Summit Therapeutics (SMMT) Panoramica del titolo
Summit Therapeutics Inc. è un'azienda biofarmaceutica che si concentra sulla scoperta, lo sviluppo e la commercializzazione di terapie mediche a favore di pazienti, medici, assistenti e società. Maggiori dettagli
| Punteggio fiocco di neve | |
|---|---|
| Valutazione | 2/6 |
| Crescita futura | 5/6 |
| Prestazioni passate | 0/6 |
| Salute finanziaria | 5/6 |
| Dividendi | 0/6 |
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The Market Is Sleeping on This Parkinson's Biotech - And I Think That's a Mistake
Gain Therapeutics: The Under-the-Radar Biotech With Big Parkinson’s Potential Key Takeaways Gain Therapeutics (GANX) is developing GT-02287 – an oral, first-in-class, potentially disease-modifying treatment for Parkinson’s disease targeting the GCase enzyme pathway. Parkinson’s disease represents a $4 billion U.S. market with zero approved disease-modifying therapies.
Read full narrativeConcorrenti di Summit Therapeutics Inc.
Storia dei prezzi e prestazioni
| Prezzi storici delle azioni | |
|---|---|
| Prezzo attuale dell'azione | US$17.15 |
| Massimo di 52 settimane | US$30.98 |
| Minimo di 52 settimane | US$13.83 |
| Beta | -1.26 |
| Variazione di 1 mese | -10.77% |
| Variazione a 3 mesi | 14.41% |
| Variazione di 1 anno | -30.43% |
| Variazione a 3 anni | 790.91% |
| Variazione a 5 anni | 215.84% |
| Variazione dall'IPO | 66.67% |
Notizie e aggiornamenti recenti
Seeking Alpha • May 04
Summit Therapeutics: More Uncertainty Heading Into The ASCO Plenary
Summary Summit Therapeutics Inc. continues its march toward potential approval in lung cancer. Recent updates put the utility of ivonescimab into question as a frontline therapy. This article is going to focus on explaining what this update means and what it does not mean. Risks to SMMT's investment thesis continue to be a major concern for me, but the risk-tolerant could see an opportunity here. Read the full article on Seeking Alpha
Nuova analisi • Apr 02
Broad Late‑Stage Immuno Oncology Pipeline Will Drive Long Term Opportunity
Catalysts About Summit Therapeutics Summit Therapeutics is a biopharmaceutical company focused on developing ivonescimab for the treatment of multiple solid tumor cancers. What are the underlying business or industry changes driving this perspective?
Nuova analisi • Mar 19
Future Clinical Setbacks In Phase III Programs Will Threaten Long Term Oncology Ambitions
Catalysts About Summit Therapeutics Summit Therapeutics is a biopharmaceutical company focused on developing and commercializing ivonescimab for cancer patients across multiple solid tumor indications. What are the underlying business or industry changes driving this perspective?Recent updates
Seeking Alpha • May 04
Summit Therapeutics: More Uncertainty Heading Into The ASCO Plenary
Summary Summit Therapeutics Inc. continues its march toward potential approval in lung cancer. Recent updates put the utility of ivonescimab into question as a frontline therapy. This article is going to focus on explaining what this update means and what it does not mean. Risks to SMMT's investment thesis continue to be a major concern for me, but the risk-tolerant could see an opportunity here. Read the full article on Seeking AlphaNuova analisi • Apr 02
Broad Late‑Stage Immuno Oncology Pipeline Will Drive Long Term Opportunity
Catalysts About Summit Therapeutics Summit Therapeutics is a biopharmaceutical company focused on developing ivonescimab for the treatment of multiple solid tumor cancers. What are the underlying business or industry changes driving this perspective?Nuova analisi • Mar 19
Future Clinical Setbacks In Phase III Programs Will Threaten Long Term Oncology Ambitions
Catalysts About Summit Therapeutics Summit Therapeutics is a biopharmaceutical company focused on developing and commercializing ivonescimab for cancer patients across multiple solid tumor indications. What are the underlying business or industry changes driving this perspective?
