Ionis Pharmaceuticals Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

DB:ISI Recent Insider Transactions by Companies or Individuals
Date	Value	Name	Entity	Shares	Max Price
03 May 24	Sell€237,902	Joseph Klein	Individual	6,000	€39.90
16 Feb 24	Sell€15,982	Brett Monia	Individual	387	€41.30
02 Feb 24	Sell€86,495	C. Bennett	Individual	1,885	€45.89
02 Feb 24	Sell€92,518	Richard Geary	Individual	1,995	€46.38
02 Feb 24	Sell€99,254	Elizabeth Hougen	Individual	2,162	€45.91
02 Feb 24	Sell€91,835	Patrick O'Neil	Individual	1,995	€46.03
02 Feb 24	Sell€99,379	Onaiza Cadoret-Manier	Individual	2,162	€45.97
02 Feb 24	Sell€1,093,829	Brett Monia	Individual	23,907	€45.75
02 Feb 24	Sell€96,781	Eugene Schneider	Individual	2,106	€45.96
02 Feb 24	Sell€608,235	Eric Swayze	Individual	12,713	€48.19
25 Jan 24	Sell€307,986	Patrick O'Neil	Individual	6,450	€47.75
25 Jan 24	Sell€109,108	Brett Monia	Individual	2,285	€47.75

Insider Trading Volume

Insider Buying: Insufficient data to determine if insiders have bought more shares than they have sold in the past 3 months.

Ownership Breakdown

What is the ownership structure of ISI?
Owner Type	Number of Shares	Ownership Percentage
State or Government	68,363	0.0429%
Individual Insiders	1,178,967	0.741%
Institutions	157,953,882	99.2%

Dilution of Shares: Shareholders have been diluted in the past year, with total shares outstanding growing by 10.1%.

Top Shareholders

Top 25 shareholders own 79.35% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
14.2%	FMR LLC	22,477,658	€734.1m	2.66%	0.04%
11.6%	T. Rowe Price Group, Inc.	18,378,288	€600.2m	10.9%	0.05%
9.54%	The Vanguard Group, Inc.	15,055,758	€491.7m	8.74%	0.01%
6.85%	BlackRock, Inc.	10,813,023	€353.2m	4.77%	0.01%
5.53%	Wellington Management Group LLP	8,735,787	€285.3m	33%	0.05%
4.97%	Bellevue Asset Management AG	7,850,000	€256.4m	-4.97%	3.16%
4.96%	Capital Research and Management Company	7,828,372	€255.7m	248%	0.01%
3.07%	State Street Global Advisors, Inc.	4,850,137	€158.4m	15.7%	0.01%
2.19%	Tweedy, Browne Company LLC	3,454,676	€112.8m	0%	1.67%
1.69%	Geode Capital Management, LLC	2,668,358	€87.1m	7.4%	0.01%
1.47%	OrbiMed Advisors LLC	2,324,447	€75.9m	-2.02%	1.08%
1.42%	Artisan Partners Limited Partnership	2,240,455	€73.2m	34.1%	0.06%
1.39%	Deep Track Capital, LP	2,200,000	€71.9m	10%	2.34%
1.22%	Marshall Wace LLP	1,920,464	€62.7m	1,010%	0.09%
1.18%	Macquarie Investment Management Business Trust	1,869,806	€61.1m	-0.21%	0.07%
1.08%	ClearBridge Investments, LLC	1,702,393	€55.6m	-21.2%	0.04%
0.92%	BVF Partners L.P.	1,451,879	€47.4m	-54.4%	1.47%
0.91%	Charles Schwab Investment Management, Inc.	1,443,020	€47.1m	8.65%	0.01%
0.88%	ARK Investment Management LLC	1,384,269	€45.2m	1.71%	0.36%
0.84%	Two Sigma Advisers, LP	1,332,411	€43.5m	3.52%	0.1%
0.83%	Pictet Asset Management Limited	1,303,501	€42.6m	-45.9%	0.04%
0.69%	TD Asset Management, Inc.	1,092,990	€35.7m	14.7%	0.03%
0.65%	Norges Bank Investment Management	1,019,341	€33.3m	0%	no data
0.6%	Candriam	948,266	€31.0m	0%	0.09%
0.6%	Morgan Stanley, Investment Banking and Brokerage Investments	945,049	€30.9m	44.2%	no data