Spyre Therapeutics Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

DB:3920 Recent Insider Transactions by Companies or Individuals
Date	Value	Name	Entity	Role	Shares	Max Price
03 Sep 24	Sell€472,895	Scott Burrows	Individual		18,531	€25.52

Insider Buying: 3920 insiders have only sold shares in the past 3 months.

Dilution of Shares: Shareholders have been substantially diluted in the past year, with total shares outstanding growing by 1158%.

Top 25 shareholders own 86.27% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
14.7%	FMR LLC	7,507,983	€192.1m	14%	0.01%
7.89%	Fairmount Funds Management LLC	4,018,101	€102.8m	962%	8.22%
6.4%	RTW Investments, LP	3,258,360	€83.4m	45.9%	1.39%
5.95%	Perceptive Advisors LLC	3,031,018	€77.6m	18.6%	1.89%
5.27%	VR Adviser, LLC	2,685,448	€68.7m	23.7%	3.1%
4.94%	Braidwell LP	2,514,538	€64.3m	388%	3.33%
4.72%	BlackRock, Inc.	2,403,441	€61.5m	332%	no data
3.9%	Commodore Capital LP	1,988,084	€50.9m	5.52%	3.51%
3.75%	The Vanguard Group, Inc.	1,911,566	€48.9m	284%	no data
3.61%	Avoro Capital Advisors LLC	1,839,138	€47.1m	0%	0.68%
3.45%	Deep Track Capital, LP	1,756,667	€44.9m	44.8%	1.34%
2.77%	State Street Global Advisors, Inc.	1,409,659	€36.1m	949%	no data
2.26%	Adage Capital Management, L.P.	1,152,411	€29.5m	4.27%	0.06%
1.73%	Goldman Sachs Group, Investment Banking and Securities Investments	880,804	€22.5m	267%	0.01%
1.56%	Wellington Management Group LLP	795,946	€20.4m	-2.08%	no data
1.5%	Geode Capital Management, LLC	765,834	€19.6m	132%	no data
1.47%	Cameron Turtle	746,907	€19.1m	0%	no data
1.46%	Franklin Resources, Inc.	741,904	€19.0m	0%	0.01%
1.39%	Citadel Advisors LLC	707,586	€18.1m	0%	0.02%
1.37%	Tavistock Life Sciences	696,480	€17.8m	179%	0.99%
1.35%	Driehaus Capital Management LLC	687,080	€17.6m	0%	0.12%
1.32%	Janus Henderson Group plc	673,867	€17.2m	4,720%	0.01%
1.31%	Farallon Capital Management, L.L.C.	666,000	€17.0m	42.9%	0.12%
1.13%	Logos Global Management, L.P.	575,000	€14.7m	130%	1.81%
1.01%	Affinity Asset Advisors, LLC	513,420	€13.1m	25.2%	2.39%