Announcement • Jan 01
PsyRX CNS Bio-Tech Ltd, Annual General Meeting, Feb 05, 2026 PsyRX CNS Bio-Tech Ltd, Annual General Meeting, Feb 05, 2026. Location: steinmetz law offices, Israel Announcement • Nov 19
Cannabotech LTD has completed a Follow-on Equity Offering in the amount of ILS 3.508 million. Cannabotech LTD has completed a Follow-on Equity Offering in the amount of ILS 3.508 million.
Security Name: Shares
Security Type: Common Stock
Securities Offered: 3,508,000
Price\Range: ILS 1 New Risk • Jan 15
New major risk - Shareholder dilution The company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 108% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks No financial data reported. Share price has been highly volatile over the past 3 months (14% average weekly change). Shareholders have been substantially diluted in the past year (108% increase in shares outstanding). Market cap is less than US$10m (₪5.06m market cap, or US$1.39m). New Risk • Mar 03
New minor risk - Share price stability The company's share price has been volatile over the past 3 months. It is more volatile than 75% of Israeli stocks, typically moving 5.8% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks No financial data reported. Market cap is less than US$10m (₪7.34m market cap, or US$2.06m). Minor Risk Share price has been volatile over the past 3 months (5.8% average weekly change). Announcement • Jan 08
Cannabotech LTD, Annual General Meeting, Feb 11, 2024 Cannabotech LTD, Annual General Meeting, Feb 11, 2024, at 11:00 Israel Standard Time. New Risk • Jul 08
New minor risk - Share price stability The company's share price has been volatile over the past 3 months. It is more volatile than 75% of Israeli stocks, typically moving 6.5% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks No financial data reported. Market cap is less than US$10m (₪21.3m market cap, or US$5.77m). Minor Risk Share price has been volatile over the past 3 months (6.5% average weekly change). Announcement • Jul 12
Promising Breakthrough in Cannabotech's Pancreatic Cancer Drug: For the first time ever, the botanical drug has shown a combined anti-cancer effect between cannabis and mushroom Cannabotech reports that further to an experiment in a cell model in April 2022, which proved that the fungus-cannabinoids combination kills pancreatic cancer cells with high efficacy of up to 100%. The present experiment proves that the combined treatment of the two, at low concentrations, shows a much higher anti-cancerous efficacy than any of the active ingredients individually (an effect called: synergy). This result reinforces the assumption that combined treatment by fungal extract and cannabinoids would effectively treat pancreatic cancer with fewer side effects. The experiment examined the effect of cannabinoids and fungal extracts on 3 subtypes of pancreatic cancer, with the best results obtained in a subtype representing Poorly Differentiated Cancer, considered the most violent and common in the population. Another element tested in these experiments was identifying the killing mechanism of cancerous cells. The experiment showed that while killing these cancerous cells by the fungus is accompanied by increased cellular mortality called apoptosis, the cannabinoid mechanism in killing the cells is different. This is a positive result because the experiment shows that other mechanisms acting to kill cancerous cells have a better capacity for synergy between them. Furthermore, the findings also indicate no non-selective mortality here but rather activation of extracellular molecular mechanisms responsible for the controlled killing of cells. It is the first time a combined anti-cancer effect has been seen between cannabis and fungal extracts in pancreatic cancer, and it is a promising breakthrough supporting the combined botanical concept led by Cannabotech: a combined effect of several active ingredients in several mechanisms, supporting each other's activity. The fungus has been researched for its anti-cancerous efficacy in the laboratory of Prof. Fuad Fares, at the University of Haifa, for about 8 years, and was selected as the preferred candidate for developing a drug for pancreatic and colon cancer after showing better anti-cancerous results than other varieties of fungi tested. A few months ago, Cannabotech received global and exclusive use rights for patents created in Prof. Fares' research and began leading an accelerated botanical drug development process, as defined by the FDA, which the company expects to be cheaper and significantly shorter than the standard drug development process. The cannabinoid composition, tested in the botanical drug trial, is also expected to be integrated into Cannabotech's 'integrative oncology' concept. Marketing is planned to commence toward the end of 2022 in California and later, also in Israel, in early 2023. Cannabotech expects to complete the feasibility study phase within 9 months, by mid-2023, at the end of which it will work to generate a developmental collaboration with a large pharmaceutical company to approve a drug with the FDA. As part of the next milestones in its developmental process, the company plans to conduct tests on an animal model in Prof. Fares' laboratory at the University of Haifa under the management of Cannabotech's scientific team. Announcement • Apr 13
Cannabotech Announces Botanical Drug for Pancreatic Cancer Demonstrated Killing 100% of Cancer Cells Without Damaging the Healthy Cells in the Cell Model Cannabotech reported that in experiments conducted on a cell model, the fungus extract eliminated 100% of pancreatic cancer cells relatively selectively and without damaging normal cells. The fungus has been the subject of research to test its anti-cancer efficacy in Prof. Fuad Fares' laboratory at the University of Haifa for about eight years. It was selected as the preferred candidate for the development of a drug for pancreatic and colon cancer after showing better anti-cancer results than a variety of other fungi tested. A few months ago, Cannabotech received global and exclusive rights of use for patents created in Prof. Fares' research and began leading an accelerated process of developing a botanical drug as defined by the FDA. The first milestone in the botanical drug development process was defined as the adaptation of fungal growth and extraction methods to the FDA protocol for botanical drug development, which the company expects to be significantly cheaper and shorter than the development process of a standard ethical drug. In addition, the anti-cancer activity of the new fungal extract and the cannabinoid composition developed by Cannabotech on pancreatic cancer were examined. Cannabotech expects to complete the feasibility study phase within 12 months, by mid-2023, at the end of which it will work to create a development collaboration with a large pharma company vis-à-vis the FDA. As the next milestone in the development process, the company plans to test both the active mechanism of killing cancer cells by extracts and the combined anti-cancer efficacy of the fungus and cannabinoids together, in cells and animals. 
