Connect Biopharma Holdings Limited

Report azionario NasdaqGM:CNTB

Capitalizzazione di mercato: US$149.9m

Connect Biopharma Holdings Performance degli utili passati

Criteri Il passato verificati 0/6

Connect Biopharma Holdings ha registrato una crescita degli utili a un tasso medio annuo di 40.5%, mentre il settore Biotechs ha registrato utili in crescita a un tasso medio annuo di 37.7%. I ricavi sono stati in crescita a un tasso medio annuo di 50.4%.

Informazioni chiave

40.53%

Tasso di crescita degli utili

52.33%

Tasso di crescita dell'EPS

Biotechs Crescita del settore17.04%
Tasso di crescita dei ricavi50.40%
Rendimento del capitale proprio-151.58%
Margine netto-27,727.90%
Ultimo aggiornamento sugli utili31 Mar 2026

Aggiornamenti sulle prestazioni recenti

Recent updates

Articolo di analisi • May 20

Here's Why Connect Biopharma Holdings (NASDAQ:CNTB) Must Use Its Cash Wisely

Just because a business does not make any money, does not mean that the stock will go down. For example, although...
Seeking Alpha • Apr 29

Connect Biopharma: New Market Opportunity In The Emergency Setting

Summary Connect Biopharma Holdings is rated a risky Buy, with high upside potential hinging on mid-2026 Phase 2 trial results for rademikibart. Rademikibart has shown superior efficacy and safety to Dupixent in China Phase 3 trials, with commercialization led by Simcere and low-double-digit royalties to CNTB. CNTB is targeting the emergency asthma and COPD settings in the US, a market with no approved biologics, and expects pivotal Phase 2 data in mid-2026. Current cash runway extends into 2H 2027, with potential China milestone payments and royalties providing further liquidity if rademikibart is approved. Read the full article on Seeking Alpha
Articolo di analisi • Sep 27

Connect Biopharma Holdings (NASDAQ:CNTB) Is In A Strong Position To Grow Its Business

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Articolo di analisi • Mar 07

Companies Like Connect Biopharma Holdings (NASDAQ:CNTB) Are In A Position To Invest In Growth

Just because a business does not make any money, does not mean that the stock will go down. For example, although...
Articolo di analisi • Sep 19

Is Connect Biopharma Holdings (NASDAQ:CNTB) In A Good Position To Invest In Growth?

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Articolo di analisi • Mar 29

Will Connect Biopharma Holdings (NASDAQ:CNTB) Spend Its Cash Wisely?

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Articolo di analisi • Dec 14

Is Connect Biopharma Holdings (NASDAQ:CNTB) In A Good Position To Deliver On Growth Plans?

