Announcement • Jun 09
Adocia Presents Full Phase 3 Results For BioChaperone Lispro In Type 2 Diabetes Presented at ADA 86th Scientific Sessions Adocia announced that the full results of the Phase 3 clinical study (Study THDB0206L02, NCT05834868) conducted on people with type 2 diabetes in China with BioChaperone Lispro were presented at the American Diabetes Association (ADA) 86th Scientific Session, completing the positive topline results of this clinical trial announced in July 2025. Positive topline results, released in July 2025, included non inferior HbA1c reduction for the whole population and a similar safety profile compared to the standard of care, Humalog. Clinically relevant benefits over Humalog include: Superior long term glycemic control in people using Metformin or with HbA1c below 8.5%, Superior glucose control throughout the day and after each meal for the whole population. For more detail, the poster is accessible on Adocia’s website. BioChaperone Lispro was licensed to Tonghua Dongbao in 2018, as part of a Licensing Agreement covering China and other Asian countries. BioChaperone Lispro is an Ultra-Rapid Insulin, belonging to the latest generation of prandial insulins. It combines Adocia's proprietary BioChaperone technology with insulin lispro, the active ingredient in the standard of care, Humalog. This innovative formulation acts significantly faster than earlier insulin generations, effectively reducing post-meal hyperglycemia, which is a key contributor to long-term complications such as retinopathy, diabetic foot ulcers, or kidney failure. Additionally, its rapid elimination minimizes the risk of hypoglycemia, often caused when insulin level remains high after post-meal glucose levels have normalized. The faster action profile of BioChaperone Lispro associated to an excellent local tolerance enhances its compatibility with modern diabetes management systems, particularly insulin pump systems, and provides better integration into advanced treatment algorithms. Beyond its clinical advantages, the quick onset of BioChaperone Lispro improves quality of life by offering greater flexibility in dose timing. Patients can administer insulin at mealtime, or even right-after-mealtime, allowing for more accurate dosing based on known meal timing and content. This reduces the risks of overdosing or underdosing, which can lead to hypo- or hyperglycemia and their associated complications. The simplified dosing process eases the psychological burden on patients and caregivers, significantly alleviating the stress associated with diabetes management. In 2022, the partner Tonghua Dongbao initiated two Phase 3 studies with the ultra-rapid insulin BioChaperone Lispro involving approximately 1,500 people with type 1 or type 2 diabetes in China. The positive results of these studies have been announced in July 2025 and October 2025. The contract with Tonghua Dongbao includes a milestone payment of USD 20 million, which would be triggered upon obtaining marketing authorization in China, and subsequent double-digit royalties on sales to Adocia. The marketing authorization filing is in preparation and is under Tonghua Dongbao’s responsibility. Announcement • Jun 05
Adocia Announces Virtual Kol Event to Review Phase 3 Results of Ultra-Rapid Insulin Biochaperone Lispro Adocia announced that it will host a virtual Key Opinion Leader (KOL) event on Tuesday June 16, 2026 at 10:00 AM EST /4:00 PM CEST. Tim Heise, MD (Profil, Neuss, Germany), will join company management, Olivier Soula, CEO and co-founder of Adocia and You-Ping Chan, Head of R&D, to review the results of the Phase 3 trial conducted in China on BioChaperone Lispro (“BC Lispro”) for the treatment of type 2 diabetes. The event will cover the following topics: Introduction to Adocia’s proprietary BioChaperone technology platform, by You-Ping Chan; Current mealtime insulin treatment paradigm for diabetes and limitations by Tim Heise; Ultra-Rapid insulin BC Lispro Phase 3 data on type 2 diabetes by Tim Heise MD; Next steps and potential value creation by Olivier Soula. A live question and answer session will follow the presentation. The webcast will be conducted in English. A replay of the webcast and presentation materials will be made available on Adocia’s website following the event. BioChaperone Lispro was licensed to Tonghua Dongbaoin 2018, as part of a Licensing Agreement covering China and other Asian countries. BioChaperone Lispro is an Ultra-Rapid Insulin, belonging to the latest generation of prandial insulins. It combines