Nuova analisi • Mar 05
Late Stage Oncology Footprint Will Transform This Single Asset Into A Global Cancer Franchise
Catalysts About Summit Therapeutics Summit Therapeutics is a biopharmaceutical company focused on developing and commercializing ivonescimab for solid tumor cancers. What are the underlying business or industry changes driving this perspective?Seeking Alpha • Apr 26
Summit Therapeutics: New Ivonescimab Data Raise Concerns
Summary Summit Therapeutics' share price plunged 36% after Akeso's ivonescimab data showed no statistically significant overall survival benefit versus Merck's Keytruda in the HARMONi-2 trial. Ivonescimab showed a 22% reduction in the risk of death versus Keytruda, but statistical significance was not reached after an interim analysis at 39% data maturity. Prior progression-free survival data and positive overall survival trends still point to a positive outcome in the HARMONi-2 trial. However, substantial doubts over ivonescimab and its potential benefits remain. Key upcoming catalysts include HARMONi trial results in mid-2025, additional overall survival data from HARMONi-2, and HARMONi-6 trial results from Akeso later this year. Read the full article on Seeking AlphaSeeking Alpha • Apr 12
Summit Therapeutics: Not Pharmacyclics, Not Yet
Summary Summit Therapeutics' ivonescimab shows promise but faces significant risks; HARMONi-2 results are promising but not definitive, with key questions about overall survival and applicability outside China. The CEO's recent stock moves signal confidence, but SMMT's current valuation appears overly optimistic given the uncertainties and lack of mature data. Multiple ongoing trials for ivonescimab in various cancers could provide future opportunities, but current hype may not justify the high market cap. My sentiment remains a "Sell" here due to downside risk if there is any marginal or negative data readout, either from SMMT, their partner, or any other PD1/VEGF developer. Read the full article on Seeking AlphaSeeking Alpha • Mar 28
Summit Therapeutics: Major Upcoming Ivonescimab Data Catalyst May Not Be All It Seems (Rating Downgrade)
Summary Summit Therapeutics' ivonescimab has shown superior efficacy to ~$30bn per annum selling Keytruda in Phase 3 lung cancer trials, albeit only in Chinese patients. Summit's task is to secure approval for ivonescimab in Western markets - hence its upcoming HARMONi Phase 3 study data readout is crucial as it includes Western patients. Positive results could open up the path to a quick approval, and significantly boost Summit's valuation, while negative results could severely impact it. Seemingly, most of the patients in the HARMONi study are Chinese patients, who already showed strong results in the HARMONi-A study. Summit may be attempting to circumvent FDA rules preventing overseas studies being used in approval submissions, by adding a few Western patients to an already successful study. I have my doubts that this strategy can work. Read the full article on Seeking AlphaSeeking Alpha • Feb 24
Summit Therapeutics: Mid-2025 NSCLC Data Could Further Entrench Ivonescimab Program
Summary Summit Therapeutics Inc. established a clinical trial collaboration agreement with Pfizer to develop ivonescimab together with vedotin ADCs to target patients with NSCLC and other various types of solid tumors. Top-line data from the phase 3 HARMONi study, using ivonescimab +chemotherapy to target 2nd-line EGFR-mutant NSCLC patients, expected in mid-2025. The global non-small cell lung cancer market size is projected to reach $36.9 billion by 2031. Ivonescimab + chemotherapy has already been approved in China to treat 2nd-line EGFR-mutant locally advanced or metastatic non-squamous NSCLC patients who progressed on EGFR-TKI drug. Read the full article on Seeking AlphaSeeking Alpha • Jan 18
Summit Therapeutics: Data Signals A Potential Paradigm Shift In NSCLC (Rating Upgrade)
Summary Summit Therapeutics' stock rose 888% since September 2023, driven by positive Phase 3 data for ivonescimab showing superior PFS vs Keytruda in NSCLC. Phase 3 HARMONi-2 trial showed 11.14 vs 5.82 months PFS benefit over Keytruda, with OS data expected in first half of 2025. Company has strong cash position ($486.9M) but faces increased burn rate with multiple Phase 3 trials ongoing. My NPV model suggests $20.5B-$29B value potential, assuming 50-60% market penetration and 2027 launch. Major risks include OS data outcomes, geographic translation of results, and complete dependence on single asset success. Read the full article on Seeking AlphaSeeking Alpha • Jan 05
