Lyra Therapeutics, Inc.

OTCPK:LYRA Stock Report

Market Cap: US$1.2m

Lyra Therapeutics Past Earnings Performance

Past criteria checks 0/6

Lyra Therapeutics's earnings have been declining at an average annual rate of -12.2%, while the Pharmaceuticals industry saw earnings growing at 9.4% annually. Revenues have been growing at an average rate of 20.2% per year.

Key information

-12.21%

Earnings growth rate

27.30%

EPS growth rate

Pharmaceuticals Industry Growth5.95%
Revenue growth rate20.23%
Return on equityn/a
Net Margin-7,266.08%
Last Earnings Update31 Dec 2025

Recent past performance updates

Recent updates

Seeking Alpha • Jun 16

Lyra Therapeutics: Regulatory Pathway For Non-Polyp Patients, An Underappreciated Catalyst

Summary Lyra Therapeutics has lost >90% of its value since announcing the failed ENLIGHTEN-1 trial, despite the recent announcement of a clearly positive ENLIGHTEN-2. Considering a clearly positive phase 3, strong supporting data, and a good explanation for the ENLIGHTEN-1 failure, I believe the market is underestimating the potential for NDA submission without the need of another phase 3. Assuming positive FDA feedback, I expect considerable upside, allowing LYRA to raise much needed cash from a strong position. However, the FDA asking for another phase 3 trial would delay commercialization by several years. Without a partnership or other transaction, this would mean considerable dilution. Read the full article on Seeking Alpha
Analysis Article • Jan 25

Will Lyra Therapeutics (NASDAQ:LYRA) Spend Its Cash Wisely?

Just because a business does not make any money, does not mean that the stock will go down. For example, biotech and...
Analysis Article • Sep 10

We Think Lyra Therapeutics (NASDAQ:LYRA) Needs To Drive Business Growth Carefully

We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...
Analysis Article • Mar 12

Is Lyra Therapeutics (NASDAQ:LYRA) In A Good Position To Deliver On Growth Plans?

We can readily understand why investors are attracted to unprofitable companies. For example, although...
Seeking Alpha • Jul 05

Lyra Therapeutics appoints Nieman as Chief Medical Officer

Lyra Therapeutics (NASDAQ:LYRA) has appointed Dr. Richard Nieman as Chief Medical Officer, effective July 11, 2022.  The industry leader with substantial U.S. and global experience in drug development and medical affairs joins Lyra as the company's late-stage product candidates advance in the clinic. Dr. Nieman assumes the role of Chief Medical Officer, previously held by Dr. Robert Kern, who will continue to work closely with the company in the role of Chief Clinical Advisor. The firm has approved the issuance of an equity-based award pursuant to its 2022 Inducement Award Plan to Dr. Nieman upon the commencement of his employment.  The inducement grant consists of a non-qualified stock option to purchase an aggregate of 230,000 shares of the company's common stock.
Seeking Alpha • May 18

Lyra Therapeutics: Progress In The Clinic

Phase 3 trials for LYR-210 are underway. LYR-210 has shown an excellent efficacy and safety profile. The company is well funded. In this risk-off environment, there may be an even better entry point for investors.
Seeking Alpha • Apr 21

A First Look At Lyra Therapeutics

Today, we put Lyra Therapeutics in the spotlight for the first time. This small biopharma concern has disappointed investors since coming public in mid-2020. The drop in the shares has triggered some huge insider buying by insiders and beneficial owners of the stock via a capital raise in April. Time to buy this equity? A full investment analysis follows in the paragraphs below.
Analysis Article • Mar 30

Is Lyra Therapeutics (NASDAQ:LYRA) In A Good Position To Deliver On Growth Plans?

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Analysis Article • Dec 14

Is Lyra Therapeutics (NASDAQ:LYRA) In A Good Position To Invest In Growth?

We can readily understand why investors are attracted to unprofitable companies. For example, although...

Revenue & Expenses Breakdown

How Lyra Therapeutics makes and spends money. Based on latest reported earnings, on an LTM basis.

Earnings and Revenue History

OTCPK:LYRA Revenue, expenses and earnings (USD Millions)
DateRevenueEarningsG+A ExpensesR&D Expenses
31 Dec 250-291217
30 Sep 251-33130
30 Jun 251-39140
31 Mar 251-80160
31 Dec 242-931942
30 Sep 241-98190
30 Jun 242-101200
31 Mar 242-69200
31 Dec 232-63190
30 Sep 231-62160
30 Jun 231-61170
31 Mar 231-60180
31 Dec 221-55180
30 Sep 222-55180
30 Jun 221-51170
31 Mar 221-48160
31 Dec 210-44140
30 Sep 210-37160
30 Jun 210-3214-5
31 Mar 210-2611-3
31 Dec 200-22100
30 Sep 200-2083
30 Jun 200-18611
31 Mar 200-17512
31 Dec 190-17412
31 Dec 181-645

Quality Earnings: LYRA is currently unprofitable.

Growing Profit Margin: LYRA is currently unprofitable.

Free Cash Flow vs Earnings Analysis

Past Earnings Growth Analysis

Earnings Trend: LYRA is unprofitable, and losses have increased over the past 5 years at a rate of 12.2% per year.

Accelerating Growth: Unable to compare LYRA's earnings growth over the past year to its 5-year average as it is currently unprofitable

Earnings vs Industry: LYRA is unprofitable, making it difficult to compare its past year earnings growth to the Pharmaceuticals industry (-4.8%).

Return on Equity

High ROE: LYRA's liabilities exceed its assets, so it is difficult to calculate its Return on Equity.

Return on Assets

Return on Capital Employed

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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/06/07 02:35
End of Day Share Price 2026/06/05 00:00
Earnings2025/12/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Lyra Therapeutics, Inc. is covered by 4 analysts. 0 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Jason Matthew GerberryBofA Global Research
Matthew CaufieldH.C. Wainwright & Co.
Christopher HowertonJefferies LLC