Agios Pharmaceuticals Management
Management criteria checks 4/4
Agios Pharmaceuticals' CEO is Brian Goff, appointed in Aug 2022, has a tenure of 3.92 years. total yearly compensation is $5.37M, comprised of 15.8% salary and 84.2% bonuses, including company stock and options. directly owns 0.31% of the company’s shares, worth $7.90M. The average tenure of the management team and the board of directors is 4.5 years and 3.9 years respectively.
Key information
Brian Goff
Chief executive officer
US$5.4m
Total compensation
| CEO salary percentage | 15.77% |
| CEO tenure | 3.9yrs |
| CEO ownership | 0.3% |
| Management average tenure | 4.5yrs |
| Board average tenure | 3.9yrs |
Recent management updates
Recent updates
Narrative Update • Jul 07
AGIO: Sickle Cell Priority Review Momentum Will Limit Future Share Upside
Agios Pharmaceuticals' fair value estimate has moved from $28.00 to $31.00 as analysts factor in the recent series of higher price targets tied to FDA Priority Review for mitapivat in sickle cell disease, along with expectations for an accelerated launch timeline supported by an expanding hematologist prescriber base. Analyst Commentary Recent Street research on Agios Pharmaceuticals highlights a mix of optimism around mitapivat in sickle cell disease and a more cautious stance on execution risk, label breadth, and broader biotech sector conditions.Analysis Article • Jun 17
Agios Pharmaceuticals (AGIO) Stock Could Be 22% Undervalued After RISE UP Phase 3 Data
Agios Pharmaceuticals (AGIO) stock is back in focus after the company shared detailed 52 week data from its RISE UP Phase 3 trial of mitapivat in sickle cell disease at EHA 2026. See our latest analysis for Agios Pharmaceuticals. Agios Pharmaceuticals shares have recently picked up momentum, with a 7 day share price return of 10.25% and a 30 day share price return of 12.87%. However, the 1 year total shareholder return is still down 10.31%, showing short term enthusiasm against a mixed longer...Narrative Update • Jun 16
AGIO: Sickle Cell FDA Path And Thalassemia Launch Will Restrain Stock Enthusiasm
Analysts have trimmed their average price targets on Agios Pharmaceuticals stock, with recent moves such as JPMorgan's cut to $31 from $36 and BofA's adjustment to $40 from $41. These changes reflect a focus on mitapivat's thalassemia launch, the sickle cell disease regulatory path, and the pipeline changes following tebapivat's discontinued development in lower risk myelodysplastic syndromes.
Narrative Update • Jun 02
AGIO: Sickle Cell FDA Path And Thalassemia Launch Will Drive Next Phase Upside
Agios Pharmaceuticals' updated analyst price target has shifted slightly lower to $40.88 from $41.13, as analysts factor in the tebapivat setback and refocus their models on mitapivat launch execution and the sickle cell disease regulatory path. Analyst Commentary Recent Street research on Agios Pharmaceuticals highlights a split view, with some analysts focusing on potential value from mitapivat and regulatory milestones, while others concentrate on pipeline setbacks, competitive pressures and addressable market questions.Seeking Alpha • May 29
Agios: 'Sell' On Tebapivat Setback LR-MDS And Competitive PK Activator Drug Class
Summary Agios Pharmaceuticals, Inc. is initiated at Sell due to pipeline setbacks and intensifying competition in PK activators. AGIO discontinued tebapivat in LR-MDS after failing a phase 2b threshold, leaving SCD as its primary near-term catalyst. Novo Nordisk's etavopivat has achieved positive phase 3 SCD results and is expected to file for approval in the 2nd half of 2026. Despite $1B in cash, company faces uncertain differentiation and commercial prospects for tebapivat in SCD, with current sales momentum limited in PYRUKYND and AQVESME. Read the full article on Seeking AlphaNarrative Update • May 18
AGIO: FDA Sickle Cell Decision And Trial Data Will Shape Next Phase Upside
Analysts have trimmed their consolidated price target for Agios Pharmaceuticals by about $0.40 to roughly $41.10. This reflects updated assumptions on market size, profit margins and future P/E after a mix of recent target cuts and raises across the Street.Narrative Update • May 01
