Ultragenyx Pharmaceutical Management

Management criteria checks 2/4

Ultragenyx Pharmaceutical's CEO is Emil Kakkis, appointed in Apr 2010, has a tenure of 14.58 years. total yearly compensation is $13.08M, comprised of 6.3% salary and 93.7% bonuses, including company stock and options. directly owns 2.91% of the company’s shares, worth MX$2.60B. The average tenure of the management team and the board of directors is 8.9 years and 8.6 years respectively.

Key information

Emil Kakkis

Chief executive officer

US$13.1m

Total compensation

CEO salary percentage	6.3%
CEO tenure	14.6yrs
CEO ownership	2.9%
Management average tenure	8.9yrs
Board average tenure	8.6yrs

Recent management updates

Recent updates

CEO Compensation Analysis

How has Emil Kakkis's remuneration changed compared to Ultragenyx Pharmaceutical's earnings?
Date	Total Compensation	Salary	Company Earnings
Sep 30 2024	n/a	n/a	-US$559m
Jun 30 2024	n/a	n/a	-US$585m
Mar 31 2024	n/a	n/a	-US$613m
Dec 31 2023	US$13m	US$824k	-US$607m
Sep 30 2023	n/a	n/a	-US$635m
Jun 30 2023	n/a	n/a	-US$721m
Mar 31 2023	n/a	n/a	-US$719m
Dec 31 2022	US$12m	US$796k	-US$707m
Sep 30 2022	n/a	n/a	-US$678m
Jun 30 2022	n/a	n/a	-US$506m
Mar 31 2022	n/a	n/a	-US$470m
Dec 31 2021	US$10m	US$769k	-US$454m
Sep 30 2021	n/a	n/a	-US$356m
Jun 30 2021	n/a	n/a	-US$351m
Mar 31 2021	n/a	n/a	-US$204m
Dec 31 2020	US$5m	US$759k	-US$187m
Sep 30 2020	n/a	n/a	-US$256m
Jun 30 2020	n/a	n/a	-US$301m
Mar 31 2020	n/a	n/a	-US$425m
Dec 31 2019	US$7m	US$714k	-US$403m
Sep 30 2019	n/a	n/a	-US$397m
Jun 30 2019	n/a	n/a	-US$371m
Mar 31 2019	n/a	n/a	-US$325m
Dec 31 2018	US$5m	US$680k	-US$198m
Sep 30 2018	n/a	n/a	-US$192m
Jun 30 2018	n/a	n/a	-US$183m
Mar 31 2018	n/a	n/a	-US$204m
Dec 31 2017	US$7m	US$638k	-US$302m

Compensation vs Market: Emil's total compensation ($USD13.08M) is above average for companies of similar size in the MX market ($USD1.26M).

Compensation vs Earnings: Emil's compensation has increased whilst the company is unprofitable.

CEO

Emil Kakkis (64 yo)

14.6yrs

Tenure

US$13,077,993

Compensation

Dr. Emil D. Kakkis, M.D., Ph D., is Executive Director of Amlogenyx Inc. Dr. Kakkis has been a Director of Actio Biosciences Inc. since July 2024. He is Venture Advisor of Forge Life Science Partners.He i...

Leadership Team

Name	Position	Tenure	Compensation	Ownership
Emil Kakkis	Founder	14.6yrs	US$13.08m	2.91% MX$ 2.6b
Howard Horn	Executive VP of Corporate Strategy & CFO	1.1yrs	US$5.94m	0.014% MX$ 12.2m
Karah Parschauer	Chief Legal Officer & Executive VP of Corporate Affairs	8.4yrs	US$4.04m	0.017% MX$ 14.9m
John Pinion	Chief Quality Operations Officer & Executive VP of Translational Sciences	9.3yrs	US$4.05m	0.050% MX$ 45.2m
Erik Harris	Executive VP & Chief Commercial Officer	no data	US$4.07m	0.025% MX$ 22.2m
Theodore Huizenga	Senior VP	10.8yrs	no data	0.019% MX$ 17.3m
Ernie Meyer	Chief Human Resources Officer & Executive VP	4.2yrs	no data	no data
Thomas Kassberg	Chief Business Officer & Executive VP	13yrs	US$2.46m	0.23% MX$ 203.9m
Vimal Srivastava	Senior Vice President of Business Development & Alliance Management	6.7yrs	no data	no data
Dennis Huang	Chief Technical Operations Officer and Executive VP of Gene Therapy Research & Development	9.5yrs	US$4.24m	0.044% MX$ 39.1m
Aaron Olsen	Senior Vice President of Corporate Strategy & Finance	no data	no data	no data
Eric Crombez	Chief Medical Officer & Executive VP	1.5yrs	no data	0.020% MX$ 17.8m

