View ValuationXenetic Biosciences 将来の成長Future 基準チェック /06現在、 Xenetic Biosciencesの成長と収益を予測するのに十分なアナリストの調査がありません。主要情報n/a収益成長率n/aEPS成長率Biotechs 収益成長24.8%収益成長率n/a将来の株主資本利益率n/aアナリストカバレッジNone最終更新日n/a今後の成長に関する最新情報Price Target Changed • Nov 16Price target increased to US$4.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 841% above last closing price of US$0.43. Stock is down 74% over the past year. The company is forecast to post a net loss per share of US$0.45 next year compared to a net loss per share of US$0.55 last year.Major Estimate Revision • Aug 18Consensus forecasts updatedThe consensus outlook for 2022 has been updated. 2022 losses of -US$0.68 per share expected, vs -US$0.46 per share profit forecast previously. Revenue forecast reaffirmed at US$1.39m. Biotechs industry in the US expected to see average net income decline 57% next year. Consensus price target of US$4.00 unchanged from last update. Share price fell 6.9% to US$0.82 over the past week.Major Estimate Revision • Aug 19Consensus EPS estimates increase to -US$0.55The consensus outlook for earnings per share (EPS) in 2021 has improved. 2021 revenue forecast increased from US$787.2k to US$799.7k. EPS estimate increased from -US$0.66 to -US$0.55. Biotechs industry in the US expected to see average net income decline 21% next year. Consensus price target of US$5.00 unchanged from last update. Share price fell 3.4% to US$3.13 over the past week.Price Target Changed • Jul 01Price target increased to US$5.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 145% above last closing price of US$2.04. Stock is up 89% over the past year.すべての更新を表示Recent updatesReported Earnings • May 14First quarter 2026 earnings released: US$0.20 loss per share (vs US$0.59 loss in 1Q 2025)First quarter 2026 results: US$0.20 loss per share (improved from US$0.59 loss in 1Q 2025). Revenue: US$806.9k (up 36% from 1Q 2025). Net loss: US$456.4k (loss narrowed 50% from 1Q 2025). Over the last 3 years on average, earnings per share has increased by 26% per year but the company’s share price has only increased by 5% per year, which means it is significantly lagging earnings growth.Reported Earnings • Mar 15Full year 2025 earnings: EPS and revenues exceed analyst expectationsFull year 2025 results: US$1.58 loss per share (improved from US$2.57 loss in FY 2024). Revenue: US$2.98m (up 19% from FY 2024). Net loss: US$2.68m (loss narrowed 32% from FY 2024). Revenue exceeded analyst estimates by 17%. Earnings per share (EPS) also surpassed analyst estimates by 23%. Revenue is forecast to grow 43% p.a. on average during the next 3 years, compared to a 20% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 26% per year but the company’s share price has fallen by 13% per year, which means it is significantly lagging earnings.New Risk • Mar 10New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of American stocks, typically moving 11% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 27% per year for the foreseeable future. Shareholders have been substantially diluted in the past year (49% increase in shares outstanding). Market cap is less than US$10m (US$5.29m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$7.2m net loss in 3 years). Share price has been volatile over the past 3 months (11% average weekly change). Revenue is less than US$5m (US$2.9m revenue).Reported Earnings • Nov 14Third quarter 2025 earnings: EPS and revenues exceed analyst expectationsThird quarter 2025 results: US$0.33 loss per share (further deteriorated from US$0.28 loss in 3Q 2024). Revenue: US$1.03m (up 67% from 3Q 2024). Net loss: US$509.9k (loss widened 17% from 3Q 2024). Revenue exceeded analyst estimates by 63%. Earnings per share (EPS) also surpassed analyst estimates by 33%. Revenue is forecast to grow 42% p.a. on average during the next 3 years, compared to a 22% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 27% per year but the company’s share price has fallen by 17% per year, which means it is significantly lagging earnings.お知らせ • Nov 03Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2025Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2025.New Risk • Oct 21New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 48% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (43% average weekly change). Earnings are forecast to decline by an average of 26% per year for the foreseeable future. Shareholders have been substantially diluted in the past year (48% increase in shares outstanding). Market cap is less than US$10m (US$9.34m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$7.9m net loss in 3 years). Revenue is less than US$5m (US$2.4m revenue).お知らせ • Oct 10+ 1 more updateXenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $4.4982 million.Xenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $4.4982 million. Security Name: Common Stock Security Type: Common Stock Securities Offered: 735,000 Price\Range: $6.12New Risk • Aug 17New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 26% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 26% per year for the foreseeable future. Market cap is less than US$10m (US$4.41m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$7.9m net loss in 3 years). Share price has been volatile over the past 3 months (13% average weekly change). Revenue is less than US$5m (US$2.4m revenue).Reported Earnings • Aug 14Second quarter 2025 earnings: EPS exceeds analyst expectations while revenues lag behindSecond quarter 2025 results: US$0.45 loss per share (improved from US$0.83 loss in 2Q 2024). Revenue: US$589.9k (down 19% from 2Q 2024). Net loss: US$688.7k (loss narrowed 46% from 2Q 2024). Revenue missed analyst estimates by 9.4%. Earnings per share (EPS) exceeded analyst estimates by 30%. Revenue is forecast to grow 42% p.a. on average during the next 3 years, compared to a 19% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 31% per year but the company’s share price has fallen by 29% per year, which means it is significantly lagging earnings.New Risk • Jun 25New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of American stocks, typically moving 13% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 29% per year for the foreseeable future. Market cap is less than US$10m (US$4.85m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$11m net loss in 3 years). Share price has been volatile over the past 3 months (13% average weekly change). Revenue is less than US$5m (US$2.6m revenue).Reported Earnings • May 16First quarter 2025 earnings: EPS exceeds analyst expectations while revenues lag behindFirst quarter 2025 results: US$0.59 loss per share (improved from US$0.78 loss in 1Q 2024). Revenue: US$593.3k (up 16% from 1Q 2024). Net loss: US$903.1k (loss narrowed 24% from 1Q 2024). Revenue missed analyst estimates by 13%. Earnings per share (EPS) exceeded analyst estimates by 18%. Revenue is forecast to grow 37% p.a. on average during the next 3 years, compared to a 17% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 30% per year but the company’s share price has fallen by 26% per year, which means it is significantly lagging earnings.Reported Earnings • Mar 19Full year 2024 earnings: Revenues exceed analysts expectations while EPS lags behindFull year 2024 results: US$2.57 loss per share (improved from US$2.71 loss in FY 2023). Revenue: US$2.50m (down 1.6% from FY 2023). Net loss: US$3.96m (loss narrowed 4.2% from FY 2023). Revenue exceeded analyst estimates by 11%. Earnings per share (EPS) missed analyst estimates by 154%. Revenue is forecast to grow 40% p.a. on average during the next 3 years, compared to a 20% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 30% per year but the company’s share price has fallen by 32% per year, which means it is significantly lagging earnings.