お知らせ • Sep 20
CSL Seqirus Shares Data Demonstrating the Potential for Influenza Vaccination to Reduce the Burden on Healthcare Resources
CSL Seqirus, a business of CSL, unveiled new analyses that underscore the potential of influenza vaccines in alleviating the burden of seasonal influenza on hospitals and broader healthcare systems. These data are being presented in poster sessions at the European Scientific Working Group on Influenza (ESWI) Conference taking place in Valencia, from 17-20 September 2023. In France, approximately 2 to 6 million individuals are affected by influenza annually, leading to over 20,000 hospitalizations and 10,000 excess deaths, 90% of which occur in older adults. A new analysis spotlights how influenza vaccines can offer a powerful prevention tool that reduces healthcare resource use. Findings from a dynamic transmission model indicated that standard-dose quadrivalent influenza vaccines for this demographic could reduce hospitalizations by 11.1%-30.0% and ICU admissions by 9.7%-28.7%. Additionally, enhanced vaccines are projected to further reduce the strain on hospitals and intensive care units by 10-15%, supporting bed availability during a potential COVID-19 endemic wave. In Belgium, where roughly 62% of older adults received a standard-dose egg-based influenza vaccine between 2015-2019, an analysis was conducted to investigate the potential cost effectiveness of using an adjuvanted quadrivalent influenza vaccine (aQIV). Findings from the analysis, based on a static cost-effectiveness model, showed that transitioning to aQIV could prevent 6,920 influenza infections a year that would typically seek medical care, along with 530 hospitalizations and 66 deaths. From a cost perspective, aQIV was both cost-effective with an incremental cost of €15,227/QALY when compared to the standard dose and cost-saving compared with the high-dose vaccine. Estimating the Impact of Influenza Vaccination on Acute and ICU Hospital Bed Usage in an Influenza Season Under Endemic Covid-19 in France. Researchers used a dynamic susceptible-exposed-infected-recovered model to simulate influenza transmission and current French influenza vaccination recommendations (e.g. older population, subjects below 65yrs with comorbidities, etc.), with varying rates of vaccine coverage in multiple French population age-groups (6m-2y, 2-17y, 18-49y, 50-64y, 65-74y, 75y+).1 Four scenarios were evaluated: 57% (baseline), 62%, 69%, and 74% coverage in the older population. Results found that standard-dose quadrivalent influenza vaccines for the elderly can reduce hospital (11.09%-30.04%) and ICU (9.67%-28.65%) beds needed to attend subjects with seasonal influenza. In addition enhanced vaccines for the elderly are thought to have an additional impact on hospitals and ICU beds use in France. Cost-Effectiveness of the Adjuvanted Quadrivalent Influenza Vaccine in the Belgian Elderly Population. Researchers used a static cost-effectiveness model customized with the available national data to evaluate costs and outcomes of different vaccination strategies for this analysis. The model forecasts influenza-related costs and benefits for one regular influenza season using the average strain distribution coming from 04 available seasons in Belgium. The analyses, which was recently published in Expert Review of Vaccines, concluded that replacing the standard dose (SD-QIV) with a high dose (HD-QIV) vaccine in the Belgian elderly population would prevent annually 6,920 influenza infections seeking medical care, 530 hospitalizations and 66 deaths. The results of the model suggest that the aQIV is cost-effective compared to the SD-QIV with an incremental cost of €15,227/QALY and is cost-saving compared to the HD-QIV. The latter, due aQIV has a lower unit cost. Sensitivity analyses conducted confirm the robustness of base case results. Economic evaluations in health can be a very useful complement to the decision-making process, and the methodological approaches should be continually refined and improved. Caution must be exercised in interpreting the results of economic evaluations performed in a given setting and in extrapolating to a different population, location, healthcare systems and resource use. It's strongly suggested that economic evaluations should be performed on a regular basis to ensure that the results are valid and up-to-date, and consistent with payer's views and priorities of the societies which are under research. Influenza is a frequently occurring, contagious seasonal respiratory disease that may cause severe illness and life-threatening complications in some people.[3] Influenza can lead to clinical symptoms varying from mild to moderate respiratory illness to severe complications, hospitalization and in some cases, death. Because transmission of influenza viruses to others may occur before symptoms develop and up to 5 to 7 days after becoming sick, the disease can be easily transmitted to others. Preliminary estimates from the Centers for Disease Control and Prevention (CDC) report that during the 2022/23 influenza season, there were an estimated 300,000-650,000 influenza-related hospitalizations in the U.S. The CDC recommends annual vaccination for individuals aged 6 months and older, who do not have any contraindications.[5] Since it takes about two weeks after vaccination for antibodies to develop in the body that help protect against influenza virus infection, it is recommended that people get vaccinated before influenza begins spreading in their community.5 The CDC recommends that people get vaccinated by the end of October. Influenza is a contagious airborne respiratory disease. Pandemic flu occurs when a novel strain emerges that infects people, spreads easily from person-to-person, and to which most people do not have immunity. The risk of influenza-associated morbidity and mortality is greater with pandemic influenza than with seasonal influenza because there is likely to be little or no pre-existing immunity to the novel virus in the human population. The timing and severity of pandemic influenza is unpredictable, four influenza pandemics have occurred over the past century, with the 1918 pandemic being the most severe in recent history, estimated to have killed up to 50 million people worldwide. Strain-specific pandemic influenza vaccines are manufactured in response to the declaration of a pandemic. Pre-pandemic (also called zoonotic) influenza vaccines are developed in the inter-pandemic period to help protect against influenza strains with pandemic potential; these vaccines can be deployed under government instruction to mitigate the risk of an outbreak or provide a first line of defense in advance of a pandemic vaccine if a pandemic were to be declared.