Announcement • Sep 03

Purple Biotech Receives Notice of Allowance for U.S. Patent Covering Tri-Specific Antibody Constructs and Methods of Use

Purple Biotech Ltd. announced that the U.S. Patent and Trademark Office (USPTO) has issued a Notice of Allowance for a patent application covering tri-specific antibody constructs and methods of use. The patent allowance further expands the Company's intellectual property portfolio supporting its proprietary CAPTN-3 platform for conditionally activated multispecific antibodies. The newly allowed U.S. patent strengthens protection for the modular architecture underlying CAPTN-3, a platform designed to enable the efficient generation of tri-specific antibodies by exchanging tumor-associated antigen (TAA) binding domains and other functional arms while leveraging a common platform backbone. This flexibility is intended to accelerate the development of new therapeutic candidates across multiple cancer indications. The U.S. patent allowance complements Purple Biotech's growing patent estate and reflects the Company’s strategy of continuously expanding both the capabilities of, and the intellectual property supporting, its conditionally activated multispecific antibody technologies. As the technology evolves, the Company expects to introduce additional antibody candidates built on this adaptable platform. The USPTO has issued a Notice of Allowance for U.S. patent application entitled "Precursor Tri-Specific Antibody Constructs and Methods of Use Thereof." The allowed claims cover tri-specific antibody constructs comprising dual TAA binders alongside other features of the CAPTN-3 platform, further strengthening the intellectual property protecting the CAPTN-3 platform, expanding its versatility and its future development and partnering potential. A Notice of Allowance indicates that the USPTO has determined the allowed claims meet the requirements for patentability, subject to payment of the required issue fees. Purple Biotech is focused on advancing its lead program, CAPTN-3 - a platform of masked tri-specific antibodies that simultaneously target tumors while engaging both T cells and NK cells. Capping technology confines immune activation to the tumor microenvironment, significantly expanding the therapeutic window compared to conventional T-cell engagers. The platform's lead candidate, IM1240, is advancing toward the clinic, and its second candidate, IM1305, is in preclinical development. The Company's pipeline also includes additional clinical-stage assets, for which further development is pending partnering or investment, including CM24, a CEACAM1-blocking antibody that demonstrated improved outcomes across all efficacy endpoints in a Phase 2 study for the treatment of pancreatic ductal adenocarcinoma, and NT219, a dual IRS1/2 and STAT3 inhibitor that completed a Phase 2 study for the treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck.

Announcement • Jun 13

Purple Biotech Presents New Preclinical Data At Eacr 2026 Highlighting Im1240’S Anti-Tumor Activity, Favorable Safety and Pharmacokinetic Profile, and Broad Therapeutic Window

Purple Biotech Ltd. announced the presentation of new preclinical data from its lead CAPTN-3 program, IM1240, at the European Association for Cancer Research (EACR) 2026 Annual Congress, being held June 8-11, 2026, in Budapest, Hungary. A non-GLP toxicology study in non-human primates (NHPs) validates the CAPTN-3 masking strategy and supports the planned advancement of IM1240 toward a first-in-human clinical study in 2027. Efficacy data in patient-derived samples from PD-1-resistant head and neck squamous cell carcinoma (HNSCC) metastatic lymph nodes, NSCLC and bladder cancer, generated in collaboration with the laboratory of Dr. Amir Horowitz at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, highlight the essential role of the NKG2A arm in IM1240-mediated anti-tumor immunity and further strengthen CAPTN-3’s differentiation and clinical potential. IM1240 induced apoptosis of PD-1-resistant patient-derived biopsies from six HNSCC metastatic lymph node samples and one enfortumab vedotin/pembrolizumab-resistant muscle-invasive bladder cancer sample, with both the CD3 and NKG2A functional arms required for full activity. In a PD-1/chemotherapy-resistant NSCLC patient-derived explant, IM1240 induced mature tertiary lymphoid structures (TLS) – immune cell organizations associated with effective anti-tumor immunity and favorable clinical prognosis – while increasing CD8 T cell and NK cell abundance and reducing regulatory T cells (Tregs) and tumor cells. These effects were not observed with IM1340, the NKG2A loss-of-function variant, underscoring the essential and differentiated contribution of the NKG2A arm. In a non-GLP dose-range finding toxicology study in NHPs, IM1240 demonstrated markedly superior pharmacokinetics (PK) compared to the non-capped variant IM1222, including an approximately 8-fold longer half-life and 16-fold greater systemic exposure. IM1240 showed dose-proportional PK with a broad therapeutic window, as systemic exposure associated with tumor regression in mouse models remained well below the tolerated levels in NHPs. The CAPTN-3 masking strategy effectively mitigated peripheral T-cell activation and prevented systemic cytokine release in NHPs, which is associated with one of the main safety challenges of T-cell engagers, cytokine release syndrome (CRS). IM1240 induced minimal IL-6 and TNF-a at 10 mg/kg dose, whereas the non-capped IM1222 induced robust cytokine release at just 0.03 mg/kg – a more than 300-fold difference in the dose required to trigger cytokine release. The IM1240 capping design also improved the PK profile by reducing the CD3-mediated antigen sink effect and incorporating human serum albumin to further extend half-life, as compared to the non-capped variant IM1222. IM1240 demonstrated ~14-fold slower clearance than active non-capped IM1222, supporting extended exposure and potential efficacy; rapid clearance of peripherally released non-capped IM1222 reduces systemic accumulation and lowers CRS risk and off-tumor toxicity.

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Purple Biotech Receives Notice of Allowance for U.S. Patent Covering Tri-Specific Antibody Constructs and Methods of Use

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Purple Biotech Presents New Preclinical Data At Eacr 2026 Highlighting Im1240’S Anti-Tumor Activity, Favorable Safety and Pharmacokinetic Profile, and Broad Therapeutic Window

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