Adocia's proprietary BioChaperone technology with insulin lispro, the active ingredient in the standard of care, Humalog (Eli Lilly). This innovative formulation acts significantly faster than earlier insulin generations, effectively reducing post-meal hyperglycemia, which is a key contributor to long-term complications such as retinopathy, diabetic foot ulcers, or kidney failure. Additionally, its rapid elimination minimizes the risk of hypoglycemia, often caused when insulin level remains high after post-meal glucose levels have normalized. The faster action profile of BioChaperone Lispro associated to an excellent local tolerance enhances its compatibility with modern diabetes management systems, particularly insulin pump systems, and provides better integration into advanced treatment algorithms. Beyond its clinical advantages, the quick onset of BioChaperone Lispro improves quality of life by offering greater flexibility in dose timing. Patients can administer insulin at mealtime, or even right-after-mealtime, allowing for more accurate dosing based on known meal timing and content. This reduces the risks of overdosing or underdosing, which can lead to hypo- or hyperglycemia and their associated complications. The simplified dosing process eases the psychological burden on patients and caregivers, significantly alleviating the stress associated with diabetes management. Announcement • Feb 25
Adocia SA Announces Board Changes Adocia SA announced that after 20 years as Chairman of Adocia, and as announced during the shareholders’ meeting of Adocia conducted on June 11th 2025, Gérard Soula, co-founder of the Company, is stepping down from his positions as Chairman of the Board of Directors and Board member, in consultation with the Board of Directors, in accordance with the statutory age limit. The termination of Gérard Soula’s functions will be effective as of February 23, 2026. The Board also decided that Stéphane Boissel, a director of Adocia since 2021, will succeed Gérard Soula as Chairman of the Board of Directors of Adocia. Stéphane Boissel is an experienced executive in the biotechnology sector, currently serving as President and CEO of SparingVision, a Company specializing in genomic medicine for hereditary eye diseases. After 10 years of experience in consulting and investment banking in France and internationally, he has spent the past 25 years serving as an executive leader and board member in the biotechnology sector. He previously held chief executive, strategic, and financial leadership positions at several international biotech companies, including Innate Pharma, Transgene, TxCell, and Sangamo Therapeutics in San Francisco, and currently serves as an independent member of the Board of Directors of EG427. As a replacement of the office held by Gérard Soula, the Board of Directors co-opted Jacky Vonderscher as a director, considered as an independent director. His co-optation as director will be submitted for shareholders’ ratification at the next Annual shareholders’ meeting of Adocia. Jacky Vonderscher is an experienced pharma and biotech leader. He is the CEO of ENYO Pharma SA, a Company specializing in developing therapeutics for diseases with impaired kidney function. His extensive 40 years’ experience in pharma development at Novartis and Roche, and more recently as director and leader in different biotech companies, will be a valuable contribution for the development of Adocia. Announcement • Dec 20
Adocia SA, Annual General Meeting, Jun 03, 2026 Adocia SA, Annual General Meeting, Jun 03, 2026. Announcement • Nov 12
Adocia Announces Filing of Patent for New Long-Acting Peptides Platform in Diabetes and Obesity - Adoxlong Adocia announced the submission of a patent for a new long-acting peptide platform, and two feasibility studies using its BioChaperone technology with two undisclosed pharmaceutical companies. The new AdoXLongTM platform has been developed to address a critical challenge in diabetes and obesity treatments based on GLP-1 agonists, amylin, or other metabolic peptide: long-acting formulations. Moving from weekly to monthly administration would significantly improve long-term treatment persistence, while reducing the manufacturing capacity required per patient, thereby increasing the number of patients who can be treated. The patented technology is a long-acting peptide platform composed of a biocompatible polymer chemically linked to the peptides without modifying their mechanisms of action. Pharmaceutical products derived from this technology are low