Poxel（0RA2）株式概要Poxel S.A.は臨床段階にあるバイオ医薬品会社で、代謝病態生理学、2型糖尿病、肝疾患の新規治療法を開発している。 詳細0RA2 ファンダメンタル分析スノーフレーク・スコア評価4/6将来の成長0/6過去の実績0/6財務の健全性0/6配当金0/6報酬当社が推定した公正価値より72.1%で取引されている 過去5年間の収益は年間7.8%増加しました。 リスク分析マイナスの株主資本 UK市場と比較して、過去 3 か月間の株価の変動が非常に大きい意味のある時価総額がありません ( €11M )すべてのリスクチェックを見る0RA2 Community Fair Values Create NarrativeSee what others think this stock is worth. Follow their fair value or set your own to get alerts.Your Fair Value€Current Price€0.20190.1% 割高 内在価値ディスカウントGrowth estimate overAnnual revenue growth rate5 Yearstime period%/yrDecreaseIncreasePastFuture-44m44m2016201920222025202620282031Revenue €1.6mEarnings €288.2kAdvancedSet Fair ValueView all narrativesPoxel S.A. 競合他社Genflow BiosciencesSymbol: LSE:GENFMarket cap: UK£11.9mVerici DxSymbol: AIM:VRCIMarket cap: UK£5.7mSkinBioTherapeuticsSymbol: AIM:SBTXMarket cap: UK£29.8mOptiBiotix HealthSymbol: AIM:OPTIMarket cap: UK£6.4m価格と性能株価の高値、安値、推移の概要Poxel過去の株価現在の株価€0.2052週高値€0.7152週安値€0.20ベータ1.281ヶ月の変化-14.48%3ヶ月変化-13.57%1年変化-65.75%3年間の変化-68.27%5年間の変化-97.09%IPOからの変化-97.46%最新ニュースお知らせ • Jun 12Poxel S.A. Announces CEO ChangesPoxel S.A. announced the appointment of Yves Decadt as Chief Executive Officer with effect from June 10, 2026. He succeeded Nicolas Trouche, whose role was specifically designed to support Poxel during the restructuring period that began in August 2025, with the aim of successfully developing and implementing the Continuation Plan. The transition, previously agreed to take place during the first half of 2026, proceeded according to schedule. Yves Decadt has been a member of the Board of Directors since October 21, 2025 and has been heavily involved in defining the Company's strategic and commercial priorities. With over 25 years of international experience in the pharmaceutical industry, Yves Decadt spent nearly 20 years at Johnson & Johnson in the international business development department, responsible for licensing and contract negotiations, with particular expertise in the Asia region. He has also held several senior management positions at leading biopharma and medtech companies. Since August 2025, he has been working with the Poxel teams on a consultancy basis, notably leading an in-depth strategic review of the Company's asset portfolio, which formed the basis for the proposed recovery plan presented to creditors and the Court. It was also under his leadership that the Company finalised the sale of PXL770 to Scynexis, a strategic transaction enabling the monetisation of this asset whilst freeing up the resources necessary for the continued development of Poxel's priority assets. Yves Decadt holds degrees in bioengineering and industrial management from the University of Ghent (Vlerick School), as well as in pharmacology and pharmaceutical medicine from the Université Libre de Bruxelles. He also holds the Board Director certification from Duke University.お知らせ • Apr 30Poxel S.A. to Report Fiscal Year 2025 Results on Jun 15, 2026Poxel S.A. announced that they will report fiscal year 2025 results at 5:40 PM, Central European Standard Time on Jun 15, 2026Board Change • Dec 19Less than half of directors are independentFollowing the recent departure of a director, there are only 2 independent directors on the board. The company's board is composed of: 2 independent directors. 3 non-independent directors. Independent Chairman of the Board Sophie Lapointe was the last independent director to join the board, commencing their role in 2025. The company's minority of independent directors is a risk according to the Simply Wall St Risk Model.Reported Earnings • Dec 12First half 2025 earnings releasedFirst half 2025 results: Revenue: €2.18m (up 88% from 1H 2024). Net loss: €2.62m (loss narrowed 64% from 1H 2024).お知らせ • Nov 27Poxel S.A., Annual General Meeting, Dec 11, 2025Poxel S.A., Annual General Meeting, Dec 11, 2025. Location: 12 cours de verdun rambaud esplanade de la gare, lyon FranceReported Earnings • Oct 18Full year 2024 earnings releasedFull year 2024 results: Revenue: €6.64m (up 235% from FY 2023). Net loss: €18.3m (loss narrowed 48% from FY 2023).最新情報をもっと見るRecent updatesお知らせ • Jun 12Poxel S.A. Announces CEO ChangesPoxel S.A. announced the appointment of Yves Decadt as Chief Executive Officer with effect from June 10, 2026. He succeeded Nicolas Trouche, whose role was specifically designed to support Poxel during the restructuring period that began in August 2025, with the aim of successfully developing and implementing the Continuation Plan. The transition, previously agreed to take place during the first half of 2026, proceeded according to schedule. Yves Decadt has been a member of the Board of Directors since October 21, 2025 and has been heavily involved in defining the Company's strategic and commercial priorities. With over 25 years of international experience in the pharmaceutical industry, Yves Decadt spent nearly 20 years at Johnson & Johnson in the international business development department, responsible for licensing and contract negotiations, with particular expertise in the Asia region. He has also held several senior management positions at leading biopharma and medtech companies. Since August 2025, he has been working with the Poxel teams on a consultancy basis, notably leading an in-depth strategic review of the Company's asset portfolio, which formed the basis for the proposed recovery plan presented to creditors and the Court. It was also under his leadership that the Company finalised the sale of PXL770 to Scynexis, a strategic transaction enabling the monetisation of this asset whilst freeing up the resources necessary for the continued development of Poxel's priority assets. Yves Decadt holds degrees in bioengineering and industrial management from the University of Ghent (Vlerick School), as well as in pharmacology and pharmaceutical medicine from the Université Libre de Bruxelles. He also holds the Board Director certification from Duke University.お知らせ • Apr 30Poxel S.A. to Report Fiscal Year 2025 Results on Jun 15, 2026Poxel S.A. announced that they will report fiscal year 2025 results at 5:40 PM, Central European Standard Time on Jun 15, 2026Board Change • Dec 19Less than half of directors are independentFollowing the recent departure of a director, there are only 2 independent directors on the board. The company's board is composed of: 2 independent directors. 