AGIO: Sickle Cell FDA Path And Novo Readthroughs Will Shape Future Enthusiasm
Analysts have adjusted their outlook on Agios Pharmaceuticals with a modestly lower average price target, reflecting updated assumptions around discount rates, revenue growth, profit margins and future P/E following recent mixed research, including several target cuts tied to Novo Nordisk related market views and earlier target hikes linked to potential regulatory catalysts for mitapivat. Analyst Commentary Recent Street research on Agios Pharmaceuticals shows a mix of optimism around potential regulatory catalysts for mitapivat and caution around market sizing and competitive readthroughs, particularly following data points tied to Novo Nordisk.Narrative Update • Apr 16
AGIO: Sickle Cell Regulatory Uncertainty Will Continue To Restrain Enthusiasm
Analysts have raised their price target on Agios Pharmaceuticals by $3 to a new fair value estimate of $28, citing recent target increases from major firms and growing attention on upcoming regulatory and clinical catalysts. Analyst Commentary Recent Street research on Agios Pharmaceuticals reflects a mix of optimism around upcoming regulatory events and ongoing caution around execution risks, valuation and timing of potential catalysts.Narrative Update • Apr 02
AGIO: Upcoming Regulatory Decisions In Sickle Cell Disease Will Drive Next Phase Upside
Analysts have adjusted the fair value estimate for Agios Pharmaceuticals to $41.50 from $39.88, citing updated price targets and expectations tied to upcoming regulatory clarity on mitapivat, as well as broader support from recent research commentary. Analyst Commentary Recent Street research on Agios Pharmaceuticals centers on price target revisions, expectations around regulatory clarity for mitapivat in sickle cell disease, and the implications of the recent approval of Aqvesme.Narrative Update • Mar 18
AGIO: Regulatory Clarity On Mitapivat In Sickle Cell Disease Will Drive Next Phase Upside
Analysts have lifted the fair value estimate for Agios Pharmaceuticals by $1 to $39.88, citing higher price targets, expectations for regulatory clarity around mitapivat in sickle cell disease, and the recent approval of Aqvesme as key drivers of their updated outlook. Analyst Commentary Recent Street research reflects a mix of optimism and caution around Agios Pharmaceuticals, with several price target revisions clustering in the US$25 to US$46 range and commentary centered on regulatory milestones, the impact of Aqvesme, and broader biotech sector conditions.Narrative Update • Mar 04
AGIO: Thalassemia Decision And Recent Approval Will Drive Next Phase Upside
Analysts have nudged their intrinsic value estimate for Agios Pharmaceuticals higher to about $38.88 from $36.75, reflecting refreshed price targets in the $25 to $35 range and updated models following recent product approval and broader biotech sector tailwinds cited in recent research. Analyst Commentary Bullish Takeaways Bullish analysts are lifting price targets into the mid US$20s to mid US$30s, which aligns with the higher intrinsic value estimate around US$38.88 and indicates they see room for the shares to better reflect updated assumptions.Narrative Update • Feb 18
AGIO: Sickle Cell Setback Will Continue To Restrain Enthusiasm Despite Thalassemia Approval
Analysts have lifted their fair value estimate for Agios Pharmaceuticals shares from $20 to $25, citing updated models that reflect recent drug approvals, ongoing FDA review milestones, and a series of higher Street price targets across the biotech sector. Analyst Commentary Recent Street research on Agios Pharmaceuticals reflects a split view, with several bullish initiations and target hikes alongside more cautious revisions that highlight execution and growth risks around the company’s pipeline and commercial plans.Narrative Update • Feb 03
AGIO: Thalassemia Decision And Aqvesme Approval Will Define Post RISE UP Upside
