New Risk • Aug 18
New minor risk - Profitability The company is currently unprofitable and not forecast to become profitable over the next 3 years. Trailing 12-month net loss: US$31m Forecast net loss in 3 years: US$29m This is considered a minor risk. Companies that are not profitable are more likely to be burning through cash and less likely to be well established. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. Without profits, the company is under pressure to grow significantly while potentially having to reduce costs and possibly needing to take on debt or raise capital to remain afloat. Currently, the following risks have been identified for the company: Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$29m net loss in 3 years). Share price has been volatile over the past 3 months (9.9% average weekly change). Shareholders have been diluted in the past year (21% increase in shares outstanding). Reported Earnings • Aug 13
Second quarter 2026 earnings released: US$0.13 loss per share (vs US$0.15 loss in 2Q 2025) Second quarter 2026 results: US$0.13 loss per share (improved from US$0.15 loss in 2Q 2025). Revenue: US$14.9m (down 2.7% from 2Q 2025). Net loss: US$12.0m (loss narrowed 9.5% from 2Q 2025). Revenue is forecast to grow 22% p.a. on average during the next 3 years, compared to a 17% growth forecast for the Life Sciences industry in the United Kingdom. Over the last 3 years on average, earnings per share has increased by 29% per year but the company’s share price has fallen by 2% per year, which means it is significantly lagging earnings. New Risk • Aug 12
New major risk - Shareholder dilution The company's shareholders have been substantially diluted in the past year. Increase in shares outstanding: 32% This is considered a major risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Major Risk Shareholders have been substantially diluted in the past year (32% increase in shares outstanding). Minor Risk Share price has been volatile over the past 3 months (10% average weekly change). Annuncio • Aug 12
Codexis, Inc. Reaffirms Earnings Guidance for the Full Year 2026 Codexis, Inc. reaffirmed earnings guidance for the full year 2026. For the period, the company continues to expect revenues to be in the range of $72 million to $76 million. Annuncio • Aug 04
Codexis, Inc. Announces Strategic Advisory Board Changes Codexis, Inc. announced the appointment of David Butler, PhD, to its Strategic Advisory Board. Dr. Butler will provide technical guidance, industry expertise, and strategic insight to support Codexis’ ongoing growth, innovation and core mission. David Butler has over 20 years of experience in the oligonucleotide field, most recently serving as Chief Technology Officer with Hongene Biotech Corporation from 2023 to 2026. Prior to Hongene, he led chemistry organizations at Wave Life Sciences, Korro Bio, and Alltrna. Earlier in his career at Alnylam, he contributed to the development of liquid nanoparticle (LNP) delivery technologies, the foundation for today’s mRNA-based therapeutics and vaccines. He holds a BSc and PhD in Chemistry from St. Andrews University. Codexis, Inc. also announced that Carole Cobb will be stepping down from the Strategic Advisory Board. Annuncio • Jul 28
Codexis, Inc. to Report Q2, 2026 Results on Aug 11, 2026 Codexis, Inc. announced that they will report Q2, 2026 results After-Market on Aug 11, 2026 Annuncio • Jul 25
Codexis, Inc. has completed a Follow-on Equity Offering in the amount of $25.000001 million. Codexis, Inc. has completed a Follow-on Equity Offering in the amount of $25.000001 million.
Security Name: Common Stock
Security Type: Common Stock
Securities Offered: 16,666,667
Price\Range: $1.5
Discount Per Security: $0.09 New Risk • Jul 25
New major risk - Share price stability The company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of British stocks, typically moving 11% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. This is currently the only risk that has been identified for the company. Annuncio • May 22
Codexis Inc Highlights Stereochemistry Advances for Scalable RNA Manufacturing At Tides USA Codexis, Inc. shared new advances in RNA therapeutic manufacturing at TIDES USA 2026 at the Hynes Convention Center in Boston. Through presentations and a panel discussion, the Company highlighted how its ECO Synthesis Manufacturing Platform is advancing the production of siRNA, now enabling stereochemical control while addressing key industry challenges in scalability and sustainability. At the conference, Codexis presented new data demonstrating, for the first time, full-length siRNA synthesis with precise control of phosphorothioate stereochemistry using its ECO Synthesis platform. Stereochemistry—the three-dimensional arrangement of atoms within a molecule—plays an important role in how oligonucleotide therapeutics perform, influencing their efficacy and product quality. During Codexis’ expert panel, “Stereochemistry Control in RNAi Manufacturing: Signal or Noise?”, drug development leaders from Corsera Health, Arrowhead Pharmaceuticals, and Wave Life Sciences emphasized that stereochemical control is an important—and increasingly necessary—factor in advancing next-generation RNA therapeutics in order to optimize potency, and potentially enable novel dosage forms using higher concentrations of active pharmaceutical ingredient. Codexis also announced a new advancement for its ECO Synthesis platform: the ability to initiate enzymatic RNA synthesis starting from a single nucleotide. This will eliminate the need for a chemically-synthesized starter oligonucleotide, commonly used to initiate enzymatic nucleotide additions. This advancement is particularly important for the increasingly popular practice of ligating fragments into a complete siRNA molecule. The ability to make fully enzymatic fragments, together with highly engineered, highly efficient ligases such as those developed by Codexis, present a future state optimal production strategy for siRNA. Codexis shared sustainability data, showing the ECO Synthesis platform achieved more than a 50% reduction in global warming potential compared to conventional synthetic approaches. The company reported approximately 2.7-fold lower global warming potential on an input materials basis, driven in part by reduced organic solvent use and aqueous processing. Ligation and stereochemical control are becoming increasingly important as the RNA therapeutics field matures. The aqueous production of the ECO Synthesis Manufacturing Platform together with the potential to eliminate purification steps when using ligation strategies result in both superior process and environmental efficiency. Codexis continues to advance its ECO Synthesis platform as part of its broader strategy to discover and industrialize scalable manufacturing solutions for complex RNA therapeutics. Reported Earnings • May 10
