공시 • Jun 02
Bruker Corporation Launches Novel Mass Spectrometry Systems and Advances in 4D Proteomics and Metabolomics
Bruker Corporation announced the launch of the unique timsMRMS system, bringing the power of trapped ion mobility separation to ultra-high-resolution magnetic resonance mass spectrometry (MRMS). The timsMRMS redefines extreme-resolution mass spectrometry of complex mixtures, delivering mass resolving power of 1M to 10M, down to ppb mass accuracy, and a four orders of magnitude single-acquisition dynamic range through a fundamental breakthrough of TIMS gas-phase separation from MRMS detection. The unique timsMRMS delivers unrivaled performance for diverse applications, from molecular-level characterization in petroleomics to dissolved organic matter to biofuel fingerprinting and battery research in the energy industry. Further instruments improvements, razor-PASEF methods and Spectronaut 21 software now further enhance deep proteome coverage at high throughput on the timsUltra AIP, enabling ID and quantification of >10,000 proteins in HeLa, and >6,500 proteins at 500 SPD. Major timsUltra AIP and further timsOmni advances, razor-PASEF workflows, Spectronaut 21 and OmniScape software advance proteomics to >10,000 proteins per sample, more than 6,500 proteins at 500 samples per day (SPD), and make sensitive and information-rich top-down characterization 4x more sensitive for proteoforms, antibodies, glycoproteins, oligonucleotides. Revolutionary timsOmni enables unmatched multi-stage, ultra-sensitive trapped ExD (tExD) fragmentation for deeper structural and functional characterization of proteoforms and PTMs, with even greater top-down 4x sensitivity, including for glycoproteomics and small molecule structural characterization. Further enhancing CID sensitivity by 4x for biomolecules, Argon offers advantages as a collision gas. As a heavy, mono-atomic noble gas with no internal vibrational or rotational modes, it transfers collision energy efficiently to precursor ions to drive efficient, reproducible dissociation. Integrated Protein Technologies now interfaces their SampleStream directly with timsOmni under HyStar control, delivering automated, high-throughput buffer exchange via a molecular weight cutoff membrane that concentrates protein in a microfluidic flow cell while flushing buffers, salts, and adduct-forming excipients to waste, achieving MS-ready sample elution in under two minutes per sample with no carryover. Bruker’s software makes a leap forward with releases of OmniScape 2027, ProteoScape 2027, and GlycoScape 2027, for confidence in top-down proteoform sequence and PTM analysis. A novel addition to Omniscape 2027 is LYRA, a de novo algorithm that transforms high-quality sequence reads from complex top-down spectra into annotated protein sequences. LYRA features ultrafast PTM screening for proteoform ID across billions of possibilities and an advanced result combination module for higher sequence coverage and safer proteoform and PTM assessment. New automated glycoproteomics workflows incorporate both trapped electron capture dissociation (tECD) with low-energy electrons and complementary trapped electron ionization dissociation (tEID) using higher-energy electrons, for dissociation reaction times as short as 10 ms. All glycoproteomics workflows are now compatible with MSFragger. tims-Casanovo, a collaboration with Professor William Nobel at University of Washington, Professor Fabian Theis at Helmholtz Munich, and Professor Wout Bittremieux at University of Antwerp, and the Bruker software team, uses a transformer neural network to translate peaks in MS/MS spectra into amino acid sequences with exceptional precision. MetaboScape now supports ecTOF dual ionization, enabling processing of simultaneous EI and CI spectra for GC-HRAM chemical exposure coverage. Bruker launches an early-access program for hybrid metabolomics on timsMetabo, combining kit-based absolute quantitation with discovery in a ‘holy grail’ qual/quant simultaneous targeted and discovery experiment. Following its acquisition of TOFWERK in January 2026, Bruker is launching an Air Exposomics initiative that combines TOFWERK Vocus real-time VOC monitoring and mipTOF field-deployable trace-metal aerosol analyzer with 4D metabolomics and lipidomics. This portfolio can connect real-time environmental exposure measurements to respiratory illness, neurodegeneration, and cancer. Bruker launches novel TOFWERK airborne molecular contaminants (AMC) TOF-MS solutions for yield optimization in semiconductor manufacturing; multi-million-dollar multiple-systems order received from leading global memory manufacturer.