8.9yrs

Average Tenure

58yo

Average Age

Experienced Management: RARE *'s management team is seasoned and experienced (8.9 years average tenure).

Board Members

Name	Position	Tenure	Compensation	Ownership
Emil Kakkis	Founder	14.6yrs	US$13.08m	2.91% MX$ 2.6b
Daniel Welch	Independent Non-Executive Chairman	9.6yrs	US$499.89k	0.023% MX$ 21.0m
Matthew Fust	Independent Director	10.8yrs	US$479.89k	0.016% MX$ 14.4m
Shehnaaz Suliman	Independent Director	5.8yrs	US$466.89k	0.016% MX$ 14.4m
Deborah Dunsire	Independent Director	7.6yrs	US$459.89k	0.021% MX$ 19.1m
Corazon Sanders	Independent Director	3.4yrs	US$469.39k	0.0058% MX$ 5.2m
Michael Narachi	Independent Director	9.8yrs	US$482.39k	0.023% MX$ 21.0m
Amrit Ray	Independent Director	2.6yrs	US$460.39k	0.011% MX$ 10.3m

8.6yrs

Average Tenure

63yo

Average Age

Experienced Board: RARE *'s board of directors are considered experienced (8.6 years average tenure).

Ultragenyx Pharmaceutical Management

Management criteria checks 2/4

Key information

Recent management updates

Insufficient new directors

Ultragenyx Pharmaceutical Inc., Annual General Meeting, Jun 18, 2024

Ultragenyx Pharmaceutical Inc. Announces Appointment of Howard Horn as Chief Financial Officer, Effective October 16, 2023

Chief Medical Officer & Executive VP recently sold Mex$3.2m worth of stock

Ultragenyx Pharmaceutical Inc. Announces Departure of Mardi Dier, Executive Vice President

Executive VP & CFO recently sold Mex$2.7m worth of stock

Recent updates

Ultragenyx Pharmaceutical Inc. Presents Positive Update on GTX-102 Angelman Syndrome Program at FAST’s 17th Annual Global Science Summit

Third quarter 2024 earnings released: US$1.40 loss per share (vs US$2.23 loss in 3Q 2023)

Ultragenyx Pharmaceutical Inc. Reaffirms Earnings Guidance for the Full Year 2024

Insufficient new directors

Ultragenyx Pharmaceutical Inc. Receives Breakthrough Therapy Designation for Setrusumab (UX143) in Osteogenesis Imperfecta

Ultragenyx Pharmaceutical Inc. Provides Update on Stage 1 Cohorts in Pivotal Phase 1/2/3 Cyprus2+ Study Evaluating UX701 Gene Therapy for the Treatment of Wilson Disease

Ultragenyx Pharmaceutical Inc. Increases Revenue Guidance for the Year 2024

Ultragenyx Pharmaceutical Inc. Announces Successful End-Of-Phase 2 Meeting with Fda for Gtx-102 Angelman Syndrome Program

Ultragenyx Pharmaceutical Inc. has completed a Follow-on Equity Offering in the amount of $350.000022 million.