お知らせ • Nov 22Xenetic Biosciences, Inc. Presents Positive Preclinical Data Highlighting Potential of Co-Administration of DNase I with CAR T Cells in Murine Model of Melanoma Lung MetastasisXenetic Biosciences, Inc. announced the presentation of preclinical data investigating the potential of co-administration of deoxyribonuclease I (DNase I) with chimeric antigen receptor (CAR) T cells in a syngeneic B16 melanoma murine model of lung metastasis. The poster titled, The synergistic action of DNase I and CAR T cells enhances the therapeutic efficacy of adoptive immunotherapy in the syngeneic murine metastasis model, was presented on behalf of the Company by Alexey Stepanov, PhD, Institute Investigator at The Scripps Research Institute, at the AACR Special Conference in Cancer Research: Tumor-body Interactions: The Roles of Micro- and Macroenvironment in Cancer, held November 17-20, 2024, in Boston. For the preclinical study co-administration of DNase I with CAR T cells was investigated in a syngeneic B16 murine melanoma model of lung metastasis. Bioluminescent imaging of melanoma metastatic processes has shown that a single injection of DNase I (10 mg/kg) together with CAR T cells suppressed B16-EGFR lung metastasis at early stages in comparison to the vehicle control group and extended survival. Key Highlights: Co-administration of single injection of DNase I (10 mg/kg) with murine EGFR-CAR T cells demonstrated to significantly suppress metastatic tumor burden, decreases the number of metastatic foci, and substantially prolongs survival compared to the CAR T cell monotherapy group. Degrading of NETs by DNase I increases the amount of tumor-infiltrating T and CAR T cells and reduces the immunosuppressive effects of the TME. Tumor immune cell infiltrate analysis revealed that the CD8 population of tumor-infiltrating CAR T cells from the DNase I treated group have lower expression of PD-1 and TIM-3 exhaustion markers. Xenetic continues to advance its DNase-based oncology program towards Phase 1 clinical development for the treatment of pancreatic carcinoma and other locally advanced or metastatic solid tumors. Preliminary preclinical studies evaluating the combinations of DNase I with chemotherapy and DNase I with immuno-therapies in colorectal cancer models as well as CAR-T therapy have been completed.Reported Earnings • Nov 14Third quarter 2024 earnings: EPS and revenues miss analyst expectationsThird quarter 2024 results: US$0.28 loss per share (improved from US$0.69 loss in 3Q 2023). Revenue: US$614.2k (flat on 3Q 2023). Net loss: US$436.7k (loss narrowed 59% from 3Q 2023). Revenue missed analyst estimates by 17%. Earnings per share (EPS) also missed analyst estimates by 100%. Revenue is forecast to grow 36% p.a. on average during the next 3 years, compared to a 22% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 30% per year but the company’s share price has fallen by 36% per year, which means it is significantly lagging earnings.お知らせ • Nov 14Xenetic Biosciences, Inc. Announces the Presentation of Positive Preclinical DataXenetic Biosciences, Inc. announced the presentation of positive preclinical data. The poster titled, " DNase I Targeting of Neutrophil Extracellular Traps Improves CTLA-4 Immune Checkpoint blockade in Models of MSS/MMRp CRC," was presented byReid3 Bissonnette, Ph.D., Executive Consultant for Translational Research and Development at Xenetic at the Society for Immunotherapy of Cancer (SITC) 39 th Annual Meeting held on November 6-10, 2024, in Houston, Texas and virtually. For the preclinical study, mice were implanted with either CT26 or Colon26 cells, both mouse models of MSS/MMRp CRC. The mice were treated with anti-CTLA-4 and either daily or biweekly DNase I (administered either ip or iv). Response was monitored by measuring tumor volume. Key Highlights: Data demonstrates beneficial effects of targeting NETs with systemic DNase I in models of primary tumor and metastatic CRC, improving the efficacy of CTLA-4 immune checkpoint blockade. Both published and newer data suggests that DNase I impedes neutrophil tumor infiltration, promotes CD4 and CD8 T cell infiltration, and enhances intratumoral T cell activation. DNase I plus ??-CTLA-4 combination therapy results in tumor growth inhibition, several CRs and enhanced survival in mice bearing CT26 or Colon26 MSS/MMRp CRC tumors. Dose response evaluations of DNase I combined with ??-CTLA-4, examining both route and frequency of administration was performed. DNase I plus ??-CTLA-4 combination therapy resulted in complete responses (CRs) in mice bearing either CT26 or Colon26 tumors. Significantly, rechallenge of Colon26 and CT26 complete responder animals resulted in no (0 mm3) tumor take or growth, suggesting that DNase I combined with ??-CTLA-4 promoted antitumor immunity and immunological memory. Xenetic's DNase-based oncology platform is designed to target NETs, which are weblike structures composed of extracellular chromatin coated with histones and other proteins. In cancer, NETs are expelled by activated neutrophils into the TME and blood, thereby promoting cancer spread and local and systemic immunosuppression. Reduction of NETs burden via application of Xenetic's proprietary recombinant human DNase I has been shown to improve efficacy of immunotherapy, adoptive cell therapy and chemotherapy in preclinical animal models.お知らせ • Nov 02Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2024Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2024.Reported Earnings • Aug 15Second quarter 2024 earnings: EPS in line with analyst expectations despite revenue beatSecond quarter 2024 results: US$0.83 loss per share (further deteriorated from US$0.69 loss in 2Q 2023). Revenue: US$726.4k (up 12% from 2Q 2023). Net loss: US$1.27m (loss widened 21% from 2Q 2023). Revenue is forecast to grow 34% p.a. on average during the next 3 years, compared to a 23% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 48% per year but the company’s share price has fallen by 54% per year, which means it is significantly lagging earnings.お知らせ • May 23Xenetic Biosciences, Inc. Announces the Appointment of James Parslow as Interim Chief Executive OfficerXenetic Biosciences, Inc. announced the appointment of James Parslow, the Company's Chief Financial Officer, as interim Chief Executive Officer, effective May 16, 2024. Mr. Parslow is a seasoned executive with over 35 years of experience providing financial and business leadership to the biotech, e-commerce and clean tech industries. Over the course of his career, Mr. Parslow has demonstrated expertise with strategic planning, general management and operations, budgeting, financial planning and analysis, accessing capital markets, M&A, investor relations, risk management, SOX compliance, and SEC/GAAP reporting. Mr. Parslow has served as the Company's Chief Financial Officer since April 2017.Reported Earnings • May 12First quarter 2024 earnings: EPS exceeds analyst expectations while revenues lag behindFirst quarter 2024 results: US$0.78 loss per share (further deteriorated from US$0.56 loss in 1Q 2023). Revenue: US$510.8k (down 16% from 1Q 2023). Net loss: US$1.20m (loss widened 40% from 1Q 2023). Revenue missed analyst estimates by 20%. Earnings per share (EPS) exceeded analyst estimates by 1.3%. Revenue is forecast to grow 33% p.a. on average during the next 3 years, compared to a 19% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 59% per year but the company’s share price has fallen by 38% per year, which means it is significantly lagging earnings.New Risk • May 12New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 32% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 32% per year for the foreseeable future. Market cap is less than US$10m (US$6.00m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$16m net loss in 3 years). Share price has been volatile over the past 3 months (11% average weekly change). Revenue is less than US$5m (US$2.5m revenue).New Risk • Apr 22New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of American stocks, typically moving 10% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 33% per year for the foreseeable future. Market cap is less than US$10m (US$6.47m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$18m net loss in 3 years). Share price has been volatile over the past 3 months (10% average weekly change). Revenue is less than US$5m (US$2.5m revenue).Reported Earnings • Mar 24Full year 2023 earnings: EPS exceeds analyst expectations while revenues lag behindFull year 2023 results: US$2.71 loss per share (improved from US$4.61 loss in FY 2022). Revenue: US$2.54m (up 49% from FY 2022). Net loss: US$4.13m (loss narrowed 37% from FY 2022). Revenue missed analyst estimates by 5.3%. Earnings per share (EPS) exceeded analyst estimates by 3.9%. Revenue is forecast to grow 28% p.a. on average during the next 3 years, compared to a 17% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 64% per year but the company’s share price has fallen by 45% per year, which means it is significantly lagging earnings.