viscosity aqueous solutions compatible with standard injection devices and administered subcutaneously using 29 Gauge or smaller needles. The technology is designed to offer a long circulating peptide over at least one month. The technology can be applied to a variety of peptides such as GLP-1, GIP, amylin, or dual/triple agonists - including semaglutide, tirzepatide, cagrilintide - with the possibility to combine these modified peptides with each other. Positive preliminary in vitro and in vivo results have been obtained with AdoXLong®? applied to semaglutide. The patent application is expected to provide worldwide protection until 2046, if granted. The peptides using the technology would also benefit from reinforced intellectual property with extension until 2046. The technology is applicable to both innovative and biosimilar peptides, including Semaglutide, which will become off-patent starting in 2026 in certain territories. Announcement • Sep 03
Adocia Announces Oral Presentations on Adocia and Biochaperone At Easd, Esb and Podd 2025 Annual Meetings Adocia announced oral presentations highlighting the latest preclinical results obtained on its innovative technological platform AdoShell at EASD and ESB 2025 annual meetings. Adocia will also present at the next PODD 2025 its latest preclinical results on the BioChaperone platform. Oral presentations at EASD et ESB will highlight the latest AdoShell preclinical results: Successful scale up from animal to human device for First-In-Human study; In vitro and in vivo maturation after encapsulation of immature stem cell-derived islets in AdoShell; Sustained long-term in vivo function and efficacy of stem cell-derived islets encapsulated in AdoShell; EASD (European Association for the Study of Diabetes) annual meeting, Vienna, Austria, 15-19 September 2025; Title: ADO12, a non-fibrotic encapsulation system for human islet transplantation without immunosuppression; Presentation: Tuesday, September 16th 2025 - 12:00 -13:00 pm CEST; Session: It's beta cell replacement time (SO 019; 400); Room: Station 04; Authors: Ouardane Jou cannot, Anne-Lise Gaffuri, Madeleine Frelon, Gregory Blache, Julie Brun, Guillaume Lefebvre, Camille Gautier, Romain Besnard, Alexandre Martin, Claire Megret, Nicolas Laurent, Martin Gaudier, Rosy Eloy, Olivier Soula. Announcement • Jul 25
Adocia and Tonghua Dongbao Announces Positive Topline Results of Phase 3 Clinical Trial on Ultra-Rapid Insulin BioChaperone Lispro (THDB0206 injection) in People with T2D Adocia announced that its partner Tonghua Dongbao releases positive topline results on the Phase 3 clinical trial on BioChaperone Lispro (THDB0206 injection), a novel Ultra-Rapid Insulin formulation. Conducted by Tonghua Dongbao, this Phase 3 study (NCT05834868) was approved by the Chinese Regulatory Authorities (CDE1). The randomized, open, multicenter study evaluated the safety and efficacy of THDB0206 injection compared to Humalog in adults with Type 2 diabetes. Results A total of 1,040 Chinese adults with Type 2 diabetes with inadequate glycemic control and using daily multiple injections of insulin were randomized. After 26 weeks of treatment, HbA1c decreased significantly in both groups compared to the baseline. The reduction in the THDB0206 injection group was comparable to that of the Humalog group, meeting the primary endpoint. The key secondary endpoints were also demonstrated, with a statistically significant lower rise of blood glucose after a standard meal for the THDB0206 injection group, compared to the Humalog group. The 10-point self-monitoring blood glucose (SMBG) of patients at week 26, an important supportive endpoint of the trial, confirmed the advantage of this product in controlling postprandial blood glucose fluctuations, with a statistically improved daily blood glucose level. A series of prespecified subgroup analyzes of the primary HbA1c endpoint also fully confirmed the benefits of this product in long-term blood glucose control in patients with Type 2 diabetes. In addition, the safety and tolerability of THDB0206 injection were good. Most of the adverse events were mild or moderate, and the incidence of adverse events and hypoglycemic events were similar to those of Humalog. BioChaperone Lispro was licensed to Tonghua Dongbaoin 2018, as part of a Licensing Agreement covering China and other Asian countries. BioChaperone Lispro is an Ultra-Rapid Insulin, belonging to the latest generation of prandial insulins. It combines Adocia's proprietary BioChaperone® technology with insulin lispro, the active ingredient in the standard of care, Humalog (Eli Lilly). This innovative formulation acts significantly faster than earlier insulin generations, effectively reducing post-meal hyperglycemia, which is a key contributor to long-term complications such as retinopathy, diabetic foot ulcers, or kidney failure. Additionally, its rapid elimination minimizes the risk of hypoglycemia, often caused when insulin level remains high after post-meal glucose levels have normalized. Announcement • Jun 24
