Prothena Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

Insider Buying: Insufficient data to determine if insiders have bought more shares than they have sold in the past 3 months.

Dilution of Shares: Shareholders have not been meaningfully diluted in the past year.

Top 25 shareholders own 92.17% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
21.5%	EcoR1 Capital, LLC	11,584,280	€191.3m	0%	6.2%
15%	FMR LLC	8,065,670	€133.2m	0.74%	0.01%
7.88%	T. Rowe Price Group, Inc.	4,237,404	€70.0m	0.85%	0.01%
7.17%	BlackRock, Inc.	3,857,079	€63.7m	3.72%	no data
6.77%	Wellington Management Group LLP	3,639,429	€60.1m	-3%	0.01%
6.63%	William Scully	3,566,481	€58.9m	0%	no data
3.11%	State Street Global Advisors, Inc.	1,674,909	€27.7m	-13.3%	no data
3.1%	Palo Alto Investors LP	1,666,378	€27.5m	0.18%	3.53%
2.9%	Armistice Capital LLC	1,560,000	€25.8m	42.3%	0.62%
2.18%	The Vanguard Group, Inc.	1,171,747	€19.4m	4.13%	no data
1.91%	Janus Henderson Group plc	1,026,558	€17.0m	-21.6%	0.01%
1.86%	Artal Group S.A.	1,001,360	€16.5m	0%	0.37%
1.85%	Geode Capital Management, LLC	994,278	€16.4m	7.54%	no data
1.6%	Dimensional Fund Advisors LP	861,584	€14.2m	-0.14%	no data
1.28%	Tavistock Life Sciences	690,000	€11.4m	0%	0.72%
1.23%	Morgan Stanley, Investment Banking and Brokerage Investments	659,886	€10.9m	14%	no data
1.16%	Rock Springs Capital Management LP	625,048	€10.3m	0%	0.3%
0.81%	Finepoint Capital LP	433,471	€7.2m	7.72%	1.56%
0.68%	Northern Trust Global Investments	364,106	€6.0m	-8.35%	no data
0.66%	Citadel Advisors LLC	353,153	€5.8m	50.3%	0.01%
0.62%	Granahan Investment Management, LLC	335,660	€5.5m	0.52%	0.21%
0.61%	Renaissance Technologies LLC	329,500	€5.4m	-15.5%	0.01%
0.61%	Charles Schwab Investment Management, Inc.	327,139	€5.4m	0%	no data
0.53%	Prosight Management, LP	286,926	€4.7m	68.3%	1.42%
0.48%	Todd Fennell	258,723	€4.3m	0%	no data