Aptose Biosciences Inc.

Report azionario OTCPK:APTO.F

Capitalizzazione di mercato: US$4.3m

Aptose Biosciences Gestione

Criteri Gestione verificati 3/4

Aptose Biosciences Il CEO è William Rice, nominato in Oct2013, e ha un mandato di 12.58 anni. la retribuzione annua totale è $ 1.08M, composta da 62.8% di stipendio e 37.2% di bonus, comprese azioni e opzioni aziendali. possiede direttamente 0.18% delle azioni della società, per un valore di $ 7.56K. La durata media del mandato del team dirigenziale e del consiglio di amministrazione è rispettivamente 6.3 anni e 12.6 anni.

Informazioni chiave

William Rice

Amministratore delegato

US$1.1m

Compenso totale

Percentuale dello stipendio del CEO62.81%
Mandato del CEO12.6yrs
Proprietà del CEO0.2%
Durata media del management6.3yrs
Durata media del Consiglio di amministrazione12.6yrs

Aggiornamenti recenti sulla gestione

Recent updates

Seeking Alpha • Aug 01

Aptose Biosciences Q2 2022 Earnings Preview

Aptose Biosciences (NASDAQ:APTO) is scheduled to announce Q2 earnings results on Monday, August 1st, after market close. The consensus EPS Estimate is -$0.13 and the consensus Revenue Estimate is $0M Over the last 3 months, EPS estimates have seen 6 upward revisions and 0 downward.
Seeking Alpha • Jul 19

Aptose Biosciences Continues To Drift Without Thesis-Changing Data

Aptose has made some progress in the clinic this year, including additional complete responses for lead program HM43239 and a new formulation of luxeptinib. Expansion studies of '239 in 2023 could pave the way toward registration studies, and dose escalation studies of the new luxeptinib formulation could begin in early 2023. There is a sizable market opportunity for drugs to address patients with hematological cancers who've progressed on other therapies, but the odds and timelines are long. I believe fair value for Aptose is around $4 today, but upside is tied to future positive clinical developments and there's not much room for stumbles or setbacks. It wouldn't be fair to say that there's been no clinical progress at Aptose Biosciences (APTO) since my last update, but there certainly hasn't been enough to really sway investor sentiment, particularly in light of a more risk-averse biotech market. Aptose has two credible hematological oncology products in the pipeline, but there is a still lot of de-risking needed for both programs. I do believe that the market is still heavily discounting the odds of clinical success here, but given the history of oncology drug development, and Aptose's own shaky clinical progress, that's not exactly unfair. I can still see a path toward a substantially higher fair value, but the reality is that investors are likely going to need to wait a year or more for sentiment-moving data. '239 Is Worth Further Exploration From five complete responses and one partial response back at the December 2021 ASH update, Aptose has seen two more complete responses in its HM43239 (or '239) program in relapsed or refractory AML, bringing the total to seven complete responses and one partial response among a 80mg, 120mg, and 160mg dosing group that has treated at least 41 patients as off the last cut-off (early June, ahead of the EHA meeting). Thus far the drug has shown encouraging safety/tolerability, with only one dose-limiting toxicity reported so far (muscle weakness in a patient getting a 200mg dose). While the response rates aren't eye-popping at this point, it's worth remembering that these are not the healthiest patients, as they've already seen drug progression after prior treatments. Based on the early clinical results, management is moving forward with further dose exploration at 80mg, 120mg, and 160mg (the 80mg segment has been completed, with the 120mg and 160mg cohorts about half-complete as of early June) and then two expansion studies. One expansion study will use 120mg (with 80mg and 160mg as bracketing dosages) of '293 as a single-agent therapy in FLT-3 mutated and unmutated AML, while the other will be a combination study with venetoclax (Venclexta, marketed by AbbVie (ABBV) and Roche (RHHBY)). The single-agent study should start later this year, with the combo study slated for the first half of 2023. Should the results of these studies merit it, registrational studies would then start - presumably in 2024 for the single-agent study. It's worth remembering that '293 is targeting the challenging r/r AML market. While there are solid treatment options available as front-line therapies, some patients cannot tolerate them, some do not respond, and others ultimately see their disease mutate around the treatment and become non-responsive/relapsing. Keep this in mind when comparing response rates to other drugs in the space (make sure it's an "apples to apples" comparison). Another Chance For Luxeptinib Aptose's prior lead drug, luxeptinib, still factors significantly into the company's clinical plans today. While the drug showed exciting pre-clinical attributes, clinical results today have not matched that potential. It would seem that the pharmacokinetics of the drug are at least partly to blame, and the company is hoping that a reformulated version of the drug (known as "G3") can lead to patients getting consistent therapeutic doses that produce clinical results. Clinical trial work is underway now, with patients getting G3 at 50mg, 100mg, and 200mg doses and the 50mg dose of G3 demonstrating 200x the exposure level of a 150mg dose of G1. Assuming that the pharmacokinetics and pharmacodynamics (PK and PD) studies merit further development, Aptose should be able to start dose escalation studies of the new formulation in the first half of 2023 in patients with r/r B-cell or r/r AML disease.
Seeking Alpha • Feb 02