Narrative Update: Agios Pharmaceuticals (AGIO) Analysts have lifted Agios Pharmaceuticals' price targets into a US$25 to US$38 range, with recent tweaks to models reflecting the approval of Aqvesme, updated views on mitapivat and Pyrukynd, and a generally more constructive stance on U.S. biotech capital and deal activity. Analyst Commentary Recent Street research on Agios Pharmaceuticals shows a wide spread of views, with price targets clustered in the US$25 to US$38 range after earlier cuts from much higher levels.Narrative Update • Jan 20
AGIO: Upcoming Thalassemia Decision Will Shape Post RISE UP Opportunity Narrative
Agios Pharmaceuticals’ fair value estimate edges up from US$36.00 to US$36.75 as analysts recalibrate models following recent target changes across the Street, reflecting updated views on Pyrukynd’s opportunity set, revised profit margin assumptions, and a higher future P/E multiple, despite some ongoing trial related uncertainties. Analyst Commentary Street research around Agios has become more divided, with some analysts leaning into the updated opportunity around Pyrukynd and other mitapivat indications, while others focus on execution risk and regulatory uncertainty following the RISE UP sickle cell disease data.Narrative Update • Jan 06
AGIO: Upcoming FDA Thalassemia Decision Will Shape Post RISE UP Bullish Outlook
Analysts have lifted their aggregate fair value estimate for Agios Pharmaceuticals to $36.00 from $32.13, citing updated revenue and margin assumptions. This follows mixed views on the recent RISE UP data and new Street targets that range widely from US$20 to US$48, alongside Citi's fresh US$38 initiation and a near-term FDA catalyst watch.Narrative Update • Dec 18
AGIO: Sickle Cell Setback Will Drive Cautious View Despite Upcoming FDA Decision
Analysts have cut their average price target on Agios Pharmaceuticals to $20 from $37, reflecting reduced expectations for mitapivat in sickle cell disease and more conservative long term revenue and expense assumptions, even as some still see upside around upcoming regulatory catalysts for Pyrukynd. Analyst Commentary Bearish analysts have responded to the RISE UP data by sharply recalibrating expectations for mitapivat in sickle cell disease, cutting price targets and, in some cases, ratings.Narrative Update • Dec 04
AGIO: Upcoming FDA Decision Will Drive Bullish Outlook After Mixed Trial Data
Analysts have reduced their average price target on Agios Pharmaceuticals from about $42 to roughly $32 per share. This reflects higher perceived risk after mixed Phase 3 RISE UP data, tempered revenue and margin expectations, and a wider debate over the regulatory and commercial outlook for mitapivat and Pyrukynd across indications.Narrative Update • Nov 20
AGIO: Regulatory Decisions Will Drive Outlook After Mixed Late-Stage Clinical Results
Agios Pharmaceuticals’ analyst price target has been reduced from approximately $47.50 to $42.33 per share. Analysts cite increased uncertainty for mitapivat in sickle cell disease following underwhelming Phase 3 trial results, as well as a more challenging regulatory and commercial pathway.Narrative Update • Sep 05
FDA Approval And Global Partnerships Will Yield Mixed Prospects
Analysts modestly trimmed Agios Pharmaceuticals’ price target from $47.67 to $47.50, reflecting a brief FDA approval delay for Pyrukynd and cautious near-term modeling, while maintaining long-term conviction on the strength of clinical data and emerging commercial partnerships. Analyst Commentary Bullish analysts remain confident in FDA approval of Pyrukynd despite a three-month PDUFA delay due to the submission of a REMS for hepatocellular injury, which is viewed as a standard regulatory step and not due to new data requests.Analysis Article • Feb 20
Why Agios Pharmaceuticals' (NASDAQ:AGIO) Earnings Are Weaker Than They Seem
We didn't see Agios Pharmaceuticals, Inc.'s ( NASDAQ:AGIO ) stock surge when it reported robust earnings recently. We...Seeking Alpha • Feb 14
Agios Pharmaceuticals: Liver Toxicity Issues May Threaten Thalassemia Approval (Rating Downgrade)
