View Future GrowthInstil Bio 과거 순이익 실적과거 기준 점검 0/6Instil Bio은 연평균 11.7%의 비율로 수입이 증가해 온 반면, Biotechs 산업은 연평균 31.9%의 비율로 증가했습니다. 매출은 연평균 110%의 비율로 감소했습니다.핵심 정보11.69%순이익 성장률27.21%주당순이익(EPS) 성장률Biotechs 산업 성장률17.04%매출 성장률-110.03%자기자본이익률-62.68%순이익률n/a최근 순이익 업데이트31 Mar 2026최근 과거 실적 업데이트업데이트 없음모든 업데이트 보기Recent updates공시 • Apr 27Instil Bio, Inc., Annual General Meeting, Jun 11, 2026Instil Bio, Inc., Annual General Meeting, Jun 11, 2026. Location: 3963, maple avenue, suite 350, texas, dallas United StatesPrice Target Changed • Jan 07Price target decreased by 76% to US$29.00Down from US$119, the current price target is an average from 2 analysts. New target price is 304% above last closing price of US$7.18. Stock is down 67% over the past year. The company is forecast to post a net loss per share of US$11.53 next year compared to a net loss per share of US$11.39 last year.New Risk • Jan 07New major risk - Share price stabilityThe company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of American stocks, typically moving 17% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (17% average weekly change). Revenue is less than US$1m. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$93m net loss in 3 years). Market cap is less than US$100m (US$83.4m market cap).Price Target Changed • Sep 14Price target decreased by 16% to US$95.75Down from US$114, the current price target is an average from 4 analysts. New target price is 297% above last closing price of US$24.10. Stock is down 71% over the past year. The company is forecast to post a net loss per share of US$12.22 next year compared to a net loss per share of US$11.39 last year.Recent Insider Transactions Derivative • Sep 11CFO & Chief Business Officer notifies of intention to sell stockSandeep Laumas intends to sell 30k shares in the next 90 days after lodging an Intent To Sell Form on the 10th of September. If the sale is conducted around the recent share price of US$23.39, it would amount to US$702k. Since June 2025, Sandeep has not owned shares directly (This sale likely refers to shares that have not yet been received). There have been no trades via on-market transactions or options from company insiders in the last 12 months.New Risk • Aug 17New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 0.05% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (24% average weekly change). Earnings are forecast to decline by an average of 0.05% per year for the foreseeable future. Revenue is less than US$1m. Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$90m net loss in 3 years).공시 • Jul 31Immuneonco Biopharmaceuticals (Shanghai) Inc. Announces Preliminary Safety & Efficacy Data from the Clinical Trial Studying Imm2510, A Pd-L1xvegf Bispecific Antibody, in Front-Line Nsclc in ChinaInstil Bio, Inc. noted that ImmuneOnco Biopharmaceuticals (Shanghai) Inc. announced preliminary safety and efficacy data from the Phase 2 open-label, multicenter study of IMM2510 (2510) in combination with chemotherapy for front-line patients with advanced non-small cell lung cancer (NSCLC) conducted in China by ImmuneOnco. As of July 1, 2025, 33 patients were dosed at 10 mg/kg, with 21 patients having at least one tumor assessment (efficacy evaluable). The majority of efficacy evaluable patients had only one tumor assessment at data cut-off. ImmuneOnco expects to present safety and efficacy data in the '2510 chemotherapy combination trial in front-line NSCLC at a future medical conference. The '2510 safety profile supports further clinical development, with no dose-limiting toxicities observed in the 33 safety evaluable patients.공시 • Jul 02Instil Bio, Inc. Announces U.S. F.D.A. Clearance of Investigational New Drug (IND) Application for AXN-2510Instil Bio, Inc. announced the clearance of an Investigational New Drug (IND) application for AXN-2510 (2510) by the U.S. Food and Drug Administration. Instil expects to initiate a phase 1 trial of '2510 as monotherapy for patients with relapsed/refractory solid tumors before the end of 2025. The trial is designed to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of '2510 in patients with solid tumors. Additionally, Instil continues to anticipate that initial safety and efficacy results from the ongoing phase 2 study of '2510 in combination with chemotherapy in first-line NSCLC in China will be shared in the second half of 2025 by ImmuneOnco.Seeking Alpha • Jun 30Instil Bio: Chasing After Summit And BioNTech, Albeit With Some HiccupsSummary Instil Bio's pipeline includes AXN-2510/IMM2510, a differentiated PD-L1xVEGF bispecific antibody with upcoming data in H2 2025. Sympathy trades are possible if competitors like SMMT and BNTX report positive results, given TIL's AXN-2510 has a similar mechanism of action. TIL's AXN-2510 did produce one grade 5 event in the dose escalation/expansion trial in various tumor types, although the drug is active in non-small cell lung cancer. Read the full article on Seeking Alpha공시 • Jun 11Instil Bio, Inc. Announces the Addition of John Maraganore, Ph.D., to the Board of Directors of Axion Bio, Inc., Its Wholly-Owned SubsidiaryInstil Bio, Inc. announced the addition of John Maraganore, Ph.D., to the Board of Directors of Axion Bio, Inc., its wholly-owned subsidiary. Dr. Maraganore is a seasoned biotechnology executive with over 30 years of experience in building and leading innovative life sciences companies. He was the founding CEO of Alnylam Pharmaceuticals, where he led the company from its inception in 2002 through nearly two decades of growth. Dr. Maraganore’s passion and hard work advanced RNA interference (RNAi) from a nascent platform into a validated therapeutic modality, bringing multiple first-in-class RNAi medicines to market. He currently serves on the boards of several public and private biotech companies focused on areas such as oncology, immunology, and precision medicine, and advises leading investment firms in the life sciences sector. His breadth of experience across drug discovery, clinical development, and strategic partnering makes him an invaluable partner in guiding the advancement of next-generation cancer therapies.공시 • Jun 04Instil Bio, Inc Announces Appointment of Jamie Freedman as Chief Medical OfficerInstil Bio, Inc. announced the appointment of Jamie Freedman, M.D., Ph.D., as Chief Medical Officer. Dr. Freedman brings deep experience in oncology drug development and other therapeutic areas, and a track record of leading programs through all phases of development, regulatory approval and commercialization. Jamie Freedman is a Hematologist-Oncologist and seasoned biopharmaceutical executive with over 20 years of leadership experience in biopharma drug development. Dr. Freedman has held executive roles at leading pharmaceutical companies including Genentech, AstraZeneca, GSK, and Merck in clinical development, in medical affairs, as oncology business head, and as country-level general manager. Dr. Freedman’s career has led to 15 drug approvals and successful launches across multiple therapeutic areas. He received M.D. and Ph.D. degrees from Tufts University and trained in Medicine and Hematology-Oncology at the University of California, San Francisco, and Harvard University, respectively. He is also passionate about health equity having pioneered some of the first dedicated inclusive trials for underserved and underrepresented patients in the US and Africa. He continues to see patients with blood and solid tumor cancers at the UCSF VA Medical Center where he is also on staff as an adjunct faculty member.공시 • May 22Instil Bio, Inc. and ImmuneOnco Biopharmaceuticals (Shanghai) Inc. Announces the Phase 2 Trial in First-Line NSCLC of IMM2510Instil Bio, Inc. and ImmuneOnco Biopharmaceuticals (Shanghai) Inc. announced clinical trial updates of '2510 and NSCLC clinical development strategy. Instil's Phase 1b/2 trial of '2510 in the United States is expected to be initiated before the end of 2025, assuming the necessary regulatory approvals are obtained. The trial is expected to be a monotherapy dose optimization trial in relapsed/refractory solid tumors, which is intended to bridge the doses to the ongoing China trials and replaces the previously planned US '2510 and chemotherapy combination trial in first-line NSCLC.공시 • Apr 16Instil Bio, Inc., Annual General Meeting, May 28, 2025Instil Bio, Inc., Annual General Meeting, May 28, 2025. Location: 3963 maple avenue, suite 350, texas 75219, dallas United StatesNew Risk • Apr 06New minor risk - Market cap sizeThe company's market capitalization is less than US$100m. Market cap: US$95.3m This is considered a minor risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (17% average weekly change). Earnings are forecast to decline by an average of 7.4% per year for the foreseeable future. Revenue is less than US$1m. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$107m net loss in 3 years). Market cap is less than US$100m (US$95.3m market cap).New Risk • Mar 30New major risk - Share price stabilityThe company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of American stocks, typically moving 17% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (17% average weekly change). Earnings are forecast to decline by an average of 7.4% per year for the foreseeable future. Revenue is less than US$1m. Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$107m net loss in 3 years).Breakeven Date Change • Mar 06No longer forecast to breakevenThe 4 analysts covering Instil Bio no longer expect the company to break even during the foreseeable future. The company was expected to make a profit of US$600.0k in 2027. New consensus forecast suggests the company will make a loss of US$106.5m in 2027.New Risk • Mar 05New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 7.4% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 7.4% per year for the foreseeable future. Revenue is less than US$1m. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$107m net loss in 3 years). Share price has been volatile over the past 3 months (17% average weekly change).공시 • Jan 14Instil Bio Announces Clinical Progress in China for IMM2510/SYN-2510, a Clinical-Stage PD-L1xVEGF Bispecific AntibodyInstil Bio, Inc. announced clinical progress of IMM2510/SYN-2510 in China by its collaborator, ImmuneOnco Biopharmaceuticals (Shanghai) Inc. ImmuneOnco announced that the first patient has been dosed in its phase 1b/2 clinical trial of IMM2510/SYN-2510 in combination with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) in China. ImmuneOnco announced it plans to enroll first-line patients in this trial and anticipates presenting initial clinical data, including data for first-line NSCLC patients, from this trial as soon as the second half of 2025. Additionally, Instil announced that for its anticipated initial U.S. clinical trial of SYN-2510/IMM2510 in lung cancer, it plans to target enrollment of first-line patients with NSCLC in combination with chemotherapy with an expected initiation in the second half of 2025, assuming the necessary regulatory approvals are obtained. About SYN-2510/IMM2510: SYN-2510/IMM2510 is a PD-L1xVEGF bispecific antibody in development for the treatment of multiple solid tumor cancers. SYN-2510/IMM2510 is differentiated from other PD-(L)1xVEGF bispecific antibodies by its VEGF trap, which binds multiple VEGF receptor ligands beyond VEGF-A, a bispecific structure which leverages PD-L1 as an anchor in the tumor microenvironment (TME), and enhanced antibody-dependent cellular cytotoxicity (ADCC) to direct killing of PD-L1-positive tumor cells.Price Target Changed • Jan 07Price target increased by 10.0% to US$114Up from US$104, the current price target is an average from 3 analysts. New target price is 388% above last closing price of US$23.37. Stock is up 204% over the past year. The company is forecast to post a net loss per share of US$12.72 next year compared to a net loss per share of US$24.00 last year.Breakeven Date Change • Dec 31Forecast to breakeven in 2027The 4 analysts covering Instil Bio expect the company to break even for the first time. New consensus forecast suggests the company will make a profit of US$600.0k in 2027. Average annual earnings growth of 54% is required to achieve expected profit on schedule.New Risk • Sep 10New major risk - Share price stabilityThe company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of American stocks, typically moving 19% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (19% average weekly change). Revenue is less than US$1m. Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$4.3m net loss in 3 years).공시 • Apr 28+ 1 more updateInstil Bio, Inc., Annual General Meeting, Jun 13, 2024Instil Bio, Inc., Annual General Meeting, Jun 13, 2024, at 11:00 Central Standard Time. Location: Instil Bio, Inc. 3963 Maple Avenue, Suite 350 Dallas Texas United States Agenda: To elect two director nominees, Gwendolyn Binder and R. Kent McGaughy, Jr., as Class III directors to hold office until the 2027 Annual Meeting of Stockholders; to ratify the selection by the Audit Committee of the board of directors of Deloitte & Touche LLP as the independent registered public accounting firm of the Company for the year ending December 31, 2024; and to conduct any other business properly brought before the meeting.Board Change • Apr 16Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 6 experienced directors. No highly experienced directors. Independent Non-Employee Director Gwen Binder was the last director to join the board, commencing their role in 2020. The company’s insufficient board refreshment is considered a risk according to the Simply Wall St Risk Model.공시 • Jan 17Instil Bio, Inc. Announces the Closure of Its UK Manufacturing and Clinical OperationsInstil Bio, Inc. announced a strategic update. Instil has entered into an agreement with a collaborator that has a successful track record of manufacturing and dosing patients with cell therapies to conduct preclinical manufacturing feasibility studies in the ITIL-306 program. With the objective of saving costs and improving time efficiency, the company is announcing the closure of its UK manufacturing and clinical operations, thereby reducing its UK workforce which is expected to be substantially completed by the first half of 2024.Board Change • Aug 01Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 6 experienced directors. No highly experienced directors. Independent Non-Employee Director Gwen Binder was the last director to join the board, commencing their role in 2020. The company’s insufficient board refreshment is considered a risk according to the Simply Wall St Risk Model.공시 • Jun 29Instil Bio, Inc. Announces Oral Presentation of ITIL-306 Preclinical Data at British Society for Gene and Cell Therapy Annual ConferenceInstil Bio, Inc. reported an oral presentation at the British Society for Gene and Cell Therapy Annual Conference, demonstrating that its proprietary CoStimulatory Antigen Receptor (CoStAR) platform enhances activity of TILs against autologous tumor. The presentation highlighted CoStAR’s unique mechanism of action which results in greatly enhanced activity of TILs when activation occurs through both the native TCR and engineered CoStAR receptors. Additionally, novel data demonstrated that Instil’s FRa-CoStAR enhances activity of TILs against autologous tumors with varied expression of FRa including ovarian, renal, and non-small cell lung cancer tumors. The robust activity of NSCLC, ovarian, and renal carcinoma CoStAR-TILs against autologous tumor exceeded that of genetically unmodified melanoma TILs, as measured by secretion of IFN?.공시 • Jan 10Instil Bio Announces Resumption of Clinical Trial of Costar-Til Candidate Itil-306 in Lung, Ovarian, and Renal CancerInstil Bio, Inc. announced the resumption of its Phase 1 clinical trial of ITIL-306 for the treatment of non-small cell lung cancer (NSCLC), ovarian cancer, and renal cell carcinoma (RCC). With the resumption of the ITIL-306 Phase 1 study, the Company expects to release initial safety, translational, and efficacy data from dose escalation cohorts at a medical conference in 2023. The trial was resumed after the implementation of additional quality safeguards designed to further protect the manufacturing process from potential contaminants. Following its recent reprioritization of clinical programs and corporate restructuring, Instil expects its cash runway to extend into 2025, excluding the potential financing or other monetization of its Tarzana manufacturing site. Instil intends to provide further updates on its pre-clinical pipeline in 2023, including the potential to nominate additional CoStAR candidates and novel TIL technologies for clinical development.