First quarter 2026 earnings released: US$0.096 loss per share (vs US$0.25 loss in 1Q 2025) First quarter 2026 results: US$0.096 loss per share (improved from US$0.25 loss in 1Q 2025). Revenue: US$15.2m (up 102% from 1Q 2025). Net loss: US$8.70m (loss narrowed 58% from 1Q 2025). Revenue is forecast to grow 18% p.a. on average during the next 3 years, compared to a 18% growth forecast for the Life Sciences industry in the United Kingdom. Over the last 3 years on average, earnings per share has increased by 18% per year but the company’s share price has only increased by 2% per year, which means it is significantly lagging earnings growth. Annuncio • Apr 30
Codexis, Inc., Annual General Meeting, Jun 17, 2026 Codexis, Inc., Annual General Meeting, Jun 17, 2026. New Risk • Apr 26
New minor risk - Profitability The company is currently unprofitable and not forecast to become profitable over the next 3 years. Trailing 12-month net loss: US$44m Forecast net loss in 3 years: US$1.1m This is considered a minor risk. Companies that are not profitable are more likely to be burning through cash and less likely to be well established. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. Without profits, the company is under pressure to grow significantly while potentially having to reduce costs and possibly needing to take on debt or raise capital to remain afloat. Currently, the following risks have been identified for the company: Major Risk Share price has been highly volatile over the past 3 months (17% average weekly change). Minor Risk Currently unprofitable and not forecast to become profitable over next 3 years (US$1.1m net loss in 3 years). Breakeven Date Change • Apr 26
No longer forecast to breakeven The 7 analysts covering Codexis no longer expect the company to break even during the foreseeable future. The company was expected to make a profit of US$20.0m in 2028. New consensus forecast suggests the company will make a loss of US$1.11m in 2028. Annuncio • Apr 23
Codexis, Inc. to Report Q1, 2026 Results on May 07, 2026 Codexis, Inc. announced that they will report Q1, 2026 results After-Market on May 07, 2026 Reported Earnings • Mar 12
Full year 2025 earnings released: US$0.51 loss per share (vs US$0.89 loss in FY 2024) Full year 2025 results: US$0.51 loss per share (improved from US$0.89 loss in FY 2024). Revenue: US$70.4m (up 19% from FY 2024). Net loss: US$44.0m (loss narrowed 33% from FY 2024). Revenue is forecast to grow 22% p.a. on average during the next 3 years, compared to a 9.6% growth forecast for the Life Sciences industry in Europe. Over the last 3 years on average, earnings per share has increased by 4% per year but the company’s share price has fallen by 26% per year, which means it is significantly lagging earnings. Annuncio • Mar 12
Codexis, Inc. Provides Earnings Guidance for Full Year 2026 Codexis, Inc. provided earnings guidance for full year 2026. The company expects total revenues are expected to be in the range of $72 million to $76 million. Annuncio • Feb 25
Codexis, Inc. to Report Q4, 2025 Results on Mar 11, 2026 Codexis, Inc. announced that they will report Q4, 2025 results After-Market on Mar 11, 2026 New Risk • Feb 24
New minor risk - Market cap size The company's market capitalization is less than US$100m. Market cap: US$96.6m This is considered a minor risk. Companies with a small market capitalization are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Minor Risks Less than 1 year of cash runway based on current free cash flow (-US$62m). Share price has been volatile over the past 3 months (11% average weekly change). Market cap is less than US$100m (US$96.6m market cap). Breakeven Date Change • Feb 06
Forecast to breakeven in 2028 The 6 analysts covering Codexis expect the company to break even for the first time. New consensus forecast suggests the company will make a profit of US$20.0m in 2028. Average annual earnings growth of 61% is required to achieve expected profit on schedule. Board Change • Feb 06
High number of new directors There are 6 new directors who have joined the board in the last 3 years. President, CEO & Director Alison Moore was the last director to join the board, commencing their role in 2025. The company’s lack of board continuity is considered a risk according to the Simply Wall St Risk Model. Annuncio • Oct 23
Codexis, Inc. to Report Q3, 2025 Results on Nov 06, 2025 Codexis, Inc. announced that they will report Q3, 2025 results After-Market on Nov 06, 2025 Reported Earnings • Aug 14
Second quarter 2025 earnings released: US$0.15 loss per share (vs US$0.32 loss in 2Q 2024) Second quarter 2025 results: US$0.15 loss per share (improved from US$0.32 loss in 2Q 2024). Revenue: US$15.3m (up 92% from 2Q 2024). Net loss: US$13.3m (loss narrowed 42% from 2Q 2024). Revenue is forecast to grow 24% p.a. on average during the next 3 years, compared to a 19% growth forecast for the Life Sciences industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 20% per year whereas the company’s share price has fallen by 25% per year. Annuncio • Jul 31
Codexis, Inc. to Report Q2, 2025 Results on Aug 13, 2025 Codexis, Inc. announced that they will report Q2, 2025 results After-Market on Aug 13, 2025 Annuncio • May 22
Codexis, Inc. Presents Data at the Tides USA Annual Meeting in San Diego, California Codexis, Inc. presented data at the TIDES USA annual meeting in San Diego, California. Codexis' presentations showcased its proprietary ECO Synthesis platform's ability to support siRNA manufacturing by reducing purification costs, improving process performance, and demonstrating the potential to control stereochemistry. During an oral Main Stage presentation, Codexis used inclisiran as an example to showcase how the use of mobilized enzymes in its ECO Synthesis platform delivers a consistent process with improved performance. Using sequential enzymatic synthesis, company: Continued to achieve consistent coupling efficiency of >98% Maintained the delivery of high product quality; Successfully decreased average cycle time by approximately 24%, translating into reduced production time; Demonstrated high yields of 30 grams of siRNA per liter. Using Codexis' ligase to manufacture siRNA, company data demonstrated the potential to reduce or eliminate costly downstream purification steps. This benefit of ligation has led many companies to explore using this method in siRNA manufacturing. The company's poster presentation highlighted how the Company's recently launched machine learning tool is improving the success rate of ligation to produce siRNA. The tool aids process design by guiding the selection of optimal pairings of ligases and RNA fragments and has been shown to significantly outperform traditional fragment selection by four to sixfold. By accelerating the ligase selection process and maximizing ligation efficiency, this tool demonstrates the potential to reduce process development time, lower costs, and enable an efficient manufacturing process for customers. Three CDMO Collaborator Presentations feature the Use of Codexis Ligases to Combine Short RNA Fragments: In addition to Codexis' presentations, Bachem, Nitto Avecia, and ST Pharm, three leading CDMOs in siRNA manufacturing, presented data on the use of Codexis ligases to successfully combine short RNA fragments. In a separate TIDES Talk presentation, Codexis highlighted a new feature under development for the ECO Synthesis technology to allow for stereochemical control during oligonucleotide synthesis. In contrast, the data in this oral presentation demonstrate how the ECO Synthesis platform can enable control over stereochemistry under process-relevant conditions. Annuncio • May 15
