Announcement • Jun 11
Barinthus Biotherapeutics plc, Annual General Meeting, Jul 02, 2026 Barinthus Biotherapeutics plc, Annual General Meeting, Jul 02, 2026. Location: goodwin procter (uk) llp, sancroft, 10-15, newgate street, london, United Kingdom Board Change • May 20
Insufficient new directors No new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 6 experienced directors. 1 highly experienced director. Independent Non-Executive Director Joseph Caspar Scheeren was the last director to join the board, commencing their role in 2021. The company’s insufficient board refreshment is considered a risk according to the Simply Wall St Risk Model. Announcement • Jan 07
Nasdaq Grants Barinthus Biotherapeutics 180-Calendar Day Period to Regain Compliance with Nasdaq Listing Rules On December 30, 2025, Barinthus Biotherapeutics plc (the “Company”) received a letter from the Nasdaq Stock Market LLC (“Nasdaq”) indicating that the closing bid price of the Company’s American Depositary Shares (the “ADS”), each representing one ordinary share of the Company, was below $1.00 per share for 30 consecutive business days, and that, therefore, the Company is not in compliance with Nasdaq Listing Rule 5450(a)(1), which is the minimum bid price requirement for continued listing on the Nasdaq Global Market. The notice from Nasdaq has no immediate effect on the listing of the ADSs, and the ADSs will continue to be listed on the Nasdaq Global Market under the symbol “BRNS.” Pursuant to Nasdaq Listing Rule 5810(c)(3)(A), the Company has automatically been afforded a 180-calendar day period, or until June 29, 2026, to regain compliance with the minimum bid price requirement. The continued listing standard will be met if the closing bid price of the ADSs is at least $1.00 per share for a minimum of ten consecutive business days during the 180-calendar day period. If the Company is not in compliance by June 29, 2026, the Company may be afforded a second 180-calendar day period to regain compliance if it meets certain requirements. The Company intends to monitor the closing bid price of the ADSs and is currently evaluating its options for regaining compliance, which could include a reverse stock split of the ADSs. Announcement • Dec 11
Barinthus Bio Announces Update on Phase 1 AVALON Clinical Trial of VTP-1000 for the Treatment of Celiac Disease Barinthus Biotherapeutics plc announced an update on its first-in-human Phase 1 trial of VTP-1000 in adults with celiac disease. In the single ascending dose ("SAD") portion of the trial, VTP-1000 was wellolerated with no treatment-related serious adverse events ("SAEs") and a dose-dependent pharmacological effect observed. The multiple ascending dose ("MAD") portion of the trials, which includes a gluten challenge, is ongoing with data expected in the second half of 2026. Celiac disease is an area of high unmet need with no currently approved treatments; instead, people with celiac disease are advised to strictly avoid consuming gluten, which can be difficult due to the presence of gluten in many foods and cross-contamination of food production surfaces. Announcement • Oct 02
Barinthus Biotherapeutics plc and Clywedog Therapeutics, Inc Announces Executive and Board Changes Barinthus Biotherapeutics plc and Clywedog Therapeutics, Inc. announced that Dr. Iain Dukes, a venture partner at OrbiMed will serve as Executive Chairman of Clywedog Therapeutics after the transaction closes. He is MA, D.Phil (current Chief Executive Officer of Clywedog), and will consist of designees of each of Clywedog and Barinthus Bio. The combined company will be led by Bill Enright, Chief Executive Officer, Dr. Leon Hooftman, Chief Medical Officer, and Nick Fullenkamp, Vice President Corporate Development from Barinthus Bio, as well as Dr. Iain Dukes and Dr. Nikolay Savchuk, currently serving as Clywedog’s Chief Executive Officer and Chief Operating Officer, respectively. Announcement • Sep 30
Clywedog Therapeutics, Inc. entered into a definitive merger agreement to acquire Barinthus Biotherapeutics plc (NasdaqGM:BRNS). Clywedog Therapeutics, Inc. entered into a definitive merger agreement to acquire Barinthus Biotherapeutics plc (NasdaqGM:BRNS) on September 29, 2025. Upon the closing of the transaction, the combined company will be renamed “Clywedog Therapeutics, Inc.” and is expected to trade on the NASDAQ under the new ticker symbol “CLYD.” Upon completion of the transaction, the shareholders of Barinthus Bio are expected to own approximately 34%, and the stockholders of Clywedog are expected to own approximately 66% of the combined company on a fully diluted basis, based on the respective valuations of Barinthus Bio and Clywedog as of the execution of the merger agreement. Shareholders of Barinthus Bio will receive one share of common stock in the new combined company for each American Depositary Share (“ADS”) or ordinary share owned, and each stockholder of Clywedog will receive 4.358932 shares of common stock in the new combined company for each common or preferred share owned. Prior to the closing of the transaction, the combined company may commence a partial tender offer to acquire shares of the combined company then issued and outstanding and held by Barinthus Bio shareholders for an aggregate offer price of up to $27 million. The transaction is subject to approval by both companies’ stockholders as well as to customary closing conditions and regulatory approvals. The transaction was unanimously approved by the Boards of Directors of each of the companies. The expected completion of the transaction is January 1, 2026 to June 30, 2026.
