Laekna（LAEK.F）株式概要投資持株会社であるLaekna, Inc.は、がん、代謝性疾患、肝線維症の患者に対する治療法の発見、開発、商業化に世界中で取り組んでいる。 詳細LAEK.F ファンダメンタル分析スノーフレーク・スコア評価0/6将来の成長2/6過去の実績0/6財務の健全性4/6配当金0/6報酬収益は年間55.74%増加すると予測されています 過去5年間の収益は年間43.5%増加しました。 リスク分析今後3年間の収益は年平均2.2%減少すると予測されている。 株式の流動性は非常に低い 収益が 100 万ドル未満 ( CN¥5M )現在は利益が出ておらず、今後3年間で利益が出る見込みはない +1 さらなるリスクすべてのリスクチェックを見るLAEK.F Community Fair Values Create NarrativeSee what others think this stock is worth. Follow their fair value or set your own to get alerts.Your Fair ValueUS$Current PriceUS$2.214.8k% 割高 内在価値ディスカウントGrowth estimate overAnnual revenue growth rate5 Yearstime period%/yrDecreaseIncreasePastFuture-765m42m2016201920222025202620282031Revenue CN¥42.4mEarnings CN¥7.7mAdvancedSet Fair ValueView all narrativesLaekna, Inc. 競合他社AbsciSymbol: NasdaqGS:ABSIMarket cap: US$793.6mCytomX TherapeuticsSymbol: NasdaqGS:CTMXMarket cap: US$818.6mKura OncologySymbol: NasdaqGS:KURAMarket cap: US$988.1mEvommuneSymbol: NYSE:EVMNMarket cap: US$848.2m価格と性能株価の高値、安値、推移の概要Laekna過去の株価現在の株価HK$2.2152週高値HK$7.3052週安値HK$1.90ベータ-0.911ヶ月の変化0%3ヶ月変化n/a1年変化n/a3年間の変化n/a5年間の変化n/aIPOからの変化-69.73%最新ニュースお知らせ • May 15Laekna, Inc., Annual General Meeting, Jun 05, 2026Laekna, Inc., Annual General Meeting, Jun 05, 2026, at 09:00 China Standard Time. Location: 5f, 987 cailun road, pudong, shanghai, china, Hong Kongお知らせ • Mar 06Laekna, Inc. to Report Fiscal Year 2025 Results on Mar 18, 2026Laekna, Inc. announced that they will report fiscal year 2025 results at 4:00 PM, China Standard Time on Mar 18, 2026お知らせ • Jan 14Laekna, Inc. Announces That the U.S. Food and Drug Administration Has Accepted Its Investigational New Drug Application for LAE118The board of directors of Laekna, Inc. announced that the U.S. Food and Drug Administration has accepted its Investigational New Drug application for LAE118, a novel PI3K a pan-mutant selective inhibitor for the treatment of patients with PIK3CA-mutant solid tumors. The Company will work closely with the regulatory authorities to complete the application. Building on its proven track record in successfully developing and out-licensing LAE002 (afuresertib), the Company aims to bring this precision therapy to cancer patients who are in need of novel treatment options.お知らせ • Jan 02Laekna, Inc. Commences Study Recruitment in Phase I Single Ascending Dose Study of LAE103The board of directors of Laekna, Inc. announced that the Group has commenced study recruitment in phase I single ascending dose study of LAE103, an internally discovered monoclonal antibody against ActRIIB, in Australia. As of the date of this announcement, first subject has been dosed. The SAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE103, administered subcutaneously, in healthy overweight or obese participants. The Group targets to read out the topline data of this SAD study in the third quarter of 2026. The Group targets to bring this precision therapy to cardiovascular and metabolic diseases with high unmet medical needs, such as obesity, sarcopenia and heart failure.お知らせ • Sep 18Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listingお知らせ • Sep 11Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listing最新情報をもっと見るRecent updatesお知らせ • May 15Laekna, Inc., Annual General Meeting, Jun 05, 2026Laekna, Inc., Annual General Meeting, Jun 05, 2026, at 09:00 China Standard Time. Location: 5f, 987 cailun road, pudong, shanghai, china, Hong Kongお知らせ • Mar 06Laekna, Inc. to Report Fiscal Year 2025 Results on Mar 18, 2026Laekna, Inc. announced that they will report fiscal year 2025 results at 4:00 PM, China Standard Time on Mar 18, 2026お知らせ • Jan 14Laekna, Inc. Announces That the U.S. Food and Drug Administration Has Accepted Its Investigational New Drug Application for LAE118The board of directors of Laekna, Inc. announced that the U.S. Food and Drug Administration has accepted its Investigational New Drug application for LAE118, a novel PI3K a pan-mutant selective inhibitor for the treatment of patients with PIK3CA-mutant solid tumors. The Company will work closely with the regulatory authorities to complete the application. Building on its proven track record in successfully developing and out-licensing LAE002 (afuresertib), the Company aims to bring this precision therapy to cancer patients who are in need of novel treatment options.