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Seeking Alpha • Oct 10

Market Appears To Relegate Connect Biopharma To A Long-Term Hold

Summary Lead product candidate CBP-201 had a successful pivotal trial. After an initial surge, traders selling the news brought prices 15% below the previous close. CBP-201 is now on a near-certain path to approval in the world's 2nd largest market. (Editor's Note: This is a follow-up to the contributor's September 26, 2022 article) On October 4, 2022, Connect Biopharma (CNTB) announced topline results for CBP-201's atopic dermatitis (or AD) study in China. The primary endpoint and key secondary endpoints were all met with high statistical significance (Table 1). CBP-201 turned in Dupixent-level numbers and more, but the stock was punished on a day the iShares Biotechnology ETF (IBB) and SPDR S&P Biotech ETF (XBI) rose 2.86% and 3.78%, respectively. This may be a prime opportunity for long-term investors looking for value to buy the dip. Table 1. Efficacy results of CN002 CBP-201 Placebo P-value Primary endpoint: IGA 0 or 11 30.3 7.5 <0.001 EASI-502 83.1 41.1 <0.001 EASI-753 62.9 23.4 <0.001 EASI-904 35.8 6.3 <0.001 % change in EASI5 -73.7 -36.6 <0.001 PP-NRS [4+]6 35 9.6 <0.001 PP-NRS [3+]7 46.7 16.7 <0.001 % change in PP-NRS8 -38.1 -12.3 <0.001 1 % of patients with 0 or 1 point ("clear" or "almost clear") on validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD) scale and ≥2-point reduction in IGA from baseline at Week 16 2 % of patients with ≥50% improvement in Eczema Area and Severity Index ((EASI)) score from baseline to Week 16 3 % of patients with ≥75% improvement in EASI score from baseline at Week 16 4 % of patients with ≥90% improvement in EASI score from baseline at Week 16 5 % improvement in EASI at Week 16 6 % of patients with ≥4-point reduction on Peak Pruritus-Numerical Rating Scale (PP-NRS) from baseline at Week 16 7 % of patients with ≥3-point reduction on PP-NRS from baseline at Week 16 8 % change in PP-NRS at Week 16 CN002 is a randomized, double-blind, multi-center, controlled trial in Chinese subjects aged 12 to 75 with moderate to severe AD. At the screening and baseline visit, patients had to have, among other things, a) IGA score of ≥3 out of 4 (see Figure 1), b) EASI score ≥16 out of 72 and c) average daily score on the PP-NRS of ≥4 out of 10. Figure 1. Eli Lilly The FDA has recommended an IGA as the primary endpoint for new drug approval trials in AD since the days of Elidel cream, while the global Harmonising Outcome Measures for Eczema (or HOME) initiative prefers the EASI. HOME also endorses PP-NRS to measure itch intensity, a core symptom of AD, based on the question: 'On a scale of 0 to 10, with 0 being "no itch" and 10 being "worst itch imaginable", how would you rate your itch at the worst moment during the previous 24 hours?' Thus, China's Center for Drug Evaluation of the National Medical Products Administration (or CDE) deemed that a positive primary analysis on a subset of 255 adult patients who had completed the initial 16-week period (Stage 1) of this well-designed study would support a New Drug Application (or NDA). CBP-201 delivered, with efficacy results comparable to Dupixent, the only interleukin-4 receptor alpha (IL-4Rα) on the market and jointly sold by Sanofi (SNY) and Regeneron (REGN). Table 2 shows additional data aligning with the CN002 topline results. So why did the market react so negatively? It might be a case of too little, too late. Table 2. Efficacy results of Dupixent in major trials of adult subjects with moderate-to-severe AD, using the current recommended initial dose of 600 mg, followed by 300 mg given every other week (Q2W) SOLO 1 SOLO 2 LIBERTY AD CHRONOS Chinese Phase III Dupixent Placebo Dupixent Placebo Dupixent Placebo Dupixent Placebo IGA 0 or 1 37.9 10.3 36.1 8.5 38.7 12.4 26.8 4.8 EASI-50 68.8 24.6 65.2 22.0 80.2 37.5 70.7 28.9 EASI-75 51.3 14.7 44.2 11.9 68.9 23.2 57.3 14.5 EASI-90 35.7 7.6 30.0 7.2 39.6 11.1 40.2 6.0 % change in EASI -72.3 -37.6 -67.1 -30.9 -76.7 -43.2 -75.23 -39.4 PP-NRS [4+] 40.8 12.3 36.0 9.5 58.8 19.7 39.0 4.8 PP-NRS [3+] 46.8 17.2 50.6 12.8 65.7 27.8 52.4 9.6 % change in PP-NRS -51.0 -26.1 -44.3 -15.4 -56.2 -28.6 -48.59 -21.13 Connect Bio did not release data among the topline results that clearly maintained a quicker onset by CBP-201 over Dupixent. Yes, improvements in EASI at Week 2 (26.3% change with CBP-201 vs 13.8% for placebo, p < 0.001) were significant and clinically meaningful. Baseline EASI score was 29.6, so the average improvement was approximately 7.8 points, which is higher than minimal clinically important difference of 6.6 points and also correlates to at least a 1-point improvement in the IGA. It was a good start, but not better than Dupixent. Now, management is angling for a positive showing for the more convenient Q4W dosing, as well as increased efficacy post-16 weeks (Figure 2), as potential areas of differentiation. Figure 2. CBP-201 Secondary Endpoint CNTB October 2022 Corporate Presentation, p. 14 Now the waiting begins for the Stage 2 36-week readout. If the last Stage 1 patient was dosed in June, their 36-week visit would occur by May of next year. Stage 2 will more likely than not show statistical significance for both active regimens. This will also include 52-week safety data, which so far has been exemplary. By that time, data from additional adult and adolescent Stage 1 patients outside the primary analysis population could also be available. Connect Bio will next be requesting a pre-biologics license application with the CDE to determine the next steps for a potential NDA filing. Risks and Takeaways Some of the key points from our article from a few weeks ago remain: CNTB is a risky biotechnology stock. Investors in a bear market prefer companies with stable earnings, even in the defensive health sector, so might pass over biotech, especially microcaps. So long as CNTB is below $5, the threshold will also preclude most institutions and mutual funds from buying. ETFs such as IBB and XBI may be safer means of exposure to the sector.
Seeking Alpha • Sep 26