Ultragenyx Pharmaceutical Inc. Announces Successful Meeting with the FDA

Ultragenyx Pharmaceutical Inc. and Mereo BioPharma Group plc Announce Positive 14-Month Results from the Phase 2 Portion of the Ongoing Phase 2/3 Orbit Study

Ultragenyx Pharmaceutical Inc. Announces Positive Top-Line Results from Phase 3 Study of DTX401 Gene Therapy for Glycogen Storage Disease Type Ia (GSDIa)

Ultragenyx Pharmaceutical Inc. Reaffirms Earnings Guidance for the Year 2024

Ultragenyx Pharmaceutical Inc. Announces Completion of Enrollment in Phase 3 Orbit and Cosmic Studies Evaluating Setrusumab (UX143) for the Treatment of Osteogenesis Imperfecta (OI)

Ultragenyx Pharmaceutical Inc., Annual General Meeting, Jun 18, 2024

Ultragenyx Pharmaceutical Inc. Announces Positive Interim Phase 1/2 Data in Patients with Angelman Syndrome After Treatment with GTX-102

Ultragenyx Pharmaceutical Inc. has filed a Follow-on Equity Offering in the amount of $350 million.

Ultragenyx Pharmaceutical Inc. Reaffirms Earnings Guidance for the Full Year 2024

Ultragenyx Pharmaceutical Inc. Announces Data Demonstrating Treatment with UX111 Results in Significant Reduction in Heparan Sulfate Exposure in Cerebrospinal Fluid Correlated with Improved Long-term Cognitive Function in Patients with Sanfilippo Syndrome Type A (MPS IIIA)

Ultragenyx Pharmaceutical Inc. Announces Completion of Dosing Across Stage 1 Cohorts in Pivotal Phase 1/2/3 Cyprus2+ Study Evaluating UX701 Gene Therapy for the Treatment of Wilson Disease

Mereo Biopharma Group plc Provides Update on Pipeline Progress and Corporate Developments

Ultragenyx Pharmaceutical Inc. Provides Revenue Guidance for 2024

Ultragenyx Receives European Commission Decision for Evkeeza® (evinacumab) Expanded Indication in Children Aged 5 Years and Older with Homozygous Familial Hypercholesterolemia (HoFH)

Ultragenyx Pharmaceutical Inc. Provides Earnings Guidance for the Full Year 2023

Third quarter 2023 earnings released: US$2.23 loss per share (vs US$3.50 loss in 3Q 2022)

Ultragenyx Pharmaceutical Inc. Announces Program and Pipeline Updates At Analyst Day Including Interim Data from Ongoing Studies in Osteogenesis Imperfecta (Oi), Angelman Syndrome (As) and Wilson Disease

Ultragenyx and Mereo BioPharma Announce Interim Phase 2 Data from Phase 2/3 Orbit Study Demonstrating Setrusumab (UX143) Significantly Reduced Fracture Rates in Patients with Osteogenesis Imperfecta (OI)

Ultragenyx Pharmaceutical Inc. Launches Evkeeza (Enacumab for Injection) in Canada for the Treatment of Homozygous Familial Hypercholesterolemia (HoFH)

Second quarter 2023 earnings released: US$2.25 loss per share (vs US$2.26 loss in 2Q 2022)

Ultragenyx Pharmaceutical Inc. Reaffirms Earnings Guidance for the Full Year 2023

Ultragenyx Pharmaceutical Inc. Announces Initiation of Dosing in Second Cohort of Pivotal Phase 1/2/3 Cyprus2+ Trial Evaluating UX701 Gene Therapy for the Treatment of Wilson Disease

Ultragenyx Pharmaceutical Inc. Announces Appointment of Howard Horn as Chief Financial Officer, Effective October 16, 2023

Ultragenyx Announces First Patients Dosed in Phase 3 Program Evaluating Setrusumab (UX143) for the Treatment of Osteogenesis Imperfecta (OI)

Ultragenyx Pharmaceutical Inc.(NasdaqGS:RARE) dropped from Russell Small Cap Comp Value Index

Ultragenyx Pharmaceutical Inc. Announces Data from the Dose- Selection Phase 2/3 Orbit Study

Ultragenyx Pharmaceutical Inc. Announces U.S. Food and Drug Administration Reviews and Agrees to Protocol Amendment to the Phase 1/2 Study of GTX-102

Ultragenyx Pharmaceutical Inc. Announces Upcoming Data Presentations at American Society of Gene & Cell Therapy 2023 Annual Meeting