お知らせ • Jan 02Laekna, Inc. Commences Study Recruitment in Phase I Single Ascending Dose Study of LAE103The board of directors of Laekna, Inc. announced that the Group has commenced study recruitment in phase I single ascending dose study of LAE103, an internally discovered monoclonal antibody against ActRIIB, in Australia. As of the date of this announcement, first subject has been dosed. The SAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE103, administered subcutaneously, in healthy overweight or obese participants. The Group targets to read out the topline data of this SAD study in the third quarter of 2026. The Group targets to bring this precision therapy to cardiovascular and metabolic diseases with high unmet medical needs, such as obesity, sarcopenia and heart failure.お知らせ • Sep 18Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listingお知らせ • Sep 11Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listingお知らせ • Jul 29Laekna, Inc. to Report First Half, 2025 Results on Aug 13, 2025Laekna, Inc. announced that they will report first half, 2025 results on Aug 13, 2025お知らせ • Jun 30Laekna, Inc. Submits Investigational New Drug Application to the U.S. Food and Drug AdministrationThe board of directors of Laekna, Inc. announced that the Group has submitted an Investigational New Drug application to the U.S. Food and Drug Administration for LAE103, an internally discovered monoclonal antibody against ActRIIB for the treatment of patients with sarcopenic obesity and muscle related disease. The Company will work closely with the regulatory authorities to complete the application and targets to bring this precision therapy to metabolic patients who are in need of novel treatment options. The Group plans to separately evaluate the efficacy and safety of monoclonal antibodies targeting at ActRIIA and ActRIIB in humans.お知らせ • Jun 24Laekna Presents Clinical and Pre-clinical Studies Results of LAE102, LAE103 and LAE123Laekna announced that the results of: i) the phase I SAD study of LAE102 (an ActRIIA-selective antibody) for the treatment of obesity; and ii) the pre-clinical study of LAE102, LAE103 (an ActRIIB-selective antibody) and LAE123 (an ActRIIA/IIB dual antagonistic monoclonal antibody) as therapeutics for muscle growth and fat reduction were presented at the 85th scientific sessions of the American Diabetes Association (ADA). ADA is one of the global leading conferences dedicated to diabetes research, care, and innovation and has taken place in Chicago, USA, from June 20 to 23 this year. Professor Xuening LI, Zhongshan Hospital affiliated to Fudan University,Principal Investigator of the Phase I Clinical Trial of LAE102 in China. At the ADA Scientific Sessions, Laekna showcased LAE102, LAE102, LAE 103, and LAE123 - an innovative portfolio targeting the ActRII pathway - highlighting team's extensive expertise and leadership in this field. Highlights: A total of 40 participants were enrolled in Part A (IV) and 24 participants in Part B (SC). All participants completed the study as designed. The mean age was 29.0 years and 31.2 years, with the mean BMI 23.32 kg/m2 and 23.08 kg/m2 in Part A and Part B, respectively.