The Play On Summit Therapeutics
Summary Summit Therapeutics' stock has pulled back over 40% from its all-time high due to concerns over ivonescimab's Chinese trial not being an apples-to-apples comparison. Ivonescimab, a bispecific antibody, has shown promising results in China, outperforming Merck's Keytruda in a Phase 3 trial, but faces scrutiny over trial design differences. Summit's financial health is bolstered by significant investments and private placements, providing a decent operating runway with ongoing and planned NSCLC trials. An analysis around Summit Therapeutics and how I am placing a trade on this stock is highlighted in the paragraphs below. Read the full article on Seeking AlphaSeeking Alpha • Dec 02
Summit Therapeutics Stock Set To Soar By Mid-2025 On HARMONi Phase 3 Trial
Summary Summit Therapeutics reached a milestone in its Phase III trial for ivonescimab, aiming to treat second-line EGFR mutated advanced NSCLC. The FDA has fast tracked the HARMONi trial. Positive Phase III results for ivonescimab versus KEYTRUDA in first-line NSCLC are promising, but registration in the US will require completion of HARMONI-7, which has just begun recruiting. Top-line data from the HARMONi trial is expected in mid-2025, potentially leading to FDA approval with complete enrollment as of Q3. SMMT stock remains a strong buy, with excellent execution led by CEO Bob Duggan. Read the full article on Seeking AlphaSeeking Alpha • Oct 04
Summit Therapeutics: Cancer Drug With Great Potential On 'Fast Track' To US Market
Summary Summit Therapeutics Inc. may have the successor to Merck's >$25bn selling keytruda in its pipeline. Partner Akeso's data from China clinical studies shows outperformance against Merck's standard of care in NSCLC. This is no small feat — repeat this performance in US studies and Summit will have a “mega-blockbuster” on its hands/. After sensational share price gains in September, the market is more circumspect. It may be time to watch on and see how Summit's plans for US approval develop. Read the full article on Seeking AlphaSeeking Alpha • Sep 19
Summit Therapeutics Bests Merck's Top Selling Drug In Phase III Trial
Summary Summit Therapeutics' ivonescimab shows improved efficacy over Merck's Keytruda in Phase III trials, targeting both PD-1 and VEGF, potentially expanding the PD-1 inhibitor market. Despite risks, Summit's promising data and significant insider investment suggest a speculative buy, with potential for major upside if FDA approval is achieved. Ivonescimab's dual mechanism could disrupt the oncology market, similar to Regeneron's Eylea, positioning Summit for substantial growth if it captures market share. With sufficient funding to complete trials and strong insider confidence, Summit is well-positioned for future success, making it a speculative buy on pullbacks. Read the full article on Seeking AlphaSeeking Alpha • Sep 09
Summit Therapeutics: World Lung Data Not Enough For Ivonescimab To Unseat Keytruda (Yet)
Summary Summit Therapeutics' ivonescimab shows a significant PFS improvement over pembrolizumab in NSCLC, but regulatory and clinical hurdles remain before it can challenge the current standard of care. HARMONi-2 trial results are promising, but ivonescimab faces approval challenges in the US due to reliance on China-only trials and lack of overall survival data. SMMT's financial stability is precarious, with a cash runway of 5-6 quarters (maybe time enough to get to a phase 3 readout in their US trial). Given the high market cap and current uncertainties, it's prudent to wait for more concrete evidence of ivonescimab's superiority before investing heavily in SMMT stock. Read the full article on Seeking AlphaSeeking Alpha • Aug 03
Summit Therapeutics May Have Further Upside From Here
Summary Summit Therapeutics to release second-quarter earnings and operational update on 6 August. Analysts are bullish on Phase 3 trial results for Ivonescimab in September, with a potential de-risking of the drug's profile. The company boosted its balance sheet with a $200 million institutional capital raise and expanded licensing territories after positive Phase I and II trial results. Read the full article on Seeking AlphaSeeking Alpha • May 31
Summit Therapeutics Stock: Plunging Despite A Win?
