Announcement • Apr 18
Penetrium Bioscience Unveils Breakthrough Mechanism for Targeted Cancer Therapy Penetrium Bioscience announced compelling new scientific evidence demonstrating, for the first time at the cellular level, the underlying mechanism behind the long-standing "Seed & Soil" theory originally proposed by Stephen Paget in 1889. The findings reveal how pathological tumor microenvironments ("soil") fundamentally limit the efficacy of targeted therapies—and how Penetrium's novel approach overcomes this barrier. The data, presented ahead of the company's participation at AACR 2026, introduce a paradigm-shifting mechanism that directly addresses the long-standing challenge of sub-lethal drug exposure, a key driver of therapeutic resistance in oncology. Penetrium's mechanism directly targets this barrier. By modulating pathological macrophages and cancer-associated fibroblasts (CAFs), the therapy disrupts the tumor's protective ecosystem, enabling co-administered therapies to achieve full lethal concentrations at the tumor site. This approach not only enhances therapeutic efficacy but also prevents the emergence of adaptive resistance at its source. The findings were independently validated through collaborative studies conducted by Seoul National University Hospital and KAIST (Korea Advanced Institute of Science and Technology). These studies confirmed that Penetrium's observed effects in pathological models are fully consistent with prior RNA sequencing (RNA-seq) data derived from pancreatic cancer organoids. This alignment provides strong evidence that Penetrium's mechanism is not limited to a specific tumor type, but rather represents a broadly applicable platform for microenvironment normalization across multiple cancers. A critical implication of this research is the resolution of the "sub-lethal dose" dilemma—where insufficient drug exposure leads to incomplete tumor killing and subsequent resistance. By dismantling the tumor's physical and biological defense systems, Penetrium enables therapies to reach effective lethal concentrations, thereby: Eliminating the conditions that foster adaptive resistance; Enhancing the durability of existing targeted therapies; Potentially restoring efficacy to blockbuster drugs limited by resistance. The company is actively pursuing strategic collaborations with global biopharma partners to integrate Penetrium into combination therapy regimens across oncology indications. Penetrium Bioscience will present its full dataset and global clinical development roadmap at AACR 2026 Annual Meeting in San Diego, engaging with leading oncology experts and multinational pharmaceutical companies. The company aims to position Penetrium as a first-in-class microenvironment-normalizing platform capable of redefining therapeutic strategies across oncology and beyond. New Risk • Mar 13
New major risk - Financial data availability The company's latest financial reports are more than a year old. Last reported fiscal period ended December 2024. This is considered a major risk. If the company has not reported its earnings on time, it may have been delayed due to audit problems or it may be finding it difficult to reconcile its accounts. In the worst case scenario, it may be facing other major going concern issues jeopardizing its viability as a listed company. Currently, the following risks have been identified for the company: Major Risks Latest financial reports are more than 1 year old (reported December 2024 fiscal period end). Share price has been highly volatile over the past 3 months (27% average weekly change). Revenue has declined by 29% over the past year. Minor Risk Shareholders have been diluted in the past year (30% increase in shares outstanding). Announcement • Feb 20
Hyundai ADM Bio Inc., Annual General Meeting, Mar 06, 2026 Hyundai ADM Bio Inc., Annual General Meeting, Mar 06, 2026, at 09:01 Tokyo Standard Time. Location: conference room, 166, magokdong-ro, gangseo-gu, seoul South Korea 