お知らせ • Jun 23Laekna, Inc. Announces Results of Phase I Sad Study of Lae102Laekna, Inc. announced that the results of (i) phase I SAD study of LAE102 (an ActRIIA-selective antibody) for the treatment of obesity; and (ii) the pre-clinical study of LAE102, LAE103 (an ActRIIB-selective antibody) and LAE123 (an ActRIIA/IIB dual antagonistic monoclonal antibody) as therapeutics for muscle growth and fat reduction were presented at the 85th scientific sessions of the American Diabetes Association (ADA). Presentations details are as follows: Poster No.1. Abstract Number: 2205-LB, Title: First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LAE102 in Healthy volunteers, Time: Sunday, June 22, 2025, 12:30 p.m.-13:30 p.m. CST, Location: Poster Hall (Hall F1) McCormick Place Convention Center, Chicago, Illinois, the USA. Highlights: A total of 40 participants were enrolled in Part A (IV) and 24 participants in Part B (SC). All participants completed the study as designed. The mean age was 29.0 years and 31.2 years, with the mean BMI 23.32 kg/m2 and 23.08 kg/m2 in Part A and Part B, respectively. Baseline demographic and clinical characteristics were generally balanced across the intravenous (IV) and subcutaneous (SC) cohorts of the study. Overall, LAE102 was well tolerated following a single IV or SC dose. No serious adverse events or treatment emergent adverse events (TEAEs) leading to discontinuation of treatment were reported. The majority of the TEAEs were mild laboratory test abnormalities, which were asymptomatic and did not require medical intervention. There was no reported case of diarrhea. Activin A was significantly increased in 24 hours following a single intravenous or subcutaneous dose of LAE102. The duration of Activin A elevation was dose-dependent. The high-dose groups (8 mg/kg IV group, 16 mg/kg IV group, and 8 mg/kg SC group) maintained 2-to-3-fold increases above the baseline level through 28 days post-administration, indicating prolonged pathway blocking. In addition, they also inhibit activin E and GDF3, which promote lipid accumulation of adipose tissue. In mouse models, LAE102 alone significantly induced muscle growth and reduced fat mass, while LAE103 had less effect. Notably, a synergistic effect on muscle increase and fat loss was observed when combining LAE102 with LAE103, achieving the maximal effect comparable to the ActRIIA-IIB dual-specific antibody LAE123. This positions LAE102 as a promising drug candidate for achieving quality weight control.お知らせ • May 13Laekna, Inc., Annual General Meeting, Jun 03, 2025Laekna, Inc., Annual General Meeting, Jun 03, 2025, at 09:00 China Standard Time. Location: 5f, 987 cailun road, pudong, shanghai Chinaお知らせ • Mar 26Laekna, Inc. Commences Study Recruitment in Phase I Multiple Ascending Dose Study of Lae102 for the Treatment of ObityThe board of directors of Laekna, Inc. announced that the Group has commenced study recruitment in phase I multiple ascending dose study of LAE102 in China for the treatment of obesity. As of the date of this announcement, the first visit for the first subject has been completed. The MAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE102, administered subcutaneously, in 60 overweight/obese subjects. The Group aims to bring this precision therapy to overweight and obese patients who are in need of novel treatment options for achieving quality weight control.