3 non-independent directors. Independent Chairman of the Board Sophie Lapointe was the last independent director to join the board, commencing their role in 2025. The company's minority of independent directors is a risk according to the Simply Wall St Risk Model.Reported Earnings • Dec 12First half 2025 earnings releasedFirst half 2025 results: Revenue: €2.18m (up 88% from 1H 2024). Net loss: €2.62m (loss narrowed 64% from 1H 2024).お知らせ • Nov 27Poxel S.A., Annual General Meeting, Dec 11, 2025Poxel S.A., Annual General Meeting, Dec 11, 2025. Location: 12 cours de verdun rambaud esplanade de la gare, lyon FranceReported Earnings • Oct 18Full year 2024 earnings releasedFull year 2024 results: Revenue: €6.64m (up 235% from FY 2023). Net loss: €18.3m (loss narrowed 48% from FY 2023).お知らせ • Aug 01+ 1 more updatePoxel S.A. Announces Board ChangesPoxel SA announced significant changes within its Board of Directors following the filing for reorganization proceedings. All the current directors of the Company, Ms. Pascale Boissel, Mr. Richard Kender, Mr. Thomas Kuhn, and Mr. Khoso Baluch, submitted their resignations with immediate effect as of July 31, 2025. The Board of Directors decided to replace them individually by co-optation with immediate effect by the following new directors: Ms. Sophie Jacq Lapointe, Mr. Nicolas Trouche, Mr. Amit Kohli, and Mr. Alexandre Bragadir. These co-optations will be subject to ratification at the next general meeting of shareholders of the Company. Ms. Sophie Jacq Lapointe has been appointed by the new Board of Directors as Chairman of the Board of Directors, succeeding Mr. Khoso Baluch. Sophie Jacq Lapointe has over 20 years of experience in the pharmaceutical industry, having held numerous executive roles and contributed to many commercial successes in oncology, immunology, neuroscience, rare diseases, and endocrinology. She has led or been involved in more than twenty product launches in France, across Europe, and in emerging markets, during her time at Roche, Sanofi, and Ipsen. This includes major R&D transformation projects at Sanofi and Ipsen, as well as serving as General Manager for the Belgium–Luxembourg region at Ipsen and the biotech company Perha Pharmaceuticals. For the past two years, she has been advising biotech Chief Executive Officers and executive committees on clinical and commercial development of innovative product portfolios, with successful business development outcomes. Sophie holds a degree from ESSEC Business School. Amit Kohli has over 3 decades of leadership experience operating at the intersection of science, finance, and commercialization. Amit has extensive experience in the diabetes therapy area, having held senior roles at Sanofi (1997-2010) and Becton Dickinson (2011-2016) where he launched diabetes-related products across developed and emerging markets growing them to multi-billion euros in revenue. Lately, as Chief Executive Officer of privately held biotech, Antev (2020 onwards), he led the company’s $75M sale to Medicus. Mr. Kohli has held Global and regional leadership roles at Pharnext, Eurofins, Becton Dickinson, and Sanofi, encompassing sales, marketing, finance, supply chain, and manufacturing. Mr. Kohli earned an M.B.A. in Finance from the Management Development Institute (MDI) Gurgaon, in India, and a Bachelor of Mechanical Engineering from the University of Pune in India. Alexandre Bragadir has been a Senior Investment Director at IPF Partners, a fund specializing in non-dilutive financing for innovative healthcare companies across Europe. He structures and oversees debt investments, having been involved with a dozen companies in the biotech, biopharma, medtech, and digital health sectors over the past six years. He began his career in 2003 in audit at Salustro Reydel before joining BNP Paribas, in strategic client coverage in Portugal, in structured finance in Paris, and in the commodity trade finance team in Geneva. Alexandre holds a degree from ESCP Europe.New Risk • Jul 11New minor risk - Financial data availabilityThe company's latest financial reports are more than 6 months old. Last reported fiscal period ended June 2024. This is considered a minor risk. If the company has not reported its earnings on time, it may have been delayed due to audit problems or it may be finding it difficult to reconcile its accounts. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (20% average weekly change). Negative equity (-€51m). Minor Risks Latest financial reports are more than 6 months old (reported June 2024 fiscal period end). Revenue is less than US$5m (€2.2m revenue, or US$2.6m). Market cap is less than US$100m (€33.0m market cap, or US$38.5m).お知らせ • May 28Poxel SA Announces New Clinical and Scientific Data on TWYMEEG® to Be Presented at the 68th Annual Meeting of the Japan Diabetes SocietyPOXEL SA announced that new clinical and scientific data on TWYMEEG will be presented at the 68th Annual Meeting of the Japan Diabetes Society (JDS 2025), taking place from May 29 to 31, 2025, in Okayama, Japan. A total of 15 presentations, including results from 7 clinical trials, 3 post-hoc analyses and 5 non-clinical studies supported by Sumitomo Pharma, will be delivered by leading Japanese diabetes experts. These findings further confirm TWYMEEG's efficacy in monotherapy and combination therapies, safety, dual mechanism of action and potential benefits in specific patient populations. Main topics include: TWINKLE (TWYMEEG®? in diabetic patients with renal impairment: A post-marketing long-term study) study (Phase 4 study): confirmation of TWYMEEG®? efficacy and safety in diabetic patients with renal impairment; FAMILIAR Study: confirmation of TWYMEE G®? efficacy and safety in combination with DPP-4 inhibitors; PARADIME Clamp: confirmation of TWYMeeG®? dual mechanism of action in diabetic patients - clinical data showing effects on insulin sensitivity (clamp part) and glucose stimulated insulin secretion (OGTT part); PARADIME TIR: confirmation of TWYMCEG®? effects on glucose variability; PET/MRI Study: confirmation of TWY MEEG®? effect on glucose excretion in the gut.