Adocia Announces the Presentation of the Latest Preclinical Data from its Innovative Adocia Technology Platform At ADA & IPITA Scientific Conferences Highlight Scalability and Good Translation of AdoShell Adocia announced the presentation of the latest preclinical data from its innovative AdoShell®? technology platform at ADA & IPITA Scientific Conferences Highlight Scalability and Good Translation of AdoShell®? from Human Islets to Stem Cell-Derived Islets. AdoShell®? is designed to implant human pancreatic islets from deceased donors or stem cell-derived islets cell to cure type 1 diabetes without immunosuppression. Adocia preclinical data presented at the International Pancreas and Islet Transplant Association (IPITA) 2025 World Congress, held in Pisa, Italy, June 15-18, 2025, was titled "AdoShell®?, a non-fibrotic encapsulation system for human islet transplantation without immunosuppression". After implanting AdoShell®? containing human islets in mice, C-peptide secretion increased during the first two weeks to reach a therapeutic dose (707+-218 pM) that was maintained in 100% of mice until explantation after more than 2 months. Moreover, AdoShell®? Human Islets was shown to regulate mice glycemia to human levels. In vitro, explants showed a maintained viability and glucose-responsive insulin secretion. This presentation also highlights that AdoShell has been successfully scaled-up to embark the human dose of islets for a first clinical application. The Adocia presentation at the American Diabetes Association's (ADA) 85th Scientific Sessions, held in Chicago, USA, June 20-23, 2025, focused on the application of AdoShell®? to stem cell-derived islets (SCDI). Encapsulation of SCDI in AdoShell®? maintained viability, proliferation state and secretion of insulin similar to non-encapsulated SCDI. AdoShell®? permits the maturation of immature SCDI both in vitro and in vivo. Finally, AdoShell®? enables long-term function and efficacy of SCDI in mice for at least 24 weeks. Announcement • Apr 29
Adocia to Present New Data on AdoShell at Upcoming Scientific Conferences - Showcasing Potential Curative Treatment for Type 1 Diabetes Adocia announced the latest preclinical data from its innovative AdoShell®? technology platform have been selected for presentations at four upcoming scientific conferences. AdoShell®? Islets is an innovative immunoprotective hydrogel designed to encapsulate pancreatic islets, with the goal of curing diabetes through cell therapy without requiring immunosuppression. This semi-permeable hydrogel allows the diffusion of insulin and glucose, while preventing the infiltration of antibodies and immune cells that would lead to graft rejection. Currently, to prevent this normal body reaction, every allogeneic transplant patient must take immunosuppressive drugs on a chronic basis, with significant side effects. AdoShell®? is easily implantable and fully retrievable via laparoscopy. The new data to be presented by Adocia notably disclose the success of the scale-up to deliver the therapeutic dose for the first-in-human study, which is planned to be submitted with the regulatory authorities in 2025. In addition, new in vitro and in vivo data to be presented confirm the compatibility of AdoShell®? with stem cell-derived islets, notably their ability to mature into insulin producing cells within AdoShell®?. The integration of these stem cell-derived islets into technology represents a key step toward broader access to type 1 diabetes treatment through cell therapy, without the need for immunosuppression. Adocia envisions that AdoShell®? could be applied beyond pancreatic cells to other cell types. Data with primary and differentiated stem cells for the release of various therapeutic molecules other than insulin will also be presented, illustrating the possibility to make AdoShell®? a technology platform. Announcement • Feb 27
Adocia SA has completed a Follow-on Equity Offering in the amount of €9.7325 million. Adocia SA has completed a Follow-on Equity Offering in the amount of €9.7325 million.