Summary Summit Therapeutics has achieved massive market success in 2024, with a market capitalization of over $7 billion. Summit's main pipeline candidate is ivonescimab, a bispecific antibody targeting both PD-1 and VEGF. Ivonescimab has shown "decisive" progression-free survival benefit compared to Keytruda in patients with NSCLC that is PD-L1 positive. The massive valuation of SMMT means they have too much proving to do to make this a sound investment at these levels, in my opinion. Read the full article on Seeking AlphaSeeking Alpha • May 06
Summit Therapeutics' Ivonescimab: Strong Buy Its Dual-Action Approach To Cancer
Summary Summit Therapeutics specializes in developing innovative therapeutic solutions for oncology and infectious diseases. Their flagship drug candidate, Ivonescimab, is in phase 3 clinical trials and shows promise in treating non-small cell lung cancer. The company's Ivonescimab, a bispecific antibody, is supported by a partnership with Akeso. Ivonescimab targets PD-1 and VEGF pathways, potentially treating NSCLC and other cancers. Summit’s promising clinical trials, HARMONi and HARMONi-3, focus on advanced lung cancers and aim for FDA approval. SMMT is a strong buy because of ivonescimab’s potential in oncology and the company’s proven leadership under Robert Duggan. Read the full article on Seeking AlphaSeeking Alpha • Jan 30
Summit Therapeutics: A Strategic Analysis Of Ivonescimab's Progress
Summary Summit's financial position is stable with adequate funds to support operations until H2 2024, despite a significant drop in cash reserves. Ivonescimab, SMMT's dual-acting compound targeting PD-1 and VEGF, shows promise in the field of oncology, particularly in non-small cell lung cancer. The success of Ivonescimab in Phase III trials is crucial for Summit's future, and investors will closely monitor clinical data and market positioning. Read the full article on Seeking AlphaSeeking Alpha • Oct 04
Summit Therapeutics slips on plans to terminate study for lead candidate
Summit Therapeutics (NASDAQ:SMMT), a biotech focused on infectious diseases, dropped ~5% pre-market Tuesday after the company announced it would discontinue a pediatric clinical trial for lead asset ridinilazole for Clostridioides difficile infection. The decision follows a Type C meeting the company conducted with the FDA in which the regulator cited the need for at least one additional registrational trial to allow a potential marketing authorization for ridinilazole. After that, the company has decided to divest ridinilazole or seek partners to advance its studies further, SMMT said in a regulatory filing on Tuesday. In December, the company said that its Phase 3 Ri-CoDIFy study for ridinilazole failed to meet the main goal in patients with C. difficile infection.Seeking Alpha • Aug 17
Summit Therapeutics: Developing Antibiotics Is A Noble Cause But The Company Is Wise To Expand Its Portfolio
Ridinilazole failed to meet the endpoint of superiority over vancomycin in phase 3 trials. Summit Therapeutics has a preclinical antibiotic for Enterobacteriaceae, an infection where there is a clear need for novel therapeutics. Antibiotics are an extremely difficult segment of the pharmaceutical business and while novel anti-infectives are urgently needed, the company is wise to have a more broadly diversified business plan. Summary Summit Therapeutics (SMMT) reported disappointing results for their lead asset, ridinilazole which is unlikely to generate significant revenue if ever approved. The company is in early stage testing of its antibiotic which has activity against Enterobacteriaceae, a pathogen which is increasingly resistant to standard antibiotics. The company is a few years away from proof of concept human efficacy data for this asset, SMT-737. Given the difficulty of focusing on anti-infectives, the company has made a decision to expand into the microbiome and/or oncology through business development. Ridinilazole is unlikely to be widely prescribed Summit Therapeutics announced that they met with the FDA to discuss results of the CoDIFy Phase III clinical trials. The trials were pivotal trials comparing ridinilazole to vancomycin and designed to show superiority over one of the current standard of care antibiotics, vancomycin. In the clinical trials conducted to date, ridinilazole failed to show superiority over vancomycin. Summit was advised that an additional clinical trial would be required and they plan to explore this possibility. The company described the pathway as requiring "reasonable efforts." The real issue however is