공시 • Nov 16Instil Bio, Inc. Announces Executive ChangesInstil Bio, Inc. announced Appointment of cell therapy pioneer Dr. Robert Hawkins as Head of Research and Development, and resignation of Chief Medical Officer, Dr. Zachary Roberts. Appointment of Head of Research nd Development: Instil announced the appointment of Robert Hawkins, M.B.B.S. Ph.D., as Head of Research and Development. Dr. Hawkins is a world-renowned oncologist and biotechnology innovator, with a focus on development of novel cell and gene therapies. Dr. Hawkins was the founder and CEO of Immetacyte Ltd., a cell therapy company spun out of the University of Manchester where Dr. Hawkins served as Professor of Medical Oncology. Immetacyte Ltd. generated the foundational TIL technology and clinical data on which Instil was founded. Resignation of Chief Medical Officer: Instil announced that, pursuant to a separation agreement, Zachary Roberts, M.D., Ph.D., Chief Medical Officer of the Company, has resigned effective November 11, 2022 to pursue other opportunities. The company appreciates Dr. Roberts’ contributions and wishes him the best in his future endeavors.Price Target Changed • Nov 16Price target decreased to US$14.50Down from US$21.00, the current price target is an average from 4 analysts. New target price is 587% above last closing price of US$2.11. Stock is down 90% over the past year. The company is forecast to post a net loss per share of US$1.77 next year compared to a net loss per share of US$1.48 last year.Price Target Changed • Nov 01Price target decreased to US$18.00Down from US$21.00, the current price target is an average from 3 analysts. New target price is 445% above last closing price of US$3.30. Stock is down 85% over the past year. The company is forecast to post a net loss per share of US$1.77 next year compared to a net loss per share of US$1.48 last year.공시 • Nov 01+ 1 more updateInstil Bio, Inc. Announces Voluntary Pause of Enrollment in Ongoing Clinical Trials of ITIL-168 and ITIL-306Instil Bio, Inc. announced that it has voluntarily paused enrollment in its ongoing clinical trials of ITIL-168 and ITIL-306 and has notified regulatory authorities in the United States, Canada, and the UK. No regulatory agencies, including the FDA, have notified the Company of a clinical hold in any of its clinical trials. The voluntary pause by the Company was instituted following a recent decrease in the rate of successful manufacturing of ITIL-168, resulting in the inability to dose some patients whose individual product of ITIL-168 was not successfully manufactured. A pre-specified safety analysis in the DELTA-1 trial has been conducted on patients who received ITIL-168 and did not identify any unexpected safety issues. The Company has commenced an end-to-end analysis of its manufacturing processes and upon completion of this analysis, plans to take corrective actions to improve the rate of manufacturing success and resume the study. Although no manufacturing failures have been observed to date in the ongoing Phase 1 trial of ITIL-306, the Company has also voluntarily paused enrollment in this trial as part of its overall manufacturing analysis. The Company intends to provide an update on the manufacturing analysis by early first quarter 2023. The Company confirms its previously disclosed cash runway into 2025 upon the successful completion of a potential sale-leaseback transaction of its Tarzana manufacturing facility.공시 • Oct 19Instil Bio Announces First Patient Dosed with ITIL-306, First Engineered TIL Therapy Using the CoStAR Platform Targeting Folate Receptor Alpha (FRa), in Non-Small Cell Lung CancerInstil Bio, Inc. announced that the first patient has been dosed in a Phase 1 dose escalation study of ITIL-306 (NCT05397093) for the treatment of multiple solid tumors. ITIL-306 is Instil’s first genetically-engineered Costimulatory Antigen Receptor-TIL (CoStAR-TIL) therapy. Instil’s first-in-human Phase 1 study of ITIL-306 is an open-label, multicenter study in patients with non-small cell lung cancer, ovarian cancer, and renal cell carcinoma. Patients in the first dose cohort will receive a target dose of one billion CoStAR-transduced TILs after receiving a reduced intensity lymphodepletion regimen and no post-infusion interleukin-2. The study will evaluate safety of ITIL-306 in addition to efficacy and translational endpoints. The company anticipates reporting initial clinical data from the Phase 1 trial in 2023. ITIL-306 is an autologous TIL cell therapy engineered with a novel and proprietary CoStAR molecule that is activated by folate receptor alpha (FRa) to provide robust costimulatory signals within the tumor microenvironment. CoStAR builds on the key advantages of native TILs to enhance the cytokine release, cytolytic activity, and proliferation of TILs in the tumor microenvironment. Previously published preclinical data demonstrates the ability of CoStAR-T cells to enhance tumor control in vivo in the absence of exogenous IL-2, supporting a treatment regimen free of IL-2 in the Phase 1 study of ITIL-306.공시 • Sep 07Instil Bio, Inc. Appoints Tim Moore as Chief Operating OfficerInstil Bio, Inc. announced the appointment of Tim Moore to the role of Chief Operating Officer. Tim Moore has more than three decades of leadership experience in biopharmaceutical manufacturing and operations, including at Genentech, Kite and most recently PACT Pharma. From 2016 to 2019, Mr. Moore was Executive Vice President, Technical Operations at Kite Pharma, where he was responsible for technical operations and successfully launched Yescarta®, one of the first FDA-approved CAR-T cell therapies. Prior to Instil, Mr. Moore was the President and Chief Operating Officer of PACT Pharma, a cell therapy company focusing on neo-antigen directed TCR-T cell therapy. Tim Moore Biography: Prior to joining Instil Bio, Mr. Moore served as the President and Chief Operating Officer at PACT Pharma since April of 2020, and as the company’s President and Chief Technology Officer since October of 2019. Before joining PACT, he served as Executive Vice President, Technical Operations at Kite, a Gilead Company, since March of 2016. During this time Mr. Moore was responsible for overseeing the process development, manufacturing, quality and supply chain for the launch of Yescarta®, one of the first CAR T therapies to be developed, manufactured and commercialized, as well as advancement of the Kite pipeline. In addition, Mr. Moore globally expanded the biopharmaceutical operations to serve and support the US and EU as well as key partners in Asia. Prior to Kite, Mr. Moore served as the Senior Vice President, Head of Global Technical Operations – Biologics of Genentech, Inc. and as a member of the Genentech Executive Committee since 2010. In this role, Mr. Moore oversaw global leadership for more than 7,500 professionals across 10 internal sites and over 37 contract manufacturing organizations, as well as global manufacturing and end-to-end quality supply performance of more than 20 biological product families. Prior to that, Mr. Moore was Genentech’s Senior Vice President, Global Supply Chain and Global Engineering from 2007 to 2010. Previously, Mr. Moore served as Vice President, Operations at ZLB Behring (formerly Aventis Behring). He is currently a member of ISPE, PDA and has been a part of the Executive Committee of BioPhorum and serves as a Board member for Cerus and BioLife Solutions. Mr. Moore received a B.S. in Chemical Engineering from Tulsa University and a M.S. in Engineering Management from Northwestern University.Seeking Alpha • Sep 06Instil Bio appoints Tim Moore as COOInstil Bio (NASDAQ:TIL) has appointed Tim Moore to the role of COO. Mr. Moore most recently served as the President and COO of PACT Pharma, a cell therapy company focusing on neo-antigen directed TCR-T cell therapy.Price Target Changed • Aug 23Price target decreased to US$22.00Down from US$24.75, the current price target is an average from 3 analysts. New target price is 314% above last closing price of US$5.32. Stock is down 70% over the past year. The company is forecast to post a net loss per share of US$1.81 next year compared to a net loss per share of US$1.48 last year.분석 기사 • Jul 20We're Keeping An Eye On Instil Bio's (NASDAQ:TIL) Cash Burn RateThere's no doubt that money can be made by owning shares of unprofitable businesses. For example, biotech and mining...공시 • Jun 26+ 1 more updateInstil Bio, Inc.(NasdaqGS:TIL) dropped from Russell 2000 Growth IndexInstil Bio, Inc.