Security Name: Common Shares
Security Type: Common Stock
Securities Offered: 2,125,000
Price\Range: €4.58
Security Features: Attached Warrants
Transaction Features: Subsequent Direct Listing Announcement • Dec 26
Adocia SA, Annual General Meeting, Jun 11, 2025 Adocia SA, Annual General Meeting, Jun 11, 2025. Announcement • Dec 13
Adocia and Tonghua Dongbao Pharmaceutical Co. Ltd Announce the Final Dosing in A Phase 3 Clinical Study of Biochaperone®? Lispro Adocia announced the completion of the final dosing of the last Type 2 diabetes patient in a Phase 3 clinical trial evaluating BioChaperone® Lispro, the Company's novel ultra-rapid insulin. This clinical trial is being conducted in China by Adocia's partner, Tonghua Dongbao Pharmaceutical in people with Type 2 Diabetes. The final dosing of the last type 2 diabetes patient is associated with a milestone payment of $10 million to Adocia. This payment will be received in the second quarter of 2025 as per the payment terms of the Licensing Agreement. A second study in people with Type 1 diabetes is nearing the end of treatment, which is expected to be in early 2025. Both Phase 3 topline results, in people with Type 1 and Type 2 diabetes, are expected in first quarter of 2025. Tonghua Dongbao is expected to submit the Marketing Authorization Application to the Chinese Centre for Drug Evaluation (CDE) in 2025. The grant of the Marketing Authorization would lead to an additional milestone payment of $20 million and double-digit royalties on sales to Adocia. The Phase 3 clinical program, conducted by Tonghua Dongbao, involves over 1,500 people with Type 1 and Type2 diabetes in 100 clinical centres across China. The aim of both pivotal trials is to demonstrate the safety and efficacy of BioChaperone®Lispro compared to standard of care Humalog® (Eli Lilly). The primary efficacy endpoints is the change in HbA1c (glycosylated haemoglobin) from baseline to 26 weeks of treatment, with a non-inferiority objective. The secondary efficacy endpoints are 1-hour and 2-hour Postprandial Glucose (PPG) excursions at week 26. BioChaperone®Lispro was licensed to Tonghua Dongbao in 2018, as part of a Licensing Agreement covering China and other Asian countries. Announcement • Oct 15
Adocia SA Announces Patenting Stable Combinations of GLP-1 and Amylin Analogs for the Treatment of Obesity and Diabetes Using Its BioChaperone® Platform Adocia announced that it has filed patents of stable formulations of hormone combinations for the treatment of obesity and diabetes using its BioChaperone® platform. Several families of hormones can be used to achieve significant weight loss, starting with GLP-1 (e.g. semaglutide, tirzepatide), but also amylin analogs (e.g. cagrilintide, eloralintide, petrelintide…), which would have the advantage of targeting fat mass, while preserving muscle mass. Future generations of obesity treatments, for which analysts expect the market to reach USD 100 billion by 2030, combine these different mechanisms of action to achieve better weight loss in terms of both quantity and quality. However, this promising strategy is hampered by the incompatibility of many of these hormones, which cannot be formulated into a single product. To avoid double injection, pharmaceutical companies are developing injection devices, such as dual-chamber injectors, but they are limited to single use and are more complex to manufacture. Adocia has patented, among other examples, a stable combination of cagrilintide and semaglutide (“CagriSema”, amylin analog and GLP-1 receptor agonist respectively, Novo Nordisk) with BioChaperone®, which could be administered in standard single- and multiple-use auto-injectors or pens, representing an improvement over a dual-chamber device. The value of Adocia's innovation also lies in the intellectual property generated, which aims to extend the protection of these combinations by several years. The patent applications filed aim to provide worldwide protection for the combinations covered until 2045. Announcement • Jun 05
Adocia Announces Appointment of Mathieu-William Gilbert as Chief Operating Officer Adocia SA announced the appointment of Mathieu-William Gilbert as Chief Operating Officer (COO). Mathieu joins Adocia after serving as Vice-President Strategic Projects of International Commercial Operations at Novo Nordisk. Prior to this, he held the position of Vice President & General Manager of six Latin American countries, with responsibility for all Novo Nordisk activities in the region, as well as the establishment of the Obesity franchise and the commercial launch of Ozempic®. Mathieu began his career with KPMG and Sanofi Aventis, in internal control and auditing, before joining Novo Nordisk's finance functions and being appointed CFO of Algeria and then of the Latin American region. Throughout his career, Mathieu has been passionate about innovative solutions for patients and leading his teams to success. His appointment reflects Adocia's commitment to strengthening its management team and reinforcing its position as an innovative company in the field of diabetes and obesity. Announcement • May 16