First quarter 2023 earnings released: US$2.33 loss per share (vs US$2.19 loss in 1Q 2022)

Ultragenyx Pharmaceutical Inc. Reaffirms Earning Guidance for the Full Year 2023

Chief Medical Officer & Executive VP recently sold Mex$3.2m worth of stock

Ultragenyx Pharmaceutical Inc. Reaffirms Full Year Earnings Guidance for the Year 2023

Ultragenyx Pharmaceutical Inc. Provides Revenue Guidance for the Year 2022 and 2023

Ultragenyx Pharmaceutical Inc. Announces Departure of Mardi Dier, Executive Vice President

Third quarter 2022 earnings released: US$3.50 loss per share (vs US$1.08 loss in 3Q 2021)

Ultragenyx Pharmaceutical Inc. Provides Revenue Guidance for 2022

Executive VP & CFO recently sold Mex$2.7m worth of stock

Second quarter 2022 earnings released: US$2.26 loss per share (vs US$1.81 loss in 2Q 2021)

Ultragenyx Pharmaceutical Inc. (NasdaqGS:RARE) acquired GeneTx Biotherapeutics LLC from Foundation for Angelman Syndrome Therapeutics and others for $190 million.

Ultragenyx Pharmaceutical Inc. (NasdaqGS:RARE) acquired GeneTx Biotherapeutics LLC from Foundation for Angelman Syndrome Therapeutics and others for $190 million.

Executive VP & Chief Commercial Officer recently sold Mex$331k worth of stock

Ultragenyx Pharmaceutical Inc. Announces Positive Longer-Term Durability Data from Two Phase 1/2 Gene Therapy Studies

First quarter 2022 earnings released: US$2.19 loss per share (vs US$2.03 loss in 1Q 2021)

Ultragenyx Pharmaceutical Inc. Provides Revenue Guidance for the Financial Year 2022

Ultragenyx Pharmaceutical Inc. Announces the Appointment of Amrit Ray to Board of Directors

Ultragenyx Announces First Patient Dosed in Pivotal Phase 2/3 Clinical Study of Setrusumab (UX143) for the Treatment of Osteogenesis Imperfecta

Insufficient new directors

Ultragenyx Pharmaceutical Inc. Reaffirms Revenue Guidance for the Year 2022

Insufficient new directors

Ultragenyx Pharmaceutical Inc. Provides Earnings Guidance for the Year 2022

GeneTx Biotherapeutics LLC and Ultragenyx Pharmaceutical Inc. Provides Preliminary Update on Phase 1/2 Clinical Study of GTX-102 in Canada and U.K. Patients with Angelman Syndrome

Ultragenyx Pharmaceutical Inc. Announces First Patient Dosed in Phase 1/2 Clinical Study of UX053, an mRNA Therapy for the Treatment of Glycogen Storage Disease Type III

Ultragenyx Pharmaceutical Inc. Announces New Long-Term Durability Data from Phase 1/2 Studies of DTX401 for Glycogen Storage Disease Type Ia and DTX301 for Ornithine Transcarbamylase Deficiency

Executive VP & CFO recently sold Mex$6.0m worth of stock

GeneTx Biotherapeutics LLC and Ultragenyx Pharmaceutical Inc. Announce FDA has Removed Clinical Hold on Phase 1/2 Clinical Study of GTX-102 for the Treatment of Angelman Syndrome in the U.S

Ultragenyx Pharmaceutical Inc. Announces Mepsevii® (Vestronidase Alfa) Receives Reimbursement Approval for Treatment of Mucopolysaccharidosis VII in Italy

Ultragenyx Canada Announces Health Canada Approval of Second Indication for Crysvita™ (Burosumab Injection) for the Treatment of Tumour Induced Osteomalacia in Adults

Executive VP & Chief Commercial Officer recently sold Mex$686k worth of stock

Ultragenyx Pharmaceutical Inc.(NasdaqGS:RARE) dropped from Russell 2000 Growth Index

Executive VP & Chief Commercial Officer recently sold Mex$858k worth of stock