Stock Analysis

Guardant Health (GH): Examining Valuation Following a 50% One-Month Share Price Surge

Guardant Health (GH) shares have seen significant movement lately, catching the attention of investors interested in innovative healthcare stocks. Over the past month, the stock has surged around 50 percent, reflecting a busy stretch for the genomics firm.

See our latest analysis for Guardant Health.

Guardant Health’s recent rally caps off an extraordinary year, as the company’s 1-year total shareholder return has soared 211.6 percent. The strong 30-day share price return hints at growing investor optimism around its future growth story. Momentum is clearly building, fueled by upbeat sentiment following recent milestones and continued interest in genomics innovation.

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With shares posting impressive gains but still trading at a modest discount to analyst targets, investors are left to wonder: is there more upside ahead, or has the market already factored in Guardant Health’s potential?

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Most Popular Narrative: 30% Overvalued

Guardant Health's most closely followed narrative sees its fair value as meaningfully lower than today's $94.13 share price. This suggests the market has factored in a very bullish outlook for future growth and margins. This perspective leans heavily on ambitious targets out to 2028 and highlights the importance of sustained execution across new diagnostic platforms and increased adoption in oncology and broader screening markets.

"Accelerating adoption of non-invasive blood-based cancer diagnostics is driving substantial growth across Guardant Health's key product lines (Guardant360 Liquid, Reveal, and Shield), expanding the company's total addressable market and supporting high double-digit revenue growth, with continued strong volume momentum and share gains documented for both new and established oncology applications."

Read the complete narrative.

Curious what propels such a lofty fair value? The narrative hinges on robust revenue expansion, a massive shift in profit margins, and a future earnings multiple usually reserved for elite growth stocks. Think you know what assumptions are baked in? Bold analyst forecasts and a profit trajectory few companies achieve are at the core. Unlock the full breakdown behind this aggressive valuation.

Result: Fair Value of $93.82 (OVERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, some caution is warranted, as ongoing high R&D spending and unpredictable reimbursement decisions could still present challenges to Guardant Health's path to sustained profits and growth.

Find out about the key risks to this Guardant Health narrative.

Another View: DCF Model Shows Deep Undervaluation

Looking beyond the fair value estimate based on future earnings multiples, our SWS DCF model presents a notably different perspective. According to this method, Guardant Health is trading at a steep 61.9% discount to its calculated fair value. This suggests there could be significant upside potential if long-term growth materializes. Which approach will prove more accurate as the company’s story unfolds?

Look into how the SWS DCF model arrives at its fair value.

GH Discounted Cash Flow as at Nov 2025
GH Discounted Cash Flow as at Nov 2025

Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Guardant Health for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover 870 undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match - so you never miss a potential opportunity.

Build Your Own Guardant Health Narrative

If you want to dig into the numbers or believe there’s more to the story, dive in yourself and craft your perspective. It takes less than three minutes. Do it your way

A great starting point for your Guardant Health research is our analysis highlighting 2 key rewards and 3 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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