(NasdaqGS:TIL) dropped from Russell 2000 Growth Index공시 • May 28Instil Bio, Inc. Announces IND Clearance of First CoStAR-TIL Program, ITIL-306, Designed to Enhance Activity in the Tumor MicroenvironmentInstil Bio, Inc. announced IND clearance by the U.S. Food and Drug Administration of ITIL-306, Instil’s first genetically-engineered Costimulatory Antigen Receptor TIL (CoStAR-TIL) therapy, as well as the presentation of supporting in vivo CoStAR data at the 2022 ASCO Annual Meeting. ITIL-306 is an autologous TIL cell therapy engineered with a novel and proprietary Costimulatory Antigen Receptor (CoStAR) that is activated by folate receptor alpha (FRa) to provide robust costimulatory signals. CoStAR builds on the key advantages of native TILs, including their polyclonal anti-tumor reactivity, to enhance the cytokine release, cytolytic activity, and proliferation of TILs in the tumor microenvironment. The design of Instil’s first-in-human Phase 1 study of ITIL-306 will enroll patients with non-small cell lung cancer (NSCLC), ovarian cancer, and renal cell carcinoma (RCC) and will start with a dose of one billion CoStAR-transduced TILs. Manufacturing for ITIL-306 will occur at Instil’s Tarzana, California manufacturing facility. The poster presentation at the 2022 ASCO Annual Meeting will outline findings from studies evaluating anti-FOLR1 CoStAR T cells in vitro as well as a mouse solid tumor model in vivo. The poster presentation highlights results demonstrating enhanced T cell function and tumor control by CoStAR-modified T cells. Importantly, improved tumor control in a mouse solid tumor model occurred without exogenous IL-2 administration, supporting a clinical CoStAR-TIL regimen free of high-dose IL-2. CoStAR T cells showed limited upregulation of PD-1 after target exposure and demonstrated improved persistence in vivo.Price Target Changed • May 27Price target decreased to US$26.00Down from US$28.00, the current price target is an average from 2 analysts. New target price is 333% above last closing price of US$6.00. Stock is down 66% over the past year. The company is forecast to post a net loss per share of US$1.74 next year compared to a net loss per share of US$1.48 last year.Price Target Changed • May 24Price target decreased to US$27.75Down from US$30.00, the current price target is an average from 2 analysts. New target price is 243% above last closing price of US$8.09. Stock is down 52% over the past year. The company is forecast to post a net loss per share of US$1.74 next year compared to a net loss per share of US$1.48 last year.Price Target Changed • Apr 27Price target decreased to US$26.67Down from US$30.00, the current price target is an average from 3 analysts. New target price is 228% above last closing price of US$8.14. Stock is down 55% over the past year. The company is forecast to post a net loss per share of US$1.65 next year compared to a net loss per share of US$1.48 last year.공시 • Apr 02Instil Bio, Inc., Annual General Meeting, May 20, 2022Instil Bio, Inc., Annual General Meeting, May 20, 2022, at 09:00 Central Standard Time. Location: 3963 Maple Avenue Suite 350 Dallas Texas United States Agenda: To consider election of the Board’s nominees, Bronson Crouch and Jack Nielsen, to the board of directors; to ratify the selection by the Audit Committee of the board of directors of Deloitte & Touche LLP as the independent registered public accounting firm of the company for the year ending December 31, 2022; and to conduct any other business properly brought before the meeting.공시 • Sep 19Instil Bio Presents Subset Analysis of Patients with Checkpoint-Refractory Advanced Melanoma from Compassionate Use Study at 2021 ESMO CongressInstil Bio, Inc. announced that a subset analysis of treatment outcomes with unselected autologous tumor infiltrating lymphocytes (TILs) in patients with checkpoint inhibitor-refractory advanced cutaneous melanoma was presented at the 2021 European Society for Medical Oncology (ESMO) Congress, taking place virtually from September 16-21, 2021. Among the 12 patients featured in this subset analysis who had disease progression following treatment with a PD-1 inhibitor, all were also resistant to CTLA-4 inhibition with ipilimumab. Seven (58%) patients achieved an objective response, with 1 (8%) achieving a complete response. With a median duration of follow-up of 45.5 months, the median overall survival was 21.3 months with nearly half of patients experiencing long term survival. Side effects of treatment were largely transient, manageable with supportive care, and generally attributable to the lymphodepleting chemotherapy regimen and post-TIL high-dose IL-2 treatment. Outcomes in this highly treatment-refractory subgroup were similar to those observed in all 21 treated patients, with high response rates and an expected safety profile.공시 • Sep 15Instil Bio Receives IND Clearance to Initiate a Phase 2 Clinical Trial for Patients with Advanced MelanomaInstil Bio, Inc. reported clearance of its Investigational New Drug (IND) application from the U.S. Food and Drug Administration (FDA) to initiate DELTA-1, a global Phase 2 clinical trial of ITIL-168 in patients with advanced melanoma whose disease has relapsed after a PD-1 inhibitor and, if positive for a BRAF-activating mutation, a BRAF inhibitor. The DELTA-1 trial was expanded during the IND review process, in consultation with FDA, to include additional populations of patients with advanced melanoma. Cohorts 2 and 3 will enroll patients who discontinued PD-1 inhibitor therapy due to intolerable toxicity and patients who had an unsatisfactory response to prior PD-1 inhibitor but have not yet experienced disease progression, respectively. Topline safety and efficacy results are expected in 2023 and, if positive, are anticipated to support the submission of a biologics license application (BLA) to the FDA in 2023 and a Marketing Authorization Application (MAA) to the European Medicines Agency in 2024. ITIL-168 is an investigational, autologous cell therapy made from tumor infiltrating lymphocytes, or TILs. Made from each patient’s digested and cryopreserved tumor, ITIL-168 is a TIL cell therapy manufactured to offer an unrestricted T cell receptor (TCR) repertoire. Instil’s proprietary, optimized, and scalable manufacturing process has been designed to capture and preserve the maximum diversity of each patient’s TILs. By collecting the patient’s tumor and immediately processing and then cryopreserving it, process offers significant scheduling flexibility for patients and physicians at the time of both tumor resection and TIL treatment. In addition to DELTA-1, Instil plans to investigate ITIL-168 in additional solid tumor indications in Phase 1 clinical trials beginning in 2022. DELTA-1 is a global, multicenter Phase 2 clinical trial of ITIL-168 in adult patients with advanced melanoma. Using an open-label, single-arm design, the main study cohort will evaluate the efficacy and safety of ITIL-168, when administered after a 5-day course of lymphodepleting chemotherapy and followed by up to 8 doses of high-dose interleukin-2 (IL-2), in patients whose cancer has progressed following a PD-1 inhibitor and, if positive for a BRAF-activating mutation, a BRAF inhibitor. Approximately 80 subjects are planned for enrollment and treatment in Cohort 1. Cohort 2 is anticipated to enroll approximately 25 subjects and is designed to evaluate the efficacy and safety of the regimen in patients who required discontinuation of PD-1 inhibitor(s) due to unacceptable toxicity, regardless of best overall disease response. Cohort 3 is also anticipated to enroll approximately 25 subjects and will evaluate efficacy and safety in patients whose best ongoing response to PD-1 inhibitor(s) is stable disease. Patients in Cohorts 2 and 3 whose cancer expresses a BRAF-activating mutation will be required to have experienced disease progression following BRAF inhibitor therapy. The primary endpoint of DELTA-1 is the objective response rate (ORR) according to RECIST v1.1 as assessed by independent central review. Secondary endpoints include disease control rate, duration of response, progression-free survival, overall survival, and safety.분석 기사 • Jun 21We're Hopeful That Instil Bio (NASDAQ:TIL) Will Use Its Cash WiselyEven when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...공시 • Mar 19Instil Bio, Inc. has completed an IPO in the amount of $320 million.Instil Bio, Inc. has completed an IPO in the amount of $320 million. Security Name: Common Stock Security Type: Common Stock Securities Offered: 16,000,000 Price\Range: $20 Transaction Features: Reserved Share Offering; Sponsor Backed Offering매출 및 비용 세부 내역Instil Bio가 돈을 벌고 사용하는 방법. 최근 발표된 LTM 실적 기준.순이익 및 매출 추이NasdaqCM:TIL 매출, 비용 및 순이익 (USD Millions)날짜매출순이익일반관리비연구개발비31 Dec 250-71272630 Sep 250-75322630 Jun 250-85361831 Mar 250-78411431 Dec 240-74441630 Sep 240-75451630 Jun 240-120462431 Mar 240-123473031 Dec 230-156484330 Sep 230-197575430 Jun 230-186628531 Mar 230-2266711831 Dec 220-2236913730 Sep 220-2256416030 Jun 220-2116014931 Mar 220-1885712931 Dec 210-1575110430 Sep 210-119447430 Jun 210-83335031 Mar 210-57213131 Dec 200-381318양질의 수익: TIL 은(는) 현재 수익성이 없습니다.이익 마진 증가: TIL는 현재 수익성이 없습니다.잉여현금흐름 대비 순이익 분석과거 순이익 성장 분석수익추이: TIL는 수익성이 없지만 지난 5년 동안 연평균 11.7%의 속도로 손실을 줄였습니다.