Connect Biopharma Is A Sleeper Heading Into October Data Readout

Summary The stock is down 80% year-to-date due to disappointing study results from the company’s two lead product candidates, CBP-201 and CBP-307. CBP-307 development has been put on ice. But CBP-201 is back, and if more successful this time, it could be on a fast track for approval in the world’s 2nd largest market. Connect Biopharma Holdings Limited (CNTB) is a microcap (<$75 million) biopharmaceutical company developing T cell-driven therapies to chronic inflammatory diseases with 3 drugs in the clinical-stage (Figure 1). On their Sept. 13 fiscal 2022 half year report was an announcement that they expected top-line results next month for the pivotal CBP-201 atopic dermatitis (or AD) trial in Chinese adults. CBP-201 is an antibody targeting interleukin-4 receptor alpha (IL-4Rα) like Dupixent, the blockbuster drug jointly sold by Sanofi (SNY) and Regeneron (REGN). Previously in November 2021, the WW001 global Phase 2 AD clinical trial met its primary efficacy endpoint, but Connect Biopharma didn’t provide immediate specifics. The market dropped the stock 58% (Figure 1) as it took the lack of details as an unfavorable comparison to Dupixent. Subsequent analyses released in January didn’t lift the share price. Nevertheless, the explanations shared by the company were reasonable, and the actual results bolster the likelihood of success in China. Figure 1. Pipeline, Page 4 of September 2022 Corporate Presentation Connect Biopharma pipeline (Connect Biopharma) Figure 2. One-year price chart Connect Biopharma price chart (Seeking Alpha) A Huge Showcase Opportunity for CBP-201 On July 11, Connect Biopharma said that China’s Center for Drug Evaluation of the National Medical Products Administration (or CDE) had deemed a positive primary efficacy analysis based on the 255 patients already enrolled, together with data from the CBP-201 Phase 1 and global Phase 2 AD trials, would be enough to support the filing of a New Drug Application in that country. CBP-201 patients in the current study received a loading dose of 600 mg followed by 300 mg every two weeks (Q2W). The primary endpoint is the Investigator’s Global Assessment (or IGA) 0,1 response rate, which is the proportion of patients whose IGA score is 0 and/or 1 (“clear/almost clear” skin) with a decrease of IGA score by at least 2 points from baseline, as measured through the first 16 weeks (Stage 1 of the treatment period) of the 60-week trial. Key secondary endpoints include Eczema Area and Severity Index (or EASI)-50/75/90 response rates, which are the proportion of patients with ≥50%/75%/90% improvement in EASI score from baseline to week 16. Per CDE recommendations, IGA and EASI response rates will be analyzed as co-primary endpoints. The 300 mg CBP-201 Q2W is the strongest regimen tested so far, and the only cohort in WW001 that demonstrated statistically significant improvement (p value<0.001) in the primary endpoint of EASI % reduction from baseline at Week 16 (-63% vs -40.7% for placebo), as well as multiple key secondary endpoints listed in Table 1. Scores on the EASI range from 0 to 72, while the IGA ranges from 0 to 4, with higher scores indicating greater severity on both scales. There was also a greater treatment benefit of CBP-201 among patients enrolled in the China sub-population (-82.9% vs -34.9% for placebo). Table 1. Efficacy results of WW001 Full analysis set Placebo China subgroup Placebo EASI-501 54.4% 33.9% 50.0% 33.3% EASI-752 47.4% 14.3% 50.0% 0.0% IGA 0 or 13 28.1% 10.7% 33.3% 0.0% 1 % of patients with ≥50% improvement in Eczema Area and Severity Index score from baseline to week 16 2 % of patients with ≥75% reduction in EASI score from baseline at week 16 3 % of patients with 0 or 1 point on Investigator’s Global Assessment and ≥2-point reduction in IGA from baseline at week 16 Although it is a me-too follow-up to Dupixent, CBP-201 has the potential to be best-in-class among IL-4Rα antagonists. In 2020, a Phase 1b study exhibited early, rapid and durable improvements in several measures. At week 4, EASI change from baseline was 