お知らせ • Apr 08Poxel SA Announces Regulatory Approval by Japanese Authorities to Expand TWYMEEG®? Package Insert to Include Type 2 Diabetes Patients with Renal ImpairmentPOXEL SA announced that the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has approved the revision of TWYMEEG®? package insert for patients with renal impairment with eGFR (estimated glomerular filtration rate) less than 45 mL/min/1.73m2. This approval follows positive topline results from the post-marketing clinical study TWINKLE (TWYMEEG®? in diabetic patients with renal impairment: A post-marketing long-term study) in Japanese type 2 diabetic patients with renal impairment, which confirmed TWYMEEG®®?'s safety and tolerability profile, as announced last August1. Based on these results, discussions with the Japanese regulatory authorities were initiated by Sumitomo Pharma, resulting in the approval that will be officially implemented by Sumitomo Pharma as of April 8, 2025.New Risk • Mar 03New major risk - Market cap sizeThe company's market capitalization is less than US$10m. Market cap: €9.24m (US$9.70m) This is considered a major risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Major Risks Less than 1 year of cash runway based on free cash flow trend (-€8.9m free cash flow). Share price has been highly volatile over the past 3 months (30% average weekly change). Negative equity (-€51m). Earnings have declined by 6.4% per year over the past 5 years. Shareholders have been substantially diluted in the past year (38% increase in shares outstanding). Market cap is less than US$10m (€9.24m market cap, or US$9.70m). Minor Risk Revenue is less than US$5m (€2.2m revenue, or US$2.3m).お知らせ • Jan 24+ 4 more updatesPoxel S.A. to Report First Half, 2025 Results on Sep 23, 2025Poxel S.A. announced that they will report first half, 2025 results on Sep 23, 2025Reported Earnings • Dec 11First half 2024 earnings releasedFirst half 2024 results: Revenue: €1.16m (up 22% from 1H 2023). Net loss: €7.26m (loss narrowed 72% from 1H 2023).New Risk • Dec 09New major risk - Market cap sizeThe company's market capitalization is less than US$10m. Market cap: €7.81m (US$8.26m) This is considered a major risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€49m). Earnings have declined by 20% per year over the past 5 years. Shareholders have been substantially diluted in the past year (51% increase in shares outstanding). Market cap is less than US$10m (€7.81m market cap, or US$8.26m). Minor Risk Revenue is less than US$5m (€2.0m revenue, or US$2.1m).お知らせ • Nov 08Poxel S.A. Provides Revenue Guidance for the Full Year 2024Poxel S.A. provided revenue guidance for the full year 2024. The company to see the good sales trajectory for TWYMEEG in Japan, which should lead to the achievement of JPY 5 billion net sales in the coming months, at which point, Poxel will be entitled to 10% royalties on all TWYMEEG net sales and a sales-based payment of JPY 500 million (EUR 3.1 million).These amounts, based on recent royalty monetization agreement, will serve to start repayment of bonds to OrbiMed. Additionally, Poxel will benefit from the residual amount of the reserve deposit made under the terms of the agreement with OrbiMed, in addition to the USD 42.5 million proceeds received upon closing.お知らせ • Oct 24Poxel S.A., Annual General Meeting, Nov 28, 2024Poxel S.A., Annual General Meeting, Nov 28, 2024. Location: hotel mercure lyon, centre chateau perrache, 12 cours de verdun rambaud esplanade de la gare, lyon FranceReported Earnings • Oct 04Full year 2023 earnings releasedFull year 2023 results: Revenue: €1.98m (up 194% from FY 2022). Net loss: €35.1m (loss widened 12% from FY 2022).New Risk • Sep 30New major risk - Financial data availabilityThe company's latest financial reports are more than a year old. Last reported fiscal period ended June 2023. This is considered a major risk. If the company has not reported its earnings on time, it may have been delayed due to audit problems or it may be finding it difficult to reconcile its accounts. In the worst case scenario, it may be facing other major going concern issues jeopardizing its viability as a listed company. Currently, the following risks have been identified for the company: Major Risks Latest financial reports are more than 1 year old (reported June 2023 fiscal period end). Share price has been highly volatile over the past 3 months (11% average weekly change). Negative equity (-€42m). Shareholders have been substantially diluted in the past year (52% increase in shares outstanding). Minor Risks Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€29.1m market cap, or US$32.4m).New Risk • Sep 13New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 50% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Shareholders have been substantially diluted in the past year (50% increase in shares outstanding). Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€29.2m market cap, or US$32.4m).New Risk • Aug 19New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 52% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Shareholders have been substantially diluted in the past year (52% increase in shares outstanding). Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€35.1m market cap, or US$38.7m).お知らせ • Aug 07Sumitomo Pharma and Poxel Announce Topline Results from Post-Marketing Clinical Study on TWYMEEG for the Treatment of Type 2 Diabetes in JapanSumitomo Pharma Co., Ltd. and POXEL SA announced topline results obtained from a post-marketing clinical study, TWINKLE (TWYMEEG in diabetic patients with renal impairment: A post-marketing long-term study) (“the Study”), in Japanese type 2 diabetic patients with renal impairment for TWYMEEG Tablets 500 mg (generic name: imeglimin hydrochloride, “the Drug”) being sold in Japan, based on the Risk Management Plan. The Study was an open-label, uncontrolled, long-term study in 60 Japanese type 2 diabetic patients with renal impairment, who had no experience of type 2 diabetes treatment other than diet and exercise therapy or insufficient glycemic management in monotherapy with a hypoglycemic agent excluding insulin formulation. The Drugwas administered at 500 mg twice-daily to patients with moderate and severe renal impairment, characterized by an estimated glomerular filtration rate (eGFR) between 15 mL/min/1.73 m2 or higher to less than 45 mL/min/1.73 m2, or at 500 mg once-daily to patients with end-stage renal disease, characterized by an eGFR less than 15 mL/min/1.73m2, in monotherapy or in combination therapy with a hypoglycemic agent excluding insulin formulation, to evaluate safety and tolerability when administered orally for 52 weeks. The Drug was observed to be safe and well tolerated in Japanese type 2 diabetic patients