お知らせ • Mar 10Laekna, Inc. to Report Fiscal Year 2024 Results on Mar 24, 2025Laekna, Inc. announced that they will report fiscal year 2024 results on Mar 24, 2025お知らせ • Jan 13Laekna, Inc. Announces Completion of A Successful Phase I Single Ascending Dose Study of Lae102 for the Treatment of ObesityThe board of directors of Laekna, Inc. announced that the Group has successfully completed the phase I single ascending dose study of LAE102 for the treatment of obesity. The SAD Study enrolled a total of 64 healthy subjects with an average BMI of 23.2+-2.2 kg/m2, including 5 intravenous cohorts and 3 subcutaneous cohorts. The positive outcomes of the SAD Study results have established a solid foundation for the coming phase I multiple ascending dose study in China as well as the phase I clinical study in collaboration with Eli Lilly & Company in the U.S. The SAD Study data of LAE102 analyzed to date demonstrated an encouraging safety and tolerability profile, with no serious adverse events and no discontinuations due to adverse events. All treatment emergent adverse events reported to date were very well tolerated, with the majority of them being reported as mild (grade 1) lab test abnormality without any clinical symptoms or signs. There is no reported case of diarrhea. Obvious target engagements and expected pharmacodynamic biomarker changes have been observed. Single doses of LAE102 resulted in significant and sustained increasing in activin A level, indicating a robust target engagement. The duration of target engagement correlated to the dose level. The detailed study results will be presented in a scientific conference as soon as possible. The positive SAD Study results support continuing the investigation of LAE102 for thetreatment of obesity. The Group plans to initiate the MAD Study in the first quarter of 2025 and to work closely with Lilly to commence the phase I clinical study in U.S. as soon as possible. The MAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE102, administered subcutaneously, in 60 overweight/obese subjects. The Group aims to bring this precision therapy to overweight and obese patients who are in need of novel treatment options for achieving quality weight control.株主還元LAEK.FUS BiotechsUS 市場7D0%1.2%1.0%1Yn/a34.9%28.7%株主還元を見る業界別リターン: LAEK.FがUS Biotechs業界に対してどのようなパフォーマンスを示したかを判断するにはデータが不十分です。リターン対市場: LAEK.F US市場に対してどのようなパフォーマンスを示したかを判断するにはデータが不十分です。価格変動Is LAEK.F's price volatile compared to industry and market?LAEK.F volatilityLAEK.F Average Weekly Movementn/aBiotechs Industry Average Movement11.0%Market Average Movement7.2%10% most volatile stocks in US Market16.4%10% least volatile stocks in US Market3.1%安定した株価: LAEK.Fの株価は、 US市場と比較して過去 3 か月間で変動しています。時間の経過による変動: 過去 1 年間のLAEK.Fのボラティリティの変化を判断するには データが不十分です。会社概要設立従業員CEO（最高経営責任者ウェブサイト201684Chris Luwww.laekna.com投資持株会社であるLaekna, Inc.は、がん、代謝性疾患、肝線維症の患者を対象とした治療薬の発見、開発、商業化に世界中で取り組んでいます。同社は、卵巣がん、前立腺がん、乳がん、PD-1/PD-L1薬剤耐性固形がんの治療薬として、アデノシン三リン酸競合AKT阻害剤LAE002を提供しています；CYP17A1およびCYP11B2を阻害するアンドロゲン合成阻害剤LAE001（前立腺がん治療薬）、リガンドブロッキングヒト化抗PD-L1 IgG4抗体LAE005（トリプルネガティブ乳がん治療薬）、ActRIIAに対するモノクローナル抗体LAE102（肥満症治療薬）。また、がん治療薬としてLAE109、LAE111、LAE112、LAE113、LAE117、LAE118、LAE119、LAE120、筋萎縮性疾患治療薬としてLAE103、LAE123、肝線維症治療薬としてLAE104、LAE105、線維症治療薬としてLAE106を開発しています。同社はLAE102の開発に関してイーライリリー・アンド・カンパニーと共同研究を行っている。Laekna, Inc.は2016年に法人化され、中国の余姚に本社を置いている。もっと見るLaekna, Inc. 基礎のまとめLaekna の収益と売上を時価総額と比較するとどうか。LAEK.F 基礎統計学時価総額US$801.28m収益（TTM）-US$33.93m売上高(TTM)US$653.61k1,209xP/Sレシオ-23.3xPER（株価収益率LAEK.F は割高か？公正価値と評価分析を参照収益と収入最新の決算報告書（TTM）に基づく主な収益性統計LAEK.F 損益計算書（TTM）収益CN¥4.63m売上原価CN¥0売上総利益CN¥4.63mその他の費用CN¥244.85m収益-CN¥240.23m直近の収益報告Jun 30, 2025次回決算日該当なし一株当たり利益（EPS）-0.57グロス・マージン100.00%純利益率-5,191.85%有利子負債／自己資本比率15.4%LAEK.F の長期的なパフォーマンスは？過去の実績と比較を見るView Valuation企業分析と財務データの現状データ最終更新日（UTC時間）企業分析2025/11/26 16:54終値2025/08/29 00:00収益2025/06/30年間収益2024/12/31データソース企業分析に使用したデータはS&P Global Market Intelligence LLC のものです。本レポートを作成するための分析モデルでは、以下のデータを使用しています。データは正規化されているため、ソースが利用可能になるまでに時間がかかる場合があります。パッケージデータタイムフレーム米国ソース例会社財務10年損益計算書キャッシュ・フロー計算書貸借対照表SECフォーム10-KSECフォーム10-Qアナリストのコンセンサス予想+プラス3年予想財務アナリストの目標株価アナリストリサーチレポートBlue Matrix市場価格30年株価配当、分割、措置ICEマーケットデータSECフォームS-1所有権10年トップ株主インサイダー取引SECフォーム4SECフォーム13Dマネジメント10年リーダーシップ・チーム取締役会SECフォーム10-KSECフォームDEF 14A主な進展10年会社からのお知らせSECフォーム8-K* 米国証券を対象とした例であり、非米国証券については、同等の規制書式および情報源を使用。