Codexis, Inc. Reiterates Earnings Guidance for Full-Year 2025 Codexis, Inc. Reiterated earnings guidance for full-year 2025. The company expects total revenues to be in the range of $64 million to $68 million. New Risk • May 15
New major risk - Financial position The company has less than a year of cash runway based on its current free cash flow trend. Free cash flow: -US$54m This is considered a major risk. With less than a year's worth of cash, the company will need to raise capital or take on debt unless its cash flows improve. This would dilute existing shareholders or increase balance sheet risk. Currently, the following risks have been identified for the company: Major Risks Less than 1 year of cash runway based on free cash flow trend (-US$54m free cash flow). Share price has been highly volatile over the past 3 months (15% average weekly change). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$6.8m net loss in 3 years). Shareholders have been diluted in the past year (17% increase in shares outstanding). Annuncio • May 01
Codexis, Inc. to Report Q1, 2025 Results on May 14, 2025 Codexis, Inc. announced that they will report Q1, 2025 results After-Market on May 14, 2025 Annuncio • Apr 28
Codexis, Inc., Annual General Meeting, Jun 10, 2025 Codexis, Inc., Annual General Meeting, Jun 10, 2025. Annuncio • Apr 10
Codexis, Inc. Announces Retirement of Byron L. Dorgan as Director On April 4, 2025, Byron L. Dorgan provided notice to the board of directors of Codexis, Inc. of his intention to retire and not to stand for reelection to the Board at the expiration of his current term at the Company’s 2025 Annual Meeting of Stockholders (the “2025 Annual Meeting”). Mr. Dorgan’s decision not to stand for reelection is not the result of any disagreement with the Company on any matter relating to its operations, policies, practices or otherwise. Mr. Dorgan will remain a director until the 2025 Annual Meeting. Mr. Dorgan joined the Board in 2011, served as Chairman from 2021 through 2024, and currently serves as the Chair of the Nominating and Corporate Governance Committee. He will remain a consultant to Codexis for one year following his departure from the Board. Annuncio • Apr 01
Codexis, Inc. Appoints Cynthia Collins to the Board of Directors Codexis, Inc. announced the appointment of Cynthia Collins to the company’s board of directors. Cynthia Collins is a recognized leader with more than four decades of experience working in the pharmaceutical and biotech industry. She currently serves as Executive Chair and interim CEO of Nutcracker Therapeutics, a contract, research, development and manufacturing organization with a next generation RNA precision manufacturing platform. Previously, she was the CEO of Editas Medicine, a premier CRISPR company where she oversaw the first clinical trial administration of an in vivo CRISPR gene editing therapy. Her other notable roles include CEO of Human Longevity, CEO and general manager of various life science businesses at GE Healthcare, CEO of GenVec, group vice president at Beckman Coulter, CEO of Sequoia Pharmaceuticals, and president of oncology at Baxter Healthcare. Ms. Collins also currently serves as a board member at Certara, MaxCyte, DermTech, Alanis Therapeutics, Draper Laboratories, and Foundation for mRNA Medicines. She holds a bachelor’s degree in microbiology from the University of Illinois Urbana-Champaign and an MBA from the University of Chicago Booth School of Business. New Risk • Mar 08
New minor risk - Profitability The company is currently unprofitable and not forecast to become profitable over the next 3 years. Trailing 12-month net loss: US$65m Forecast net loss in 3 years: US$11m This is considered a minor risk. Companies that are not profitable are more likely to be burning through cash and less likely to be well established. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. Without profits, the company is under pressure to grow significantly while potentially having to reduce costs and possibly needing to take on debt or raise capital to remain afloat. Currently, the following risks have been identified for the company: Major Risk Share price has been highly volatile over the past 3 months (13% average weekly change). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$11m net loss in 3 years). Shareholders have been diluted in the past year (18% increase in shares outstanding). Breakeven Date Change • Mar 07
Forecast to breakeven in 2027 The 7 analysts covering Codexis expect the company to break even for the first time. New consensus forecast suggests losses will reduce by 25% per year to 2026. The company is expected to make a profit of US$5.11m in 2027. Average annual earnings growth of 56% is required to achieve expected profit on schedule. New Risk • Mar 03
New minor risk - Profitability The company is currently unprofitable and not forecast to become profitable over the next 3 years. Trailing 12-month net loss: US$65m Forecast net loss in 3 years: US$6.6m This is considered a minor risk. Companies that are not profitable are more likely to be burning through cash and less likely to be well established. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. Without profits, the company is under pressure to grow significantly while potentially having to reduce costs and possibly needing to take on debt or raise capital to remain afloat. Currently, the following risks have been identified for the company: Major Risk Share price has been highly volatile over the past 3 months (13% average weekly change). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$6.6m net loss in 3 years). Shareholders have been diluted in the past year (18% increase in shares outstanding). Breakeven Date Change • Feb 28 The 7 analysts covering Codexis previously expected the company to break even in . New consensus forecast suggests the company will make a profit of US$0 in . Earnings growth of 59% is required to achieve expected profit on schedule.