Robert E. Puopolo, Blake Liggio and Jean A. Lee of Goodwin Procter LLP and Andrew Harrow of Goodwin Procter Llp acted as legal advisor, Oppenheimer & Co. Inc. acted as financial advisor for Barinthus Biotherapeutics plc. D. Boral Capital LLC acted as financial advisor and Snell & Wilmer, L.L.P. acted as legal advisor for Clywedog Therapeutics, Inc. Announcement • Apr 28
Barinthus Biotherapeutics plc, Annual General Meeting, Jun 10, 2025 Barinthus Biotherapeutics plc, Annual General Meeting, Jun 10, 2025. Location: goodwinprocter(uk)llp, sancroft,10-15newgatestreet, ec1a 7az, london United Kingdom Announcement • Jan 12
Barinthus Biotherapeutics plc Plans 65% Reduction in Workforce On January 10, 2025, Barinthus Biotherapeutics plc announced a restructuring plan that aims to prioritize its immune tolerance research and development programs. The Company is planning a 65% reduction in workforce, which is subject to consultation with employee representatives in the UK regarding the plan. The Company anticipates that the majority of the reduction in workforce will occur in the UK and be completed during the first half of 2025. Announcement • Nov 26
Barinthus Biotherapeutics plc Announces Executive Changes, Effective December 1, 2024 Barinthus Biotherapeutics plc announced the promotion of Geoffrey Lynn, M.D., Ph.D. to Chief Scientific Officer (CSO), effective as of December 1, 2024. Dr. Lynn succeeds Nadège Pelletier, Ph.D. who decided to pursue alternative opportunities closer to home after having served as Barinthus Bio’s CSO since early 2023. Barinthus Bio is a clinical-stage biopharmaceutical company developing novel immunotherapeutic candidates that guide T cells to control disease. Dr. Pelletier will remain with the Company until the transition of responsibilities to Dr. Lynn is complete. Dr. Lynn is a seasoned biotech innovator and executive with over 15 years of experience leading immunotherapeutic R&D from discovery through early development. Prior to joining the Company, Dr. Lynn led Avidea Technologies Inc. as CEO and Founder from its launch at Johns Hopkins FastForward in 2017 through to its acquisition by Barinthus Bio in 2021. Dr. Lynn holds a M.D. from the Johns Hopkins University School of Medicine (US), as well as a D.Phil. from the University of Oxford. Announcement • Oct 01
Barinthus Bio Completes Enrollment for Phase 2b HBV003 Clinical Trial in Chronic Hepatitis B and Phase 1 PCA001 Clinical Trial in Prostate Cancer Barinthus Biotherapeutics plc announced the completion of enrollment for two clinical trials: HBV003, a Phase 2b clinical trial of VTP-300 in adults with chronic hepatitis B (CHB); and PCA001, a Phase 1 clinical trial of VTP-850 in men with rising prostate-specific antigen (PSA) after definitive local therapy for prostate cancer (i.e., biochemical recurrence). The Phase 2b HBV003 trial (NCT05343481) has enrolled 121 participants and is designed to obtain critical dosing information for a potential functional cure regimen for CHB, with participants receiving VTP-300 and low-dose (LD) nivolumab. This trial design builds on positive monotherapy results from the clinical study HBV002, which included an evaluation of VTP-300 given alone and in combination with LD nivolumab. Earlier this year, interim data from the HBV003 trial was presented at the European Association for the Study of the Liver (EASL) Congress and demonstrated that treatment with VTP-300 and LD nivolumab is generally well-tolerated and led to a sustained decline in Hepatitis B surface antigen (HBsAg) levels. Participants reaching Day 169 were assessed for NUC therapy discontinuation eligibility in line with the study criteria, with 76% of participants meeting the criteria (n=16/21). 19% of the eligible participants (n=4/21) reached undetectable levels of HBsAg, with 2 of these patients maintaining undetectable levels for over 16 weeks. The PCA001 Phase 1 trial (NCT05617040) has enrolled 22 participants and is designed to determine the recommended Phase 2 dosing regimen of VTP-850 as well as evaluate safety and efficacy, as measured by PSA and T cell response. VTP-850 is a next-generation prostate cancer immunotherapeutic candidate which utilizes Barinthus Bio’s ChAdOx/MVA platform of two proprietary nonreplicating viral vectors in a sequential dosing approach. New Risk • Aug 13
New minor risk - Shareholder dilution The company's shareholders have been diluted in the past year. Increase in shares outstanding: 2.3% This is considered a minor risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 1.8% per year for the foreseeable future. Revenue is less than US$1m. Minor Risks Currently unprofitable and not forecast to become profitable over next 2 years (US$63m net loss in 2 years). Share price has been volatile over the past 3 months (11% average weekly change). Shareholders have been diluted in the past year (2.3% increase in shares outstanding). Market cap is less than US$100m (€48.4m market cap, or US$52.8m). Announcement • Jun 14
Barinthus Biotherapeutics plc Plans to Priority on the Development of VTP-300 in Chronic Hepatitis B Virus Infection, or CHB, and VTP-1000 in Celiac Disease On June 12, 2024, Barinthus Biotherapeutics plc announced plans to prioritize its pipeline to focus on the development of VTP-300 in chronic Hepatitis B virus infection, or CHB, and VTP-1000 in celiac disease. The development of VTP-300 in CHB and VTP-1000 in celiac disease will be prioritized and the ongoing Phase 1 clinical trial of VTP-850 in prostate cancer will be completed. The Company expects to undergo a restructuring to align resources with the streamlined pipeline, which will include a workforce reduction of approximately 25% and an estimated extension of the cash runway into the second quarter of 2026. Announcement • Jun 08