Summary Agios Pharmaceuticals' focus is on expanding Pyrukund's label to treat thalassemia and sickle cell disease, targeting multi-billion dollar markets. Despite promising Phase 3 results, safety concerns, namely liver injury, have impacted Agios' stock and could affect Pyrukund's approval and market adoption. Agios has a strong cash position of $1.5bn and potential blockbuster revenue opportunity, but safety issues warrant a cautious "Hold" rating. Monitoring progress and awaiting further clarity on safety issues and FDA decisions is advisable before making investment moves. Read the full article on Seeking Alpha
New Narrative • Feb 09
Mitapivat May Launch In 2025 For Blood Disorders But Faces Regulatory And Competition Challenges
Mitapivat's launch in thalassemia and sickle cell markets promises revenue growth from new opportunities, leveraging positive Phase III data for adoption.Seeking Alpha • Jan 14
Agios Pharmaceuticals: Considering Risk/Reward Ahead Of FDA Decision
Summary Agios Pharma submitted a sNDA to the FDA after two Phase III trials studying PYRUKYND (mitapivat) in thalassemia met their primary endpoints last year. The FDA has set a goal date of Sept. 7th 2025 to review the application and render a decision. Agios is well capitalized after $1.1 billion in milestones following the FDA's approval of vorasidenib, a drug divested when the company exited oncology in 2021. A third Phase III study named RISE UP has recruited patients to study PYRUKYND in sickle cell disease with results due in late-2025. Agios Pharma is rated a HOLD until further clarity on the commercialization of PYRUKYND occurs later this year. Read the full article on Seeking AlphaSeeking Alpha • Dec 03
Agios Pharmaceuticals: A Long Overdue Follow Up
Summary Today, we take a deeper look at commercial stage biopharma firm Agios Pharmaceuticals for the first time in more than two years. The shares have spiked up recently thanks in a large part to a huge cash infusion the company received in August. The company's one approved product on the market, PYRUKYND, has seen limited sales to date, but the compound is being evaluated to treat much larger potential indications. Read the full article on Seeking AlphaAnalysis Article • Sep 26
We're Not Very Worried About Agios Pharmaceuticals' (NASDAQ:AGIO) Cash Burn Rate
Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...Seeking Alpha • Aug 27
Agios' Mitapivat: A Potential Blockbuster In Thalassemia Treatment
Summary Agios’ Pyrukynd is FDA-approved for pyruvate kinase deficiency but generated modest sales of $8.6 million in Q2 2024. Mitapivat shows promise in treating SCD and thalassemia, with ongoing Phase 3 trials showing positive results for hemoglobin improvement. Expanding Pyrukynd’s label to include pediatric and thalassemia indications is crucial, with regulatory filings expected by 2025. Agios has a strong financial position, with a cash runway extending beyond 2027, bolstered by milestone payments. Despite risks, Agios’ mitapivat could become a blockbuster drug, making AGIO a compelling buy for biotech investors. Read the full article on Seeking AlphaAnalysis Article • Aug 04
Agios Pharmaceuticals, Inc. (NASDAQ:AGIO) Just Released Its Second-Quarter Earnings: Here's What Analysts Think
Agios Pharmaceuticals, Inc. ( NASDAQ:AGIO ) just released its latest second-quarter report and things are not looking...CEO Compensation Analysis
| Date | Total Compensation | Salary | Company Earnings |
|---|---|---|---|
| Mar 31 2026 | n/a | n/a | -US$423m |
| Dec 31 2025 | US$5m | US$847k | -US$413m |
| Sep 30 2025 | n/a | n/a | -US$401m |
| Jun 30 2025 | n/a | n/a | US$650m |
| Mar 31 2025 | n/a | n/a | US$666m |
| Dec 31 2024 | US$7m | US$822k | US$674m |
| Sep 30 2024 | n/a | n/a | US$674m |
| Jun 30 2024 | n/a | n/a | -US$365m |
| Mar 31 2024 | n/a | n/a | -US$353m |
| Dec 31 2023 | US$3m | US$798k | -US$352m |
| Sep 30 2023 | n/a | n/a | -US$220m |
| Jun 30 2023 | n/a | n/a | -US$210m |
| Mar 31 2023 | n/a | n/a | -US$218m |
| Dec 31 2022 | US$12m | US$308k | -US$232m |
Compensation vs Market: Brian's total compensation ($USD5.37M) is about average for companies of similar size in the US market ($USD6.98M).