お知らせ • Mar 19CLS Therapeutics Discloses its Views on Xenetic BiosciencesOn March 18, 2024, CLS Therapeutics, Inc. announced that it has sent a letter to the Corporate Secretary of Xenetic Biosciences, Inc., for delivery to the board of directors, CLS and CLS LLC took notice of the stockholders’ vote, on December 6, 2023 at the 2023 annual meeting of the Company’s stockholders, ‘Against’ the compensation of the Company’s named executive officers, advised that they have concerns with the Company’s current management, and advocated for change in the Company’s senior management.お知らせ • Jan 17Xenetic Biosciences, Inc. Enters into Research Agreement with the University of Virginia for the Advancement of Its DNase-Based Oncology PlatformXenetic Biosciences, Inc. announced it has entered into a Research Funding Agreement and a Material Transfer Agreement with the University of Virginia ("UVA") to advance the development of its systemic DNase program. Xenetic's DNase-based oncology platform is designed to target neutrophil extracellular traps ("NETs"), which are weblike structures composed of extracellular chromatin coated with histones and other proteins. NETs are expelled by activated neutrophils, in response to microbial or pro-inflammatory challenges. However, excessive production or reduced clearance of NETs can lead to aggravated inflammatory and autoimmune pathologies, as well as creation and support of pro-tumorigenic niches in the case of cancer growth and metastasis, thereby potentially limiting response to therapy. Under the terms of the UVA agreements, in addition to advancing Xenetic's existing intellectual property, Xenetic has an option to acquire an exclusive license to any new intellectual property arising from the DNase research program. Allan Tsung, MD, member of the Company's Scientific Advisory Board and Chair of the Department of Surgery at the UVA School of Medicine, will oversee the research conducted under the agreement. As a surgical oncologist and scientist, Dr. Tsung is internationally recognized for leading substantial research on the role of NETs in tumor growth, metastasis, and resistance to existing cancer therapies. Xenetic is working toward its planned first-in-human study to evaluate DNase combined with immune checkpoint inhibitors or chemotherapy.お知らせ • Nov 14Xenetic Biosciences, Inc., Annual General Meeting, Dec 06, 2023Xenetic Biosciences, Inc., Annual General Meeting, Dec 06, 2023, at 10:00 US Eastern Standard Time. Agenda: To elect the Board’s nominees, Grigory Borisenko, James Callaway, Firdaus Jal Dastoor, Jeffrey Eisenberg, Dmitry Genkin, Roger Kornberg, Adam Logal, Moshe Mizrahy and Alexey Vinogradov, to the Board of Directors to serve until the next annual meeting and their successors are duly elected and qualified; to ratify the selection by the Audit Committee of Marcum LLP as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2023; to approve, by non-binding advisory vote, the resolution approving the named executive officer compensation (“Say on Pay”); and to conduct any other business properly brought before the meeting.Reported Earnings • Nov 12Third quarter 2023 earnings: EPS and revenues exceed analyst expectationsThird quarter 2023 results: US$0.69 loss per share (further deteriorated from US$0.56 loss in 3Q 2022). Revenue: US$611.2k (up 48% from 3Q 2022). Net loss: US$1.06m (loss widened 31% from 3Q 2022). Revenue exceeded analyst estimates by 35%. Earnings per share (EPS) also surpassed analyst estimates by 38%. Revenue is forecast to stay flat during the next 3 years compared to a 15% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 64% per year but the company’s share price has fallen by 30% per year, which means it is significantly lagging earnings.Reported Earnings • Aug 13Second quarter 2023 earnings: EPS and revenues exceed analyst expectationsSecond quarter 2023 results: US$0.69 loss per share (improved from US$1.90 loss in 2Q 2022). Revenue: US$651.0k (up 56% from 2Q 2022). Net loss: US$1.05m (loss narrowed 61% from 2Q 2022). Revenue exceeded analyst estimates by 45%. Earnings per share (EPS) also surpassed analyst estimates by 39%. Revenue is forecast to grow 5.7% p.a. on average during the next 3 years, compared to a 15% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 67% per year but the company’s share price has fallen by 33% per year, which means it is significantly lagging earnings.Reported Earnings • May 12First quarter 2023 earnings: EPS and revenues exceed analyst expectationsFirst quarter 2023 results: US$0.056 loss per share (improved from US$0.12 loss in 1Q 2022). Revenue: US$605.8k (up 56% from 1Q 2022). Net loss: US$856.6k (loss narrowed 46% from 1Q 2022). Revenue exceeded analyst estimates by 45%. Earnings per share (EPS) also surpassed analyst estimates by 45%. Revenue is forecast to grow 7.1% p.a. on average during the next 3 years, compared to a 19% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 70% per year but the company’s share price has fallen by 28% per year, which means it is significantly lagging earnings.Reported Earnings • Mar 24Full year 2022 earnings: Revenues exceed analysts expectations while EPS lags behindFull year 2022 results: US$0.46 loss per share. Revenue: US$1.71m (up 47% from FY 2021). Net loss: US$6.55m (loss widened 16% from FY 2021). Revenue exceeded analyst estimates by 16%. Earnings per share (EPS) missed analyst estimates by 2.2%. Revenue is forecast to grow 8.4% p.a. on average during the next 3 years, compared to a 13% growth forecast for the Biotechs industry in the US.分析記事 • Dec 15Most Shareholders Will Probably Find That The Compensation For Xenetic Biosciences, Inc.'s (NASDAQ:XBIO) CEO Is ReasonableKey Insights Xenetic Biosciences to hold its Annual General Meeting on 21 December 2022 CEO Jeff Eisenberg's total...分析記事 • Dec 01Why We Think Xenetic Biosciences, Inc.'s (NASDAQ:XBIO) CEO Compensation Is Not Excessive At AllShareholders may be wondering what CEO Jeff Eisenberg plans to do to improve the less than great performance at Xenetic...Price Target Changed • Nov 16Price target increased to US$4.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 841% above last closing price of US$0.43. Stock is down 74% over the past year. The company is forecast to post a net loss per share of US$0.45 next year compared to a net loss per share of US$0.55 last year.Reported Earnings • Nov 12Third quarter 2022 earnings: EPS and revenues exceed analyst expectationsThird quarter 2022 results: US$0.056 loss per share (improved from US$0.13 loss in 3Q 2021). Revenue: US$414.3k (up 19% from 3Q 2021). Net loss: US$804.0k (loss narrowed 41% from 3Q 2021). Revenue exceeded analyst estimates by 26%. Earnings per share (EPS) also surpassed analyst estimates by 67%. Revenue is forecast to grow 10% p.a. on average during the next 3 years, compared to a 14% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 100% per year but the company’s share price has fallen by 27% per year, which means it is significantly lagging earnings.Major Estimate Revision • Aug 18Consensus forecasts updatedThe consensus outlook for 2022 has been updated. 