Barthus Biotherapeutics plc Announces Updated Data from Two Clinical Trials in People with Chronic Hepat B Barinthus Biotherapeutics plc announced the presentation of updated data from two clinical trials in people with chronic hepatitis B (CHB) at the European Association for the Study of the Liver (EASL) Congress 2024. The presentations include updated interim data from the Phase 2b clinical trial (HBV003), as well as new interim EOT data from the Phase 2a clinical trial (IM-PROVE II, AB-729-202) in partnership with Arbutus Biopharma, both in people with CHB receiving ongoing SoC NUC therapy. Interim data from the HBV003 trial indicate that treatment with VTP-300 and low-dose nivolumab is generally well-tolerated and sustained HBsAg declines were observed across all groups, with some participants reaching undetectable levels of HBsAg. As of the data cutoff on April 15, 2024, 91 out of a planned 120 virally suppressed patients with CHB on stable NUC therapy were enrolled in the trial, 40 of whom had screening HBsAg =200 IU/mL as per the study protocol amendment in 2023 and 21 of whom had been assessed for NUC discontinuation. Participants reaching Day 169 were assessed to confirm if they were eligible to discontinue NUC therapy in line with the study criteria. Data presented focuses on participants with baseline HBsAg =200 IU/mL: 76% of assessed participants (n=16/21) were eligible for NUC discontinuation at EOT, 7 of these discontinued. 71% (n=5/7) remained off NUC therapy, up to 44 weeks post-discontinuation in one case. 19% of participants (n=4/21) across the groups assessed for NUC discontinuation, had undetectable HBsAg at any time. This has been maintained for =16 weeks in 2 cases. 67% of participants (n=14/21) across all groups assessed for NUC discontinuation had HBsAg <10 IU/mL at Week 24 or later. Robust T cell responses as measured by IFN? ELISpot were observed to all encoded antigens. There were no Serious Adverse Events (SAEs), Grade 3 or 4 Adverse Events (AEs) related to treatment. There was one treatment discontinuation due to an AE. The most common treatment-related AE was thyroid dysfunction, reported in 9% of participants (n=8/91) with normal Thyroid Function Tests reported in 7 of 8 (88%) at last recorded visit. Transient alanine transaminase (ALT) elevations occurred in 14 participants through to Day 85. Data from IM-PROVE II as of the data cutoff on April 12, 2024, indicate that treatment with imdusiran, Arbutus’ RNAi therapeutic candidate, followed by Barinthus Bio's T-cell stimulating immunotherapeutic candidate, VTP-300, was generally well-tolerated and observed to maintain low HBsAg levels during the post-treatment follow-up period. The data were presented today by Dr. Kosh Agarwal, MD, Consultant Hepatologist and Transplant Physician at the Institute of Liver Studies at King’s College Hospital, London, during a session focused on new treatments for viral hepatitis B at the EASL Congress. Dr. Agarwal presented the following data from 38 of 40 participants that were on stable NUC therapy throughout the treatment period. They received imdusiran (60mg every 8 weeks) for 24 weeks and were then randomized to receive either VTP-300 or placebo at Weeks 26 and 30: Robust reductions of HBsAg were observed during the imdusiran lead-in period with 95% of patients achieving HBsAg <100 IU/mL before undergoing dosing in the VTP-300 treatment or placebo groups. At 24-weeks post-EOT, there was a significant difference (p<0.05) in HBsAg levels between the VTP-300 treatment group (n=5) and placebo (n=6). 94% of participants (n=18/19) in the VTP-300 treatment group achieved HBsAg levels of <100 IU/mL and 36% had <10 IU/mL (n=7/19) at EOT (Week 48) compared to the placebo group, 84% (n=16/19) and 21% (n=4/19), respectively. ?Similarly, at 24-weeks post-EOT (Week 72), the VTP-300 treatment group had lower HBsAg levels with 80% of participants at <100 IU/mL (n= 4/5) and 60% at <10 IU/mL (n=3/5) than the placebo group, 16% (n=1/6) and 0% (n=0/6), respectively. 84% of participants (n=16/19) in the VTP-300 treatment group met criteria at EOT (Week 48) to discontinue NUC therapy vs 52% in the placebo group (n=10/19). In the VTP-300 treatment group, 20% of participants (n=1/5) achieved undetectable HBsAg at 24-weeks post-EOT and a further 20% of participants (n=1/5) had a >1.5log10 decline between the last two visits during the NUC therapy discontinuation follow-up period. Treatment with imdusiran and VTP-300 was generally well-tolerated. There were no reported SAEs, Grade 3 or 4 AEs or discontinuations due to treatment. The most common treatment-related AEs in two or more patients were injection site-related (both imdusiran and VTP-300) and transient ALT increases (imdusiran). Reported Earnings • May 13
First quarter 2024 earnings released: US$0.40 loss per share (vs US$0.48 loss in 1Q 2023) First quarter 2024 results: US$0.40 loss per share (improved from US$0.48 loss in 1Q 2023). Net loss: US$15.5m (loss narrowed 15% from 1Q 2023). Revenue is forecast to grow 65% p.a. on average during the next 3 years, compared to a 18% growth forecast for the Biotechs industry in Europe. Over the last 3 years on average, earnings per share has increased by 32% per year but the company’s share price has fallen by 47% per year, which means it is significantly lagging earnings. Announcement • May 01
Barinthus Biotherapeutics plc Appoints Leon Hooftman as Chief Medical Officer, Effective from Beginning of June 2024 Barinthus Biotherapeutics plc announced the appointment of Leon Hooftman, M.D., as Chief Medical Officer (CMO). Dr. Hooftman brings significant drug development expertise across a broad array of therapeutic areas including oncology, infectious diseases, and inflammation. His R&D portfolio includes successful clinical trial programs that resulted in the development of novel agents: mycophenolate mofetil (transplantation), rituximab (Non-Hodgkin’s Lymphoma), gemtuzumab ozogamycin (Leukemia), and lipid complex amphotericin B (serious fungal infections). He has held senior management positions at Roche and UCB Celltech and has subsequently been a CMO of several biotechnology companies. He joins Barinthus Bio from ISA Pharmaceuticals, a specialist immune-oncology company. Dr. Hooftman holds a MD from Utrecht State University (Netherlands) and performed his specialist training in Cambridge and London (UK). Dr. Hooftman will step into his new role at the beginning of June 2024. Announcement • Apr 19
BarinthuBarinthus Biotherapeutics plc Announces Topline Data from Phase 1b/2 APOLLO Trial of VTP-200 in Persistent High-Risk Human Papillomavirus (HPV) Infections Barinthus Biotherapeutics plc announced topline final data from the APOLLO trial (also known as HPV001), a completed randomized, placebo-controlled Phase 1b/2 dose-ranging trial of VTP-200 in women with low-grade cervical lesions associated with persistent hrHPV infection. APOLLO (NCT04607850) was a randomized, placebo-controlled Phase 1b/2 multi-center trial of 108 participants across the UK and EU evaluating the safety, tolerability and immunogenicity of VTP-200 in women aged 25-55 with persistent hrHPV infection and low-grade cervical lesions. The primary objective was to evaluate the safety and tolerability of VTP-200. The trial was also designed to assess the effect of VTP-200 on clearance of hrHPV infection and cervical lesion(s), as well as select appropriate doses for further development. The APOLLO study met its primary safety endpoint, demonstrating that VTP-200 was generally well-tolerated and was administered with no treatment-related grade 3 or higher unsolicited AEs and no treatment-related SAEs. The hrHPV clearance rate of 60% at Month 12 was observed in group 2, which included the dose of ChAdOx, compared to a 33% clearance rate in the placebo group. Groups 1, 3, 4 and 5 showed 12%, 11%, 33% and 36% hrHPV clearance rates, respectively. The study also evaluated cervical lesion clearance rates in participants with both reported lesions at screening and visualization of the cervical transformation zone at 12 months (n=57). The cervical lesion clearance rate of 67% was observed in group 2 and group 5, both received the dose of ChAdOx, compared to 39% in the placebo group. Groups 1, 3 and 4 showed 40%, 20% and 33% cervical lesion clearance rates, respectively. Pooled data from the five active dose groups showed no significant improvement in hrHPV clearance or cervical lesion clearance rates in comparison to the placebo group. Future development options for the VTP-200 program are currently being evaluated with further analyses ongoing. New Risk • Apr 06