Aptose Deep In The Doghouse Due To Lack Of Pipeline Progress

A lack of progress in the clinic, including another disappointing ASH meeting, has led investors to bail out of this risky early-stage biotech. A new formulation of luxeptinib, and potentially greater exposure to the drug, may finally unlock the potential of this once-promising drug, but it's a "show me" story. Recently-acquired '239 looks like an interesting asset for AML, with promising Phase 1 response rates, but it's still early in the development cycle. Between '239 and luxeptinib there is still potential in Aptose's pipeline, but it will take real evidence of clinical efficacy to rebuild sentiment.

Analisi delle retribuzioni degli amministratori delegati

Come è cambiata la remunerazione di William Rice rispetto agli utili di Aptose Biosciences?
DataCompenso totaleStipendioUtili della società
Mar 31 2026n/an/a

-US$28m

Dec 31 2025US$1mUS$677k

-US$25m

Sep 30 2025n/an/a

-US$19m

Jun 30 2025n/an/a

-US$21m

Mar 31 2025n/an/a

-US$21m

Dec 31 2024US$1mUS$647k

-US$25m

Sep 30 2024n/an/a

-US$36m

Jun 30 2024n/an/a

-US$40m

Mar 31 2024n/an/a

-US$47m

Dec 31 2023US$925kUS$623k

-US$51m

Sep 30 2023n/an/a

-US$49m

Jun 30 2023n/an/a

-US$48m

Mar 31 2023n/an/a

-US$44m

Dec 31 2022US$2mUS$599k

-US$42m

Sep 30 2022n/an/a

-US$56m

Jun 30 2022n/an/a

-US$58m

Mar 31 2022n/an/a

-US$61m

Dec 31 2021US$2mUS$582k

-US$65m

Sep 30 2021n/an/a

-US$56m

Jun 30 2021n/an/a

-US$58m

Mar 31 2021n/an/a

-US$60m

Dec 31 2020US$12mUS$582k

-US$55m

Sep 30 2020n/an/a

-US$48m

Jun 30 2020n/an/a

-US$42m

Mar 31 2020n/an/a

-US$32m

Dec 31 2019US$2mUS$562k

-US$26m

Compensazione vs Mercato: La retribuzione totale di William ($USD 1.08M ) è superiore alla media delle aziende di dimensioni simili nel mercato US ($USD 638.05K ).

Compensazione vs guadagni: La retribuzione di William è stata coerente con le performance aziendali dell'ultimo anno.

AMMINISTRATORE DELEGATO

William Rice (66 yo)

12.6yrs
Mandato
US$1,077,641
Compensazione

Dr. William G. Rice, Ph D., had served as an Independent Director of Oncolytics Biotech Inc. since June 08, 2015 until June 30, 2021. He has been the Chief Executive Officer and President of Aptose Bioscie...