2022 losses of -US$0.68 per share expected, vs -US$0.46 per share profit forecast previously. Revenue forecast reaffirmed at US$1.39m. Biotechs industry in the US expected to see average net income decline 57% next year. Consensus price target of US$4.00 unchanged from last update. Share price fell 6.9% to US$0.82 over the past week.Reported Earnings • Aug 12Second quarter 2022 earnings: Revenues exceed analysts expectations while EPS lags behindSecond quarter 2022 results: US$0.19 loss per share (down from US$0.13 loss in 2Q 2021). Revenue: US$416.7k (up 45% from 2Q 2021). Net loss: US$2.67m (loss widened 142% from 2Q 2021). Revenue exceeded analyst estimates by 23%. Earnings per share (EPS) missed analyst estimates by 58%. Over the next year, revenue is expected to shrink by 5.9% compared to a 51% growth forecast for the industry in the US. Over the last 3 years on average, earnings per share has increased by 102% per year but the company’s share price has fallen by 21% per year, which means it is significantly lagging earnings.Seeking Alpha • Aug 12Xenetic Biosciences reports Q2 resultsXenetic Biosciences press release (NASDAQ:XBIO): Q2 Net loss of $2.7M The Company ended the quarter with approximately $14.9 million of cash. Shares +7.9% PM.Seeking Alpha • Aug 02Xenetic Biosciences, VolitionRx collaborate to develop cell therapies to treat cancerBiopharmaceutical firm Xenetic Biosciences (NASDAQ:XBIO) and VolitionRx (NYSE:VNRX), a developer of blood tests, have signed a research and development agreement for certain targeted cell therapies to treat cancer, the companies said on Tuesday. Xenetic (XBIO) stock had lost 5.4% to $0.87 in premarket trading, while shares of VolitionRx (VNRX) had gained 6.5% to $2.13. VNRX separately announced another R&D collaboration agreement with Salarius Pharmaceuticals (SLRX). XBIO and VNRX will develop neutrophil extracellular traps (NETs) which are net-like structures composed of DNA complexes and proteins. They are involved in cancer progression and metastatic dissemination. The R&D collaboration will evaluate the potential combination of VNRX's Nu.Q NETs Test and XBIO's CAR-T platform to develop cell therapies for the potential treatment of cancer. VolitionRx (VNRX) will fund the research program and the two parties will share proceeds from any products licensed or commercialized under the collaboration.Seeking Alpha • Jul 07Xenetic inks clinical manufacturing contract with CatalentXenetic Biosciences (NASDAQ:XBIO) said it engaged Catalent (NYSE:CTLT) to manufacture the company's recombinant protein Human DNase 1 for use in a cancer study. Catalent Pharma Solutions will carry out the cGMP manufacturing of DNase to help Xenetic advance to a phase 1 study, according to a July 7 press release. "We look forward to leveraging Catalent's proven biomanufacturing expertise at our site in Madison, Wisconsin to support the advancement of Xenetic's DNase clinical development program and accelerating their path to first-in-human studies," said Vikalp Mohan, global vice president, head of Drug Substance at Catalent Biologics Xenetic said its interventional DNase based cancer platform is aimed at improving outcomes of existing treatments, including immunotherapies.Reported Earnings • May 13First quarter 2022 earnings: Revenues exceed analysts expectations while EPS lags behindFirst quarter 2022 results: US$0.12 loss per share. Revenue: US$389.0k (up 103% from 1Q 2021). Net loss: US$1.59m (loss widened 18% from 1Q 2021). Revenue exceeded analyst estimates by 17%. Earnings per share (EPS) missed analyst estimates by 9.1%. Over the next year, revenue is forecast to grow 3.0%, compared to a 25% growth forecast for the industry in the US.Board Change • Apr 27High number of new directorsThere are 5 new directors who have joined the board in the last 3 years. Member Scientific Advisory Board Greg MacMichael was the last director to join the board, commencing their role in 2020. The company’s lack of board continuity is considered a risk according to the Simply Wall St Risk Model.Reported Earnings • Nov 14Third quarter 2021 earnings released: US$0.13 loss per share (vs US$1.20 loss in 3Q 2020)Third quarter 2021 results: Net loss: US$1.35m (loss narrowed 82% from 3Q 2020). Over the last 3 years on average, earnings per share has increased by 63% per year but the company’s share price has fallen by 62% per year, which means it is significantly lagging earnings.Major Estimate Revision • Aug 19Consensus EPS estimates increase to -US$0.55The consensus outlook for earnings per share (EPS) in 2021 has improved. 2021 revenue forecast increased from US$787.2k to US$799.7k. EPS estimate increased from -US$0.66 to -US$0.55. Biotechs industry in the US expected to see average net income decline 21% next year. Consensus price target of US$5.00 unchanged from last update. Share price fell 3.4% to US$3.13 over the past week.Reported Earnings • Aug 14Second quarter 2021 earnings released: US$0.13 loss per share (vs US$0.15 loss in 2Q 2020)Second quarter 2021 results: Net loss: US$1.11m (loss widened 16% from 2Q 2020). Over the last 3 years on average, earnings per share has increased by 41% per year but the company’s share price has fallen by 54% per year, which means it is significantly lagging earnings.Price Target Changed • Jul 01Price target increased to US$5.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 145% above last closing price of US$2.04. Stock is up 89% over the past year.お知らせ • Dec 16Xenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $6.000001 million.Xenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $6.000001 million. Security Name: Common Stock Security Type: Common Stock Securities Offered: 2,448,980 Price\Range: $2.45 Discount Per Security: $0.1715 Transaction Features: Registered Direct Offeringお知らせ • Nov 02Xenetic Biosciences Receives Notice from the Listing Qualifications Department of the Nasdaq Stock Market LLCOn October 29, 2020, Xenetic Biosciences, Inc. (the "Company") received a written notification (the "Notice") from the Listing Qualifications Department of the NASDAQ Stock Market LLC ("Nasdaq") notifying the Company that the closing bid price for its common stock had been below $1.00 for 30 consecutive business days and that the Company therefore is not in compliance with the minimum bid price requirement for continued inclusion on The Nasdaq Capital Market under Nasdaq Listing Rule 5550(a)(2) (the "Bid Price Requirement"). The Notice has no immediate effect on the listing of the Company's common stock on the Nasdaq Capital Market. The company has until April 27, 2021 (the "Compliance Date"), to regain compliance with the Bid Price Requirement. To regain compliance, the closing bid price of the Company's common stock must be at least $1.00 for a minimum of ten consecutive business days prior to the Compliance Date. In the event the Company does not regain compliance by the Compliance Date, the Company may be eligible for an additional 180 calendar day compliance period. To qualify for this second compliance period, the Company will be required to meet the continued listing requirement for market value of publicly held shares and all other initial listing standards for The Nasdaq Capital Market, with the exception of the Bid Price Requirement, and will need to provide written notice of its intention to cure the deficiency during the second compliance period, by effecting a reverse stock split, if necessary. The Company intends to monitor the closing bid price of its common stock and may, if appropriate, consider available options to regain compliance with the Bid Price Requirement. However, there can be no assurance that the Company will be able to regain compliance with the Bid Price Requirement, or will otherwise be in compliance with other Nasdaq Listing Rules. このセクションでは通常、投資家が会社の利益創出能力を理解する一助となるよう、プロのアナリストのコンセンサス予想に基づく収益と利益の成長予測を提示する。しかし、Xenetic Biosciences は十分な過去のデータを提供しておらず、アナリストの予測もないため、過去のデータを外挿したり、アナリストの予測を使用しても、その将来の収益を確実に算出することはできません。 シンプリー・ウォール・ストリートがカバーする企業の97%は過去の財務データを持っているため、これはかなり稀な状況です。 業績と収益の成長予測NasdaqCM:XBIO - アナリストの将来予測と過去の財務データ ( )USD Millions日付収益収益フリー・キャッシュフロー営業活動によるキャッシュ平均アナリスト数3/31/20263-2-2-2N/A12/31/20253-3-2-2N/A9/30/20253-3-3-3N/A6/30/20252-3-3-3N/A3/31/20253-4-3-3N/A12/31/20243-4-3-3N/A9/30/20243-4-3-3N/A6/30/20243-5-3-3N/A3/31/20242-4-4-4N/A12/31/20233-4-4-4N/A9/30/20232-4-4-4N/A6/30/20232-4-4-4N/A3/31/20232-6-4-4N/A12/31/20222-7-5-5N/A9/30/20222-7-6-5N/A6/30/20221-7-6-5N/A3/31/20221-6-5-5N/A12/31/20211-6-5-5N/A9/30/20211-5-4-4N/A6/30/20211-11-4-4N/A3/31/20211-11-5-5N/A12/31/20200-11-4-4N/A9/30/20200-11-5-5N/A6/30/20200-14-6-6N/A3/31/20200-14-6-6N/A12/31/20190-18N/A-6N/A9/30/2019N/A-19N/A-6N/A6/30/2019N/A-10N/A-5N/A3/31/2019N/A-11N/A-6N/A12/31/2018N/A-7N/A-6N/A9/30/20188-1N/A-1N/A6/30/20188-2N/A-1N/A3/31/20188-3N/A0N/A12/31/20178-4N/A1N/A9/30/20173-12N/A-8N/A6/30/20173-13N/A-7N/A3/31/20173-58N/A-7N/A12/31/20163-58N/A-9N/A9/30/2016N/A-57N/A-5N/A6/30/2016N/A-60N/A-6N/A3/31/2016N/A-14N/A-5N/A12/31/2015N/A-13N/A-5N/A9/30/2015N/A-13N/A-7N/Aもっと見るアナリストによる今後の成長予測収入対貯蓄率: XBIOの予測収益成長が 貯蓄率 ( 3.5% ) を上回っているかどうかを判断するにはデータが不十分です。