성장 가속화: 현재 수익성이 없어 지난 1년간 TIL의 수익 성장률을 5년 평균과 비교할 수 없습니다.수익 대 산업: TIL은 수익성이 없어 지난 해 수익 성장률을 Biotechs 업계(43%)와 비교하기 어렵습니다.자기자본이익률높은 ROE: TIL는 현재 수익성이 없으므로 자본 수익률이 음수(-62.68%)입니다.총자산이익률투하자본수익률우수한 과거 실적 기업을 찾아보세요7D1Y7D1Y7D1YPharmaceuticals-biotech 산업에서 과거 실적이 우수한 기업.View Financial Health기업 분석 및 재무 데이터 상태데이터최종 업데이트 (UTC 시간)기업 분석2026/05/17 17:05종가2026/05/15 00:00수익2026/03/31연간 수익2025/12/31데이터 소스당사의 기업 분석에 사용되는 데이터는 S&P Global Market Intelligence LLC에서 제공됩니다. 아래 데이터는 이 보고서를 생성하기 위해 분석 모델에서 사용됩니다. 데이터는 정규화되므로 소스가 제공된 후 지연이 발생할 수 있습니다.패키지데이터기간미국 소스 예시 *기업 재무제표10년손익계산서현금흐름표대차대조표SEC 양식 10-KSEC 양식 10-Q분석가 컨센서스 추정치+3년재무 예측분석가 목표주가분석가 리서치 보고서Blue Matrix시장 가격30년주가배당, 분할 및 기타 조치ICE 시장 데이터SEC 양식 S-1지분 구조10년주요 주주내부자 거래SEC 양식 4SEC 양식 13D경영진10년리더십 팀이사회SEC 양식 10-KSEC 양식 DEF 14A주요 개발10년회사 공시SEC 양식 8-K* 미국 증권에 대한 예시이며, 비(非)미국 증권에는 해당 국가의 규제 서식 및 자료원을 사용합니다.별도로 명시되지 않는 한 모든 재무 데이터는 연간 기간을 기준으로 하지만 분기별로 업데이트됩니다. 이를 TTM(최근 12개월) 또는 LTM(지난 12개월) 데이터라고 합니다. 자세히 알아보기.분석 모델 및 스노우플레이크이 보고서를 생성하는 데 사용된 분석 모델에 대한 자세한 내용은 당사의 Github 페이지에서 확인하실 수 있습니다. 또한 보고서 활용 방법에 대한 가이드와 YouTube 튜토리얼도 제공합니다.Simply Wall St 분석 모델을 설계하고 구축한 세계적 수준의 팀에 대해 알아보세요.산업 및 섹터 지표산업 및 섹터 지표는 Simply Wall St가 6시간마다 계산하며, 프로세스에 대한 자세한 내용은 Github에서 확인할 수 있습니다.분석가 소스Instil Bio, Inc.는 7명의 분석가가 다루고 있습니다. 이 중 2명의 분석가가 우리 보고서에 입력 데이터로 사용되는 매출 또는 수익 추정치를 제출했습니다. 분석가의 제출 자료는 하루 종일 업데이트됩니다.분석가기관Jack AllenBairdMitchell KapoorH.C. Wainwright & Co.Yuxi DongJefferies LLC4명의 분석가 더 보기
공시 • Apr 27Instil Bio, Inc., Annual General Meeting, Jun 11, 2026Instil Bio, Inc., Annual General Meeting, Jun 11, 2026. Location: 3963, maple avenue, suite 350, texas, dallas United States
Price Target Changed • Jan 07Price target decreased by 76% to US$29.00Down from US$119, the current price target is an average from 2 analysts. New target price is 304% above last closing price of US$7.18. Stock is down 67% over the past year. The company is forecast to post a net loss per share of US$11.53 next year compared to a net loss per share of US$11.39 last year.
New Risk • Jan 07New major risk - Share price stabilityThe company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of American stocks, typically moving 17% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (17% average weekly change). Revenue is less than US$1m. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$93m net loss in 3 years). Market cap is less than US$100m (US$83.4m market cap).
Price Target Changed • Sep 14Price target decreased by 16% to US$95.75Down from US$114, the current price target is an average from 4 analysts. New target price is 297% above last closing price of US$24.10. Stock is down 71% over the past year. The company is forecast to post a net loss per share of US$12.22 next year compared to a net loss per share of US$11.39 last year.
Recent Insider Transactions Derivative • Sep 11CFO & Chief Business Officer notifies of intention to sell stockSandeep Laumas intends to sell 30k shares in the next 90 days after lodging an Intent To Sell Form on the 10th of September. If the sale is conducted around the recent share price of US$23.39, it would amount to US$702k. Since June 2025, Sandeep has not owned shares directly (This sale likely refers to shares that have not yet been received). There have been no trades via on-market transactions or options from company insiders in the last 12 months.
New Risk • Aug 17New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 0.05% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (24% average weekly change). Earnings are forecast to decline by an average of 0.05% per year for the foreseeable future. Revenue is less than US$1m. Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$90m net loss in 3 years).
공시 • Jul 31Immuneonco Biopharmaceuticals (Shanghai) Inc. Announces Preliminary Safety & Efficacy Data from the Clinical Trial Studying Imm2510, A Pd-L1xvegf Bispecific Antibody, in Front-Line Nsclc in ChinaInstil Bio, Inc. noted that ImmuneOnco Biopharmaceuticals (Shanghai) Inc. announced preliminary safety and efficacy data from the Phase 2 open-label, multicenter study of IMM2510 (2510) in combination with chemotherapy for front-line patients with advanced non-small cell lung cancer (NSCLC) conducted in China by ImmuneOnco. As of July 1, 2025, 33 patients were dosed at 10 mg/kg, with 21 patients having at least one tumor assessment (efficacy evaluable). The majority of efficacy evaluable patients had only one tumor assessment at data cut-off. ImmuneOnco expects to present safety and efficacy data in the '2510 chemotherapy combination trial in front-line NSCLC at a future medical conference. The '2510 safety profile supports further clinical development, with no dose-limiting toxicities observed in the 33 safety evaluable patients.
공시 • Jul 02Instil Bio, Inc. Announces U.S. F.D.A. Clearance of Investigational New Drug (IND) Application for AXN-2510Instil Bio, Inc. announced the clearance of an Investigational New Drug (IND) application for AXN-2510 (2510) by the U.S. Food and Drug Administration. Instil expects to initiate a phase 1 trial of '2510 as monotherapy for patients with relapsed/refractory solid tumors before the end of 2025. The trial is designed to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of '2510 in patients with solid tumors. Additionally, Instil continues to anticipate that initial safety and efficacy results from the ongoing phase 2 study of '2510 in combination with chemotherapy in first-line NSCLC in China will be shared in the second half of 2025 by ImmuneOnco.
Seeking Alpha • Jun 30Instil Bio: Chasing After Summit And BioNTech, Albeit With Some HiccupsSummary Instil Bio's pipeline includes AXN-2510/IMM2510, a differentiated PD-L1xVEGF bispecific antibody with upcoming data in H2 2025. Sympathy trades are possible if competitors like SMMT and BNTX report positive results, given TIL's AXN-2510 has a similar mechanism of action. TIL's AXN-2510 did produce one grade 5 event in the dose escalation/expansion trial in various tumor types, although the drug is active in non-small cell lung cancer. Read the full article on Seeking Alpha
공시 • Jun 11Instil Bio, Inc. Announces the Addition of John Maraganore, Ph.D., to the Board of Directors of Axion Bio, Inc., Its Wholly-Owned SubsidiaryInstil Bio, Inc. announced the addition of John Maraganore, Ph.D., to the Board of Directors of Axion Bio, Inc., its wholly-owned subsidiary. Dr. Maraganore is a seasoned biotechnology executive with over 30 years of experience in building and leading innovative life sciences companies. He was the founding CEO of Alnylam Pharmaceuticals, where he led the company from its inception in 2002 through nearly two decades of growth. Dr. Maraganore’s passion and hard work advanced RNA interference (RNAi) from a nascent platform into a validated therapeutic modality, bringing multiple first-in-class RNAi medicines to market. He currently serves on the boards of several public and private biotech companies focused on areas such as oncology, immunology, and precision medicine, and advises leading investment firms in the life sciences sector. His breadth of experience across drug discovery, clinical development, and strategic partnering makes him an invaluable partner in guiding the advancement of next-generation cancer therapies.
공시 • Jun 04Instil Bio, Inc Announces Appointment of Jamie Freedman as Chief Medical OfficerInstil Bio, Inc. announced the appointment of Jamie Freedman, M.D., Ph.D., as Chief Medical Officer. Dr. Freedman brings deep experience in oncology drug development and other therapeutic areas, and a track record of leading programs through all phases of development, regulatory approval and commercialization. Jamie Freedman is a Hematologist-Oncologist and seasoned biopharmaceutical executive with over 20 years of leadership experience in biopharma drug development. Dr. Freedman has held executive roles at leading pharmaceutical companies including Genentech, AstraZeneca, GSK, and Merck in clinical development, in medical affairs, as oncology business head, and as country-level general manager. Dr. Freedman’s career has led to 15 drug approvals and successful launches across multiple therapeutic areas. He received M.D. and Ph.D. degrees from Tufts University and trained in Medicine and Hematology-Oncology at the University of California, San Francisco, and Harvard University, respectively. He is also passionate about health equity having pioneered some of the first dedicated inclusive trials for underserved and underrepresented patients in the US and Africa. He continues to see patients with blood and solid tumor cancers at the UCSF VA Medical Center where he is also on staff as an adjunct faculty member.