Gruppo dirigente

NomePosizioneMandatoCompensazioneProprietà
William Rice
Chairman12.6yrsUS$1.08m0.18%
$ 7.6k
Fletcher Payne
Senior VP3.9yrsUS$710.58k0.0096%
$ 412.6
Rafael Bejar
Senior VP & Chief Medical Officer6.3yrsUS$754.62k0.0096%
$ 412.6
6.3yrs
Durata media
62yo
Età media

Gestione esperta: Il team dirigenziale di APTO.F è esperto e expertise (durata media dell'incarico 6.3 anni).

Membri del Consiglio di amministrazione

NomePosizioneMandatoCompensazioneProprietà
William Rice
Chairman12.6yrsUS$1.08m0.18%
$ 7.6k
Mark Vincent
Independent Director18.7yrsUS$95.00k0.00055%
$ 23.7
Bernd Seizinger
Independent Director3.7yrsUS$103.50k0.022%
$ 956.9
Denis Burger
Lead Independent Director18.7yrsUS$128.50k0.0019%
$ 81.1
Stephen Howell
Member of Scientific Advisory Boardno dataNessun datoNessun dato
Daniel Von Hoff
Member of Scientific Advisory Boardno dataNessun datoNessun dato
Erich Platzer
Independent Director11.4yrsUS$90.00k0.044%
$ 1.9k
Warren Whitehead
Independent Director15.1yrsUS$80.00k0.0013%
$ 55.7
Brian Druker
Chairman of Scientific Advisory Board12.6yrsNessun datoNessun dato
Michael Andreeff
Member of Scientific Advisory Board11.2yrsNessun datoNessun dato
12.6yrs
Durata media
73yo
Età media

Consiglio di amministrazione esperto: Il consiglio di amministrazione di APTO.F è composto da personale esperto e esperto (durata media dell'incarico 12.6 anni).

Analisi aziendale e situazione dei dati finanziari

DatiUltimo aggiornamento (ora UTC)
Analisi dell'azienda2026/05/21 06:15
Prezzo dell'azione a fine giornata2026/05/21 00:00
Utili2026/03/31
Utili annuali2025/12/31

Fonti dei dati

I dati utilizzati nella nostra analisi aziendale provengono da S&P Global Market Intelligence LLC. I seguenti dati sono utilizzati nel nostro modello di analisi per generare questo report. I dati sono normalizzati, il che può comportare un ritardo nella disponibilità della fonte.

PacchettoDatiTempisticaEsempio Fonte USA *
Dati finanziari della società10 anni
  • Conto economico
  • Rendiconto finanziario
  • Bilancio
Stime di consenso degli analisti+3 anni
  • Previsioni finanziarie
  • Obiettivi di prezzo degli analisti
Prezzi di mercato30 anni
  • Prezzi delle azioni
  • Dividendi, scissioni e azioni
Proprietà10 anni
  • Top azionisti
  • Insider trading
Gestione10 anni
  • Team di leadership
  • Consiglio di amministrazione
Sviluppi principali10 anni
  • Annunci aziendali

* Esempio per i titoli statunitensi, per i titoli non statunitensi si utilizzano forme e fonti normative equivalenti.

Se non specificato, tutti i dati finanziari si basano su un periodo annuale ma vengono aggiornati trimestralmente. Si tratta dei cosiddetti dati TTM (Trailing Twelve Month) o LTM (Last Twelve Month). Per saperne di più.

Modello di analisi e Snowflake

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Metriche di settore e industriali

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Fonti analitiche

Aptose Biosciences Inc. è coperta da 9 analisti. 0 di questi analisti ha fornito le stime di fatturato o di utile utilizzate come input per il nostro report. Le stime degli analisti vengono aggiornate nel corso della giornata.

AnalistaIstituzione
Matthew VeneziaAlliance Global Partners
Dylan DupuisB. Riley Securities, Inc.
John NewmanCanaccord Genuity