収益対市場: XBIOの収益がUS市場よりも速く成長すると予測されるかどうかを判断するにはデータが不十分です高成長収益: XBIOの収益が今後 3 年間で 大幅に 増加すると予想されるかどうかを判断するにはデータが不十分です。収益対市場: XBIOの収益がUS市場よりも速く成長すると予測されるかどうかを判断するにはデータが不十分です。高い収益成長: XBIOの収益が年間20%よりも速く成長すると予測されるかどうかを判断するにはデータが不十分です。一株当たり利益成長率予想将来の株主資本利益率将来のROE: XBIOの 自己資本利益率 が 3 年後に高くなると予測されるかどうかを判断するにはデータが不十分です成長企業の発掘7D1Y7D1Y7D1YPharmaceuticals-biotech 業界の高成長企業。View Past Performance企業分析と財務データの現状データ最終更新日（UTC時間）企業分析2026/06/14 23:47終値2026/06/12 00:00収益2026/03/31年間収益2025/12/31データソース企業分析に使用したデータはS&P Global Market Intelligence LLC のものです。本レポートを作成するための分析モデルでは、以下のデータを使用しています。データは正規化されているため、ソースが利用可能になるまでに時間がかかる場合があります。パッケージデータタイムフレーム米国ソース例会社財務10年損益計算書キャッシュ・フロー計算書貸借対照表SECフォーム10-KSECフォーム10-Qアナリストのコンセンサス予想+プラス3年予想財務アナリストの目標株価アナリストリサーチレポートBlue Matrix市場価格30年株価配当、分割、措置ICEマーケットデータSECフォームS-1所有権10年トップ株主インサイダー取引SECフォーム4SECフォーム13Dマネジメント10年リーダーシップ・チーム取締役会SECフォーム10-KSECフォームDEF 14A主な進展10年会社からのお知らせSECフォーム8-K* 米国証券を対象とした例であり、非米国証券については、同等の規制書式および情報源を使用。特に断りのない限り、すべての財務データは1年ごとの期間に基づいていますが、四半期ごとに更新されます。これは、TTM（Trailing Twelve Month）またはLTM（Last Twelve Month）データとして知られています。詳細はこちら。分析モデルとスノーフレーク本レポートを生成するために使用した分析モデルの詳細は当社のGithubページでご覧いただけます。また、レポートの使用方法に関するガイドやYoutubeのチュートリアルも掲載しています。シンプリー・ウォールストリート分析モデルを設計・構築した世界トップクラスのチームについてご紹介します。業界およびセクターの指標私たちの業界とセクションの指標は、Simply Wall Stによって6時間ごとに計算されます。アナリスト筋Xenetic Biosciences, Inc. 0 これらのアナリストのうち、弊社レポートのインプットとして使用した売上高または利益の予想を提出したのは、 。アナリストの投稿は一日中更新されます。4 アナリスト機関Joseph PantginisH.C. Wainwright & Co.Kevin DeGeeterLadenburg Thalmann & CompanyRahul JasujaNOBLE Capital Markets, Inc.1 その他のアナリストを表示
Price Target Changed • Nov 16Price target increased to US$4.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 841% above last closing price of US$0.43. Stock is down 74% over the past year. The company is forecast to post a net loss per share of US$0.45 next year compared to a net loss per share of US$0.55 last year.
Major Estimate Revision • Aug 18Consensus forecasts updatedThe consensus outlook for 2022 has been updated. 2022 losses of -US$0.68 per share expected, vs -US$0.46 per share profit forecast previously. Revenue forecast reaffirmed at US$1.39m. Biotechs industry in the US expected to see average net income decline 57% next year. Consensus price target of US$4.00 unchanged from last update. Share price fell 6.9% to US$0.82 over the past week.
Major Estimate Revision • Aug 19Consensus EPS estimates increase to -US$0.55The consensus outlook for earnings per share (EPS) in 2021 has improved. 2021 revenue forecast increased from US$787.2k to US$799.7k. EPS estimate increased from -US$0.66 to -US$0.55. Biotechs industry in the US expected to see average net income decline 21% next year. Consensus price target of US$5.00 unchanged from last update. Share price fell 3.4% to US$3.13 over the past week.
Price Target Changed • Jul 01Price target increased to US$5.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 145% above last closing price of US$2.04. Stock is up 89% over the past year.
Reported Earnings • May 14First quarter 2026 earnings released: US$0.20 loss per share (vs US$0.59 loss in 1Q 2025)First quarter 2026 results: US$0.20 loss per share (improved from US$0.59 loss in 1Q 2025). Revenue: US$806.9k (up 36% from 1Q 2025). Net loss: US$456.4k (loss narrowed 50% from 1Q 2025). Over the last 3 years on average, earnings per share has increased by 26% per year but the company’s share price has only increased by 5% per year, which means it is significantly lagging earnings growth.
Reported Earnings • Mar 15Full year 2025 earnings: EPS and revenues exceed analyst expectationsFull year 2025 results: US$1.58 loss per share (improved from US$2.57 loss in FY 2024). Revenue: US$2.98m (up 19% from FY 2024). Net loss: US$2.68m (loss narrowed 32% from FY 2024). Revenue exceeded analyst estimates by 17%. Earnings per share (EPS) also surpassed analyst estimates by 23%. Revenue is forecast to grow 43% p.a. on average during the next 3 years, compared to a 20% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 26% per year but the company’s share price has fallen by 13% per year, which means it is significantly lagging earnings.
New Risk • Mar 10New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of American stocks, typically moving 11% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 27% per year for the foreseeable future. Shareholders have been substantially diluted in the past year (49% increase in shares outstanding). Market cap is less than US$10m (US$5.29m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$7.2m net loss in 3 years). Share price has been volatile over the past 3 months (11% average weekly change). Revenue is less than US$5m (US$2.9m revenue).
Reported Earnings • Nov 14Third quarter 2025 earnings: EPS and revenues exceed analyst expectationsThird quarter 2025 results: US$0.33 loss per share (further deteriorated from US$0.28 loss in 3Q 2024). Revenue: US$1.03m (up 67% from 3Q 2024). Net loss: US$509.9k (loss widened 17% from 3Q 2024). Revenue exceeded analyst estimates by 63%. Earnings per share (EPS) also surpassed analyst estimates by 33%. Revenue is forecast to grow 42% p.a. on average during the next 3 years, compared to a 22% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 27% per year but the company’s share price has fallen by 17% per year, which means it is significantly lagging earnings.
お知らせ • Nov 03Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2025Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2025.
New Risk • Oct 21New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 48% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (43% average weekly change). Earnings are forecast to decline by an average of 26% per year for the foreseeable future. Shareholders have been substantially diluted in the past year (48% increase in shares outstanding). Market cap is less than US$10m (US$9.34m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$7.9m net loss in 3 years). Revenue is less than US$5m (US$2.4m revenue).
お知らせ • Oct 10+ 1 more updateXenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $4.4982 million.Xenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $4.4982 million. Security Name: Common Stock Security Type: Common Stock Securities Offered: 735,000 Price\Range: $6.12
New Risk • Aug 17New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 26% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 26% per year for the foreseeable future. Market cap is less than US$10m (US$4.41m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$7.9m net loss in 3 years). Share price has been volatile over the past 3 months (13% average weekly change). Revenue is less than US$5m (US$2.4m revenue).
Reported Earnings • Aug 14Second quarter 2025 earnings: EPS exceeds analyst expectations while revenues lag behindSecond quarter 2025 results: US$0.45 loss per share (improved from US$0.83 loss in 2Q 2024). Revenue: US$589.9k (down 19% from 2Q 2024). Net loss: US$688.7k (loss narrowed 46% from 2Q 2024). Revenue missed analyst estimates by 9.4%. Earnings per share (EPS) exceeded analyst estimates by 30%. Revenue is forecast to grow 42% p.a. on average during the next 3 years, compared to a 19% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 31% per year but the company’s share price has fallen by 29% per year, which means it is significantly lagging earnings.
New Risk • Jun 25New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of American stocks, typically moving 13% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 29% per year for the foreseeable future. Market cap is less than US$10m (US$4.85m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$11m net loss in 3 years). Share price has been volatile over the past 3 months (13% average weekly change). Revenue is less than US$5m (US$2.6m revenue).