New major risk - Share price stability The company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of German stocks, typically moving 12% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). Earnings are forecast to decline by an average of 13% per year for the foreseeable future. Revenue is less than US$1m (US$802k revenue). Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$126m net loss in 3 years). Announcement • Mar 23
Barinthus Biotherapeutics plc, Annual General Meeting, May 10, 2024 Barinthus Biotherapeutics plc, Annual General Meeting, May 10, 2024, at 08:00 US Eastern Standard Time. Location: Goodwin Procter (UK) LLP, Sancroft 10-15 Newgate Street - London United Kingdom Agenda: To re-elect as a director William Enright, who retires by rotation in accordance with the Company's Articles of Association; to re-elect as a director Alex Hammacher, who retires by rotation in accordance with the Company's Articles of Association; to re-elect as a director Robin Wright, who retires by rotation in accordance with the Company's Articles of Association; to re-appoint pricewaterhouseCoopers LLP, as U.K. statutory auditors of the Company, to hold office until the conclusion of the next annual general meeting of shareholders; to ratify the appointment of PricewaterhouseCoopers LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2024. Reported Earnings • Mar 21
Full year 2023 earnings released: US$1.91 loss per share (vs US$0.14 profit in FY 2022) Full year 2023 results: US$1.91 loss per share (down from US$0.14 profit in FY 2022). Net loss: US$73.3m (down US$78.7m from profit in FY 2022). Revenue is expected to decline by 17% p.a. on average during the next 3 years, while revenues in the Biotechs industry in Germany are expected to grow by 18%. Board Change • Mar 01
Insufficient new directors No new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 12 experienced directors. No highly experienced directors. Independent Non-Executive Director Karen Dawes was the last director to join the board, commencing their role in 2021. The following issues are considered to be risks according to the Simply Wall St Risk Model: Insufficient board refreshment. New Risk • Feb 07
New minor risk - Market cap size The company's market capitalization is less than US$100m. Market cap: €92.2m (US$99.1m) This is considered a minor risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (15% average weekly change). Earnings are forecast to decline by an average of 11% per year for the foreseeable future. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$103m net loss in 3 years). Shareholders have been diluted in the past year (3.4% increase in shares outstanding). Market cap is less than US$100m (€92.2m market cap, or US$99.1m). Announcement • Nov 11
Arbutus Biopharma Corporation and Barinthus Biotherapeutics plc Present Preliminary Data from Phase 2A Clinical Trial Combining Imdusiran with VTP-300 at AASLD Arbutus Biopharma Corporation and Barinthus Biotherapeutics plc announced preliminary data from the Phase 2a clinical trial (AB-729-202) combining Arbutus' RNAi therapeutic, imdusiran (AB-729), with Barinthus Bio's T-cell stimulating immunotherapeutic, VTP-300, and standard-of-care nucleos(t)ide analogue (NA) therapy. Clinical trial AB-729-202 enrolled 40 non-cirrhotic, virally suppressed cHBV patients that were on stable NA therapy. The patients initially received imdusiran (60mg every 8 weeks) for 24 weeks and were then randomized to receive either VTP-300 or placebo at week 26 and 30 (and conditionally at week 38 if they experienced a >0.5 log10 decline in HBsAg between weeks 26 and 34), in addition to ongoing NA therapy. The preliminary data include a subset of patients that received the two dose VTP- 300 regimen (28/40 patients) and available follow-up data to week 48 (12/40 patients) and showed the following: · Robust reductions of HBsAg were seen during the imdusiran treatment period (-1.86 log10 mean reduction from baseline after 24 weeks of treatment). This decline in HBsAg is comparable to the declines seen with imdusiran in other clinical trials conducted to date. · 97% of the imdusiran treated patients (33/34) had HBsAg <100 IU/mL at the time of the first VTP-300/placebo dose. VTP-300 treatment appears to contribute to the maintenance of low HBsAg levels in the early post-treatment period, as the mean HBsAg levels in the placebo group begin to increase starting ~12 weeks after the last dose of imdusiran. All VTP-300 treated patients have maintained HBsAg <100 IU/mL through week 48, 60% have maintained HBsAg <10 IU/mL, and all have qualified to stop NA therapy. Preliminary immunology data suggests HBV-specific T cell IFN- production is enhanced in patients receiving imdusiran plus VTP-300 compared to placebo. The preliminary safety data from this trial demonstrate that imdusiran and VTP-300 were both safe and well-tolerated. There were no serious adverse events, Grade 3 or 4 adverse events or treatment discontinuations. Reported Earnings • Nov 11
Third quarter 2023 earnings released: US$0.36 loss per share (vs US$0.22 profit in 3Q 2022) Third quarter 2023 results: US$0.36 loss per share (down from US$0.22 profit in 3Q 2022). Net loss: US$14.1m (down 271% from profit in 3Q 2022). Revenue is expected to decline by 75% p.a. on average during the next 3 years, while revenues in the Biotechs industry in Germany are expected to grow by 15%. Announcement • Nov 08
Vaccitech plc(NasdaqGM:VACC) dropped from NASDAQ Composite Index Vaccitech plc has been removed from NASDAQ Composite Index . Reported Earnings • Aug 11
Second quarter 2023 earnings released: US$0.62 loss per share (vs US$0.42 profit in 2Q 2022) Second quarter 2023 results: US$0.62 loss per share (down from US$0.42 profit in 2Q 2022). Revenue: US$334.0k (down 98% from 2Q 2022). Net loss: US$23.8m (down 252% from profit in 2Q 2022). Revenue is expected to decline by 116% p.a. on average during the next 3 years, while revenues in the Biotechs industry in Germany are expected to grow by 15%. Announcement • Jul 28
