Protagonist Therapeutics, Inc.

NasdaqGM:PTGX Stock Report

Market Cap: US$2.5b

Protagonist Therapeutics Valuation

Is PTGX undervalued compared to its fair value, analyst forecasts and its price relative to the market?

Valuation Score

5/6

Valuation Score 5/6

  • Below Fair Value

  • Significantly Below Fair Value

  • Price-To-Earnings vs Peers

  • Price-To-Earnings vs Industry

  • Price-To-Earnings vs Fair Ratio

  • Analyst Forecast

Share Price vs Fair Value

What is the Fair Price of PTGX when looking at its future cash flows? For this estimate we use a Discounted Cash Flow model.

Below Fair Value: PTGX ($41.49) is trading below our estimate of fair value ($186.16)

Significantly Below Fair Value: PTGX is trading below fair value by more than 20%.

Key Valuation Metric

Which metric is best to use when looking at relative valuation for PTGX?

Key metric: As PTGX is profitable we use its Price-To-Earnings Ratio for relative valuation analysis.

The above table shows the Price to Earnings ratio for PTGX. This is calculated by dividing PTGX's market cap by their current earnings.
What is PTGX's PE Ratio?
PE Ratio14.5x
EarningsUS$170.85m
Market CapUS$2.47b

Price to Earnings Ratio vs Peers

How does PTGX's PE Ratio compare to its peers?

The above table shows the PE ratio for PTGX vs its peers. Here we also display the market cap and forecasted growth for additional consideration.
CompanyForward PEEstimated GrowthMarket Cap
Peer Average30.5x
AGIO Agios Pharmaceuticals
3x-57.3%US$2.0b
CPRX Catalyst Pharmaceuticals
17.8x17.5%US$2.5b
PNT POINT Biopharma Global
13.8x9.2%US$1.3b
MNKD MannKind
87.6x38.8%US$1.9b
PTGX Protagonist Therapeutics
14.5x-36.0%US$2.5b

Price-To-Earnings vs Peers: PTGX is good value based on its Price-To-Earnings Ratio (14.5x) compared to the peer average (30.5x).

Price to Earnings Ratio vs Industry

How does PTGX's PE Ratio compare vs other companies in the US Biotechs Industry?

12 CompaniesPrice / EarningsEstimated GrowthMarket Cap
ROIV Roivant Sciences
1.8x-58.7%US$8.42b
AGIO Agios Pharmaceuticals
3x-57.3%US$2.02b
INBX Inhibrx Biosciences
0.1xn/aUS$211.35m
DTIL Precision BioSciences
3.2x-41.0%US$36.21m
PTGX 14.5xIndustry Avg. 15.7xNo. of Companies12PE020406080100+
12 CompaniesEstimated GrowthMarket Cap
No more companies

Price-To-Earnings vs Industry: PTGX is good value based on its Price-To-Earnings Ratio (14.5x) compared to the US Biotechs industry average (15.2x).

Price to Earnings Ratio vs Fair Ratio

What is PTGX's PE Ratio compared to its Fair PE Ratio? This is the expected PE Ratio taking into account the company's forecast earnings growth, profit margins and other risk factors.

PTGX PE Ratio vs Fair Ratio.
Fair Ratio
Current PE Ratio14.5x
Fair PE Ratio10.2x

Price-To-Earnings vs Fair Ratio: PTGX is expensive based on its Price-To-Earnings Ratio (14.5x) compared to the estimated Fair Price-To-Earnings Ratio (10.2x).

Analyst Price Targets

What is the analyst 12-month forecast and do we have any statistical confidence in the consensus price target?

The above table shows the analyst PTGX forecast and predictions for the stock price in 12 month’s time.
DateShare PriceAverage 1Y Price TargetDispersionHighLow1Y Actual priceAnalysts
CurrentUS$41.49
US$57.50
+38.6%
10.8%US$67.00US$47.00n/a10
Dec ’25US$43.80
US$56.38
+28.7%
13.3%US$67.00US$43.00n/a8
Nov ’25US$46.76
US$52.71
+12.7%
13.1%US$65.00US$43.00n/a7
Oct ’25US$44.37
US$52.13
+17.5%
12.7%US$65.00US$43.00n/a8
Sep ’25US$42.89
US$47.00
+9.6%
9.0%US$52.00US$40.00n/a6
Aug ’25US$37.96
US$47.00
+23.8%
9.8%US$52.00US$38.00n/a6
Jul ’25US$35.20
US$43.83
+24.5%
11.4%US$52.00US$38.00n/a6
Jun ’25US$28.15
US$43.50
+54.5%
12.4%US$52.00US$37.00n/a6
May ’25US$25.56
US$43.00
+68.2%
12.5%US$52.00US$37.00n/a6
Apr ’25US$28.28
US$43.00
+52.1%
12.5%US$52.00US$37.00n/a6
Mar ’25US$32.15
US$43.00
+33.7%
12.5%US$52.00US$37.00n/a6
Feb ’25US$28.52
US$42.50
+49.0%
14.1%US$52.00US$34.00n/a6
Jan ’25US$22.93
US$40.17
+75.2%
11.8%US$49.00US$34.00n/a6
Dec ’24US$18.56
US$38.50
+107.4%
14.3%US$49.00US$32.00US$43.806
Nov ’24US$15.11
US$38.17
+152.6%
14.8%US$49.00US$32.00US$46.766
Oct ’24US$16.68
US$39.40
+136.2%
13.7%US$49.00US$34.00US$44.375
Sep ’24US$19.54
US$39.00
+99.6%
12.6%US$49.00US$35.00US$42.896
Aug ’24US$19.02
US$39.00
+105.0%
12.6%US$49.00US$35.00US$37.966
Jul ’24US$27.62
US$37.83
+37.0%
16.8%US$49.00US$28.00US$35.206
Jun ’24US$27.49
US$36.33
+32.2%
11.7%US$41.00US$28.00US$28.156
May ’24US$23.55
US$34.50
+46.5%
13.5%US$41.00US$28.00US$25.566
Apr ’24US$23.00
US$34.50
+50.0%
13.5%US$41.00US$28.00US$28.286
Mar ’24US$15.65
US$32.50
+107.7%
19.3%US$41.00US$21.00US$32.156
Feb ’24US$14.06
US$33.50
+138.3%
18.2%US$41.00US$21.00US$28.526
Jan ’24US$10.91
US$33.50
+207.1%
18.2%US$41.00US$21.00US$22.936
Dec ’23US$7.80
US$33.50
+329.5%
18.2%US$41.00US$21.00US$18.566

Analyst Forecast: Target price is more than 20% higher than the current share price and analysts are within a statistically confident range of agreement.

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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2024/12/22 09:59
End of Day Share Price 2024/12/20 00:00
Earnings2024/09/30
Annual Earnings2023/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more here.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on .

Analyst Sources

Protagonist Therapeutics, Inc. is covered by 20 analysts. 10 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Douglas TsaoBarclays
Mayur SomaiyaBMO Capital Markets Equity Research
Etzer DaroutBMO Capital Markets Equity Research