with renal impairment and no significant differences were found in the incidence of adverse events, their types and severities in this study from previous clinical studies. Specifically, most of the adverse events were mild or moderate in severity. The incidence of serious adverse events was 16.7% (10 of 60 subjects) and causality with the Drug could be ruled out in all cases. Incidence of adverse events leading to study treatment discontinuation was also limited (4 of 60 subjects). At present, administration of the Drug is not recommended for patients with renal impairment with eGFR less than 45 mL/min/1.73m2. Based on the results of the Study, Sumitomo Pharma is planning to conduct discussions with the regulatory authorities in Japan, on revising the package insert in fiscal 20241 for patients with renal impairment with eGFR less than 45 mL/min/1.73m2.New Risk • Jun 11New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 50% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Negative equity (-€42m). Earnings have declined by 27% per year over the past 5 years. Shareholders have been substantially diluted in the past year (50% increase in shares outstanding). Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Share price has been volatile over the past 3 months (11% average weekly change). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€28.8m market cap, or US$30.9m).New Risk • Apr 17New minor risk - Financial data availabilityThe company's latest financial reports are more than 6 months old. Last reported fiscal period ended June 2023. This is considered a minor risk. If the company has not reported its earnings on time, it may have been delayed due to audit problems or it may be finding it difficult to reconcile its accounts. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Earnings have declined by 27% per year over the past 5 years. Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Shareholders have been diluted in the past year (34% increase in shares outstanding). Revenue is less than US$5m (€1.5m revenue, or US$1.6m). Market cap is less than US$100m (€25.0m market cap, or US$26.5m).New Risk • Apr 08New major risk - Revenue and earnings growthEarnings have declined by 27% per year over the past 5 years. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are declining over an extended period, then in most cases the share price will decline over time unless the company can turn around its fortunes. A trend of falling earnings can be very difficult to turn around. If the company is well already established it may also be a sign the company has matured and is in decline. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Earnings have declined by 27% per year over the past 5 years. Minor Risks Shareholders have been diluted in the past year (34% increase in shares outstanding). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€25.8m market cap, or US$27.9m).Breakeven Date Change • Oct 18Forecast to breakeven in 2024The 2 analysts covering Poxel expect the company to break even for the first time. New consensus forecast suggests losses will reduce by 18% to 2023. The company is expected to make a profit of €26.2m in 2024. Average annual earnings growth of 22% is required to achieve expected profit on schedule.Reported Earnings • Sep 28First half 2023 earnings releasedFirst half 2023 results: Net loss: €26.2m (loss widened 96% from 1H 2022). Revenue is forecast to grow 90% p.a. on average during the next 3 years, compared to a 14% growth forecast for the Biotechs industry in the United Kingdom.お知らせ • May 16Poxel S.A., Annual General Meeting, Jun 21, 2023Poxel S.A., Annual General Meeting, Jun 21, 2023, at 09:00 Central European Standard Time. Location: Mercure Hotel, Lyon Centre Saxe Lafayette, 29 rue de Bonnel, 69003 LYON, France. Lyon Franceお知らせ • Jan 04+ 3 more updatesPoxel S.A. to Report Q3, 2023 Results on Nov 08, 2023Poxel S.A. announced that they will report Q3, 2023 results on Nov 08, 2023Board Change • Nov 16Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.Reported Earnings • Sep 23First half 2022 earnings releasedFirst half 2022 results: Net loss: €13.4m (loss widened 67% from 1H 2021). Revenue is forecast to grow 45% p.a. on average during the next 3 years, compared to a 15% growth forecast for the Biotechs industry in the United Kingdom.Breakeven Date Change • Aug 11Forecast to breakeven in 2024The 3 analysts covering Poxel expect the company to break even for the first time. New consensus forecast suggests the company will make a profit of €19.5m in 2024.Reported Earnings • May 24Full year 2021 earnings released: €0.83 loss per share (vs €1.16 loss in FY 2020)Full year 2021 results: €0.83 loss per share (up from €1.16 loss in FY 2020). Revenue: €13.4m (up 97% from FY 2020). Net loss: €23.8m (loss narrowed 25% from FY 2020). Products in clinical trials Phase I: 3 Phase II: 2 Post-clinical trial products Approved (during full year): 1 Launched (during full year): 1 Over the next year, revenue is expected to shrink by 23% compared to a 11% growth forecast for the pharmaceuticals industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 29% per year but the company’s share price has fallen by 35% per year, which means it is performing significantly worse than earnings.Board Change • Apr 27Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.Board Change • Apr 01Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.Board Change • Mar 02Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.Reported Earnings • Sep 25First half 2021 earnings releasedThe company reported a solid first half result with reduced losses, improved revenues and improved control over expenses. First half 2021 results: Revenue: €13.3m (up 108% from 1H 2020). Net loss: €8.03m (loss narrowed 33% from 1H 2020).Reported Earnings • Mar 27Full year 2020 earnings releasedThe company reported a poor full year result with increased losses, weaker revenues and weaker control over costs. Full year 2020 results: Revenue: €6.81m (down 74% from FY 2019). Net loss: €31.9m (loss widened 24% from FY 2019).Is New 90 Day High Low • Jan 18New 90-day high: €7.60The company is up 21% from its price of €6.30 on 20 October 2020. The British market is up 15% over the last 90 days, indicating the company outperformed over that time. It also outperformed the Biotechs industry, which is up 11% over the same period.Is New 90 Day High Low • Nov 14New 90-day high: €7.15The company is up 6.0% from its price of €6.75 on 14 August 2020. The British market is up 4.0% over the last 90 days, indicating the company outperformed over that time. It also outperformed the Biotechs industry, which is up 4.0% over the same period. According to the Simply Wall St valuation model, the estimated intrinsic value of the company is per share.Is New 90 Day High Low • Oct 28New 90-day low: €5.90The company is down 9.0% from its price of €6.49 on 29 July 2020. The British market is down 3.0% over the last 90 days, indicating the company underperformed over that time. It also underperformed the Biotechs industry, which is up 9.0% over the same period. According to the Simply Wall St valuation model, the estimated intrinsic value of the company is per share.