Reported Earnings • May 16First quarter 2025 earnings: EPS exceeds analyst expectations while revenues lag behindFirst quarter 2025 results: US$0.59 loss per share (improved from US$0.78 loss in 1Q 2024). Revenue: US$593.3k (up 16% from 1Q 2024). Net loss: US$903.1k (loss narrowed 24% from 1Q 2024). Revenue missed analyst estimates by 13%. Earnings per share (EPS) exceeded analyst estimates by 18%. Revenue is forecast to grow 37% p.a. on average during the next 3 years, compared to a 17% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 30% per year but the company’s share price has fallen by 26% per year, which means it is significantly lagging earnings.
Reported Earnings • Mar 19Full year 2024 earnings: Revenues exceed analysts expectations while EPS lags behindFull year 2024 results: US$2.57 loss per share (improved from US$2.71 loss in FY 2023). Revenue: US$2.50m (down 1.6% from FY 2023). Net loss: US$3.96m (loss narrowed 4.2% from FY 2023). Revenue exceeded analyst estimates by 11%. Earnings per share (EPS) missed analyst estimates by 154%. Revenue is forecast to grow 40% p.a. on average during the next 3 years, compared to a 20% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 30% per year but the company’s share price has fallen by 32% per year, which means it is significantly lagging earnings.
お知らせ • Nov 22Xenetic Biosciences, Inc. Presents Positive Preclinical Data Highlighting Potential of Co-Administration of DNase I with CAR T Cells in Murine Model of Melanoma Lung MetastasisXenetic Biosciences, Inc. announced the presentation of preclinical data investigating the potential of co-administration of deoxyribonuclease I (DNase I) with chimeric antigen receptor (CAR) T cells in a syngeneic B16 melanoma murine model of lung metastasis. The poster titled, The synergistic action of DNase I and CAR T cells enhances the therapeutic efficacy of adoptive immunotherapy in the syngeneic murine metastasis model, was presented on behalf of the Company by Alexey Stepanov, PhD, Institute Investigator at The Scripps Research Institute, at the AACR Special Conference in Cancer Research: Tumor-body Interactions: The Roles of Micro- and Macroenvironment in Cancer, held November 17-20, 2024, in Boston. For the preclinical study co-administration of DNase I with CAR T cells was investigated in a syngeneic B16 murine melanoma model of lung metastasis. Bioluminescent imaging of melanoma metastatic processes has shown that a single injection of DNase I (10 mg/kg) together with CAR T cells suppressed B16-EGFR lung metastasis at early stages in comparison to the vehicle control group and extended survival. Key Highlights: Co-administration of single injection of DNase I (10 mg/kg) with murine EGFR-CAR T cells demonstrated to significantly suppress metastatic tumor burden, decreases the number of metastatic foci, and substantially prolongs survival compared to the CAR T cell monotherapy group. Degrading of NETs by DNase I increases the amount of tumor-infiltrating T and CAR T cells and reduces the immunosuppressive effects of the TME. Tumor immune cell infiltrate analysis revealed that the CD8 population of tumor-infiltrating CAR T cells from the DNase I treated group have lower expression of PD-1 and TIM-3 exhaustion markers. Xenetic continues to advance its DNase-based oncology program towards Phase 1 clinical development for the treatment of pancreatic carcinoma and other locally advanced or metastatic solid tumors. Preliminary preclinical studies evaluating the combinations of DNase I with chemotherapy and DNase I with immuno-therapies in colorectal cancer models as well as CAR-T therapy have been completed.
Reported Earnings • Nov 14Third quarter 2024 earnings: EPS and revenues miss analyst expectationsThird quarter 2024 results: US$0.28 loss per share (improved from US$0.69 loss in 3Q 2023). Revenue: US$614.2k (flat on 3Q 2023). Net loss: US$436.7k (loss narrowed 59% from 3Q 2023). Revenue missed analyst estimates by 17%. Earnings per share (EPS) also missed analyst estimates by 100%. Revenue is forecast to grow 36% p.a. on average during the next 3 years, compared to a 22% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 30% per year but the company’s share price has fallen by 36% per year, which means it is significantly lagging earnings.
お知らせ • Nov 14Xenetic Biosciences, Inc. Announces the Presentation of Positive Preclinical DataXenetic Biosciences, Inc. announced the presentation of positive preclinical data. The poster titled, " DNase I Targeting of Neutrophil Extracellular Traps Improves CTLA-4 Immune Checkpoint blockade in Models of MSS/MMRp CRC," was presented byReid3 Bissonnette, Ph.D., Executive Consultant for Translational Research and Development at Xenetic at the Society for Immunotherapy of Cancer (SITC) 39 th Annual Meeting held on November 6-10, 2024, in Houston, Texas and virtually. For the preclinical study, mice were implanted with either CT26 or Colon26 cells, both mouse models of MSS/MMRp CRC. The mice were treated with anti-CTLA-4 and either daily or biweekly DNase I (administered either ip or iv). Response was monitored by measuring tumor volume. Key Highlights: Data demonstrates beneficial effects of targeting NETs with systemic DNase I in models of primary tumor and metastatic CRC, improving the efficacy of CTLA-4 immune checkpoint blockade. Both published and newer data suggests that DNase I impedes neutrophil tumor infiltration, promotes CD4 and CD8 T cell infiltration, and enhances intratumoral T cell activation. DNase I plus ??-CTLA-4 combination therapy results in tumor growth inhibition, several CRs and enhanced survival in mice bearing CT26 or Colon26 MSS/MMRp CRC tumors. Dose response evaluations of DNase I combined with ??-CTLA-4, examining both route and frequency of administration was performed. DNase I plus ??-CTLA-4 combination therapy resulted in complete responses (CRs) in mice bearing either CT26 or Colon26 tumors. Significantly, rechallenge of Colon26 and CT26 complete responder animals resulted in no (0 mm3) tumor take or growth, suggesting that DNase I combined with ??-CTLA-4 promoted antitumor immunity and immunological memory. Xenetic's DNase-based oncology platform is designed to target NETs, which are weblike structures composed of extracellular chromatin coated with histones and other proteins. In cancer, NETs are expelled by activated neutrophils into the TME and blood, thereby promoting cancer spread and local and systemic immunosuppression. Reduction of NETs burden via application of Xenetic's proprietary recombinant human DNase I has been shown to improve efficacy of immunotherapy, adoptive cell therapy and chemotherapy in preclinical animal models.
お知らせ • Nov 02Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2024Xenetic Biosciences, Inc., Annual General Meeting, Dec 11, 2024.
Reported Earnings • Aug 15Second quarter 2024 earnings: EPS in line with analyst expectations despite revenue beatSecond quarter 2024 results: US$0.83 loss per share (further deteriorated from US$0.69 loss in 2Q 2023). Revenue: US$726.4k (up 12% from 2Q 2023). Net loss: US$1.27m (loss widened 21% from 2Q 2023). Revenue is forecast to grow 34% p.a. on average during the next 3 years, compared to a 23% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 48% per year but the company’s share price has fallen by 54% per year, which means it is significantly lagging earnings.
お知らせ • May 23Xenetic Biosciences, Inc. Announces the Appointment of James Parslow as Interim Chief Executive OfficerXenetic Biosciences, Inc. announced the appointment of James Parslow, the Company's Chief Financial Officer, as interim Chief Executive Officer, effective May 16, 2024. Mr. Parslow is a seasoned executive with over 35 years of experience providing financial and business leadership to the biotech, e-commerce and clean tech industries. Over the course of his career, Mr. Parslow has demonstrated expertise with strategic planning, general management and operations, budgeting, financial planning and analysis, accessing capital markets, M&A, investor relations, risk management, SOX compliance, and SEC/GAAP reporting. Mr. Parslow has served as the Company's Chief Financial Officer since April 2017.