공시 • May 22Instil Bio, Inc. and ImmuneOnco Biopharmaceuticals (Shanghai) Inc. Announces the Phase 2 Trial in First-Line NSCLC of IMM2510Instil Bio, Inc. and ImmuneOnco Biopharmaceuticals (Shanghai) Inc. announced clinical trial updates of '2510 and NSCLC clinical development strategy. Instil's Phase 1b/2 trial of '2510 in the United States is expected to be initiated before the end of 2025, assuming the necessary regulatory approvals are obtained. The trial is expected to be a monotherapy dose optimization trial in relapsed/refractory solid tumors, which is intended to bridge the doses to the ongoing China trials and replaces the previously planned US '2510 and chemotherapy combination trial in first-line NSCLC.
공시 • Apr 16Instil Bio, Inc., Annual General Meeting, May 28, 2025Instil Bio, Inc., Annual General Meeting, May 28, 2025. Location: 3963 maple avenue, suite 350, texas 75219, dallas United States
New Risk • Apr 06New minor risk - Market cap sizeThe company's market capitalization is less than US$100m. Market cap: US$95.3m This is considered a minor risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (17% average weekly change). Earnings are forecast to decline by an average of 7.4% per year for the foreseeable future. Revenue is less than US$1m. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$107m net loss in 3 years). Market cap is less than US$100m (US$95.3m market cap).
New Risk • Mar 30New major risk - Share price stabilityThe company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of American stocks, typically moving 17% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (17% average weekly change). Earnings are forecast to decline by an average of 7.4% per year for the foreseeable future. Revenue is less than US$1m. Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$107m net loss in 3 years).
Breakeven Date Change • Mar 06No longer forecast to breakevenThe 4 analysts covering Instil Bio no longer expect the company to break even during the foreseeable future. The company was expected to make a profit of US$600.0k in 2027. New consensus forecast suggests the company will make a loss of US$106.5m in 2027.
New Risk • Mar 05New major risk - Revenue and earnings growthEarnings are forecast to decline by an average of 7.4% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Earnings are forecast to decline by an average of 7.4% per year for the foreseeable future. Revenue is less than US$1m. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$107m net loss in 3 years). Share price has been volatile over the past 3 months (17% average weekly change).
공시 • Jan 14Instil Bio Announces Clinical Progress in China for IMM2510/SYN-2510, a Clinical-Stage PD-L1xVEGF Bispecific AntibodyInstil Bio, Inc. announced clinical progress of IMM2510/SYN-2510 in China by its collaborator, ImmuneOnco Biopharmaceuticals (Shanghai) Inc. ImmuneOnco announced that the first patient has been dosed in its phase 1b/2 clinical trial of IMM2510/SYN-2510 in combination with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) in China. ImmuneOnco announced it plans to enroll first-line patients in this trial and anticipates presenting initial clinical data, including data for first-line NSCLC patients, from this trial as soon as the second half of 2025. Additionally, Instil announced that for its anticipated initial U.S. clinical trial of SYN-2510/IMM2510 in lung cancer, it plans to target enrollment of first-line patients with NSCLC in combination with chemotherapy with an expected initiation in the second half of 2025, assuming the necessary regulatory approvals are obtained. About SYN-2510/IMM2510: SYN-2510/IMM2510 is a PD-L1xVEGF bispecific antibody in development for the treatment of multiple solid tumor cancers. SYN-2510/IMM2510 is differentiated from other PD-(L)1xVEGF bispecific antibodies by its VEGF trap, which binds multiple VEGF receptor ligands beyond VEGF-A, a bispecific structure which leverages PD-L1 as an anchor in the tumor microenvironment (TME), and enhanced antibody-dependent cellular cytotoxicity (ADCC) to direct killing of PD-L1-positive tumor cells.
Price Target Changed • Jan 07Price target increased by 10.0% to US$114Up from US$104, the current price target is an average from 3 analysts. New target price is 388% above last closing price of US$23.37. Stock is up 204% over the past year. The company is forecast to post a net loss per share of US$12.72 next year compared to a net loss per share of US$24.00 last year.
Breakeven Date Change • Dec 31Forecast to breakeven in 2027The 4 analysts covering Instil Bio expect the company to break even for the first time. New consensus forecast suggests the company will make a profit of US$600.0k in 2027. Average annual earnings growth of 54% is required to achieve expected profit on schedule.
New Risk • Sep 10New major risk - Share price stabilityThe company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of American stocks, typically moving 19% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (19% average weekly change). Revenue is less than US$1m. Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$4.3m net loss in 3 years).
공시 • Apr 28+ 1 more updateInstil Bio, Inc., Annual General Meeting, Jun 13, 2024Instil Bio, Inc., Annual General Meeting, Jun 13, 2024, at 11:00 Central Standard Time. Location: Instil Bio, Inc. 3963 Maple Avenue, Suite 350 Dallas Texas United States Agenda: To elect two director nominees, Gwendolyn Binder and R. Kent McGaughy, Jr., as Class III directors to hold office until the 2027 Annual Meeting of Stockholders; to ratify the selection by the Audit Committee of the board of directors of Deloitte & Touche LLP as the independent registered public accounting firm of the Company for the year ending December 31, 2024; and to conduct any other business properly brought before the meeting.
Board Change • Apr 16Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 6 experienced directors. No highly experienced directors. Independent Non-Employee Director Gwen Binder was the last director to join the board, commencing their role in 2020. The company’s insufficient board refreshment is considered a risk according to the Simply Wall St Risk Model.
공시 • Jan 17Instil Bio, Inc. Announces the Closure of Its UK Manufacturing and Clinical OperationsInstil Bio, Inc. announced a strategic update. Instil has entered into an agreement with a collaborator that has a successful track record of manufacturing and dosing patients with cell therapies to conduct preclinical manufacturing feasibility studies in the ITIL-306 program. With the objective of saving costs and improving time efficiency, the company is announcing the closure of its UK manufacturing and clinical operations, thereby reducing its UK workforce which is expected to be substantially completed by the first half of 2024.
Board Change • Aug 01Insufficient new directorsNo new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 6 experienced directors. No highly experienced directors. Independent Non-Employee Director Gwen Binder was the last director to join the board, commencing their role in 2020. The company’s insufficient board refreshment is considered a risk according to the Simply Wall St Risk Model.
공시 • Jun 29Instil Bio, Inc. Announces Oral Presentation of ITIL-306 Preclinical Data at British Society for Gene and Cell Therapy Annual ConferenceInstil Bio, Inc. reported an oral presentation at the British Society for Gene and Cell Therapy Annual Conference, demonstrating that its proprietary CoStimulatory Antigen Receptor (CoStAR) platform enhances activity of TILs against autologous tumor. The presentation highlighted CoStAR’s unique mechanism of action which results in greatly enhanced activity of TILs when activation occurs through both the native TCR and engineered CoStAR receptors. Additionally, novel data demonstrated that Instil’s FRa-CoStAR enhances activity of TILs against autologous tumors with varied expression of FRa including ovarian, renal, and non-small cell lung cancer tumors. The robust activity of NSCLC, ovarian, and renal carcinoma CoStAR-TILs against autologous tumor exceeded that of genetically unmodified melanoma TILs, as measured by secretion of IFN?.
공시 • Jan 10Instil Bio Announces Resumption of Clinical Trial of Costar-Til Candidate Itil-306 in Lung, Ovarian, and Renal CancerInstil Bio, Inc. announced the resumption of its Phase 1 clinical trial of ITIL-306 for the treatment of non-small cell lung cancer (NSCLC), ovarian cancer, and renal cell carcinoma (RCC). With the resumption of the ITIL-306 Phase 1 study, the Company expects to release initial safety, translational, and efficacy data from dose escalation cohorts at a medical conference in 2023. The trial was resumed after the implementation of additional quality safeguards designed to further protect the manufacturing process from potential contaminants. Following its recent reprioritization of clinical programs and corporate restructuring, Instil expects its cash runway to extend into 2025, excluding the potential financing or other monetization of its Tarzana manufacturing site. Instil intends to provide further updates on its pre-clinical pipeline in 2023, including the potential to nominate additional CoStAR candidates and novel TIL technologies for clinical development.