株主還元0RA2GB BiotechsGB 市場7D1.6%-0.3%-0.9%1Y-65.8%24.7%18.7%株主還元を見る業界別リターン: 0RA2過去 1 年間で24.7 % の収益を上げたUK Biotechs業界を下回りました。リターン対市場: 0RA2は、過去 1 年間で18.7 % のリターンを上げたUK市場を下回りました。価格変動Is 0RA2's price volatile compared to industry and market?0RA2 volatility0RA2 Average Weekly Movement21.2%Biotechs Industry Average Movement7.6%Market Average Movement5.5%10% most volatile stocks in GB Market10.9%10% least volatile stocks in GB Market3.0%安定した株価: 0RA2の株価は、 UK市場と比較して過去 3 か月間で変動しています。時間の経過による変動: 0RA2の weekly volatility ( 21% ) は過去 1 年間安定していますが、依然としてUKの株式の 75% よりも高くなっています。会社概要設立従業員CEO（最高経営責任者ウェブサイト20095Yves Decadtwww.poxelpharma.com臨床段階のバイオ医薬品会社であるPoxel S.A.は、代謝病態生理学、2型糖尿病、肝疾患の新規治療薬を開発しています。また、希少代謝疾患や代謝機能障害に関連する脂肪肝炎の治療薬も開発している。同社の主力製品は、ミトコンドリア機能障害を標的とする経口薬候補で、日本では2型糖尿病の治療薬として承認されているTWYMEEG（イメグリミン）である。また、アデノシン一リン酸活性化プロテインキナーゼ酵素であるPXL770も開発しており、非アルコール性脂肪肝炎（NASH）など肝臓に影響を及ぼす疾患を含む慢性代謝性疾患の治療薬として臨床第2a相試験中である。同社はEnyo Pharma S.A.S.とB型肝炎とNASHの治療薬としてフェーズ2a試験中のファルネソイドX受容体の開発、DeuteRx LLCとミトコンドリア機能障害治療薬PXL065の開発、住友製薬とImegliminの開発と商業化に関するライセンス契約を結んでいる。Poxel S.A.は2009年に設立され、フランスのリヨンに本社を置いている。もっと見るPoxel S.A. 基礎のまとめPoxel の収益と売上を時価総額と比較するとどうか。0RA2 基礎統計学時価総額€11.01m収益（TTM）-€13.66m売上高(TTM)€7.66m1.4xP/Sレシオ-0.8xPER（株価収益率0RA2 は割高か？公正価値と評価分析を参照収益と収入最新の決算報告書（TTM）に基づく主な収益性統計0RA2 損益計算書（TTM）収益€7.66m売上原価€3.67m売上総利益€3.98mその他の費用€17.65m収益-€13.66m直近の収益報告Jun 30, 2025次回決算日該当なし一株当たり利益（EPS）-0.25グロス・マージン52.02%純利益率-178.45%有利子負債／自己資本比率-101.0%0RA2 の長期的なパフォーマンスは？過去の実績と比較を見るView Valuation企業分析と財務データの現状データ最終更新日（UTC時間）企業分析2026/06/25 19:07終値2026/06/25 00:00収益2025/06/30年間収益2024/12/31データソース企業分析に使用したデータはS&P Global Market Intelligence LLC のものです。本レポートを作成するための分析モデルでは、以下のデータを使用しています。データは正規化されているため、ソースが利用可能になるまでに時間がかかる場合があります。パッケージデータタイムフレーム米国ソース例会社財務10年損益計算書キャッシュ・フロー計算書貸借対照表SECフォーム10-KSECフォーム10-Qアナリストのコンセンサス予想+プラス3年予想財務アナリストの目標株価アナリストリサーチレポートBlue Matrix市場価格30年株価配当、分割、措置ICEマーケットデータSECフォームS-1所有権10年トップ株主インサイダー取引SECフォーム4SECフォーム13Dマネジメント10年リーダーシップ・チーム取締役会SECフォーム10-KSECフォームDEF 14A主な進展10年会社からのお知らせSECフォーム8-K* 米国証券を対象とした例であり、非米国証券については、同等の規制書式および情報源を使用。特に断りのない限り、すべての財務データは1年ごとの期間に基づいていますが、四半期ごとに更新されます。これは、TTM（Trailing Twelve Month）またはLTM（Last Twelve Month）データとして知られています。詳細はこちら。分析モデルとスノーフレークこのレポートを生成するために使用した分析モデルの詳細は、当社の Github ページ でご覧いただけます。また、レポートの使い方に関する ガイド や YouTube の チュートリアル もご用意しています。シンプリー・ウォールストリート分析モデルを設計・構築した世界トップクラスのチームについてご紹介します。業界およびセクターの指標私たちの業界とセクションの指標は、Simply Wall Stによって6時間ごとに計算されます。アナリスト筋Poxel S.A. 0 これらのアナリストのうち、弊社レポートのインプットとして使用した売上高または利益の予想を提出したのは、 。アナリストの投稿は一日中更新されます。8 アナリスト機関Jason ButlerCitizens JMP Securities, LLCDavid SeynnaeveDegroof PetercamPeter WelfordJefferies LLC5 その他のアナリストを表示
お知らせ • Jun 12Poxel S.A. Announces CEO ChangesPoxel S.A. announced the appointment of Yves Decadt as Chief Executive Officer with effect from June 10, 2026. He succeeded Nicolas Trouche, whose role was specifically designed to support Poxel during the restructuring period that began in August 2025, with the aim of successfully developing and implementing the Continuation Plan. The transition, previously agreed to take place during the first half of 2026, proceeded according to schedule. Yves Decadt has been a member of the Board of Directors since October 21, 2025 and has been heavily involved in defining the Company's strategic and commercial priorities. With over 25 years of international experience in the pharmaceutical industry, Yves Decadt spent nearly 20 years at Johnson & Johnson in the international business development department, responsible for licensing and contract negotiations, with particular expertise in the Asia region. He has also held several senior management positions at leading biopharma and medtech companies. Since August 2025, he has been working with the Poxel teams on a consultancy basis, notably leading an in-depth strategic review of the Company's asset portfolio, which formed the basis for the proposed recovery plan presented to creditors and the Court. It was also under his leadership that the Company finalised the sale of PXL770 to Scynexis, a strategic transaction enabling the monetisation of this asset whilst freeing up the resources necessary for the continued development of Poxel's priority assets. Yves Decadt holds degrees in bioengineering and industrial management from the University of Ghent (Vlerick School), as well as in pharmacology and pharmaceutical medicine from the Université Libre de Bruxelles. He also holds the Board Director certification from Duke University.
お知らせ • Apr 30Poxel S.A. to Report Fiscal Year 2025 Results on Jun 15, 2026Poxel S.A. announced that they will report fiscal year 2025 results at 5:40 PM, Central European Standard Time on Jun 15, 2026
Board Change • Dec 19Less than half of directors are independentFollowing the recent departure of a director, there are only 2 independent directors on the board. The company's board is composed of: 2 independent directors. 3 non-independent directors. Independent Chairman of the Board Sophie Lapointe was the last independent director to join the board, commencing their role in 2025. The company's minority of independent directors is a risk according to the Simply Wall St Risk Model.
Reported Earnings • Dec 12First half 2025 earnings releasedFirst half 2025 results: Revenue: €2.18m (up 88% from 1H 2024). Net loss: €2.62m (loss narrowed 64% from 1H 2024).
お知らせ • Nov 27Poxel S.A., Annual General Meeting, Dec 11, 2025Poxel S.A., Annual General Meeting, Dec 11, 2025. Location: 12 cours de verdun rambaud esplanade de la gare, lyon France
Reported Earnings • Oct 18Full year 2024 earnings releasedFull year 2024 results: Revenue: €6.64m (up 235% from FY 2023). Net loss: €18.3m (loss narrowed 48% from FY 2023).