Reported Earnings • May 12First quarter 2024 earnings: EPS exceeds analyst expectations while revenues lag behindFirst quarter 2024 results: US$0.78 loss per share (further deteriorated from US$0.56 loss in 1Q 2023). Revenue: US$510.8k (down 16% from 1Q 2023). Net loss: US$1.20m (loss widened 40% from 1Q 2023). Revenue missed analyst estimates by 20%. Earnings per share (EPS) exceeded analyst estimates by 1.3%. Revenue is forecast to grow 33% p.a. on average during the next 3 years, compared to a 19% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 59% per year but the company’s share price has fallen by 38% per year, which means it is significantly lagging earnings.
New Risk • May 12New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 32% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 32% per year for the foreseeable future. Market cap is less than US$10m (US$6.00m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$16m net loss in 3 years). Share price has been volatile over the past 3 months (11% average weekly change). Revenue is less than US$5m (US$2.5m revenue).
New Risk • Apr 22New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of American stocks, typically moving 10% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 33% per year for the foreseeable future. Market cap is less than US$10m (US$6.47m market cap). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$18m net loss in 3 years). Share price has been volatile over the past 3 months (10% average weekly change). Revenue is less than US$5m (US$2.5m revenue).
Reported Earnings • Mar 24Full year 2023 earnings: EPS exceeds analyst expectations while revenues lag behindFull year 2023 results: US$2.71 loss per share (improved from US$4.61 loss in FY 2022). Revenue: US$2.54m (up 49% from FY 2022). Net loss: US$4.13m (loss narrowed 37% from FY 2022). Revenue missed analyst estimates by 5.3%. Earnings per share (EPS) exceeded analyst estimates by 3.9%. Revenue is forecast to grow 28% p.a. on average during the next 3 years, compared to a 17% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 64% per year but the company’s share price has fallen by 45% per year, which means it is significantly lagging earnings.
お知らせ • Mar 19CLS Therapeutics Discloses its Views on Xenetic BiosciencesOn March 18, 2024, CLS Therapeutics, Inc. announced that it has sent a letter to the Corporate Secretary of Xenetic Biosciences, Inc., for delivery to the board of directors, CLS and CLS LLC took notice of the stockholders’ vote, on December 6, 2023 at the 2023 annual meeting of the Company’s stockholders, ‘Against’ the compensation of the Company’s named executive officers, advised that they have concerns with the Company’s current management, and advocated for change in the Company’s senior management.
お知らせ • Jan 17Xenetic Biosciences, Inc. Enters into Research Agreement with the University of Virginia for the Advancement of Its DNase-Based Oncology PlatformXenetic Biosciences, Inc. announced it has entered into a Research Funding Agreement and a Material Transfer Agreement with the University of Virginia ("UVA") to advance the development of its systemic DNase program. Xenetic's DNase-based oncology platform is designed to target neutrophil extracellular traps ("NETs"), which are weblike structures composed of extracellular chromatin coated with histones and other proteins. NETs are expelled by activated neutrophils, in response to microbial or pro-inflammatory challenges. However, excessive production or reduced clearance of NETs can lead to aggravated inflammatory and autoimmune pathologies, as well as creation and support of pro-tumorigenic niches in the case of cancer growth and metastasis, thereby potentially limiting response to therapy. Under the terms of the UVA agreements, in addition to advancing Xenetic's existing intellectual property, Xenetic has an option to acquire an exclusive license to any new intellectual property arising from the DNase research program. Allan Tsung, MD, member of the Company's Scientific Advisory Board and Chair of the Department of Surgery at the UVA School of Medicine, will oversee the research conducted under the agreement. As a surgical oncologist and scientist, Dr. Tsung is internationally recognized for leading substantial research on the role of NETs in tumor growth, metastasis, and resistance to existing cancer therapies. Xenetic is working toward its planned first-in-human study to evaluate DNase combined with immune checkpoint inhibitors or chemotherapy.
お知らせ • Nov 14Xenetic Biosciences, Inc., Annual General Meeting, Dec 06, 2023Xenetic Biosciences, Inc., Annual General Meeting, Dec 06, 2023, at 10:00 US Eastern Standard Time. Agenda: To elect the Board’s nominees, Grigory Borisenko, James Callaway, Firdaus Jal Dastoor, Jeffrey Eisenberg, Dmitry Genkin, Roger Kornberg, Adam Logal, Moshe Mizrahy and Alexey Vinogradov, to the Board of Directors to serve until the next annual meeting and their successors are duly elected and qualified; to ratify the selection by the Audit Committee of Marcum LLP as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2023; to approve, by non-binding advisory vote, the resolution approving the named executive officer compensation (“Say on Pay”); and to conduct any other business properly brought before the meeting.
Reported Earnings • Nov 12Third quarter 2023 earnings: EPS and revenues exceed analyst expectationsThird quarter 2023 results: US$0.69 loss per share (further deteriorated from US$0.56 loss in 3Q 2022). Revenue: US$611.2k (up 48% from 3Q 2022). Net loss: US$1.06m (loss widened 31% from 3Q 2022). Revenue exceeded analyst estimates by 35%. Earnings per share (EPS) also surpassed analyst estimates by 38%. Revenue is forecast to stay flat during the next 3 years compared to a 15% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 64% per year but the company’s share price has fallen by 30% per year, which means it is significantly lagging earnings.
Reported Earnings • Aug 13Second quarter 2023 earnings: EPS and revenues exceed analyst expectationsSecond quarter 2023 results: US$0.69 loss per share (improved from US$1.90 loss in 2Q 2022). Revenue: US$651.0k (up 56% from 2Q 2022). Net loss: US$1.05m (loss narrowed 61% from 2Q 2022). Revenue exceeded analyst estimates by 45%. Earnings per share (EPS) also surpassed analyst estimates by 39%. Revenue is forecast to grow 5.7% p.a. on average during the next 3 years, compared to a 15% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 67% per year but the company’s share price has fallen by 33% per year, which means it is significantly lagging earnings.
Reported Earnings • May 12First quarter 2023 earnings: EPS and revenues exceed analyst expectationsFirst quarter 2023 results: US$0.056 loss per share (improved from US$0.12 loss in 1Q 2022). Revenue: US$605.8k (up 56% from 1Q 2022). Net loss: US$856.6k (loss narrowed 46% from 1Q 2022). Revenue exceeded analyst estimates by 45%. Earnings per share (EPS) also surpassed analyst estimates by 45%. Revenue is forecast to grow 7.1% p.a. on average during the next 3 years, compared to a 19% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 70% per year but the company’s share price has fallen by 28% per year, which means it is significantly lagging earnings.
Reported Earnings • Mar 24Full year 2022 earnings: Revenues exceed analysts expectations while EPS lags behindFull year 2022 results: US$0.46 loss per share. Revenue: US$1.71m (up 47% from FY 2021). Net loss: US$6.55m (loss widened 16% from FY 2021). Revenue exceeded analyst estimates by 16%. Earnings per share (EPS) missed analyst estimates by 2.2%. Revenue is forecast to grow 8.4% p.a. on average during the next 3 years, compared to a 13% growth forecast for the Biotechs industry in the US.
分析記事 • Dec 15Most Shareholders Will Probably Find That The Compensation For Xenetic Biosciences, Inc.'s (NASDAQ:XBIO) CEO Is ReasonableKey Insights Xenetic Biosciences to hold its Annual General Meeting on 21 December 2022 CEO Jeff Eisenberg's total...
分析記事 • Dec 01Why We Think Xenetic Biosciences, Inc.'s (NASDAQ:XBIO) CEO Compensation Is Not Excessive At AllShareholders may be wondering what CEO Jeff Eisenberg plans to do to improve the less than great performance at Xenetic...
Price Target Changed • Nov 16Price target increased to US$4.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 841% above last closing price of US$0.43. Stock is down 74% over the past year. The company is forecast to post a net loss per share of US$0.45 next year compared to a net loss per share of US$0.55 last year.