Adocia SA announced that it has received €2 million in funding On May 14, 2024, Adocia SA closed the transaction. Announcement • May 09
Adocia SA, Annual General Meeting, Jun 13, 2024 Adocia SA, Annual General Meeting, Jun 13, 2024. Location: 2 rue de saint florentin, paris France New Risk • Nov 18
New major risk - Revenue and earnings growth Earnings have declined by 14% per year over the past 5 years. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are declining over an extended period, then in most cases the share price will decline over time unless the company can turn around its fortunes. A trend of falling earnings can be very difficult to turn around. If the company is well already established it may also be a sign the company has matured and is in decline. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Shares are highly illiquid. Negative equity (-€18m). Earnings have declined by 14% per year over the past 5 years. Shareholders have been substantially diluted in the past year (63% increase in shares outstanding). Announcement • Nov 10
Adocia Reveals Promising Preclinical Data on Adocia Islets for Cell Therapy of Diabetes Adocia disclosed additional results on AdoShell Islets during recent international congresses. Islet transplantation has long been recognized as an effective treatment for Type 1 Diabetes (T1D). However, the limitations imposed by the requirement for immunosuppression have hindered its widespread application. Adocia has set out to overcome this hurdle and has developed AdoShell Islets, an implantable and fullyretrievable scaffold for islet transplantation that eliminates the need for immunosuppression drugs while ensuring the success of the transplantation procedure. AdoShell is based on a permselective hydrogel scaffold, reinforced by a mechanical frame, specifically designed to facilitate the diffusion of insulin while effectively preventing the invasion of immune cells. This innovative biomaterial, comprised of 95% water, is synthesized using non-degradable polymers cross-linked by bio-orthogonal click chemistry. This technology is protected via three patent applications4. Human islets encapsulated in AdoShell®? scaffold maintain, in vitro, a gluco-responsive insulin secretion comparable to naked islets. The outcomes achieved by AdoShell®? Islets in preclinical trials hold true promises for people with T1D. This technology could not only obviate the need for immunosuppressive but also ensure extended functionality, and outstanding biocompatibility. The potential of AdoShell®? Islet Islets could have a fundamental impact on the lives of millions of people living with diabetes and the way approach its treatment. AdoShell®? is committed to advancing the development of AdoShell®?, making it one of its strategic priorities. Adocia is actively working towards initiating clinical trials to bring this technology to patients as quickly and safely as possible. Adocia is preparing interactions with the EMA (European Medicines Agency) to validate the proposed development plan. AdoShell®?Islets could then be tested in clinics by the end of 2024. Preclinical data generated so far trigger interest from the scientific community and pharmaceutical industry. In parallel, AdoShell®? scaff old, as a technology platform, is being considered for applications with stem cells and in other therapeutic areas (Parkinson disease, hemophilia, oncology, etc.). The physical barrier formed by AdoShell®? allows the implanted cells to be invisible to the host's immune system while allowing the necessary physiological exchanges to occur for the survival and function of the islets. AdoShell®? Is lets is easily implantable through a minimally invasive surgery (laparoscopy) and is fullyretrievable. This biomaterial has demonstrated to be biocompatible and non-fibrotic. Breakeven Date Change • Sep 19 The analyst covering Adocia previously expected the company to break even in 2023. New forecast suggests the company will make a profit of €13.2m in 2023. Earnings growth of 1.9% is required to achieve expected profit on schedule.
Announcement • Jul 07
Adocia SA announced that it expects to receive €10 million in funding from Bpifrance Investissement SAS, Vester Finance SA and other investors Adocia SA announced a private placement of €10 million on July 5, 2023. The company will raise €5 million in common shares from Gérard Soula, Gérard Soula, Chairman of company Board of Directors, new investor Bpifrance Investissement SAS and in addition it will issue of €5 million in convertible bonds, to which new investor Vester Finance SA and European investors are investing in a single tranche. The company obtained the commitment of all investors for these two fund-raising operations, and they are working on their implementation. The conditions of these operations will be defined at a later date, in accordance with the resolutions approved at the last Annual General Meeting and will be the subject of an ad hoc communication as soon as they are finalized.