Compensation vs Earnings: Brian's compensation has been consistent with company performance over the past year.
CEO
Brian Goff (57 yo)
3.9yrs
Tenure
US$5,370,389
Compensation
Mr. Brian M. Goff, M.B.A., is Independent Director of Intellia Therapeutics, Inc. since June 2024. He has been Chief Executive Officer and Director at Agios Pharmaceuticals, Inc. since August 08, 2022. He...
Leadership Team
| Name | Position | Tenure | Compensation | Ownership |
|---|---|---|---|---|
| CEO & Director | 3.9yrs | US$5.37m | 0.31% $ 7.9m | |
| Chief Financial Officer | 3.8yrs | US$2.52m | 0.092% $ 2.4m | |
| Chief Strategy & Operations Officer | no data | US$2.81m | 0.017% $ 440.0k | |
| Chief Legal Officer | 4.5yrs | US$2.37m | 0.083% $ 2.1m | |
| Chief Medical Officer and Head of Research & Development | 4.8yrs | US$2.09m | 0.14% $ 3.6m | |
| Co-Founder | no data | US$333.51k | no data | |
| Co-Founder | no data | no data | no data | |
| Co-Founder | no data | no data | no data | |
| Co-Founder | no data | no data | no data | |
| VP, Controller & Principal Accounting Officer | 4.9yrs | no data | 0.0015% $ 37.2k | |
| Vice President of Investor Relations | no data | no data | no data | |
| Vice President of Sales | no data | no data | no data |
4.5yrs
Average Tenure
54yo
Average Age
Experienced Management: AGIO's management team is considered experienced (4.5 years average tenure).
Board Members
| Name | Position | Tenure | Compensation | Ownership |
|---|---|---|---|---|
| CEO & Director | 3.9yrs | US$5.37m | 0.31% $ 7.9m | |
| Chair of the Board of Directors | 8.6yrs | US$492.16k | 0.26% $ 6.6m | |
| Independent Director | 3.1yrs | US$469.66k | 0.018% $ 464.9k | |
| Lead Independent Director | 11.6yrs | US$498.41k | 0.021% $ 534.2k | |
| Independent Director | 1yr | US$657.15k | no data | |
| Independent Director | 11.1yrs | US$464.66k | 0.033% $ 849.2k | |
| Independent Director | 3.9yrs | US$467.16k | 0.026% $ 651.7k | |
| Independent Director | 3.9yrs | US$467.16k | 0.026% $ 651.7k | |
| Independent Director | 9.2yrs | US$469.66k | 0.034% $ 873.6k | |
| Independent Director | 3.1yrs | US$458.41k | 0.018% $ 464.9k |
3.9yrs
Average Tenure
63yo
Average Age
Experienced Board: AGIO's board of directors are considered experienced (3.9 years average tenure).
Company Analysis and Financial Data Status
| Data | Last Updated (UTC time) |
|---|---|
| Company Analysis | 2026/07/10 21:26 |
| End of Day Share Price | 2026/07/10 00:00 |
| Earnings | 2026/03/31 |
| Annual Earnings | 2025/12/31 |
Data Sources
The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.
| Package | Data | Timeframe | Example US Source * |
|---|---|---|---|
| Company Financials | 10 years |
| |
| Analyst Consensus Estimates | +3 years |
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| Market Prices | 30 years |
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| Ownership | 10 years |
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| Management | 10 years |
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| Key Developments | 10 years |
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* Example for US securities, for non-US equivalent regulatory forms and sources are used.
Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.
Analysis Model and Snowflake
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Industry and Sector Metrics
Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.
Analyst Sources
Agios Pharmaceuticals, Inc. is covered by 28 analysts. 10 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.
| Analyst | Institution |
|---|---|
| Peter Lawson | Barclays |
| George Farmer | BMO Capital Markets Equity Research |
| Alec Stranahan | BofA Global Research |