that fidaxomicin, an antibiotic marketed by Merck was tested and was shown to be non-inferior to vancomycin in clinical response at the end of treatment and superior to vancomycin in sustained clinical cure at 25 days post treatment. Sustained cure rates in pivotal trials were 70% and 72 % for fidaxomicin vs 57% for vancomycin at day 25. For a first episode of C. difficile infection ((CDI)), Infectious Disease Society of America ((IDSA)) now recommends a standard course or a pulsed course of fidaxomicin as the preferred choice. Fidaxomicin, which is highly effective, will likely be generically available by 2028 making ridinilazole unlikely to be widely prescribed. In addition, Acurx Pharmaceuticals (ACXP) is developing ibezapolstat, an antibiotic for CDI. A 100 percent cure rate at day 12 was observed with no recurrence at day 38 in all of the 10 patients treated in the phase 2A trial. In addition, there were no treatment discontinuations and no SAEs. One patient out of the ten treated patients reported nausea. Of the 10 treated patients in the phase 2A trial, 86% of the stool samples tested were positive for C. difficile growth at day 1 but by day 3 of treatment and at every time point thereafter, no C. difficile was detected in stool. This indicates a rapid onset and swift eradication of C. difficile. Further clinical trials are now underway but if this profile is verified in the ongoing Phase 2B testing, ibezapolstat may be a preferred drug to treat CDI. Given the competitive landscape, further development may only be logical if Summit Therapeutics can secure outside funding (potentially from BARDA) and if the clinical trial is relatively inexpensive to conduct. The Pipeline- SMT-737 Summit Therapeutics estimates there are more than a million Enterobacteriaceae infections annually. Some of these infections are increasingly resistant to standard antibiotics such as penicillins and cephalosporins. The CDC has identified carbapenem-resistant Enterobacteriaceae as an urgent threat. Carbapenems are a class of antibiotics reserved for serious infections that are administered IM or IV. Resistance to these last resort antibiotics is very concerning. SMT-737 has a unique mechanism of action which is different from existing antibiotics. IND-enabling studies are underway. In in-vitro studies (in the laboratory) SMT-737 was potent and bactericidal against multiple strains including drug resistant Enterobacteriaceae. Testing to date has been conducted in an animal model of UTI where cure of infection was observed. While this bacteria is common in the urinary tract, and UTI may be the lead indication, the drug also achieved systemic distribution and was detected in the bloodstream and lungs. Thus, it may be effective in other infections. There is a clear unmet need for novel antibiotics to treat these infections which most commonly occur in hospitalized patients. Premium pricing would certainly be warranted given there are an estimated 2500 deaths annually from drug resistant strains. Business Development Summit Therapeutics reported that, "Our intention is to expand our pipeline product portfolio in the therapeutic area of oncology and/or product offerings that are designed to work in harmony with the human gut microbiome. We intend to enact this through business development activities, including possible acquisitions and/or collaborations in addition to internal research and discovery efforts."Seeking Alpha • Aug 11
Summit Therapeutics GAAP EPS of -$0.17, revenue of $0.23M
Summit Therapeutics press release (NASDAQ:SMMT): Q2 GAAP EPS of -$0.17. Revenue of $0.23M (+283.3% Y/Y).Rendimenti per gli azionisti
| SMMT | US Biotechs | US Mercato | |
|---|---|---|---|
| 7D | -20.1% | 1.2% | 2.1% |
| 1Y | -30.4% | 41.9% | 30.6% |
Ritorno vs Industria: SMMT ha avuto una performance inferiore rispetto al US Biotechs che ha registrato un rendimento 41.9 % nell'ultimo anno.
Rendimento vs Mercato: SMMT ha avuto una performance inferiore al mercato US che ha registrato un rendimento 30.6 % nell'ultimo anno.
Volatilità dei prezzi
| SMMT volatility | |
|---|---|
| SMMT Average Weekly Movement | 12.2% |
| Biotechs Industry Average Movement | 10.6% |
| Market Average Movement | 7.2% |
| 10% most volatile stocks in US Market | 16.1% |
| 10% least volatile stocks in US Market | 3.2% |
Prezzo delle azioni stabile: Negli ultimi 3 mesi il prezzo delle azioni di SMMT è stato volatile rispetto al mercato US.
Volatilità nel tempo: La volatilità settimanale ( 12% ) di SMMT è rimasta stabile nell'ultimo anno, ma è comunque superiore al 75% delle azioni US.
