Prothena Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

Insider Buying: Insufficient data to determine if insiders have bought more shares than they have sold in the past 3 months.

Dilution of Shares: Shareholders have not been meaningfully diluted in the past year.

Top 25 shareholders own 92.65% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
21.5%	EcoR1 Capital, LLC	11,584,280	€230.3m	0%	7.27%
15%	FMR LLC	8,065,670	€160.3m	0.74%	0.01%
7.88%	T. Rowe Price Group, Inc.	4,237,404	€84.2m	0.85%	0.01%
7.17%	BlackRock, Inc.	3,857,079	€76.7m	3.72%	no data
6.77%	Wellington Management Group LLP	3,639,429	€72.3m	-3%	0.01%
6.63%	William Scully	3,566,481	€70.9m	0%	no data
3.59%	State Street Global Advisors, Inc.	1,932,472	€38.4m	-44.4%	no data
3.1%	Palo Alto Investors LP	1,666,378	€33.1m	0.18%	4.33%
2.9%	Armistice Capital LLC	1,560,000	€31.0m	42.3%	0.84%
2.18%	The Vanguard Group, Inc.	1,171,747	€23.3m	4.13%	no data
1.91%	Janus Henderson Group plc	1,026,558	€20.4m	-21.6%	0.01%
1.86%	Artal Group S.A.	1,001,360	€19.9m	0%	0.54%
1.85%	Geode Capital Management, LLC	994,278	€19.8m	7.54%	no data
1.6%	Dimensional Fund Advisors LP	861,584	€17.1m	-0.14%	no data
1.28%	Tavistock Life Sciences	690,000	€13.7m	0%	0.73%
1.23%	Morgan Stanley, Investment Banking and Brokerage Investments	659,886	€13.1m	14%	no data
1.16%	Rock Springs Capital Management LP	625,048	€12.4m	0%	0.4%
0.81%	Finepoint Capital LP	433,471	€8.6m	7.72%	2.42%
0.68%	Northern Trust Global Investments	364,106	€7.2m	-8.35%	no data
0.66%	Citadel Advisors LLC	353,153	€7.0m	50.3%	0.01%
0.62%	Granahan Investment Management, LLC	335,660	€6.7m	0.52%	0.28%
0.61%	Renaissance Technologies LLC	329,500	€6.6m	-15.5%	0.01%
0.61%	Charles Schwab Investment Management, Inc.	327,139	€6.5m	2.58%	no data
0.53%	Prosight Management, LP	286,926	€5.7m	68.3%	1.77%
0.48%	Todd Fennell	258,723	€5.1m	0%	no data