特に断りのない限り、すべての財務データは1年ごとの期間に基づいていますが、四半期ごとに更新されます。これは、TTM（Trailing Twelve Month）またはLTM（Last Twelve Month）データとして知られています。詳細はこちら。分析モデルとスノーフレーク本レポートを生成するために使用した分析モデルの詳細は当社のGithubページでご覧いただけます。また、レポートの使用方法に関するガイドやYoutubeのチュートリアルも掲載しています。シンプリー・ウォールストリート分析モデルを設計・構築した世界トップクラスのチームについてご紹介します。業界およびセクターの指標私たちの業界とセクションの指標は、Simply Wall Stによって6時間ごとに計算されます。アナリスト筋Laekna, Inc. 4 これらのアナリストのうち、弊社レポートのインプットとして使用した売上高または利益の予想を提出したのは、 。アナリストの投稿は一日中更新されます。4 アナリスト機関Bo LiBofA Global Researchnull nullChina International Capital Corporation LimitedYaxin LiuChina International Capital Corporation Limited1 その他のアナリストを表示
お知らせ • May 15Laekna, Inc., Annual General Meeting, Jun 05, 2026Laekna, Inc., Annual General Meeting, Jun 05, 2026, at 09:00 China Standard Time. Location: 5f, 987 cailun road, pudong, shanghai, china, Hong Kong
お知らせ • Mar 06Laekna, Inc. to Report Fiscal Year 2025 Results on Mar 18, 2026Laekna, Inc. announced that they will report fiscal year 2025 results at 4:00 PM, China Standard Time on Mar 18, 2026
お知らせ • Jan 14Laekna, Inc. Announces That the U.S. Food and Drug Administration Has Accepted Its Investigational New Drug Application for LAE118The board of directors of Laekna, Inc. announced that the U.S. Food and Drug Administration has accepted its Investigational New Drug application for LAE118, a novel PI3K a pan-mutant selective inhibitor for the treatment of patients with PIK3CA-mutant solid tumors. The Company will work closely with the regulatory authorities to complete the application. Building on its proven track record in successfully developing and out-licensing LAE002 (afuresertib), the Company aims to bring this precision therapy to cancer patients who are in need of novel treatment options.
お知らせ • Jan 02Laekna, Inc. Commences Study Recruitment in Phase I Single Ascending Dose Study of LAE103The board of directors of Laekna, Inc. announced that the Group has commenced study recruitment in phase I single ascending dose study of LAE103, an internally discovered monoclonal antibody against ActRIIB, in Australia. As of the date of this announcement, first subject has been dosed. The SAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE103, administered subcutaneously, in healthy overweight or obese participants. The Group targets to read out the topline data of this SAD study in the third quarter of 2026. The Group targets to bring this precision therapy to cardiovascular and metabolic diseases with high unmet medical needs, such as obesity, sarcopenia and heart failure.
お知らせ • Sep 18Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listing
お知らせ • Sep 11Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listing
お知らせ • May 15Laekna, Inc., Annual General Meeting, Jun 05, 2026Laekna, Inc., Annual General Meeting, Jun 05, 2026, at 09:00 China Standard Time. Location: 5f, 987 cailun road, pudong, shanghai, china, Hong Kong
お知らせ • Mar 06Laekna, Inc. to Report Fiscal Year 2025 Results on Mar 18, 2026Laekna, Inc. announced that they will report fiscal year 2025 results at 4:00 PM, China Standard Time on Mar 18, 2026
お知らせ • Jan 14Laekna, Inc. Announces That the U.S. Food and Drug Administration Has Accepted Its Investigational New Drug Application for LAE118The board of directors of Laekna, Inc. announced that the U.S. Food and Drug Administration has accepted its Investigational New Drug application for LAE118, a novel PI3K a pan-mutant selective inhibitor for the treatment of patients with PIK3CA-mutant solid tumors. The Company will work closely with the regulatory authorities to complete the application. Building on its proven track record in successfully developing and out-licensing LAE002 (afuresertib), the Company aims to bring this precision therapy to cancer patients who are in need of novel treatment options.