Informazioni sull'azienda
| Fondato | I dipendenti | AMMINISTRATORE DELEGATO | Sito web |
|---|---|---|---|
| 2003 | 265 | Bob Duggan | www.smmttx.com |
Summit Therapeutics Inc. è un'azienda biofarmaceutica che si concentra sulla scoperta, lo sviluppo e la commercializzazione di terapie mediche a misura di paziente, medico, operatore sanitario e società. Il suo principale candidato allo sviluppo è l'ivonescimab, un anticorpo bispecifico per l'immunoterapia attraverso il blocco di PD-1 e l'anti-angiogenesi per il trattamento del carcinoma polmonare non a piccole cellule (NSCLC) e del carcinoma colorettale (CRC). L'azienda ha anche combinato ivonescimab con la chemioterapia, che è in fase III di sperimentazione clinica per i pazienti con recettore del fattore di crescita epidermico, mutato, e NSCLC non squamoso localmente avanzato o metastatico; NSCLC metastatico di prima linea e CRC metastatico non resecabile di prima linea.
Summit Therapeutics Inc. Riepilogo dei fondamenti
| SMMT statistiche fondamentali | |
|---|---|
| Capitalizzazione di mercato | US$13.85b |
| Utili (TTM) | -US$1.21b |
| Ricavi(TTM) | n/a |
0.0x
Rapporto P/S-11.0x
Rapporto P/ESMMT è sopravvalutato?
Vedi Fair Value e analisi di valutazioneUtili e ricavi
| SMMT Conto economico (TTM) | |
|---|---|
| Ricavi | US$0 |
| Costo del fatturato | US$0 |
| Profitto lordo | US$0 |
| Altre spese | US$1.21b |
| Utili | -US$1.21b |
Ultimi utili riportati
Mar 31, 2026
Prossima data di guadagno
n/a
| Utile per azione (EPS) | -1.55 |
| Margine lordo | 0.00% |
| Margine di profitto netto | 0.00% |
| Rapporto debito/patrimonio netto | 0% |
Come si è comportato SMMT nel lungo periodo?
Vedi performance storica e confrontoAnalisi aziendale e situazione dei dati finanziari
| Dati | Ultimo aggiornamento (ora UTC) |
|---|---|
| Analisi dell'azienda | 2026/05/07 05:45 |
| Prezzo dell'azione a fine giornata | 2026/05/07 00:00 |
| Utili | 2026/03/31 |
| Utili annuali | 2025/12/31 |
Fonti dei dati
I dati utilizzati nella nostra analisi aziendale provengono da S&P Global Market Intelligence LLC. I seguenti dati sono utilizzati nel nostro modello di analisi per generare questo report. I dati sono normalizzati, il che può comportare un ritardo nella disponibilità della fonte.
| Pacchetto | Dati | Tempistica | Esempio Fonte USA * |
|---|---|---|---|
| Dati finanziari della società | 10 anni |
| |
| Stime di consenso degli analisti | +3 anni |
|
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| Prezzi di mercato | 30 anni |
| |
| Proprietà | 10 anni |
| |
| Gestione | 10 anni |
| |
| Sviluppi principali | 10 anni |
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* Esempio per i titoli statunitensi, per i titoli non statunitensi si utilizzano forme e fonti normative equivalenti.
Se non specificato, tutti i dati finanziari si basano su un periodo annuale ma vengono aggiornati trimestralmente. Si tratta dei cosiddetti dati TTM (Trailing Twelve Month) o LTM (Last Twelve Month). Per saperne di più.
Modello di analisi e Snowflake
I dettagli del modello di analisi utilizzato per generare questo report sono disponibili sulla nostra pagina Github; abbiamo anche guide su come utilizzare i nostri report e tutorial su Youtube.
Scoprite il team di livello mondiale che ha progettato e realizzato il modello di analisi Simply Wall St.
Metriche di settore e industriali
Le nostre metriche di settore e di sezione sono calcolate ogni 6 ore da Simply Wall St; i dettagli del nostro processo sono disponibili su Github.
Fonti analitiche
Summit Therapeutics Inc. è coperta da 27 analisti. 14 di questi analisti ha fornito le stime di fatturato o di utile utilizzate come input per il nostro report. Le stime degli analisti vengono aggiornate nel corso della giornata.
| Analista | Istituzione |
|---|---|
| Etzer Darout | Barclays |
| Yun Zhong | Brean Capital Historical (Janney Montgomery) |
| Timothy Chiang | BTIG |