お知らせ • Jun 12Poxel S.A. Announces CEO ChangesPoxel S.A. announced the appointment of Yves Decadt as Chief Executive Officer with effect from June 10, 2026. He succeeded Nicolas Trouche, whose role was specifically designed to support Poxel during the restructuring period that began in August 2025, with the aim of successfully developing and implementing the Continuation Plan. The transition, previously agreed to take place during the first half of 2026, proceeded according to schedule. Yves Decadt has been a member of the Board of Directors since October 21, 2025 and has been heavily involved in defining the Company's strategic and commercial priorities. With over 25 years of international experience in the pharmaceutical industry, Yves Decadt spent nearly 20 years at Johnson & Johnson in the international business development department, responsible for licensing and contract negotiations, with particular expertise in the Asia region. He has also held several senior management positions at leading biopharma and medtech companies. Since August 2025, he has been working with the Poxel teams on a consultancy basis, notably leading an in-depth strategic review of the Company's asset portfolio, which formed the basis for the proposed recovery plan presented to creditors and the Court. It was also under his leadership that the Company finalised the sale of PXL770 to Scynexis, a strategic transaction enabling the monetisation of this asset whilst freeing up the resources necessary for the continued development of Poxel's priority assets. Yves Decadt holds degrees in bioengineering and industrial management from the University of Ghent (Vlerick School), as well as in pharmacology and pharmaceutical medicine from the Université Libre de Bruxelles. He also holds the Board Director certification from Duke University.
お知らせ • Apr 30Poxel S.A. to Report Fiscal Year 2025 Results on Jun 15, 2026Poxel S.A. announced that they will report fiscal year 2025 results at 5:40 PM, Central European Standard Time on Jun 15, 2026
Board Change • Dec 19Less than half of directors are independentFollowing the recent departure of a director, there are only 2 independent directors on the board. The company's board is composed of: 2 independent directors. 3 non-independent directors. Independent Chairman of the Board Sophie Lapointe was the last independent director to join the board, commencing their role in 2025. The company's minority of independent directors is a risk according to the Simply Wall St Risk Model.
Reported Earnings • Dec 12First half 2025 earnings releasedFirst half 2025 results: Revenue: €2.18m (up 88% from 1H 2024). Net loss: €2.62m (loss narrowed 64% from 1H 2024).
お知らせ • Nov 27Poxel S.A., Annual General Meeting, Dec 11, 2025Poxel S.A., Annual General Meeting, Dec 11, 2025. Location: 12 cours de verdun rambaud esplanade de la gare, lyon France
Reported Earnings • Oct 18Full year 2024 earnings releasedFull year 2024 results: Revenue: €6.64m (up 235% from FY 2023). Net loss: €18.3m (loss narrowed 48% from FY 2023).
お知らせ • Aug 01+ 1 more updatePoxel S.A. Announces Board ChangesPoxel SA announced significant changes within its Board of Directors following the filing for reorganization proceedings. All the current directors of the Company, Ms. Pascale Boissel, Mr. Richard Kender, Mr. Thomas Kuhn, and Mr. Khoso Baluch, submitted their resignations with immediate effect as of July 31, 2025. The Board of Directors decided to replace them individually by co-optation with immediate effect by the following new directors: Ms. Sophie Jacq Lapointe, Mr. Nicolas Trouche, Mr. Amit Kohli, and Mr. Alexandre Bragadir. These co-optations will be subject to ratification at the next general meeting of shareholders of the Company. Ms. Sophie Jacq Lapointe has been appointed by the new Board of Directors as Chairman of the Board of Directors, succeeding Mr. Khoso Baluch. Sophie Jacq Lapointe has over 20 years of experience in the pharmaceutical industry, having held numerous executive roles and contributed to many commercial successes in oncology, immunology, neuroscience, rare diseases, and endocrinology. She has led or been involved in more than twenty product launches in France, across Europe, and in emerging markets, during her time at Roche, Sanofi, and Ipsen. This includes major R&D transformation projects at Sanofi and Ipsen, as well as serving as General Manager for the Belgium–Luxembourg region at Ipsen and the biotech company Perha Pharmaceuticals. For the past two years, she has been advising biotech Chief Executive Officers and executive committees on clinical and commercial development of innovative product portfolios, with successful business development outcomes. Sophie holds a degree from ESSEC Business School. Amit Kohli has over 3 decades of leadership experience operating at the intersection of science, finance, and commercialization. Amit has extensive experience in the diabetes therapy area, having held senior roles at Sanofi (1997-2010) and Becton Dickinson (2011-2016) where he launched diabetes-related products across developed and emerging markets growing them to multi-billion euros in revenue. Lately, as Chief Executive Officer of privately held biotech, Antev (2020 onwards), he led the company’s $75M sale to Medicus. Mr. Kohli has held Global and regional leadership roles at Pharnext, Eurofins, Becton Dickinson, and Sanofi, encompassing sales, marketing, finance, supply chain, and manufacturing. Mr. Kohli earned an M.B.A. in Finance from the Management Development Institute (MDI) Gurgaon, in India, and a Bachelor of Mechanical Engineering from the University of Pune in India. Alexandre Bragadir has been a Senior Investment Director at IPF Partners, a fund specializing in non-dilutive financing for innovative healthcare companies across Europe. He structures and oversees debt investments, having been involved with a dozen companies in the biotech, biopharma, medtech, and digital health sectors over the past six years. He began his career in 2003 in audit at Salustro Reydel before joining BNP Paribas, in strategic client coverage in Portugal, in structured finance in Paris, and in the commodity trade finance team in Geneva. Alexandre holds a degree from ESCP Europe.
New Risk • Jul 11New minor risk - Financial data availabilityThe company's latest financial reports are more than 6 months old. Last reported fiscal period ended June 2024. This is considered a minor risk. If the company has not reported its earnings on time, it may have been delayed due to audit problems or it may be finding it difficult to reconcile its accounts. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (20% average weekly change). Negative equity (-€51m). Minor Risks Latest financial reports are more than 6 months old (reported June 2024 fiscal period end). Revenue is less than US$5m (€2.2m revenue, or US$2.6m). Market cap is less than US$100m (€33.0m market cap, or US$38.5m).
お知らせ • May 28Poxel SA Announces New Clinical and Scientific Data on TWYMEEG® to Be Presented at the 68th Annual Meeting of the Japan Diabetes SocietyPOXEL SA announced that new clinical and scientific data on TWYMEEG will be presented at the 68th Annual Meeting of the Japan Diabetes Society (JDS 2025), taking place from May 29 to 31, 2025, in Okayama, Japan. A total of 15 presentations, including results from 7 clinical trials, 3 post-hoc analyses and 5 non-clinical studies supported by Sumitomo Pharma, will be delivered by leading Japanese diabetes experts. These findings further confirm TWYMEEG's efficacy in monotherapy and combination therapies, safety, dual mechanism of action and potential benefits in specific patient populations. Main topics include: TWINKLE (TWYMEEG®? in diabetic patients with renal impairment: A post-marketing long-term study) study (Phase 4 study): confirmation of TWYMEEG®? efficacy and safety in diabetic patients with renal impairment; FAMILIAR Study: confirmation of TWYMEE G®? efficacy and safety in combination with DPP-4 inhibitors; PARADIME Clamp: confirmation of TWYMeeG®? dual mechanism of action in diabetic patients - clinical data showing effects on insulin sensitivity (clamp part) and glucose stimulated insulin secretion (OGTT part); PARADIME TIR: confirmation of TWYMCEG®? effects on glucose variability; PET/MRI Study: confirmation of TWY MEEG®? effect on glucose excretion in the gut.