공시 • Nov 16Instil Bio, Inc. Announces Executive ChangesInstil Bio, Inc. announced Appointment of cell therapy pioneer Dr. Robert Hawkins as Head of Research and Development, and resignation of Chief Medical Officer, Dr. Zachary Roberts. Appointment of Head of Research nd Development: Instil announced the appointment of Robert Hawkins, M.B.B.S. Ph.D., as Head of Research and Development. Dr. Hawkins is a world-renowned oncologist and biotechnology innovator, with a focus on development of novel cell and gene therapies. Dr. Hawkins was the founder and CEO of Immetacyte Ltd., a cell therapy company spun out of the University of Manchester where Dr. Hawkins served as Professor of Medical Oncology. Immetacyte Ltd. generated the foundational TIL technology and clinical data on which Instil was founded. Resignation of Chief Medical Officer: Instil announced that, pursuant to a separation agreement, Zachary Roberts, M.D., Ph.D., Chief Medical Officer of the Company, has resigned effective November 11, 2022 to pursue other opportunities. The company appreciates Dr. Roberts’ contributions and wishes him the best in his future endeavors.
Price Target Changed • Nov 16Price target decreased to US$14.50Down from US$21.00, the current price target is an average from 4 analysts. New target price is 587% above last closing price of US$2.11. Stock is down 90% over the past year. The company is forecast to post a net loss per share of US$1.77 next year compared to a net loss per share of US$1.48 last year.
Price Target Changed • Nov 01Price target decreased to US$18.00Down from US$21.00, the current price target is an average from 3 analysts. New target price is 445% above last closing price of US$3.30. Stock is down 85% over the past year. The company is forecast to post a net loss per share of US$1.77 next year compared to a net loss per share of US$1.48 last year.
공시 • Nov 01+ 1 more updateInstil Bio, Inc. Announces Voluntary Pause of Enrollment in Ongoing Clinical Trials of ITIL-168 and ITIL-306Instil Bio, Inc. announced that it has voluntarily paused enrollment in its ongoing clinical trials of ITIL-168 and ITIL-306 and has notified regulatory authorities in the United States, Canada, and the UK. No regulatory agencies, including the FDA, have notified the Company of a clinical hold in any of its clinical trials. The voluntary pause by the Company was instituted following a recent decrease in the rate of successful manufacturing of ITIL-168, resulting in the inability to dose some patients whose individual product of ITIL-168 was not successfully manufactured. A pre-specified safety analysis in the DELTA-1 trial has been conducted on patients who received ITIL-168 and did not identify any unexpected safety issues. The Company has commenced an end-to-end analysis of its manufacturing processes and upon completion of this analysis, plans to take corrective actions to improve the rate of manufacturing success and resume the study. Although no manufacturing failures have been observed to date in the ongoing Phase 1 trial of ITIL-306, the Company has also voluntarily paused enrollment in this trial as part of its overall manufacturing analysis. The Company intends to provide an update on the manufacturing analysis by early first quarter 2023. The Company confirms its previously disclosed cash runway into 2025 upon the successful completion of a potential sale-leaseback transaction of its Tarzana manufacturing facility.
공시 • Oct 19Instil Bio Announces First Patient Dosed with ITIL-306, First Engineered TIL Therapy Using the CoStAR Platform Targeting Folate Receptor Alpha (FRa), in Non-Small Cell Lung CancerInstil Bio, Inc. announced that the first patient has been dosed in a Phase 1 dose escalation study of ITIL-306 (NCT05397093) for the treatment of multiple solid tumors. ITIL-306 is Instil’s first genetically-engineered Costimulatory Antigen Receptor-TIL (CoStAR-TIL) therapy. Instil’s first-in-human Phase 1 study of ITIL-306 is an open-label, multicenter study in patients with non-small cell lung cancer, ovarian cancer, and renal cell carcinoma. Patients in the first dose cohort will receive a target dose of one billion CoStAR-transduced TILs after receiving a reduced intensity lymphodepletion regimen and no post-infusion interleukin-2. The study will evaluate safety of ITIL-306 in addition to efficacy and translational endpoints. The company anticipates reporting initial clinical data from the Phase 1 trial in 2023. ITIL-306 is an autologous TIL cell therapy engineered with a novel and proprietary CoStAR molecule that is activated by folate receptor alpha (FRa) to provide robust costimulatory signals within the tumor microenvironment. CoStAR builds on the key advantages of native TILs to enhance the cytokine release, cytolytic activity, and proliferation of TILs in the tumor microenvironment. Previously published preclinical data demonstrates the ability of CoStAR-T cells to enhance tumor control in vivo in the absence of exogenous IL-2, supporting a treatment regimen free of IL-2 in the Phase 1 study of ITIL-306.
공시 • Sep 07Instil Bio, Inc. Appoints Tim Moore as Chief Operating OfficerInstil Bio, Inc. announced the appointment of Tim Moore to the role of Chief Operating Officer. Tim Moore has more than three decades of leadership experience in biopharmaceutical manufacturing and operations, including at Genentech, Kite and most recently PACT Pharma. From 2016 to 2019, Mr. Moore was Executive Vice President, Technical Operations at Kite Pharma, where he was responsible for technical operations and successfully launched Yescarta®, one of the first FDA-approved CAR-T cell therapies. Prior to Instil, Mr. Moore was the President and Chief Operating Officer of PACT Pharma, a cell therapy company focusing on neo-antigen directed TCR-T cell therapy. Tim Moore Biography: Prior to joining Instil Bio, Mr. Moore served as the President and Chief Operating Officer at PACT Pharma since April of 2020, and as the company’s President and Chief Technology Officer since October of 2019. Before joining PACT, he served as Executive Vice President, Technical Operations at Kite, a Gilead Company, since March of 2016. During this time Mr. Moore was responsible for overseeing the process development, manufacturing, quality and supply chain for the launch of Yescarta®, one of the first CAR T therapies to be developed, manufactured and commercialized, as well as advancement of the Kite pipeline. In addition, Mr. Moore globally expanded the biopharmaceutical operations to serve and support the US and EU as well as key partners in Asia. Prior to Kite, Mr. Moore served as the Senior Vice President, Head of Global Technical Operations – Biologics of Genentech, Inc. and as a member of the Genentech Executive Committee since 2010. In this role, Mr. Moore oversaw global leadership for more than 7,500 professionals across 10 internal sites and over 37 contract manufacturing organizations, as well as global manufacturing and end-to-end quality supply performance of more than 20 biological product families. Prior to that, Mr. Moore was Genentech’s Senior Vice President, Global Supply Chain and Global Engineering from 2007 to 2010. Previously, Mr. Moore served as Vice President, Operations at ZLB Behring (formerly Aventis Behring). He is currently a member of ISPE, PDA and has been a part of the Executive Committee of BioPhorum and serves as a Board member for Cerus and BioLife Solutions. Mr. Moore received a B.S. in Chemical Engineering from Tulsa University and a M.S. in Engineering Management from Northwestern University.
Seeking Alpha • Sep 06Instil Bio appoints Tim Moore as COOInstil Bio (NASDAQ:TIL) has appointed Tim Moore to the role of COO. Mr. Moore most recently served as the President and COO of PACT Pharma, a cell therapy company focusing on neo-antigen directed TCR-T cell therapy.
Price Target Changed • Aug 23Price target decreased to US$22.00Down from US$24.75, the current price target is an average from 3 analysts. New target price is 314% above last closing price of US$5.32. Stock is down 70% over the past year. The company is forecast to post a net loss per share of US$1.81 next year compared to a net loss per share of US$1.48 last year.
분석 기사 • Jul 20We're Keeping An Eye On Instil Bio's (NASDAQ:TIL) Cash Burn RateThere's no doubt that money can be made by owning shares of unprofitable businesses. For example, biotech and mining...