Vaccitech plc Announces Retirement of Margaret Marshall as Chief Medical Officer On July 20, 2023, Dr. Margaret Marshall notified Vaccitech plc of her intention to retire from her position as chief medical officer of the company, effective immediately. Announcement • Jun 22
Vaccitech plc Announces Positive Final Data EASL Congress for Phase 1B/2 HBV002 Study in Adults with Chronic Hepatitis B Vaccitech plc announced present positive final data from the HBV002 clinical trial at the European Association for the Study of the Liver (EASL) Congress 2023 – The International Liver CongressTM taking place June 21-24 in Vienna, Austria. HBV002 (NCT04778904) is a Phase 1b/2a clinical trial of VTP-300 in adults with chronic Hepatitis B (CHB). The data will be presented as a poster at EASL on, June 24 (Poster ID: SAT-198), by Eleanor Barnes, Professor of Hepatology and Experimental Medicine at Oxford University. Meaningful, durable reductions of Hepatitis B Surface Antigen (HBsAg) were seen in all participants with a >0.5 log10 reduction in HBsAg who received VTP-300 alone (Group 2) or in combination with a single administration of low-dose PD-1 inhibitor, nivolumab (Group 3). Two of five patients with baseline HBsAg below 100 IU/mL in Group 3, developed a non-detectable HBsAg level, which continued eight months after last dose. Reductions in HBsAg were most prominent in those with lower baseline HBsAg. Importantly, all participants who received VTP-300 and experienced a >0.5 log10 reduction in HBsAg had durable responses with reductions in HBsAg persisting through to the last measurement eight months post-final dose. VTP-300, encoding Hepatitis B virus (HBV) genotype C antigens, led to a decline in HBsAg in the majority of people infected with genotypes B and C viruses. In addition, VTP-300-induced T cells showed cross-reactivity to the core antigen from genotypes A to E in ELISpot assays using PBMC from VTP-300-treated healthy subjects and genotype-specific peptides A-E. A robust T cell response was generated against all VTP-300 antigens and was highest in the VTP-300 alone group. In that group, there was a relation between ELISpot responses and HBsAg decline. Announcement • Jun 13
Vaccitech plc Doses First Patient in Pca001, A Prostate Cancer Phase 1/2 Clinical Trial of Vtp-850 Vaccitech plc announced the dosing of the first patient in the PCA001 clinical trial (NCT05617040). PCA001 is a multi-centre, Phase 1/2 clinical trial designed to determine the recommended Phase 2 regimen and evaluate the safety, efficacy, as measured by prostate-specific antigen (PSA) response, and T cell response of VTP-850 monotherapy in men with rising PSA after definitive local therapy for their disease (i.e., biochemical recurrence). VTP-850 is a next-generation prostate cancer immunotherapeutic candidate which utilizes Vaccitech's sequential dosing approach of two proprietary nonreplicating viral vectors, ChAdOx and MVA. PCA001 builds on the previous promising data from the University of Oxford VANCE01 (NCT02390063) and ADVANCE (NCT03815942) trials, Phase 1 and Phase 1/2 clinical trials respectively, of VTP-800, the first-generation product candidate which encoded 5T4, an antigen expressed by most prostate cancers.1,2 VTP-850 is a multi-antigen immunotherapeutic candidate containing four prostate-associated antigens: PSA, PAP, STEAP1 and 5T4. The first phase of the trial is enrolling participants in the US, with plans to open further sites in Italy and Spain. Reported Earnings • May 13
First quarter 2023 earnings released: US$0.48 loss per share (vs US$0.07 profit in 1Q 2022) First quarter 2023 results: US$0.48 loss per share (down from US$0.07 profit in 1Q 2022). Revenue: US$468.0k (down 97% from 1Q 2022). Net loss: US$18.2m (down US$20.8m from profit in 1Q 2022). Revenue is expected to decline by 77% p.a. on average during the next 3 years, while revenues in the Biotechs industry in Germany are expected to grow by 19%. Reported Earnings • Mar 25
Full year 2022 earnings released: EPS: US$0.14 (vs US$1.96 loss in FY 2021) Full year 2022 results: EPS: US$0.14 (up from US$1.96 loss in FY 2021). Revenue: US$44.7m (up US$44.4m from FY 2021). Net income: US$5.34m (up US$56.2m from FY 2021). Profit margin: 12% (up from net loss in FY 2021). The move to profitability was primarily driven by higher revenue. Revenue is expected to decline by 148% p.a. on average during the next 2 years, while revenues in the Biotechs industry in Europe are expected to grow by 20%. Valuation Update With 7 Day Price Move • Mar 21
Investor sentiment improves as stock rises 18% After last week's 18% share price gain to €2.72, the stock trades at a trailing P/E ratio of 9.4x. Average forward P/E is 26x in the Biotechs industry in Europe. Total loss to shareholders of 44% over the past year. Valuation Update With 7 Day Price Move • Feb 28
Investor sentiment deteriorates as stock falls 18% After last week's 18% share price decline to €2.24, the stock trades at a trailing P/E ratio of 8.6x. Average forward P/E is 28x in the Biotechs industry in Europe. Total loss to shareholders of 61% over the past year. Announcement • Jan 31
Vaccitech Appoints Nadège Pelletier as Chief Scientific Officer Vaccitech plc announced the appointment of Nadège Pelletier, Ph.D., as Chief Scientific Officer (CSO). Dr. Pelletier is stepping into the role formerly held by Tom Evans, Ph.D., who is retiring but will remain involved as a scientific consultant to the company. Dr. Pelletier will lead Vaccitech’s scientific teams in all phases of drug discovery and platform development, as well as build and oversee the strategic technical direction of the company. Dr. Pelletier brings extensive experience to Vaccitech in the areas of immunology, inflammation and infectious diseases. She joins Vaccitech from the Novartis Institutes for Biomedical Research and prior to that Roche Pharma Research & Early Development, where she served as Project Leader in the fields of autoimmunity, inflammation and infectious diseases. At Novartis, Dr. Pelletier was a discovery leader in a fast-track, multi-indication early clinical program on tolerance induction, and was responsible for maintaining accountability in building solid preclinical packages, biomarker strategies, and translational plans for disease focus and indication expansion. Prior to her role at Novartis, Dr. Pelletier was responsible for several preclinical and clinical projects in all phases of development to restore immune balance in autoimmunity and chronic infectious diseases, and was a key contributor to advancing immune modulation strategies for chronic Hepatitis B and respiratory infections. In addition to her experience with Novartis and Roche, Dr. Pelletier also served as a Senior Scientist at Merck-Serono in Geneva, Switzerland, and as a postdoctoral fellow at the Scripps Research Institute in La Jolla, California. Dr. Pelletier holds a Ph.D. in immunology from Claude Bernard University, ENS-Lyon, in Lyon, France and a Master of Science in Genetics and Immunology from ENS-Lyon. Valuation Update With 7 Day Price Move • Dec 27