お知らせ • Apr 08Poxel SA Announces Regulatory Approval by Japanese Authorities to Expand TWYMEEG®? Package Insert to Include Type 2 Diabetes Patients with Renal ImpairmentPOXEL SA announced that the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has approved the revision of TWYMEEG®? package insert for patients with renal impairment with eGFR (estimated glomerular filtration rate) less than 45 mL/min/1.73m2. This approval follows positive topline results from the post-marketing clinical study TWINKLE (TWYMEEG®? in diabetic patients with renal impairment: A post-marketing long-term study) in Japanese type 2 diabetic patients with renal impairment, which confirmed TWYMEEG®®?'s safety and tolerability profile, as announced last August1. Based on these results, discussions with the Japanese regulatory authorities were initiated by Sumitomo Pharma, resulting in the approval that will be officially implemented by Sumitomo Pharma as of April 8, 2025.
New Risk • Mar 03New major risk - Market cap sizeThe company's market capitalization is less than US$10m. Market cap: €9.24m (US$9.70m) This is considered a major risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Major Risks Less than 1 year of cash runway based on free cash flow trend (-€8.9m free cash flow). Share price has been highly volatile over the past 3 months (30% average weekly change). Negative equity (-€51m). Earnings have declined by 6.4% per year over the past 5 years. Shareholders have been substantially diluted in the past year (38% increase in shares outstanding). Market cap is less than US$10m (€9.24m market cap, or US$9.70m). Minor Risk Revenue is less than US$5m (€2.2m revenue, or US$2.3m).
お知らせ • Jan 24+ 4 more updatesPoxel S.A. to Report First Half, 2025 Results on Sep 23, 2025Poxel S.A. announced that they will report first half, 2025 results on Sep 23, 2025
Reported Earnings • Dec 11First half 2024 earnings releasedFirst half 2024 results: Revenue: €1.16m (up 22% from 1H 2023). Net loss: €7.26m (loss narrowed 72% from 1H 2023).
New Risk • Dec 09New major risk - Market cap sizeThe company's market capitalization is less than US$10m. Market cap: €7.81m (US$8.26m) This is considered a major risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€49m). Earnings have declined by 20% per year over the past 5 years. Shareholders have been substantially diluted in the past year (51% increase in shares outstanding). Market cap is less than US$10m (€7.81m market cap, or US$8.26m). Minor Risk Revenue is less than US$5m (€2.0m revenue, or US$2.1m).
お知らせ • Nov 08Poxel S.A. Provides Revenue Guidance for the Full Year 2024Poxel S.A. provided revenue guidance for the full year 2024. The company to see the good sales trajectory for TWYMEEG in Japan, which should lead to the achievement of JPY 5 billion net sales in the coming months, at which point, Poxel will be entitled to 10% royalties on all TWYMEEG net sales and a sales-based payment of JPY 500 million (EUR 3.1 million).These amounts, based on recent royalty monetization agreement, will serve to start repayment of bonds to OrbiMed. Additionally, Poxel will benefit from the residual amount of the reserve deposit made under the terms of the agreement with OrbiMed, in addition to the USD 42.5 million proceeds received upon closing.
お知らせ • Oct 24Poxel S.A., Annual General Meeting, Nov 28, 2024Poxel S.A., Annual General Meeting, Nov 28, 2024. Location: hotel mercure lyon, centre chateau perrache, 12 cours de verdun rambaud esplanade de la gare, lyon France
Reported Earnings • Oct 04Full year 2023 earnings releasedFull year 2023 results: Revenue: €1.98m (up 194% from FY 2022). Net loss: €35.1m (loss widened 12% from FY 2022).
New Risk • Sep 30New major risk - Financial data availabilityThe company's latest financial reports are more than a year old. Last reported fiscal period ended June 2023. This is considered a major risk. If the company has not reported its earnings on time, it may have been delayed due to audit problems or it may be finding it difficult to reconcile its accounts. In the worst case scenario, it may be facing other major going concern issues jeopardizing its viability as a listed company. Currently, the following risks have been identified for the company: Major Risks Latest financial reports are more than 1 year old (reported June 2023 fiscal period end). Share price has been highly volatile over the past 3 months (11% average weekly change). Negative equity (-€42m). Shareholders have been substantially diluted in the past year (52% increase in shares outstanding). Minor Risks Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€29.1m market cap, or US$32.4m).
New Risk • Sep 13New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 50% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Shareholders have been substantially diluted in the past year (50% increase in shares outstanding). Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€29.2m market cap, or US$32.4m).
New Risk • Aug 19New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 52% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Shareholders have been substantially diluted in the past year (52% increase in shares outstanding). Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€35.1m market cap, or US$38.7m).
お知らせ • Aug 07Sumitomo Pharma and Poxel Announce Topline Results from Post-Marketing Clinical Study on TWYMEEG for the Treatment of Type 2 Diabetes in JapanSumitomo Pharma Co., Ltd. and POXEL SA announced topline results obtained from a post-marketing clinical study, TWINKLE (TWYMEEG in diabetic patients with renal impairment: A post-marketing long-term study) (“the Study”), in Japanese type 2 diabetic patients with renal impairment for TWYMEEG Tablets 500 mg (generic name: imeglimin hydrochloride, “the Drug”) being sold in Japan, based on the Risk Management Plan. The Study was an open-label, uncontrolled, long-term study in 60 Japanese type 2 diabetic patients with renal impairment, who had no experience of type 2 diabetes treatment other than diet and exercise therapy or insufficient glycemic management in monotherapy with a hypoglycemic agent excluding insulin formulation. The Drugwas administered at 500 mg twice-daily to patients with moderate and severe renal impairment, characterized by an estimated glomerular filtration rate (eGFR) between 15 mL/min/1.73 m2 or higher to less than 45 mL/min/1.73 m2, or at 500 mg once-daily to patients with end-stage renal disease, characterized by an eGFR less than 15 mL/min/1.73m2, in monotherapy or in combination therapy with a hypoglycemic agent excluding insulin formulation, to evaluate safety and tolerability when administered orally for 52 weeks. The Drug was observed to be safe and well tolerated in Japanese type 2 diabetic patients with renal impairment and no significant differences were found in the incidence of adverse events, their types and severities in this study from previous clinical studies. Specifically, most of the adverse events were mild or moderate in severity. The incidence of serious adverse events was 16.7% (10 of 60 subjects) and causality with the Drug could be ruled out in all cases. Incidence of adverse events leading to study treatment discontinuation was also limited (4 of 60 subjects). At present, administration of the Drug is not recommended for patients with renal impairment with eGFR less than 45 mL/min/1.73m2. Based on the results of the Study, Sumitomo Pharma is planning to conduct discussions with the regulatory authorities in Japan, on revising the package insert in fiscal 20241 for patients with renal impairment with eGFR less than 45 mL/min/1.73m2.