Buy Or Sell Opportunity • Feb 28
Now 29% undervalued after recent price drop Over the last 90 days, the stock has fallen 35% to US$2.97. The fair value is estimated to be US$4.21, however this is not to be taken as a buy recommendation but rather should be used as a guide only. Revenue has declined by 28% over the last 3 years. Earnings per share has declined by 37%. For the next 3 years, revenue is forecast to grow by 21% per annum. Earnings are also forecast to grow by 59% per annum over the same time period. Annuncio • Feb 28
Codexis, Inc. Provides Earnings Guidance for 2025 Codexis, Inc. provided earnings guidance for 2025. The company expects total revenues to be in the range of $64 million to $68 million. Reported Earnings • Feb 28
Full year 2024 earnings released: US$0.89 loss per share (vs US$1.12 loss in FY 2023) Full year 2024 results: US$0.89 loss per share (improved from US$1.12 loss in FY 2023). Revenue: US$59.3m (down 15% from FY 2023). Net loss: US$65.3m (loss narrowed 14% from FY 2023). Revenue is forecast to grow 23% p.a. on average during the next 3 years, compared to a 11% growth forecast for the Life Sciences industry in Europe. Over the last 3 years on average, earnings per share has fallen by 37% per year whereas the company’s share price has fallen by 42% per year. Annuncio • Feb 14
Codexis, Inc. to Report Q4, 2024 Results on Feb 27, 2025 Codexis, Inc. announced that they will report Q4, 2024 results at 4:00 PM, US Eastern Standard Time on Feb 27, 2025 Annuncio • Feb 09
Codexis, Inc. Appoints Arthur Levin to Strategic Advisory Board Codexis, Inc. announced the appointment of Arthur Levin, PhD, to the Company’s Strategic Advisory Board (SAB). Dr. Levin is a founding member of Avidity Biosciences, and currently serves on its Board of Directors. He brings three decades of experience developing oligonucleotides to Codexis as it continues to onboard customers for its Enzyme Catalyzed Oligonucleotide (ECO) Synthesis™ manufacturing platform. In addition to his role on the Board of Directors, Dr. Levin previously held the positions of Distinguished Scientist, Strategic Leader and Chief Scientific Officer at Avidity. Dr. Levin is a highly regarded key opinion leader in the RNA therapeutics field who has led teams responsible for the development of many oligonucleotides. Prior to joining Avidity, Dr. Levin was the Executive Vice President of Research and Development at miRagen Therapeutics and held senior drug development roles at Ionis (formerly Isis) Pharmaceuticals and Santaris Pharmaceuticals. He has published more than 100 scientific articles and has authored several of the most cited reviews in the field. In addition to Codexis, he serves on the scientific advisory boards of multiple institutions. Dr. Levin received a doctorate in toxicology from the University of Rochester and holds a bachelor’s degree in biology from Muhlenberg College. Buy Or Sell Opportunity • Jan 23
Now 23% undervalued Over the last 90 days, the stock has risen 72% to US$5.01. The fair value is estimated to be US$6.47, however this is not to be taken as a buy recommendation but rather should be used as a guide only. Revenue has declined by 22% over the last 3 years. Earnings per share has declined by 46%. For the next 3 years, revenue is forecast to grow by 21% per annum. Earnings are also forecast to grow by 48% per annum over the same time period. Annuncio • Jan 17
Codexis, Inc. Appoints Christos Richards to Board of Directors Codexis, Inc. announced the appointment of Christos Richards to the Company’s Board of Directors. Christos Richards brings over 30 years of global executive advisory and search experience for the biopharmaceutical and healthcare industry to Codexis. To date, he has completed more than 450 executive level assignments, including over 200 Board, CEO and CEO succession projects in the Life Sciences sector. He currently serves as Global Head of Healthcare and Life Sciences at Calibre One, a global executive search firm with offices across California as well as Chicago, New York and London. Mr. Richards serves clients from venture-backed startups to leading global enterprises in devices, diagnostics, agricultural biotechnology, animal health, tools, services and digital health sectors. He has spent 20 years as a partner with two prominent boutique search firms, including serving as Chief Executive Officer of Levin & Company. Mr. Richards previously served on the Board of Directors for Coherus BioSciences and is also an advisor for the University of California, San Francisco Innovation Ventures Entrepreneurship Center. He holds a diploma in hospitality management from Schweizerische Wirteschule in Lucerne/Davos, Switzerland. Buy Or Sell Opportunity • Jan 08
Now 21% undervalued Over the last 90 days, the stock has risen 67% to US$5.10. The fair value is estimated to be US$6.46, however this is not to be taken as a buy recommendation but rather should be used as a guide only. Revenue has declined by 22% over the last 3 years. Earnings per share has declined by 46%. For the next 3 years, revenue is forecast to grow by 21% per annum. Earnings are also forecast to grow by 48% per annum over the same time period. New Risk • Dec 10
New major risk - Share price stability The company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of British stocks, typically moving 10% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risk Share price has been highly volatile over the past 3 months (10% average weekly change). Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$12m net loss in 3 years). Shareholders have been diluted in the past year (17% increase in shares outstanding). Annuncio • Nov 15
Codexis, Inc. Unveils Pioneering Enzymatic Synthesis Data to Enable the Future Manufacturing of RNAi Therapeutics Codexis, Inc. announced data from three presentations at the TIDES Europe annual meeting being held November 12-14, 2024, in Hamburg, Germany. The data demonstrate the Company’s rapid advancement of its Enzyme Catalyzed Oligonucleotide (ECO) Synthesis™ manufacturing platform and establish Codexis’ position at the forefront of enzymatic synthesis technology to enable to ongoing expansion of RNAi therapeutics. During an oral Spotlight Presentation, Codexis unveiled the successful end-to-end enzymatic synthesis of an entire approved siRNA therapeutic asset, inclisiran. Codexis enzymatically synthesized the full-length sense and antisense strands of the molecule, including the enzymatic incorporation of a tissue-targeting moiety to the sense strand. To date, this process has only been completed utilizing phosphoramidite chemistry, a process that involves the use of harsh chemical conditions and vast amounts of toxic organic solvents. By