Investor sentiment improved over the past week After last week's 15% share price gain to €2.22, the stock trades at a trailing P/E ratio of 7.8x. Average forward P/E is 27x in the Biotechs industry in Europe. Total loss to shareholders of 75% over the past year. Reported Earnings • Nov 16
Third quarter 2022 earnings released: EPS: US$0.22 (vs US$0.13 loss in 3Q 2021) Third quarter 2022 results: EPS: US$0.22 (up from US$0.13 loss in 3Q 2021). Revenue: US$6.17m (up US$6.15m from 3Q 2021). Net income: US$8.24m (up US$12.8m from 3Q 2021). Revenue is expected to decline by 67% p.a. on average during the next 3 years, while revenues in the Biotechs industry in Germany are expected to grow by 24%. Announcement • Nov 08
Vaccitech plc Provides Update on Ongoing VTP-300 Phase 1b/2a Trial Showing Sustained Reductions of HBsAg in Patients with Chronic Hepatitis B Vaccitech plc announced an update to the interim analysis of safety and efficacy data from its HBV002 trial (NCT04778904). The data will be presented as a poster at the 2022 American Association for the Study of Liver Disease (AASLD) - The Liver Meeting® by Dr. Young-Suk Lim, Professor of the Department of Gastroenterology and the Liver Center, Asian Medical Center, University of Ulsan College of Medicine, Korea. Vaccitech’s updated interim analysis includes data from the fully-enrolled trial of 55 patients with chronic hepatitis B (HBV) with at least three months of follow-up. It shows that VTP-300 induced meaningful, sustained reductions of HBV surface antigen (HBsAg) in people with chronic HBV. Declines were most prominent in patients with lower baseline HBsAg. HBsAg is a hallmark of chronic HBV infection. Fewer than 10% of patients on current standard-of-care HBV therapies achieve sustained HBsAg decrease or loss, a state associated with functional cure of the disease. VTP-300 administered as a monotherapy or in combination with a single administration of low-dose nivolumab at the time of the booster dose was administered with no treatment-related serious adverse events and infrequent transient transaminitis as of 28 September 2022. In the VTP-300 monotherapy Group 2 (N=18), five patients had baseline HBsAg under 100 IU/mL. Of those five patients, three showed meaningful and durable reductions of HBsAg of 0.9, 1.0 and 1.4 log10, respectively, five months after the last dose of VTP-300. Furthermore, these reductions persisted in all three patients at eight months after the last dose. Group 3 (N=18) patients received VTP-300 in combination with a single low dose of nivolumab at the time of the booster dose, and the mean log10 reduction in HBsAg was 0.8 (n=18) at 3 months, 0.9 (n=10) at 6 months, and 1.3 (n=7) at 9 months, with more prominent declines observed in patients with baseline HBsAg lower than 1,000 IU/mL. Five patients in this group had baseline HBsAg lower than 100 IU/mL, of which four had declines over 0.6 log10. Moreover, two of those patients developed non-detectable HBsAg at 3 months, and one of the patients, who has been evaluated at 6 and 9 months, continued to maintain non-detectable HBsAg. Patients in Groups 2 and 3 also demonstrated a robust CD8+ T cell response, against all encoded antigens; core protein, polymerase and surface antigens. No meaningful reductions in HBsAg were observed in Group 1 in which patients received two doses of Modified Vaccinia Ankara (MVA)-HBV without ChAdOx1-HBV, or in Group 4 in which patients received low-dose nivolumab with both doses of VTP-300. These groups were discontinued after interim analysis, as previously announced in June 2022. Enrollment in the HBV002 trial is complete, with a final update expected early in the second quarter of 2023. A trial to evaluate timing of low dose nivolumab and additional doses of the MVA boost component of VTP-300 (HBV003; NCT05343481) has been initiated in multiple countries within the Asia-Pacific region. Announcement • Nov 01
Vaccitech plc Doses First Patients in HBV003, a Phase 2b Clinical Trial of VTP-300 Immunotherapeutic Candidate for Chronic HBV Patients Vaccitech plc announced the dosing of the first patients in HBV003. HBV003 is a Phase 2b clinical trial designed to further evaluate the safety and efficacy of VTP-300 when combined with a low-dose anti-PD-1 antibody in patients with chronic hepatitis B infection. The study plans to assess and enable the selection of one of three different multi-dose regimens and to enroll 120 patients in countries across the Asia-Pacific region. VTP-300 includes Vaccitech’s prime-boost platform, which utilizes 2 nonreplicating viral vectors, ChAdOx1 and MVA. Each viral vector encodes HBV antigens to elicit an immune response against HBV. At interim analyses of the phase 1b/2a HBV002 study, VTP-300 demonstrated not only robust activation of cytotoxic CD8+ T cells (immune cells associated with clearance of HBV infected cells), which are believed to have the potential to lead to a functional cure and significant, but also sustained reductions in Hepatitis B surface Antigen (HBsAg), which is a surrogate marker of ongoing virus replication. Announcement • Oct 28
Vaccitech plc Announces Publication of Research in Preclinical Animal Models Demonstrating the Potential of Vaccitech’s SNAPvax Vaccitech plc announced the publication of research in preclinical animal models demonstrating the potential of Vaccitech’s SNAPvax for use in a novel paradigm for cancer treatment referred to as VAX-INNATE. The results show that intravenous (IV) administration of SNAPvax not only primes and expands tumor-specific cytotoxic T cells that mediate tumor killing but also reverses suppression in the tumor microenvironment associated with significantly improved tumor regression. The research evaluated SNAPvax co-delivering tumor antigens and a powerful Toll-like receptor (TLR)-7/8 adjuvant by two different routes (IV or subcutaneous) in tumor-bearing mice. While SNAPvax primed and expanded a high magnitude of antigen-specific T cells by both routes of administration, SNAPvax administered by the IV route induced systemic Type I interferon that markedly reduced the number of immunosuppressive monocytes and macrophages in the TME leading to improved T cell mediated tumor regression. An Investigational New Drug (IND) application submission for SNAPvax candidate (VTP-1100) targeting human papilloma virus (HPV) associated cancer is expected during the first half of 2023. Announcement • Sep 21