New Risk • Jun 11New major risk - Shareholder dilutionThe company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 50% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Negative equity (-€42m). Earnings have declined by 27% per year over the past 5 years. Shareholders have been substantially diluted in the past year (50% increase in shares outstanding). Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Share price has been volatile over the past 3 months (11% average weekly change). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€28.8m market cap, or US$30.9m).
New Risk • Apr 17New minor risk - Financial data availabilityThe company's latest financial reports are more than 6 months old. Last reported fiscal period ended June 2023. This is considered a minor risk. If the company has not reported its earnings on time, it may have been delayed due to audit problems or it may be finding it difficult to reconcile its accounts. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Earnings have declined by 27% per year over the past 5 years. Minor Risks Latest financial reports are more than 6 months old (reported June 2023 fiscal period end). Shareholders have been diluted in the past year (34% increase in shares outstanding). Revenue is less than US$5m (€1.5m revenue, or US$1.6m). Market cap is less than US$100m (€25.0m market cap, or US$26.5m).
New Risk • Apr 08New major risk - Revenue and earnings growthEarnings have declined by 27% per year over the past 5 years. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are declining over an extended period, then in most cases the share price will decline over time unless the company can turn around its fortunes. A trend of falling earnings can be very difficult to turn around. If the company is well already established it may also be a sign the company has matured and is in decline. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Negative equity (-€42m). Earnings have declined by 27% per year over the past 5 years. Minor Risks Shareholders have been diluted in the past year (34% increase in shares outstanding). Revenue is less than US$5m (€1.5m revenue, or US$1.7m). Market cap is less than US$100m (€25.8m market cap, or US$27.9m).
Breakeven Date Change • Oct 18Forecast to breakeven in 2024The 2 analysts covering Poxel expect the company to break even for the first time. New consensus forecast suggests losses will reduce by 18% to 2023. The company is expected to make a profit of €26.2m in 2024. Average annual earnings growth of 22% is required to achieve expected profit on schedule.
Reported Earnings • Sep 28First half 2023 earnings releasedFirst half 2023 results: Net loss: €26.2m (loss widened 96% from 1H 2022). Revenue is forecast to grow 90% p.a. on average during the next 3 years, compared to a 14% growth forecast for the Biotechs industry in the United Kingdom.
お知らせ • May 16Poxel S.A., Annual General Meeting, Jun 21, 2023Poxel S.A., Annual General Meeting, Jun 21, 2023, at 09:00 Central European Standard Time. Location: Mercure Hotel, Lyon Centre Saxe Lafayette, 29 rue de Bonnel, 69003 LYON, France. Lyon France
お知らせ • Jan 04+ 3 more updatesPoxel S.A. to Report Q3, 2023 Results on Nov 08, 2023Poxel S.A. announced that they will report Q3, 2023 results on Nov 08, 2023
Board Change • Nov 16Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.
Reported Earnings • Sep 23First half 2022 earnings releasedFirst half 2022 results: Net loss: €13.4m (loss widened 67% from 1H 2021). Revenue is forecast to grow 45% p.a. on average during the next 3 years, compared to a 15% growth forecast for the Biotechs industry in the United Kingdom.
Breakeven Date Change • Aug 11Forecast to breakeven in 2024The 3 analysts covering Poxel expect the company to break even for the first time. New consensus forecast suggests the company will make a profit of €19.5m in 2024.
Reported Earnings • May 24Full year 2021 earnings released: €0.83 loss per share (vs €1.16 loss in FY 2020)Full year 2021 results: €0.83 loss per share (up from €1.16 loss in FY 2020). Revenue: €13.4m (up 97% from FY 2020). Net loss: €23.8m (loss narrowed 25% from FY 2020). Products in clinical trials Phase I: 3 Phase II: 2 Post-clinical trial products Approved (during full year): 1 Launched (during full year): 1 Over the next year, revenue is expected to shrink by 23% compared to a 11% growth forecast for the pharmaceuticals industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 29% per year but the company’s share price has fallen by 35% per year, which means it is performing significantly worse than earnings.
Board Change • Apr 27Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.
Board Change • Apr 01Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.
Board Change • Mar 02Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 10 experienced directors. 2 highly experienced directors. Member of Scientific Advisory Board Masato Kasuga was the last director to join the board, commencing their role in 2019. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment.
Reported Earnings • Sep 25First half 2021 earnings releasedThe company reported a solid first half result with reduced losses, improved revenues and improved control over expenses. First half 2021 results: Revenue: €13.3m (up 108% from 1H 2020). Net loss: €8.03m (loss narrowed 33% from 1H 2020).
Reported Earnings • Mar 27Full year 2020 earnings releasedThe company reported a poor full year result with increased losses, weaker revenues and weaker control over costs. Full year 2020 results: Revenue: €6.81m (down 74% from FY 2019). Net loss: €31.9m (loss widened 24% from FY 2019).
Is New 90 Day High Low • Jan 18New 90-day high: €7.60The company is up 21% from its price of €6.30 on 20 October 2020. The British market is up 15% over the last 90 days, indicating the company outperformed over that time. It also outperformed the Biotechs industry, which is up 11% over the same period.
Is New 90 Day High Low • Nov 14New 90-day high: €7.15The company is up 6.0% from its price of €6.75 on 14 August 2020. The British market is up 4.0% over the last 90 days, indicating the company outperformed over that time. It also outperformed the Biotechs industry, which is up 4.0% over the same period. According to the Simply Wall St valuation model, the estimated intrinsic value of the company is per share.
Is New 90 Day High Low • Oct 28New 90-day low: €5.90The company is down 9.0% from its price of €6.49 on 29 July 2020. The British market is down 3.0% over the last 90 days, indicating the company underperformed over that time. It also underperformed the Biotechs industry, which is up 9.0% over the same period. According to the Simply Wall St valuation model, the estimated intrinsic value of the company is per share.