contrast, Codexis’ ECO Synthesis manufacturing platform operates under milder, aqueous conditions, that improves product quality and dramatically decreases chemical waste production. In addition to this fully enzymatic route of synthesis, the Company demonstrated similar outcomes utilizing three routes of enzymatic ligation to produce the siRNA therapeutic asset, combining oligonucleotide fragments made by sequential enzymatic synthesis and traditional phosphoramidite chemistry. Key data from the presentation include: Achieved incorporation efficiency of >98% during sequential enzymatic oligo synthesis. Successfully attached the tri-GalNAc tissue-targeting moiety by enzymatic ligation. Obtained full-length oligonucleotides of equal quality and yields, using ligation of short fragments made with enzymes or by traditional phosphoramidite chemistry. Now that Codexis has successfully achieved this unprecedented milestone, the Company will continue to optimize its process for robustness, scaled-up quantities and improved purity with the goal of providing customers with siRNA material of comparable or better quality to phosphoramidite chemistry. The Company anticipates ramping up manufacturing of siRNA in quantities for preclinical testing following the successful build out of its ECO Synthesis Innovation Lab at the end of this year. Two additional presentations focused on results of direct comparisons of Codexis’ engineered double-stranded RNA (dsRNA) ligases and wild-type (WT) enzymes when used to combine short oligonucleotide fragments to synthesize full-length siRNA therapeutic compounds. In a joint poster with Bachem, one of the world’s leading CDMOs in oligonucleotide manufacturing, the data provided compelling external validation of the superior performance of Codexis ligases over existing wild-type enzymes in use today. Codexis enzymes demonstrated superior performance over wild-type enzymes across both volumetric productivity and substrate versatility. These dsRNA ligases outperformed on multiple substrate designs and enabled a higher conversion rate of oligonucleotide fragments into siRNA at increased concentrations of raw materials. In a separate TIDES Talk presentation, Codexis demonstrated improved performance of its dsRNA ligase over WT enzymes based on real customer case studies executed through the Company’s RNA Ligase Screening and Optimization Services, launched in May 2024. Codexis’ engineered ligases delivered robust, in-process performance, including higher substrate loading, faster reaction times and improved conversation at elevated temperatures. These data demonstrate the Company’s ability to accelerate delivery of lead ligase variants to customers and optimize process conditions for a customer’s specific asset. Annuncio • Nov 13
Codexis, Inc. Appoints Raymond De Vré to Board of Directors Codexis, Inc. announced the appointment of Raymond De Vré, PhD, to the Company’s Board of Directors. Dr. De Vré brings over 20 years of executive-level experience to Codexis. He currently serves as Managing Director at RADV Advisory, an independent strategic and operational advisory company focused on investments in the global healthcare and contract development and manufacturing organization (CDMO) space. Prior to founding RADV Advisory, he was the Chief Executive Officer of PolyPeptide Group, a CDMO focused on peptide- and oligonucleotide-based therapies for pharmaceutical and biotech companies globally. Prior to PolyPeptide, Dr. De Vré held multiple senior leadership roles at Dr. Reddy’s Laboratories, including Senior Vice President, Head of Biologics, and served as a member of the Management Council. Earlier in his career, he was a Partner at McKinsey & Company, working mostly in the pharmaceutical and biotech practice. Dr. De Vré holds a PhD in Applied Physics from Stanford University and a master’s degree in engineering from Université Libre de Bruxelles. New Risk • Nov 05
New minor risk - Shareholder dilution The company's shareholders have been diluted in the past year. Increase in shares outstanding: 17% This is considered a minor risk. Shareholder dilution occurs when there is an increase in the number of shares on issue that is not proportionally distributed between all shareholders. Often due to the company raising equity capital or some options being converted into stock. All else being equal, if there are more shares outstanding then each existing share will be entitled to a lower proportion of the company's total earnings, thus reducing earnings per share (EPS). While dilution might not always result in lower EPS (like if the company is using the capital to fund an EPS accretive acquisition) in a lot cases it does, along with lower dividends per share and less voting power at shareholder meetings. Currently, the following risks have been identified for the company: Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$18m net loss in 3 years). Share price has been volatile over the past 3 months (9.3% average weekly change). Shareholders have been diluted in the past year (17% increase in shares outstanding). Reported Earnings • Nov 01
Third quarter 2024 earnings released: US$0.29 loss per share (vs US$0.50 loss in 3Q 2023) Third quarter 2024 results: US$0.29 loss per share (improved from US$0.50 loss in 3Q 2023). Revenue: US$12.8m (up 38% from 3Q 2023). Net loss: US$20.6m (loss narrowed 41% from 3Q 2023). Revenue is forecast to grow 20% p.a. on average during the next 3 years, compared to a 20% growth forecast for the Life Sciences industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 46% per year but the company’s share price has fallen by 57% per year, which means it is performing significantly worse than earnings. Annuncio • Oct 11
Codexis, Inc. to Report Q3, 2024 Results on Oct 31, 2024 Codexis, Inc. announced that they will report Q3, 2024 results After-Market on Oct 31, 2024 Annuncio • Oct 03
Codexis, Inc. Announces Executive Changes Codexis, Inc. announced an increase in its cash reserves through capital raises totaling $31 million via the Company’s existing at-the-market facility during the quarter ended September 30, 2024. In addition to the financing, the Company strengthened its management team through the appointments of Alison Moore, PhD, to the newly created role of Chief Technology Officer. The Company also announced the appointment of John Schiffhauer as Senior Vice President of Intellectual Property. Mr. Schiffhauer brings over 20 years of experience in legal operations and intellectual property at Intel, and most recently, Zymergen, to this newly created role focused on managing the Company’s complex IP portfolio and executing strategic partnerships around it. Alison Moore brings to Codexis significant experience as a biotechnology and pharmaceutical executive, including an extensive background in biomanufacturing. She is former Chief Technical Officer of Allogene Therapeutics, a pioneering clinical-stage company advancing CAR-T therapies. Prior to Allogene, she spent a total of 20 years at Amgen, most recently as Senior Vice President, Process Development, and including roles in Supply Chain and Manufacturing. Dr. Moore also has experience at Genentech as a Director in Chemistry, Manufacturing and Controls, and in Regulatory Affairs. Dr. Moore holds a bachelor’s degree in pharmacology with honors and a doctorate degree in cell biology from Manchester University, England. Reported Earnings • Aug 09