74.4% for the 300 mg dose compared with 32.9% for placebo. Additionally, 42.9% of patients receiving 300 mg achieved a score of 0 or 1 in the IGA, compared with 12.5% in the placebo group. IGA response is the primary efficacy endpoint required for FDA approval. Value and Financial Outlook According to Quantamental analysis, Connect Biopharma has been a deep value Strong Buy play for a while (Figure 3) and is trading well below cash. Liquidity is not a problem. As of June 30, 2022, the company had $212.9 million in cash, cash equivalents, and investments, which CFO Steven Chan stated was sufficient to fund operations into at least 2024, but cash outflows suggest a need for financing if no partnership help is acquired before the end of next year. H1 2022 operating loss was $60 million, of which research and development expenses took $50.8 million while supporting 6 trials involving all three clinical drugs. Two studies ended: the Phase 1 trial of CBP-174, a peripherally acting antagonist of histamine receptor 3 for the treatment of pruritus associated with AD; and a Phase 2 trial of CBP-307, a modulator of a T-cell receptor known as sphingosine 1-phosphate receptor 1, for the treatment of ulcerative colitis ((UC)). Another two have been terminated early, and the asthma study recruitment is slower than expected, so H2 R&D should be lower. The global Phase 3 initiating by year end might eventually enroll more than 600 patients, assuming patients will be randomized in a 2-to-1 ratio to receive either CBP-201 or placebo, and 200 patients in the control group, as in the Dupixent pivotal trials. Consequently, R&D will increase in 2023, but gradually because it takes longer to set up clinical sites over several countries. H1 administrative expenses totaled $10.7 million and may likely stay in the $10-12 million range for the next year. It is reasonable to expect the company to end 2022 with at least $160 million and burn $75-80 million in H1 2023. Figure 3. Quant Rating Quant rating (Seeking Alpha) Connect Bio has practically put all its eggs in one basket. If the trial meets the primary endpoint, which it likely will, they may not need financing at all. Since they hold global rights to a potential second-to-market to Dupixent, CBP-201 will draw heavy interest, even if it ends up making a fraction of the original. A mere 10% penetration of the first-in-class agent (Dupixent Q2 sales were over $2 billion) would project to at least $800 million in sales annually, or over 10 times CNTB's current market cap. Risks The greatest risk is for the China-specific trial to fail. That would render its Stage 2 irrelevant and likely derail the current plans for the worldwide 4-trial Phase 3 AD program. Since the Phase 2 study in chronic rhinosinusitis with nasal polyps was terminated due to disruptions from COVID-19 and the Ukraine War, any residual hopes for CBP-201 hinge on the readout for the asthma Phase 2b trial, which CEO Zheng Wei said was delayed 6 months to H2 2023. With nothing else on the horizon for a year, CNTB shares would probably sink well below $1, miss regaining compliance with Nasdaq Global Market’s $1 minimum price requirement, and get demoted to the third tier Capital Market. Even if positive, the results may, like WW001, not meet market expectations. Differences exist between trial designs and subjects enrolled, so caution should be exercised when comparing data across trials; but a cursory glance at the performance of the Dupixent dose that was ultimately approved (Table 2) show it to be numerically greater than CBP-201 in WW001. Table 2. Efficacy results of Dupixent in major trials of adult subjects with moderate-to-severe AD, using the current recommended initial dose of 600 mg, followed by 300 mg given every other week (Q2W) CHRONOS SOLO 1 SOLO 2 LIBERTY AD CHRONOS Chinese Phase III Dupixent Placebo Dupixent Placebo Dupixent Placebo Dupixent Placebo Dupixent Placebo EASI-50 78.1 29.5 68.8 24.6 65.2 22.0 80.2 37.5 70.7 28.9 EASI-75 68.8 23.0 51.3 14.7 44.2 11.9 68.9 23.2 57.3 14.5 IGA 0 or 1 39.1 11.5 37.9 10.3 36.1 8.5 38.7 12.4 26.8 4.8
Seeking Alpha • Sep 13

