expansion Will Support A Durable Mental Health Franchise

Phase III Progress And PTSD Expansion Will Reshape Long Term Psychedelic Mental Health Treatment

Phase III Trial Dependence Will Dominate Near Term While Long Term Potential Remains

Top Analyst Narratives

Phase III Completion And PTSD Expansion Will Support A Durable Mental Health Franchise

Phase III Progress And PTSD Expansion Will Reshape Long Term Psychedelic Mental Health Treatment

Phase III Trial Dependence Will Dominate Near Term While Long Term Potential Remains

COMPASS Pathways plc Competitors

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Price History & Performance

Recent News & Updates

CMPS: Phase 3 Durability Data Will Underpin Potential 2027 Launch Upside

Price target increased by 9.6% to US$24.47

Compass Pathways: 'Strong Buy' COMP360 Trial Wins And Q4 NDA Full Submission

Compass Pathways Reports Six-Month Data from Second Phase 3 Trial of Comp360 for Treatment-Resistant Depression

Compass Pathways Moves COMP360 Psilocybin Therapy to Final Trials with NDA Planned

COMPASS Pathways Prepares for Commercial Growth as COMP360 Shows Strong Phase 3 Results

Recent updates

CMPS: Phase 3 Durability Data Will Underpin Potential 2027 Launch Upside

Price target increased by 9.6% to US$24.47

Compass Pathways: 'Strong Buy' COMP360 Trial Wins And Q4 NDA Full Submission

Compass Pathways Reports Six-Month Data from Second Phase 3 Trial of Comp360 for Treatment-Resistant Depression

Compass Pathways Moves COMP360 Psilocybin Therapy to Final Trials with NDA Planned

COMPASS Pathways Prepares for Commercial Growth as COMP360 Shows Strong Phase 3 Results

Compass Pathways Reports Phase 3 Success for COMP360 In Treatment-Resistant Depression

Compass Pathways plc Announces Appointment of Kathleen Tregoning to Board of Directors

New minor risk - Profitability

Price target decreased by 12% to US$18.85

COMPASS Pathways plc to Report Q1, 2026 Results on May 13, 2026

Compass Pathways Plc Announces FDA Grants NDA Rolling Review Request And Awards Commissioner's National Priority Voucher

New major risk - Share price stability

Compass Pathways plc Reports Positive Phase 3 Trials and Regulatory Progress for Comp360 Synthetic Psilocybin Treatment

COMPASS Pathways plc, Annual General Meeting, May 27, 2026

Phase III Progress And PTSD Expansion Will Reshape Long Term Psychedelic Mental Health Treatment

New major risk - Shareholder dilution

New major risk - Negative shareholders equity

Phase III Completion And PTSD Expansion Will Support A Durable Mental Health Franchise

Phase III Trial Dependence Will Dominate Near Term While Long Term Potential Remains

New minor risk - Shareholder dilution

COMPASS Pathways plc has completed a Follow-on Equity Offering in the amount of $149.999875 million.

Price target increased by 12% to US$19.42

COMPASS Pathways plc Successfully Achieves Primary Endpoint in Second Phase 3 Trial Evaluating COMP360 Psilocybin for Treatment-Resistant Depression

New minor risk - Share price stability

Compass Pathways plc Announces FDA Acceptance of Ind Application for PTSD

Is COMPASS Pathways (NASDAQ:CMPS) Weighed On By Its Debt Load?

Price target increased by 7.7% to US$16.80

Compass Pathways plc Appoints Jeffrey Jonas to Board of Directors, Effective October 29, 2025

COMPASS Pathways plc to Report Q3, 2025 Results on Nov 04, 2025

Compass Pathways plc Announces Publication of Results from Phase 2 Study of COMP360 Psilocybin for Post-Traumatic Stress Disorder

Is COMPASS Pathways (NASDAQ:CMPS) Using Debt Sensibly?

Price target decreased by 8.2% to US$15.44

Compass Pathways plc Announces Board Changes

COMPASS Pathways plc to Report Q2, 2025 Results on Jul 31, 2025

New major risk - Share price stability

Compass Pathways plc Successfully Achieves Primary Endpoint in First Phase 3 Trial Evaluating COMP360 Psilocybin for Treatment-Resistant Depression

COMPASS Pathways plc has filed a Follow-on Equity Offering in the amount of $150 million.

COMPASS Pathways plc to Report Q1, 2025 Results on May 08, 2025

Compass Pathways plc Announces Dosing Complete for All Participants in Part A of Phase 3 Comp005 Trial of Comp360 Psilocybin for Treatment-Resistant Depression

COMPASS Pathways plc, Annual General Meeting, Jun 12, 2025

Compass Pathways plc Announces Completion of Recruitment for the Phase 3 COMP360 Psilocybin for Treatment-Resistant Depression

Compass Pathways plc Announces Publication of Results from COMP004 Study on COMP360 Psilocybin for Treatment-Resistant Depression

Price target decreased by 8.7% to US$17.56

Compass Pathways: Betting On The Future Of Psilocybin Therapy

COMPASS Pathways plc to Report Q4, 2024 Results on Feb 27, 2025

New major risk - Shareholder dilution

Compass Pathways plc Appoints Steve Levine, M.D., as Chief Patient Officer

compass Pathways plc Announces the Termination of Matthew Allen Owens as A Director

COMPASS Pathways plc has completed a Follow-on Equity Offering in the amount of $149.767589 million.

Does COMPASS Pathways (NASDAQ:CMPS) Have A Healthy Balance Sheet?

New minor risk - Share price stability

Compass Pathways: Minor Delay Of COMP360 Data Brings About Buy Opportunity

COMPASS Pathways plc Announces Business Updates

COMPASS Pathways plc to Report Q3, 2024 Results on Oct 31, 2024