Vaccitech plc Promotes Gemma Brown as Chief Financial Officer Vaccitech plc announced the promotion of Gemma Brown as Chief Financial Officer (CFO). Gemma Brown succeeds Georgy Egorov. Gemma Brown is an experienced financial executive who joined Vaccitech as its Head of Financial Reporting in 2021, before her promotion to CFO. In that role, she was responsible for the majority of the work related to quarterly/annual financial activities, compiling SEC filings, was a key contributor in other corporate finance activities and worked with her now predecessor to develop the annual corporate budget. Prior to joining Vaccitech, Gemma was at EY where she held positions of increasing responsibility, reaching the level of Senior Manager and participating in their accelerated leadership programs. While at EY, she worked with clients across the U.S. and UK capital markets and was responsible for servicing several emerging biopharmaceutical companies who achieved listings on Nasdaq, either through an initial public offering or M&A transaction, and subsequent follow-on capital raises. She holds a B.Sc. in Biological Sciences and is a Chartered Accountant with the Institute of Chartered Accountants in England & Wales. Reported Earnings • Aug 11
Second quarter 2022 earnings released: EPS: US$0.42 (vs US$0.64 loss in 2Q 2021) Second quarter 2022 results: EPS: US$0.42 (up from US$0.64 loss in 2Q 2021). Revenue: US$17.1m (up US$17.0m from 2Q 2021). Net income: US$15.7m (up US$31.6m from 2Q 2021). Profit margin: 92% (up from net loss in 2Q 2021). Over the next year, revenue is expected to shrink by 63% compared to a 15% growth forecast for the industry in Germany. Announcement • Jun 23
Vaccitech plc Announces an Update to the Interim Analysis of Safety and Efficacy Data from the HBV002 Study Vaccitech plc announced an update to the interim analysis of safety and efficacy data from the HBV002 study (NCT04778904), which is being presented as a poster at the 2022 EASL International Liver CongressTM by Professor Ellie Barnes, Professor of Hepatology and Experimental Medicine at the University of Oxford. The updated analysis, with a data cut-off of May 9th, which now includes 39 patients with at least three months of follow-up, shows that VTP-300 as a monotherapy or in combination with a single low-dose nivolumab at the time of the booster dose was safely administered with no treatment-related serious adverse events and two patients with mild, rapidly resolving transaminitis. In the VTP-300 monotherapy group, meaningful and durable reductions of HBsAg were seen in all three patients with baseline HBsAg under 50 IU/mL. These three patients had 0.7, 0.7 and 1.4 log10 declines two months after the last dose of VTP-300. These dramatic declines have persisted in all three patients at their latest follow-up at five or eight months after the last dose of VTP-300. For the first eight patients who received VTP-300 in combination with a single low-dose of nivolumab at the time of the booster dose, the mean reduction in HBsAg was over 1 log10 at six months, an effect that persisted, with a mean decline of 1.15 log10 at eight months after the last dose of VTP-300. The effect was most prominent in patients with baseline HBsAg lower than 1,000 IU/mL. One patient in this group developed a non-detectable HBsAg level, which continued eight months after the last dose of VTP-300. No reductions =1 log10 were seen in patients who received two doses of MVA-HBV, or in patients who received low-dose nivolumab with both doses of VTP-300. These two groups were discontinued after interim analysis. A robust T cell response against all encoded antigens (core protein, polymerase and surface antigen), measured by overnight stimulation, was observed following VTP-300 administration, notable for marked CD8+ T cell predominance. Enrollment in the HBV002 study is complete with 55 patients enrolled. An updated interim analysis for all patients at the six month follow-up timepoint is expected at the end of 2022. A trial to look at timing of low dose nivolumab and additional doses of the MVA boost component of VTP-300 (NCT05343481) is planned in multiple countries, with the first patient expected to be dosed in the third quarter of 2022. HBsAg is a hallmark of chronic hepatitis B virus (HBV) infection. Fewer than 10% of patients on current standard of care HBV therapies ever achieve distinct, sustained HBsAg decrease or loss, a state associated with functional cure of the disease. The crux of chronic HBV is the immune system’s inability to clear the virus due to insufficient immune priming and/or aberrant immune tolerance due to large quantities of HBV protein expression. Many involved in the field believe it makes sense to combine an immune-stimulating agent with an HBV protein-suppressing agent, to potentially elicit a functional cure to HBV. Announcement • Jun 07
Arbutus Biopharma Corporation and Vaccitech plc Dose First Patient in Phase 2a Clinical Trial Combining Therapies for the Treatment of Chronic Hepatitis B Virus Arbutus Biopharma Corporation and Vaccitech plc announced the first patient dosed in a Phase 2a clinical trial. This trial will evaluate Arbutus’ RNAi therapeutic candidate, AB-729, in combination with Vaccitech’s T-cell stimulating immunotherapeutic, VTP-300, and standard-of-care nucleos(t)ide reverse transcriptase inhibitor (NA) therapy for the treatment of patients with virologically-suppressed chronic HBV infection (cHBV). The randomized, multi-center, blinded, Phase 2a clinical trial will evaluate the safety, antiviral activity and immunogenicity of VTP-300 administered after AB-729 in virologically-suppressed cHBV patients. The trial is designed to enroll 40 cHBV patients. All patients will receive AB-729 (60mg every 8 weeks) plus NA therapy for 24 weeks. At week 24, treatment with AB-729 will stop. Patients will continue only their NA therapy and will be randomized to receive either VTP-300 or placebo for an additional 24 weeks. At week 48 all participants will be evaluated for eligibility to either discontinue or remain on NA therapy. Reported Earnings • May 13
First quarter 2022 earnings released: EPS: US$0.07 (vs US$1.90 loss in 1Q 2021) First quarter 2022 results: EPS: US$0.07 (up from US$1.90 loss in 1Q 2021). Revenue: US$15.0m (up US$14.8m from 1Q 2021). Net income: US$2.60m (up US$17.9m from 1Q 2021). Profit margin: 17% (up from net loss in 1Q 2021). The move to profitability was primarily driven by higher revenue. Over the next year, revenue is forecast to grow 98%, compared to a 37% growth forecast for the industry in Germany. Announcement • May 03