お知らせ • Jan 02Laekna, Inc. Commences Study Recruitment in Phase I Single Ascending Dose Study of LAE103The board of directors of Laekna, Inc. announced that the Group has commenced study recruitment in phase I single ascending dose study of LAE103, an internally discovered monoclonal antibody against ActRIIB, in Australia. As of the date of this announcement, first subject has been dosed. The SAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE103, administered subcutaneously, in healthy overweight or obese participants. The Group targets to read out the topline data of this SAD study in the third quarter of 2026. The Group targets to bring this precision therapy to cardiovascular and metabolic diseases with high unmet medical needs, such as obesity, sarcopenia and heart failure.
お知らせ • Sep 18Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has completed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listing
お知らせ • Sep 11Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million.Laekna, Inc. has filed a Follow-on Equity Offering in the amount of HKD 586.8 million. Security Name: Ordinary Shares Security Type: Common Stock Securities Offered: 36,000,000 Price\Range: HKD 16.3 Discount Per Security: HKD 0.26 Transaction Features: Subsequent Direct Listing
お知らせ • Jul 29Laekna, Inc. to Report First Half, 2025 Results on Aug 13, 2025Laekna, Inc. announced that they will report first half, 2025 results on Aug 13, 2025
お知らせ • Jun 30Laekna, Inc. Submits Investigational New Drug Application to the U.S. Food and Drug AdministrationThe board of directors of Laekna, Inc. announced that the Group has submitted an Investigational New Drug application to the U.S. Food and Drug Administration for LAE103, an internally discovered monoclonal antibody against ActRIIB for the treatment of patients with sarcopenic obesity and muscle related disease. The Company will work closely with the regulatory authorities to complete the application and targets to bring this precision therapy to metabolic patients who are in need of novel treatment options. The Group plans to separately evaluate the efficacy and safety of monoclonal antibodies targeting at ActRIIA and ActRIIB in humans.
お知らせ • Jun 24Laekna Presents Clinical and Pre-clinical Studies Results of LAE102, LAE103 and LAE123Laekna announced that the results of: i) the phase I SAD study of LAE102 (an ActRIIA-selective antibody) for the treatment of obesity; and ii) the pre-clinical study of LAE102, LAE103 (an ActRIIB-selective antibody) and LAE123 (an ActRIIA/IIB dual antagonistic monoclonal antibody) as therapeutics for muscle growth and fat reduction were presented at the 85th scientific sessions of the American Diabetes Association (ADA). ADA is one of the global leading conferences dedicated to diabetes research, care, and innovation and has taken place in Chicago, USA, from June 20 to 23 this year. Professor Xuening LI, Zhongshan Hospital affiliated to Fudan University,Principal Investigator of the Phase I Clinical Trial of LAE102 in China. At the ADA Scientific Sessions, Laekna showcased LAE102, LAE102, LAE 103, and LAE123 - an innovative portfolio targeting the ActRII pathway - highlighting team's extensive expertise and leadership in this field. Highlights: A total of 40 participants were enrolled in Part A (IV) and 24 participants in Part B (SC). All participants completed the study as designed. The mean age was 29.0 years and 31.2 years, with the mean BMI 23.32 kg/m2 and 23.08 kg/m2 in Part A and Part B, respectively.
