Announcement • Jun 30
Poolbeg Pharma Receives Patent Grant for POLB 001 in South Africa for Treatment or Prevention of Hypercytokinemia and Severe Influenza Poolbeg Pharma had received notification of the official decision to grant Poolbeg's Immunomodulator II patent in South Africa, providing protection for POLB 001 for the prevention of hypercytokinaemia and severe influenza until December 2038. POLB 001 is a potent and selective p38 MAP kinase inhibitor with strong potential across multiple disease areas, including the prevention of cancer immunotherapy-induced Cytokine Release Syndrome (CRS) and severe influenza. POLB 001 holds the potential to address significant unmet needs affecting patients and healthcare systems globally. Poolbeg has a robust portfolio of patents in place covering p38 MAP kinase inhibitors for the treatment of severe influenza; and for POLB 001 for the prevention of hypercytokinemia. Additional patent applications have been filed to strengthen and complement Poolbeg's POLB 001 patent portfolio, particularly for cancer immunotherapy-induced CRS. Developing a strong intellectual property portfolio remains a key priority for Poolbeg, enhancing POLB 001's value and appeal to potential partners. Announcement • Jun 16
Poolbeg Pharma Receives European Patent Grant for Polb 001 in Cancer Immunotherapy-Induced Crs Poolbeg Pharma received formal notification of the decision to grant for its POLB 001 cancer immunotherapy-induced Cytokine Release Syndrome ("CRS") patent application from the European Patent Office ("EPO"). The European patent, which provides protection across EPO member states, is the most commercially significant grant to date within Poolbeg's cancer immunotherapy-induced CRS patent family, covering one of the world's largest and most important pharmaceutical markets. This follows the grant of the first patent in this family by IP Australia in March 2026, followed by patent grant in Canada in May 2026 and further reinforces the Company's commitment to building a robust, worldwide IP portfolio. The patent covers the use of p38 MAPK inhibitors, including POLB 001, for the prevention of cancer immunotherapy-induced CRS, supported by proprietary data generated by the Company. The grant materially strengthens Poolbeg's competitive position as it advances POLB 001 through the clinic. With the TOPICAL trial on track to deliver interim data later this summer, the Company believes this milestone significantly enhances POLB 001's attractiveness to potential partners and its long-term value proposition. The Company looks forward to providing further updates to the market regarding the extension of coverage in other jurisdictions in due course. TOPICAL: Trial of Prevention of ImmunoCytokine Adverse events in Myeloma. A single-arm, open-label trial investigating POLB 001 as a potential preventative for CRS in relapsed/refractory multiple myeloma patients receiving the approved bispecific antibody, teclistamab, provided by Johnson and Johnson at no cost to Poolbeg. Announcement • Jun 11
Poolbeg Pharma Announces Successful Site Activation For POLB 001 TOPICAL Clinical Trial Poolbeg Pharma plc announced the first site activation for the first-in-patient POLB 001 TOPICAL clinical trial has occurred. This follows the successful completion of the site initiation visit, with patient recruitment underway and interim data expected in summer 2026. The trial, being conducted by Accelerating Clinical Trials Limited, is investigating POLB 001 as a potential preventative for Cytokine Release Syndrome in approximately 30 relapsed/refractory multiple myeloma patients that are receiving the approved bispecific antibody, teclistamab. This acute condition occurs within days to weeks of initiating bispecific antibody treatment, consequently, the TOPICAL trial is expected to generate a rapid read out of data. TOPICAL: Trial of Prevention of ImmunoCytokine Adverse events in Myeloma. A single-arm, open-label trial investigating POLB 001 as a potential preventative for Cytokine Release Syndrome in relapsed/refractory multiple myeloma patients receiving the approved bispecific antibody, teclistamab, provided by Johnson and Johnson at no cost to Poolbeg. 