Second quarter 2024 earnings released: US$0.32 loss per share (vs US$0.17 loss in 2Q 2023) Second quarter 2024 results: US$0.32 loss per share (further deteriorated from US$0.17 loss in 2Q 2023). Revenue: US$7.98m (down 63% from 2Q 2023). Net loss: US$22.8m (loss widened 98% from 2Q 2023). Revenue is forecast to grow 19% p.a. on average during the next 3 years, compared to a 18% growth forecast for the Life Sciences industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 51% per year whereas the company’s share price has fallen by 49% per year. Annuncio • Aug 09
Codexis, Inc. Reiterates Earnings Guidance for the Full Year 2024 Codexis, Inc. reiterated earnings guidance for the full year 2024. For the year, Product revenues are expected to be in the range of $38 million to $42 million, excluding revenue related to PAXLOVID. Annuncio • Jul 19
Codexis, Inc. to Report Q2, 2024 Results on Aug 08, 2024 Codexis, Inc. announced that they will report Q2, 2024 results After-Market on Aug 08, 2024 Annuncio • Jul 02
Codexis, Inc. (NasdaqGS:CDXS) entered into an asset purchase agreement to acquire Gene Therapy Assets of Crosswalk Therapeutics. Codexis, Inc. (NasdaqGS:CDXS) entered into an asset purchase agreement to acquire Gene Therapy Assets of Crosswalk Therapeutics on July 1, 2024. Annuncio • May 15
Codexis, Inc. Presents Enzymatic Synthesis Data at TIDES USA Annual Meeting and Launches RNA Ligase Screening and Optimization Services Codexis, Inc. announced it has successfully synthesized an oligonucleotide via an enzymatic route to support RNA-based therapeutics manufacturing. Data highlighting this historic manufacturing milestone are being presented on May 14, 2024 in a Spotlight Presentation at the TIDES USA annual meeting taking place in Boston, MA, and virtually May 14 – 17, 2024. Codexis Enzymatically Synthesizes Fully Modified RNA Oligonucleotide: During the presentation, Codexis will showcase data on the enzymatic synthesis of a known siRNA oligonucleotide that incorporates the nucleotide modifications most frequently found in approved therapeutic assets today. This includes the synthesis of siRNA compounds using the Company’s Enzyme Catalyzed Oligonucleotide (ECO) Synthesis manufacturing platform from a starter oligonucleotide to the inclusion of a conjugation moiety. This final step primes the oligonucleotide for the attachment of a customer’s proprietary targeting moiety to enable direct delivery of the therapeutic agent to the desired cells. Key data from the presentation noted that the ECO Synthesis manufacturing platform: Incorporated RNA bases with common modifications used in current siRNA therapeutic assets; Achieved coupling efficiency greater than 98%; Executed the enzymatic addition of a conjugation moiety; and Confirmed lack of notable impurities typically observed in phosphoramidite chemistry synthesis. Now that Codexis has successfully achieved this important technical milestone, the Company is continuing process development to optimize yield, purity and quality with the goal of providing customers with siRNA material of comparable or better quality to phosphoramidite chemistry for preclinical testing. Codexis Launches RNA Ligase Screening and Optimization Services: Codexis also on May 14, 2024 announced the launch of its RNA Ligase Screening and Optimization Services. An overview of this new offering will be highlighted during a TIDES Talk session on Thursday, May 16, 2024. During phosphoramidite chemical synthesis of RNA, each nucleotide added to the growing oligonucleotide amplifies inherent coupling errors, leading to a decrease in the yield of the desired full-length RNA construct. By utilizing a ligation approach, multiple short, single-stranded RNA (ssRNA) fragments can be synthesized, via phosphoramidite chemistry or the ECO Synthesis manufacturing platform, then duplexed and ligated together with an ecoRNA double-stranded ligase to form the desired double-stranded RNA (dsRNA) construct. This method provides the potential for higher purity and yield, which allows for increased scalability and reduced manufacturing costs. As part of Codexis’ Center of Excellence for Enzymatic RNA Synthesis, the Company provides RNA ligase screening and optimization services, which include the custom evolution of dsRNA ligase enzyme variants, screening and protocol optimization for manufacturing and use of the dsRNA ligase, and research-grade RNA production, which can be used for future preclinical studies. Reported Earnings • May 03
First quarter 2024 earnings released: US$0.17 loss per share (vs US$0.34 loss in 1Q 2023) First quarter 2024 results: US$0.17 loss per share (improved from US$0.34 loss in 1Q 2023). Revenue: US$17.1m (up 32% from 1Q 2023). Net loss: US$11.5m (loss narrowed 49% from 1Q 2023). Revenue is forecast to grow 15% p.a. on average during the next 3 years, compared to a 11% growth forecast for the Life Sciences industry in Europe. Over the last 3 years on average, earnings per share has fallen by 49% per year whereas the company’s share price has fallen by 48% per year. Annuncio • May 03
Codexis, Inc. Reiterates Financial Guidance for the Fiscal 2024 Codexis, Inc. reiterated financial guidance for the fiscal 2024. For the period, the company product revenues are expected to be in the range of $38 million to $42 million, excluding revenue related to PAXLOVID™. R&D revenues are expected to be in the range of $18 million to $22 million. Annuncio • Apr 28
Codexis, Inc., Annual General Meeting, Jun 11, 2024 Codexis, Inc., Annual General Meeting, Jun 11, 2024, at 09:00 Pacific Standard Time. Agenda: To elect the two Class II directors nominees identified in the accompanying proxy statement to hold office until the 2027 annual meeting of stockholders; to ratify the selection by the Audit Committee of the board of directors of KPMG LLP as an independent registered public accounting firm for the fiscal year ending December 31, 2024; to approve, on a non-binding, advisory basis, the compensation of named executive officers; and transact such other business as may properly come before the Annual Meeting. Annuncio • Apr 20