Connect Biopharma reports 1H results

Connect Biopharma press release (NASDAQ:CNTB): 1H Net loss totaled $59.8M. Cash, cash equivalents, and short-term and long-term investments were $212.9M as of June 30, 2022. The Company believes it has sufficient cash and investments to support planned operations into at least 2024 based on its current operating plans. Short-term and long-term investments are indicated as Investments: Financial Assets at Fair Value Through Other Comprehensive Income in the balance sheet.
Articolo di analisi • Aug 12

We're Keeping An Eye On Connect Biopharma Holdings' (NASDAQ:CNTB) Cash Burn Rate

There's no doubt that money can be made by owning shares of unprofitable businesses. For example, biotech and mining...
Articolo di analisi • Apr 29

We're Keeping An Eye On Connect Biopharma Holdings' (NASDAQ:CNTB) Cash Burn Rate

Just because a business does not make any money, does not mean that the stock will go down. For example, biotech and...
Seeking Alpha • Jan 12

Connect Biopharma's Latest Dermatitis Drug Update Fails To Pump Up Shares

Company’s stock sank after it released data on Phase 2b trials for its atopic dermatitis drug, a potential competitor to Regeneron-Sanofi blockbuster Dupixent. Loss-making Connect Biopharma says Phase 3 clinical trials of its CBP-201 drug for atopic dermatitis will begin in second half of this year. Connect Biopharma shares, which more than halved after its November release of initial Phase 2 clinical trial data, fell further after latest update.
Articolo di analisi • Jan 01

We're Hopeful That Connect Biopharma Holdings (NASDAQ:CNTB) Will Use Its Cash Wisely

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...

Ripartizione dei ricavi e delle spese

Come Connect Biopharma Holdings guadagna e spende denaro. In base agli ultimi utili dichiarati, su base LTM.