Reported Earnings • Nov 12Third quarter 2022 earnings: EPS and revenues exceed analyst expectationsThird quarter 2022 results: US$0.056 loss per share (improved from US$0.13 loss in 3Q 2021). Revenue: US$414.3k (up 19% from 3Q 2021). Net loss: US$804.0k (loss narrowed 41% from 3Q 2021). Revenue exceeded analyst estimates by 26%. Earnings per share (EPS) also surpassed analyst estimates by 67%. Revenue is forecast to grow 10% p.a. on average during the next 3 years, compared to a 14% growth forecast for the Biotechs industry in the US. Over the last 3 years on average, earnings per share has increased by 100% per year but the company’s share price has fallen by 27% per year, which means it is significantly lagging earnings.
Major Estimate Revision • Aug 18Consensus forecasts updatedThe consensus outlook for 2022 has been updated. 2022 losses of -US$0.68 per share expected, vs -US$0.46 per share profit forecast previously. Revenue forecast reaffirmed at US$1.39m. Biotechs industry in the US expected to see average net income decline 57% next year. Consensus price target of US$4.00 unchanged from last update. Share price fell 6.9% to US$0.82 over the past week.
Reported Earnings • Aug 12Second quarter 2022 earnings: Revenues exceed analysts expectations while EPS lags behindSecond quarter 2022 results: US$0.19 loss per share (down from US$0.13 loss in 2Q 2021). Revenue: US$416.7k (up 45% from 2Q 2021). Net loss: US$2.67m (loss widened 142% from 2Q 2021). Revenue exceeded analyst estimates by 23%. Earnings per share (EPS) missed analyst estimates by 58%. Over the next year, revenue is expected to shrink by 5.9% compared to a 51% growth forecast for the industry in the US. Over the last 3 years on average, earnings per share has increased by 102% per year but the company’s share price has fallen by 21% per year, which means it is significantly lagging earnings.
Seeking Alpha • Aug 12Xenetic Biosciences reports Q2 resultsXenetic Biosciences press release (NASDAQ:XBIO): Q2 Net loss of $2.7M The Company ended the quarter with approximately $14.9 million of cash. Shares +7.9% PM.
Seeking Alpha • Aug 02Xenetic Biosciences, VolitionRx collaborate to develop cell therapies to treat cancerBiopharmaceutical firm Xenetic Biosciences (NASDAQ:XBIO) and VolitionRx (NYSE:VNRX), a developer of blood tests, have signed a research and development agreement for certain targeted cell therapies to treat cancer, the companies said on Tuesday. Xenetic (XBIO) stock had lost 5.4% to $0.87 in premarket trading, while shares of VolitionRx (VNRX) had gained 6.5% to $2.13. VNRX separately announced another R&D collaboration agreement with Salarius Pharmaceuticals (SLRX). XBIO and VNRX will develop neutrophil extracellular traps (NETs) which are net-like structures composed of DNA complexes and proteins. They are involved in cancer progression and metastatic dissemination. The R&D collaboration will evaluate the potential combination of VNRX's Nu.Q NETs Test and XBIO's CAR-T platform to develop cell therapies for the potential treatment of cancer. VolitionRx (VNRX) will fund the research program and the two parties will share proceeds from any products licensed or commercialized under the collaboration.
Seeking Alpha • Jul 07Xenetic inks clinical manufacturing contract with CatalentXenetic Biosciences (NASDAQ:XBIO) said it engaged Catalent (NYSE:CTLT) to manufacture the company's recombinant protein Human DNase 1 for use in a cancer study. Catalent Pharma Solutions will carry out the cGMP manufacturing of DNase to help Xenetic advance to a phase 1 study, according to a July 7 press release. "We look forward to leveraging Catalent's proven biomanufacturing expertise at our site in Madison, Wisconsin to support the advancement of Xenetic's DNase clinical development program and accelerating their path to first-in-human studies," said Vikalp Mohan, global vice president, head of Drug Substance at Catalent Biologics Xenetic said its interventional DNase based cancer platform is aimed at improving outcomes of existing treatments, including immunotherapies.
Reported Earnings • May 13First quarter 2022 earnings: Revenues exceed analysts expectations while EPS lags behindFirst quarter 2022 results: US$0.12 loss per share. Revenue: US$389.0k (up 103% from 1Q 2021). Net loss: US$1.59m (loss widened 18% from 1Q 2021). Revenue exceeded analyst estimates by 17%. Earnings per share (EPS) missed analyst estimates by 9.1%. Over the next year, revenue is forecast to grow 3.0%, compared to a 25% growth forecast for the industry in the US.
Board Change • Apr 27High number of new directorsThere are 5 new directors who have joined the board in the last 3 years. Member Scientific Advisory Board Greg MacMichael was the last director to join the board, commencing their role in 2020. The company’s lack of board continuity is considered a risk according to the Simply Wall St Risk Model.
Reported Earnings • Nov 14Third quarter 2021 earnings released: US$0.13 loss per share (vs US$1.20 loss in 3Q 2020)Third quarter 2021 results: Net loss: US$1.35m (loss narrowed 82% from 3Q 2020). Over the last 3 years on average, earnings per share has increased by 63% per year but the company’s share price has fallen by 62% per year, which means it is significantly lagging earnings.
Major Estimate Revision • Aug 19Consensus EPS estimates increase to -US$0.55The consensus outlook for earnings per share (EPS) in 2021 has improved. 2021 revenue forecast increased from US$787.2k to US$799.7k. EPS estimate increased from -US$0.66 to -US$0.55. Biotechs industry in the US expected to see average net income decline 21% next year. Consensus price target of US$5.00 unchanged from last update. Share price fell 3.4% to US$3.13 over the past week.
Reported Earnings • Aug 14Second quarter 2021 earnings released: US$0.13 loss per share (vs US$0.15 loss in 2Q 2020)Second quarter 2021 results: Net loss: US$1.11m (loss widened 16% from 2Q 2020). Over the last 3 years on average, earnings per share has increased by 41% per year but the company’s share price has fallen by 54% per year, which means it is significantly lagging earnings.
Price Target Changed • Jul 01Price target increased to US$5.00Up from US$2.25, the current price target is provided by 1 analyst. New target price is 145% above last closing price of US$2.04. Stock is up 89% over the past year.
お知らせ • Dec 16Xenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $6.000001 million.Xenetic Biosciences, Inc. has completed a Follow-on Equity Offering in the amount of $6.000001 million. Security Name: Common Stock Security Type: Common Stock Securities Offered: 2,448,980 Price\Range: $2.45 Discount Per Security: $0.1715 Transaction Features: Registered Direct Offering
お知らせ • Nov 02Xenetic Biosciences Receives Notice from the Listing Qualifications Department of the Nasdaq Stock Market LLCOn October 29, 2020, Xenetic Biosciences, Inc. (the "Company") received a written notification (the "Notice") from the Listing Qualifications Department of the NASDAQ Stock Market LLC ("Nasdaq") notifying the Company that the closing bid price for its common stock had been below $1.00 for 30 consecutive business days and that the Company therefore is not in compliance with the minimum bid price requirement for continued inclusion on The Nasdaq Capital Market under Nasdaq Listing Rule 5550(a)(2) (the "Bid Price Requirement"). The Notice has no immediate effect on the listing of the Company's common stock on the Nasdaq Capital Market. The company has until April 27, 2021 (the "Compliance Date"), to regain compliance with the Bid Price Requirement. To regain compliance, the closing bid price of the Company's common stock must be at least $1.00 for a minimum of ten consecutive business days prior to the Compliance Date. In the event the Company does not regain compliance by the Compliance Date, the Company may be eligible for an additional 180 calendar day compliance period. To qualify for this second compliance period, the Company will be required to meet the continued listing requirement for market value of publicly held shares and all other initial listing standards for The Nasdaq Capital Market, with the exception of the Bid Price Requirement, and will need to provide written notice of its intention to cure the deficiency during the second compliance period, by effecting a reverse stock split, if necessary. The Company intends to monitor the closing bid price of its common stock and may, if appropriate, consider available options to regain compliance with the Bid Price Requirement. However, there can be no assurance that the Company will be able to regain compliance with the Bid Price Requirement, or will otherwise be in compliance with other Nasdaq Listing Rules.