Codexis, Inc. to Report Q1, 2024 Results on May 02, 2024 Codexis, Inc. announced that they will report Q1, 2024 results After-Market on May 02, 2024 Annuncio • Apr 11
Codexis, Inc. Appoints Carole Cobb to Its Strategic Advisory Board Codexis, Inc. announced the appointment of Carole Cobb, MBA, to the Company’s Strategic Advisory Board (SAB). Ms. Cobb is the former Chief Operating Officer at GreenLight Biosciences, a bio-performance company developing RNA-based solutions for agriculture and pharmaceutical applications. Her deep biotechnology experience includes leadership roles across fermentation-based commercial manufacturing, process development, plant operations and global supply chain management. Ms. Cobb has forty years of bio-based industry experience and is currently a business consultant for biotechnology companies. Most recently, she served as the Chief Operating Officer at GreenLight Biosciences where she led the Company’s efforts to scale their proprietary bioprocessing methods. Prior to joining GreenLight, Ms. Cobb served as Chief Operating Officer at Cobalt Technologies. Earlier in her career, Ms. Cobb held senior leadership roles at Danisco A/S and Genencor International. She holds a Master of Business Administration from the University of Rochester and Bachelor of Science degrees in Chemical Engineering, Biochemistry and Cell & Molecular Biology from the State University of New York at Buffalo. Current members include John Maraganore, PhD, founder and former Chief Executive Officer of Alnylam Pharmaceuticals; Masad Damha, PhD, Distinguished James McGill Professor at McGill University; Jim Lalonde, PhD, biotechnology consultant for start-up companies in enzyme engineering and former Senior Vice President of Research and Development at Codexis; and Carole Cobb, MBA, biotechnology consultant and former Chief Operating Officer at GreenLight Biosciences. Board Change • Mar 01
High number of new directors There are 5 new directors who have joined the board in the last 3 years. Member of Strategic Advisory Board John M. Maraganore was the last director to join the board, commencing their role in 2024. The company’s lack of board continuity is considered a risk according to the Simply Wall St Risk Model. Reported Earnings • Feb 29
Full year 2023 earnings released: US$1.12 loss per share (vs US$0.51 loss in FY 2022) Full year 2023 results: US$1.12 loss per share (further deteriorated from US$0.51 loss in FY 2022). Revenue: US$70.1m (down 49% from FY 2022). Net loss: US$76.2m (loss widened 127% from FY 2022). Revenue is forecast to grow 16% p.a. on average during the next 3 years, compared to a 20% growth forecast for the Life Sciences industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 48% per year whereas the company’s share price has fallen by 43% per year. New Risk • Feb 29
New major risk - Revenue and earnings growth Earnings are forecast to decline by an average of 0.4% per year for the foreseeable future. This is considered a major risk. Ultimately, shareholders want to see a good return on their investment and that generally comes from sharing in the company's profits. If profits are expected to decline, then in most cases the share price will decline over time as well. In addition, if the company pays dividends it will also likely need to reduce or cut them, striking a dual blow to total shareholder returns. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (21% average weekly change). Earnings are forecast to decline by an average of 0.4% per year for the foreseeable future. Minor Risks Currently unprofitable and not forecast to become profitable over next 3 years (US$11m net loss in 3 years). Shareholders have been diluted in the past year (5.9% increase in shares outstanding). Annuncio • Feb 21
Codexis, Inc Appoints Masad Damha, PhD and Jim Lalonde, PhD to Strategic Advisory Board Codexis, Inc. announced the appointment of Masad Damha, PhD, and Jim Lalonde, PhD, to the Company’s Strategic Advisory Board (SAB), joining John Maraganore, PhD, the founder and former Chief Executive Officer of Alnylam Pharmaceuticals. This board is now comprised of experts across oligonucleotide synthesis and manufacturing and was established to help guide the Company’s strategic direction, providing critical insights to inform the continued development of Codexis’ ECO Synthesis™ manufacturing platform. Masad Damha, PhD, is the Distinguished James McGill Professor at McGill University. His research has been instrumental in the development of new therapeutic drugs based on RNA targeting and gene editing, and he has authored more than 200 publications. Dr. Damha is a co-founder of Anagenis, Inc., a start-up with proprietary antisense technologies (ANA and FANA). His FANA technology is being applied by multiple research laboratories and industries to assess and develop modified oligonucleotides against several biological targets, including cancer and infectious diseases. Dr. Damha has served as the President of both the International Society of Nucleosides, Nucleotides and Nucleic Acids and the Oligonucleotide Therapeutic Society, and currently serves on the Editorial Board of the journal Nucleic Acids Therapeutics. He received both his PhD and BSc in Organic Chemistry from McGill University. Jim Lalonde, PhD, is a biotechnology consultant for start-up companies in enzyme engineering and biotechnology. Presently, Dr. Lalonde serves as Chairman of the Board of Directors at Willow Biosciences and as a Scientific Advisory Board member at Bota Biosciences, bitBiome, Curie Co. and Invizyne. Most recently, Dr. Lalonde served as the head of the Microbial Digital Genome Engineering Business at Inscripta. Prior to Inscripta, he spent nearly 15 years at Codexis, culminating in the role of Senior Vice President of Research and Development, where he oversaw the development of more than 50 enzymes for biotherapeutics, drug manufacturing, nutrition and molecular diagnostics applications. Earlier in his career, Dr. Lalonde held leadership roles in biocatalysis and chemical development at Altus Biologics and in scientific research at Vista Chemical Company. Dr. Lalonde earned a PhD in Organic Chemistry from Texas A&M University and a BS in Chemistry from Lakehead University. Annuncio • Feb 17
Codexis, Inc. Announces Not to Stand for Reelection of Jennifer Aaker as Board of Director Codexis, Inc. announced on February 13, 2024, Jennifer Aaker, Ph.D. provided notice to the board of directors of Codexis, Inc. of her intention not to stand for reelection to the Board at the expiration of her current term at the company’s 2024 Annual Meeting of Stockholders (the 2024 Annual Meeting). Dr. Aaker’s decision not to stand for reelection is not the result of any disagreement with the company on any matter relating to its operations, policies, practices or otherwise. Dr. Aaker will remain a director until the 2024 Annual Meeting. Annuncio • Feb 02