공시 • Jun 26+ 1 more updateInstil Bio, Inc.(NasdaqGS:TIL) dropped from Russell 2000 Growth IndexInstil Bio, Inc.(NasdaqGS:TIL) dropped from Russell 2000 Growth Index
공시 • May 28Instil Bio, Inc. Announces IND Clearance of First CoStAR-TIL Program, ITIL-306, Designed to Enhance Activity in the Tumor MicroenvironmentInstil Bio, Inc. announced IND clearance by the U.S. Food and Drug Administration of ITIL-306, Instil’s first genetically-engineered Costimulatory Antigen Receptor TIL (CoStAR-TIL) therapy, as well as the presentation of supporting in vivo CoStAR data at the 2022 ASCO Annual Meeting. ITIL-306 is an autologous TIL cell therapy engineered with a novel and proprietary Costimulatory Antigen Receptor (CoStAR) that is activated by folate receptor alpha (FRa) to provide robust costimulatory signals. CoStAR builds on the key advantages of native TILs, including their polyclonal anti-tumor reactivity, to enhance the cytokine release, cytolytic activity, and proliferation of TILs in the tumor microenvironment. The design of Instil’s first-in-human Phase 1 study of ITIL-306 will enroll patients with non-small cell lung cancer (NSCLC), ovarian cancer, and renal cell carcinoma (RCC) and will start with a dose of one billion CoStAR-transduced TILs. Manufacturing for ITIL-306 will occur at Instil’s Tarzana, California manufacturing facility. The poster presentation at the 2022 ASCO Annual Meeting will outline findings from studies evaluating anti-FOLR1 CoStAR T cells in vitro as well as a mouse solid tumor model in vivo. The poster presentation highlights results demonstrating enhanced T cell function and tumor control by CoStAR-modified T cells. Importantly, improved tumor control in a mouse solid tumor model occurred without exogenous IL-2 administration, supporting a clinical CoStAR-TIL regimen free of high-dose IL-2. CoStAR T cells showed limited upregulation of PD-1 after target exposure and demonstrated improved persistence in vivo.
Price Target Changed • May 27Price target decreased to US$26.00Down from US$28.00, the current price target is an average from 2 analysts. New target price is 333% above last closing price of US$6.00. Stock is down 66% over the past year. The company is forecast to post a net loss per share of US$1.74 next year compared to a net loss per share of US$1.48 last year.
Price Target Changed • May 24Price target decreased to US$27.75Down from US$30.00, the current price target is an average from 2 analysts. New target price is 243% above last closing price of US$8.09. Stock is down 52% over the past year. The company is forecast to post a net loss per share of US$1.74 next year compared to a net loss per share of US$1.48 last year.
Price Target Changed • Apr 27Price target decreased to US$26.67Down from US$30.00, the current price target is an average from 3 analysts. New target price is 228% above last closing price of US$8.14. Stock is down 55% over the past year. The company is forecast to post a net loss per share of US$1.65 next year compared to a net loss per share of US$1.48 last year.
공시 • Apr 02Instil Bio, Inc., Annual General Meeting, May 20, 2022Instil Bio, Inc., Annual General Meeting, May 20, 2022, at 09:00 Central Standard Time. Location: 3963 Maple Avenue Suite 350 Dallas Texas United States Agenda: To consider election of the Board’s nominees, Bronson Crouch and Jack Nielsen, to the board of directors; to ratify the selection by the Audit Committee of the board of directors of Deloitte & Touche LLP as the independent registered public accounting firm of the company for the year ending December 31, 2022; and to conduct any other business properly brought before the meeting.
공시 • Sep 19Instil Bio Presents Subset Analysis of Patients with Checkpoint-Refractory Advanced Melanoma from Compassionate Use Study at 2021 ESMO CongressInstil Bio, Inc. announced that a subset analysis of treatment outcomes with unselected autologous tumor infiltrating lymphocytes (TILs) in patients with checkpoint inhibitor-refractory advanced cutaneous melanoma was presented at the 2021 European Society for Medical Oncology (ESMO) Congress, taking place virtually from September 16-21, 2021. Among the 12 patients featured in this subset analysis who had disease progression following treatment with a PD-1 inhibitor, all were also resistant to CTLA-4 inhibition with ipilimumab. Seven (58%) patients achieved an objective response, with 1 (8%) achieving a complete response. With a median duration of follow-up of 45.5 months, the median overall survival was 21.3 months with nearly half of patients experiencing long term survival. Side effects of treatment were largely transient, manageable with supportive care, and generally attributable to the lymphodepleting chemotherapy regimen and post-TIL high-dose IL-2 treatment. Outcomes in this highly treatment-refractory subgroup were similar to those observed in all 21 treated patients, with high response rates and an expected safety profile.
공시 • Sep 15Instil Bio Receives IND Clearance to Initiate a Phase 2 Clinical Trial for Patients with Advanced MelanomaInstil Bio, Inc. reported clearance of its Investigational New Drug (IND) application from the U.S. Food and Drug Administration (FDA) to initiate DELTA-1, a global Phase 2 clinical trial of ITIL-168 in patients with advanced melanoma whose disease has relapsed after a PD-1 inhibitor and, if positive for a BRAF-activating mutation, a BRAF inhibitor. The DELTA-1 trial was expanded during the IND review process, in consultation with FDA, to include additional populations of patients with advanced melanoma. Cohorts 2 and 3 will enroll patients who discontinued PD-1 inhibitor therapy due to intolerable toxicity and patients who had an unsatisfactory response to prior PD-1 inhibitor but have not yet experienced disease progression, respectively. Topline safety and efficacy results are expected in 2023 and, if positive, are anticipated to support the submission of a biologics license application (BLA) to the FDA in 2023 and a Marketing Authorization Application (MAA) to the European Medicines Agency in 2024. ITIL-168 is an investigational, autologous cell therapy made from tumor infiltrating lymphocytes, or TILs. Made from each patient’s digested and cryopreserved tumor, ITIL-168 is a TIL cell therapy manufactured to offer an unrestricted T cell receptor (TCR) repertoire. Instil’s proprietary, optimized, and scalable manufacturing process has been designed to capture and preserve the maximum diversity of each patient’s TILs. By collecting the patient’s tumor and immediately processing and then cryopreserving it, process offers significant scheduling flexibility for patients and physicians at the time of both tumor resection and TIL treatment. In addition to DELTA-1, Instil plans to investigate ITIL-168 in additional solid tumor indications in Phase 1 clinical trials beginning in 2022. DELTA-1 is a global, multicenter Phase 2 clinical trial of ITIL-168 in adult patients with advanced melanoma. Using an open-label, single-arm design, the main study cohort will evaluate the efficacy and safety of ITIL-168, when administered after a 5-day course of lymphodepleting chemotherapy and followed by up to 8 doses of high-dose interleukin-2 (IL-2), in patients whose cancer has progressed following a PD-1 inhibitor and, if positive for a BRAF-activating mutation, a BRAF inhibitor. Approximately 80 subjects are planned for enrollment and treatment in Cohort 1. Cohort 2 is anticipated to enroll approximately 25 subjects and is designed to evaluate the efficacy and safety of the regimen in patients who required discontinuation of PD-1 inhibitor(s) due to unacceptable toxicity, regardless of best overall disease response. Cohort 3 is also anticipated to enroll approximately 25 subjects and will evaluate efficacy and safety in patients whose best ongoing response to PD-1 inhibitor(s) is stable disease. Patients in Cohorts 2 and 3 whose cancer expresses a BRAF-activating mutation will be required to have experienced disease progression following BRAF inhibitor therapy. The primary endpoint of DELTA-1 is the objective response rate (ORR) according to RECIST v1.1 as assessed by independent central review. Secondary endpoints include disease control rate, duration of response, progression-free survival, overall survival, and safety.
분석 기사 • Jun 21We're Hopeful That Instil Bio (NASDAQ:TIL) Will Use Its Cash WiselyEven when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
공시 • Mar 19Instil Bio, Inc. has completed an IPO in the amount of $320 million.Instil Bio, Inc. has completed an IPO in the amount of $320 million. Security Name: Common Stock Security Type: Common Stock Securities Offered: 16,000,000 Price\Range: $20 Transaction Features: Reserved Share Offering; Sponsor Backed Offering