Vaccitech plc, Annual General Meeting, Jun 15, 2022 Vaccitech plc, Annual General Meeting, Jun 15, 2022, at 08:00 US Eastern Standard Time. Location: Goodwin Procter (UK) LLP, 100 Cheapside, London, EC2V 6DY London United Kingdom Agenda: To re-elect as a director Pierre A. Morgon, who retires by rotation in accordance with the Company’s Articles of Association; to re-elect as a director Joseph C. F. Scheeren, who retires by rotation in accordance with the Company’s Articles of Association; to re-appoint BDO LLP, a United Kingdom entity, as U.K. statutory auditors of the Company, to hold office until the conclusion of the next annual general meeting of shareholders; to authorize the Audit Committee to determine the Company’s auditors’ remuneration for the fiscal year ending December 31, 2022; To receive the U.K. statutory annual accounts and reports for the fiscal year ended December 31, 2021 and to note that the Company’s directors do not recommend the payment of any dividend for the fiscal year ended December 31, 2021; and to consider other matters if any. Board Change • Apr 28
Less than half of directors are independent Following the recent departure of a director, there are only 3 independent directors on the board. The company's board is composed of: 3 independent directors. 4 non-independent directors. Independent Director Karen Dawes was the last independent director to join the board, commencing their role in 2021. The company's minority of independent directors is a risk according to the Simply Wall St Risk Model. Reported Earnings • Mar 28
Full year 2021 earnings released: US$1.96 loss per share (vs US$692 loss in FY 2020) Full year 2021 results: US$1.96 loss per share. Net loss: US$50.9m (loss widened 187% from FY 2020). Over the next year, revenue is forecast to grow 9,490%, compared to a 86% growth forecast for the pharmaceuticals industry in Germany. Board Change • Jan 20
Less than half of directors are independent There is 1 new director who has joined the board in the last 3 years. The new board member was an independent director. The company's board is composed of: 1 new director. 11 experienced directors. No highly experienced directors. 3 independent directors (4 non-independent directors). Independent Director Anne Phillips was the last independent director to join the board, commencing their role in 2021. The following issues are considered to be risks according to the Simply Wall St Risk Model: Minority of independent directors. Insufficient board refreshment. Announcement • Jan 18
Vaccitech plc Announces First Patient Dose in Phase I/Iia Trial of Lung Cancer Immunotherapy Vaccine Vaccitech plc and the Ludwig Institute for Cancer Research announced the first patient dosed in the MAGE trial, which is testing a novel immunotherapeutic, VTP-600, in patients with the most common type of lung cancer. The phase I/IIa trial is expected to enroll approximately 86 people who have been newly diagnosed with non-small cell lung cancer (NSCLC) and will be testing the safety and initial efficacy of VTP-600 in these patients. VTP-600 will be given in combination with the current first line treatment for NSCLC. If further clinical trials are successful, VTP-600 could prove to be a powerful new treatment for a group of patients in need of better options. Depending on its effectiveness in NSCLC, VTP-600 could be evaluated in other types of cancer in the future, including breast, bowel, bladder and melanoma. Cancer Research UK’s Centre for Drug Development (CDD) is managing and providing significant funding for the phase I/IIa trial. Vaccitech Oncology Limited (VOLT), a strategic collaboration between Vaccitech and Ludwig, are supplying VTP-600 for the trial. The Chief Investigator for the trial is Professor Fiona Blackhall, Professor of Thoracic Oncology and Honorary Consultant in Medical Oncology, at The Christie NHS Foundation Trust. VOLT holds an option to license the results of the trial to aid future clinical development and commercialisation of the immunotherapy. If VOLT elects not to exercise its option, Cancer Research UK will have the right to take the programme forward in all cancer indications. Unlike preventative vaccines, such as the influenza vaccine, which is given to healthy people to protect them against future disease, VTP-600 is given to people who already have lung cancer. VTP-600 is an immunotherapy, designed to stimulate the body’s immune system to attack cancer cells. It does this by delivering cancer-associated proteins — known as MAGE-A3 and NY-ESO-1 antigens — to antigen presenting cells (dendritic cells), causing the immune system to produce cytotoxic T cells which are able to target and kill cancer cells expressing these antigens. It cannot target healthy tissues because MAGE-A3 and NY-ESO-1 are not found on non-cancerous cells. VTP-600 is a ‘prime-boost’ immunotherapy, meaning an initial ‘prime’ dose is administered, and then a second ‘booster’ dose is given 21 days later. This ‘prime-boost’ approach is expected to improve the size and length of the anti-cancer immune response. Even though two doses are administered, the immunotherapy comprises three parts. ChAdOx1-MAGE-A3-NY-ESO-1 is the prime immunotherapy administered to all patients, MVA MAGE-A3 with or without MVA NY-ESO-1 is given as the second booster immunotherapy, depending on the type of antigens expressed on the patient's tumour. In the prime dose, ‘ChAdOx1’ refers to the viral vector used in the vaccine to deliver the antigens. It is a virus which causes a common cold in chimpanzees, but it has been modified so that it can no longer cause disease. ChAdOx1 is the same viral vector used in the Oxford/AstraZeneca Covid-19 vaccine (which was co-invented by Vaccitech) and is being used in phase II trials for other diseases. In the boost doses, ‘MVA’ is a second viral vector containing the MAGE-A3 or NY-ESO-1 antigens, and is a Modified Vaccinia Ankara virus, which is a type of poxvirus which has been severely weakened so that it can no longer cause disease. The trial is expected to run over 2-3 years. Announcement • Dec 15
Vaccitech plc (NasdaqGM:VACC) acquired Avidea Technologies for $40 million. Vaccitech plc (NasdaqGM:VACC) acquired Avidea Technologies for $40 million on December 13, 2021. The consideration to Avidea’s existing shareholders is $40 million comprised of approximately $12.5 million in cash and $27.5 million in Vaccitech American Depository Shares. Robert E. Puopolo of Goodwin Procter LLP provides legal advisory to Vaccitech plc and Kevin C. Clayton of Hogan Lovells US LLP provides legal advisory to Avidea Technologies in the transaction.
Vaccitech plc (NasdaqGM:VACC) completed the acquisition of Avidea Technologies on December 13, 2021. Reported Earnings • Nov 14
Third quarter 2021 earnings released: US$0.13 loss per share Third quarter 2021 results: Net loss: US$4.56m (flat on 3Q 2020). 