お知らせ • Jun 23Laekna, Inc. Announces Results of Phase I Sad Study of Lae102Laekna, Inc. announced that the results of (i) phase I SAD study of LAE102 (an ActRIIA-selective antibody) for the treatment of obesity; and (ii) the pre-clinical study of LAE102, LAE103 (an ActRIIB-selective antibody) and LAE123 (an ActRIIA/IIB dual antagonistic monoclonal antibody) as therapeutics for muscle growth and fat reduction were presented at the 85th scientific sessions of the American Diabetes Association (ADA). Presentations details are as follows: Poster No.1. Abstract Number: 2205-LB, Title: First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LAE102 in Healthy volunteers, Time: Sunday, June 22, 2025, 12:30 p.m.-13:30 p.m. CST, Location: Poster Hall (Hall F1) McCormick Place Convention Center, Chicago, Illinois, the USA. Highlights: A total of 40 participants were enrolled in Part A (IV) and 24 participants in Part B (SC). All participants completed the study as designed. The mean age was 29.0 years and 31.2 years, with the mean BMI 23.32 kg/m2 and 23.08 kg/m2 in Part A and Part B, respectively. Baseline demographic and clinical characteristics were generally balanced across the intravenous (IV) and subcutaneous (SC) cohorts of the study. Overall, LAE102 was well tolerated following a single IV or SC dose. No serious adverse events or treatment emergent adverse events (TEAEs) leading to discontinuation of treatment were reported. The majority of the TEAEs were mild laboratory test abnormalities, which were asymptomatic and did not require medical intervention. There was no reported case of diarrhea. Activin A was significantly increased in 24 hours following a single intravenous or subcutaneous dose of LAE102. The duration of Activin A elevation was dose-dependent. The high-dose groups (8 mg/kg IV group, 16 mg/kg IV group, and 8 mg/kg SC group) maintained 2-to-3-fold increases above the baseline level through 28 days post-administration, indicating prolonged pathway blocking. In addition, they also inhibit activin E and GDF3, which promote lipid accumulation of adipose tissue. In mouse models, LAE102 alone significantly induced muscle growth and reduced fat mass, while LAE103 had less effect. Notably, a synergistic effect on muscle increase and fat loss was observed when combining LAE102 with LAE103, achieving the maximal effect comparable to the ActRIIA-IIB dual-specific antibody LAE123. This positions LAE102 as a promising drug candidate for achieving quality weight control.
お知らせ • May 13Laekna, Inc., Annual General Meeting, Jun 03, 2025Laekna, Inc., Annual General Meeting, Jun 03, 2025, at 09:00 China Standard Time. Location: 5f, 987 cailun road, pudong, shanghai China
お知らせ • Mar 26Laekna, Inc. Commences Study Recruitment in Phase I Multiple Ascending Dose Study of Lae102 for the Treatment of ObityThe board of directors of Laekna, Inc. announced that the Group has commenced study recruitment in phase I multiple ascending dose study of LAE102 in China for the treatment of obesity. As of the date of this announcement, the first visit for the first subject has been completed. The MAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE102, administered subcutaneously, in 60 overweight/obese subjects. The Group aims to bring this precision therapy to overweight and obese patients who are in need of novel treatment options for achieving quality weight control.
お知らせ • Mar 10Laekna, Inc. to Report Fiscal Year 2024 Results on Mar 24, 2025Laekna, Inc. announced that they will report fiscal year 2024 results on Mar 24, 2025
お知らせ • Jan 13Laekna, Inc. Announces Completion of A Successful Phase I Single Ascending Dose Study of Lae102 for the Treatment of ObesityThe board of directors of Laekna, Inc. announced that the Group has successfully completed the phase I single ascending dose study of LAE102 for the treatment of obesity. The SAD Study enrolled a total of 64 healthy subjects with an average BMI of 23.2+-2.2 kg/m2, including 5 intravenous cohorts and 3 subcutaneous cohorts. The positive outcomes of the SAD Study results have established a solid foundation for the coming phase I multiple ascending dose study in China as well as the phase I clinical study in collaboration with Eli Lilly & Company in the U.S. The SAD Study data of LAE102 analyzed to date demonstrated an encouraging safety and tolerability profile, with no serious adverse events and no discontinuations due to adverse events. All treatment emergent adverse events reported to date were very well tolerated, with the majority of them being reported as mild (grade 1) lab test abnormality without any clinical symptoms or signs. There is no reported case of diarrhea. Obvious target engagements and expected pharmacodynamic biomarker changes have been observed. Single doses of LAE102 resulted in significant and sustained increasing in activin A level, indicating a robust target engagement. The duration of target engagement correlated to the dose level. The detailed study results will be presented in a scientific conference as soon as possible. The positive SAD Study results support continuing the investigation of LAE102 for thetreatment of obesity. The Group plans to initiate the MAD Study in the first quarter of 2025 and to work closely with Lilly to commence the phase I clinical study in U.S. as soon as possible. The MAD Study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of LAE102, administered subcutaneously, in 60 overweight/obese subjects. The Group aims to bring this precision therapy to overweight and obese patients who are in need of novel treatment options for achieving quality weight control.
