Announcement • Aug 14
Destiny Pharma Initiates Research to Explore XF Drug Potential for CF Destiny Pharma announced the initiation of a research project to test a potential treatment for people with cystic fibrosis. This programme, supported in part by the U.S. Cystic Fibrosis Foundation, will evaluate the potency of XF platform drugs against a range of contemporary clinical isolates of the bacterial superbug Methicillin-resistant Staphylococcusaureus (MRSA) collected from the lungs of people with cystic fibrosis (CF) in the United States. Destiny Pharma is providing the Company's proprietary XF-73 drug to the CF Foundation National Resource Center for Microbiology at the Seattle Children's Hospital. The studies will involve: Measuring the potency of XF-73 against 33 contemporary MRSA isolates from people with CF, The impact of mucus, which protects MRSA from traditional antibiotic treatment, on the activity of XF-73 will also be evaluated. CF is a progressive, genetic disease that affects the lungs, pancreas, and other organs. There are nearly 40,0001 children and adults living with CF in the United States and an estimated 105,000 people have been diagnosed with CF across 94 countries, with a further 35% estimated to be undiagnosed2. People with CF have a dysfunctional cell membrane protein, which causes the overproduction of thick and sticky mucus. The mucus clogs airways in the lungs and traps bacteria, leading to infection, respiratory failure, and other complications. MRSA infections are much higher in people with CF than in the general population. It is now found in more than 15% of people with the disease. MRSA is resistant to multiple antibiotics, and lung infections caused by the bacteria often become long-term. The work investigating the utility of XF-73 against MRSA in CF follows on from recent peer-reviewed publications demonstrating that XF-73 has superior activity compared to mupirocin against MRSA isolates in a superficial skin infection model3; and that XF-73 has activity against 840 MRSA clinical isolates from patient infections from around the world4. Further data on the ability of XF-73 to prevent bacterial invasion of the bloodstream by MRSA in an in vivo burn wound model is to be presented at this year'sInfection Prevention Society Conference. Announcement • Aug 12
Destiny Pharma plc Announces Last Day of Dealings on AIM Destiny Pharma plc reminded shareholders that the last day of trading in Destiny Pharma's ordinary shares on AIM is 12 August 2024. The cancellation of the admission of the Company's ordinary shares to trading on AIM (the "Cancellation") was originally announced on 15 July 2024 and was approved by shareholders at the general meeting held on 31 July 2024. The Cancellation will become effective at 7:00 a.m. on 13 August 2024. Following Cancellation, the Company will re-register as a private company under the name Destiny Pharma Limited. Announcement • Jul 23
Destiny Pharma plc Announces New Clinical Data from its Phase 2b Clinical Trial on XF-73 in Cardiovascular Surgery Patients Destiny Pharma announced that new clinical data from its Phase 2b clinical trial on XF-73 in cardiac surgery patients has been accepted for presentation at the ID Week conference, the joint annual meeting of the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America on the 16-19 October 2024 in Los Angeles, USA. Further planned data analysis of a secondary endpoint within the clinical trial investigated the use by physicians of post-surgical systemic antibiotics prescribed >48 hours after surgery. Significantly fewer patients in the XF-73 treatment arm received post-operative anti-staphylococcal antibiotics: 46.5% (20 of a total population of 43), compared to 70% (28 of a total population of 40) in the placebo group, p=0.045, which suggests that antibiotics may have been prescribed as an early intervention in more patients in the placebo arm. The observed reduction of the use of post-operative antibiotics in the XF-73 arm is consistent with the principles of good antimicrobial stewardship which are crucial for managing and preventing infections more effectively and for maintaining the efficacy of antibiotics, reducing healthcare complications, and improving patient safety. Additional advantages of the XF-73 Nasal gel include the short, 24 hour, pre-surgical dosing regimen, rapidity of S. aureus nasal decolonisation, remote likelihood of resistance emergence, and the duration of effect. These features provide a good fit with clinical practice, potentially enabling infection risk reduction peri-operatively, enhancing flexibility for scheduling surgeries, and augmenting antibiotic stewardship efforts. Phase 3 studies are being planned to evaluate and gain regulatory approval for XF-73. XF-73 has also demonstrated efficacy against the hospital superbug methicillin-resistant Staphylococcus aureus (MRSA). In studies published last year XF-73 was potent against all 840 MRSA strains collected from infected patients from 33 countries worldwide (Rhys Williams et al. 2023)2 and was shown to be up to 1000 times more efficacious than nasal mupirocin (the most commonly used nasal antibiotic) at treating MRSA in a skin infection model, (Zhang et al. 2023). 