Storico di utili e ricavi

NasdaqGM:CNTB Ricavi, spese e utili (USD Millions )
DataRicaviUtiliSpese G+ASpese di R&amp;S
31 Mar 260-652046
31 Dec 250-552038
30 Sep 251-492234
30 Jun 252-452031
31 Mar 2526-171826
31 Dec 2426-161728
30 Sep 2425-231735
30 Jun 2424-251640
31 Mar 240-561648
31 Dec 230-621653
30 Sep 230-771764
30 Jun 230-931976
31 Mar 230-1042085
31 Dec 220-1182197
30 Sep 220-13122101
30 Jun 220-1142296
31 Mar 220-1632191
01 Jan 220-2021980
30 Sep 210-2291664
30 Jun 210-2551448
31 Mar 210-1851035
31 Dec 200-119723
31 Dec 190-24115

Guadagni di qualità: CNTB al momento non è redditizia.

Margine di profitto in crescita: CNTB al momento non è redditizia.

Flusso di cassa libero e analisi degli utili

Analisi della crescita degli utili nel passato

Andamento degli utili: CNTB non è redditizia, ma ha ridotto le perdite negli ultimi 5 anni a un tasso pari a 40.5% all'anno.

Accelerare la crescita: Impossibile confrontare la crescita degli utili di CNTB nell'ultimo anno con la sua media quinquennale poiché al momento non è redditizia

Guadagni vs Settore: CNTB non è redditizia, il che rende difficile confrontare la crescita dei suoi utili dell'anno passato con il settore Biotechs ( 59.3% ).

Rendimento del capitale proprio

ROE elevato: CNTB ha un Return on Equity negativo ( -151.58% ), in quanto al momento non è redditizio.

Rendimento delle attività

Rendimento del capitale investito

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Analisi aziendale e situazione dei dati finanziari

DatiUltimo aggiornamento (ora UTC)
Analisi dell'azienda2026/07/20 21:57
Prezzo dell'azione a fine giornata2026/07/20 00:00
Utili2026/03/31
Utili annuali2025/12/31

Fonti dei dati

I dati utilizzati nella nostra analisi aziendale provengono da S&P Global Market Intelligence LLC. I seguenti dati sono utilizzati nel nostro modello di analisi per generare questo report. I dati sono normalizzati, il che può comportare un ritardo nella disponibilità della fonte.

PacchettoDatiTempisticaEsempio Fonte USA *
Dati finanziari della società10 anni
  • Conto economico
  • Rendiconto finanziario
  • Bilancio
Stime di consenso degli analisti+3 anni
  • Previsioni finanziarie
  • Obiettivi di prezzo degli analisti
Prezzi di mercato30 anni
  • Prezzi delle azioni
  • Dividendi, scissioni e azioni
Proprietà10 anni
  • Top azionisti
  • Insider trading
Gestione10 anni
  • Team di leadership
  • Consiglio di amministrazione
Sviluppi principali10 anni
  • Annunci aziendali

* Esempio per i titoli statunitensi, per i titoli non statunitensi si utilizzano forme e fonti normative equivalenti.

Se non specificato, tutti i dati finanziari si basano su un periodo annuale ma vengono aggiornati trimestralmente. Si tratta dei cosiddetti dati TTM (Trailing Twelve Month) o LTM (Last Twelve Month). Per saperne di più.

Modello di analisi e Snowflake

I dettagli del modello di analisi utilizzato per generare questo report sono disponibili sulla nostra pagina GitHub; abbiamo anche delle guide su come utilizzare i nostri report e dei tutorial su YouTube.

Scoprite il team di livello mondiale che ha progettato e realizzato il modello di analisi Simply Wall St.

Metriche di settore e industriali

Le nostre metriche di settore e di sezione sono calcolate ogni 6 ore da Simply Wall St; i dettagli del nostro processo sono disponibili su Github.

Fonti analitiche

Connect Biopharma Holdings Limited è coperta da 12 analisti. 8 di questi analisti ha fornito le stime di fatturato o di utile utilizzate come input per il nostro report. Le stime degli analisti vengono aggiornate nel corso della giornata.

AnalistaIstituzione
Julian HarrisonBTIG
Edward NashCanaccord Genuity
Olivia BrayerCantor Fitzgerald & Co.