seqWell and Codexis to Unveil Engineered Transposase Enzyme for Genomics Applications at AGBT General Meeting seqWell and Codexis, Inc. announced the creation of an engineered high-performance transposase enzyme designed to drive superior performance in sequencing applications. The co-development of this new transposase enzyme - called TnX transposase - builds upon a multi-year partnership between the two companies, leveraging Codexis' strength in enzyme engineering, and seqWell's expertise in developing tools to improve next-generation sequencing (NGS) performance. Performance data highlighting this enzyme will be presented during the Advances in Genome Biology and Technology (AGBT) General Meeting being held February 5 - 8, 2024 in Orlando, Florida. This newly engineered transposase is designed to exhibit significantly lower bias, potentially providing more uniform coverage of sequenced DNA; improved activity, converting a higher percentage of DNA to library; and improved robustness across a range of assay conditions. seqWell plans to incorporate the TnX transposase into new NGS workflow kits currently in development. Annuncio • Dec 14
Aldevron, LLC entered into an agreement to acquire global exclusive license for Codex® HiCap RNA Polymerase from Codexis, Inc. (NasdaqGS:CDXS). Aldevron, LLC entered into an agreement to acquire global exclusive license for Codex® HiCap RNA Polymerase from Codexis, Inc. (NasdaqGS:CDXS) on December 13, 2023. Under the terms of the deal, Aldevron will receive global manufacturing and commercialization rights to the Codex® HiCap RNA Polymerase and Codexis will receive payments for near-term technical milestones, along with commercial milestones and sales-based royalties. Annuncio • Nov 03
Codexis, Inc. Reiterates Earnings Guidance for the Year 2023 Codexis, Inc. reiterated earnings guidance for the year 2023. Codexis reiterated its 2023 financial guidance ranges originally issued on July 20, 2023, and reiterated on August 3, 2023, as follows: Product revenues are expected to be in the range of $30 million to $35 million, excluding enzyme sales related to PAXLOVID™. R&D revenues are expected to be in the range of $21 million to $24 million. Reported Earnings • Nov 03
Third quarter 2023 earnings released: US$0.50 loss per share (vs US$0.15 loss in 3Q 2022) Third quarter 2023 results: US$0.50 loss per share (further deteriorated from US$0.15 loss in 3Q 2022). Revenue: US$9.28m (down 73% from 3Q 2022). Net loss: US$34.9m (loss widened 249% from 3Q 2022). Revenue is forecast to grow 17% p.a. on average during the next 3 years, compared to a 17% growth forecast for the Life Sciences industry in the United Kingdom. Annuncio • Oct 28
Codexis, Inc. to Present Update on Eco Synthesis Platform At Tides Europe Codexis, Inc. announced a presentation highlighting the role of an enzymatic approach to support RNA-based therapeutics manufacturing at the TIDES Europe annual meeting taking place in Amsterdam, Netherlands and virtually October 30- November 1, 2023. During the presentation, Codexis will showcase how engineered enzymes can complement traditional chemical synthesis methods by addressing scalability, cost and waste challenges associated with commercial-scale production. The Company will also showcase its technical progress on its Enzyme-Catalyzed Oligonucleotide (ECO) Synthesis(TM) technology platform, being developed to enable an enzymatic route of nucleic acid synthesis. The presentation will be held live and virtually on November 1, 2023. The Company will make a video recap of the TIDES Europe presentation available on its website following the conclusion of the meeting. About the ECO Synthesis(TM) Platform Ribonucleic acid (RNA) as a therapeutic modality has gained tremendous traction in recent years with the growing number of messenger RNA (mRNA) vaccines and small interfering RNA (siRNA) candidates advancing in clinical studies. However, large-scale production of RNAi therapeutics using traditional chemical synthesis faces complex challenges in nucleic acids quality and quantity, as well as overall economics. With over 450 RNA interference (RNAi) therapies currently in clinical development, including more than 40 assets in Phase 2 and Phase 3 clinical trials targeting disease indications impacting millions of patients, RNAi therapeutic demand is projected to outpace current production capabilities by the end of the decade. Codexis' proprietary ECO Synthesis(TM") technology platform is being designed to address these scalability and cost limitations by potentially enabling the commercial-scale manufacture of RNAi therapeutics through an enzymatic route. The Company is on track to demonstrate gram-scale synthesis by the end of 2023, where it will demonstrate the preparative-scale manufacture of an oligonucleotide, composed of the modified nucleotide building blocks typically used in RNAi therapeutics, under process-like conditions. Annuncio • Oct 20
Codexis, Inc. to Report Q3, 2023 Results on Nov 02, 2023 Codexis, Inc. announced that they will report Q3, 2023 results After-Market on Nov 02, 2023 Buying Opportunity • Jun 01
Now 23% undervalued after recent price drop Over the last 90 days, the stock is down 54%. The fair value is estimated to be US$2.94, however this is not to be taken as a buy recommendation but rather should be used as a guide only. Revenue has grown by 27% over the last 3 years. Earnings per share has declined by 24%. For the next 3 years, revenue is forecast to grow by 20% per annum. Earnings is also forecast to grow by 28% per annum over the same time period. Annuncio • May 11
Codexis, Inc. Unveils Eco Synthesis Platform for Large-Scale RNAi Therapeutics Production at Tides USA Codexis, Inc. announced the unveiling of its Enzyme-Catalyzed Oligonucleotide (ECO) Synthesis(TM) technology, a proprietary new synthesis platform being developed for manufacturing RNA oligonucleotide therapeutics at scale. The ECO Synthesis(TM) technology was unveiled during a pre-conference workshop at the TIDES USA annual meeting, being held May 7-10, 2023, in San Diego, CA. Ribonucleic acid (RNA) as a therapeutic modality has gained tremendous traction in recent years with the growing number of messenger RNA (mRNA) vaccines and small interfering RNA (siRNA) product candidates advancing in clinical studies. However, large-scale production faces complex challenges in nucleic acids quality and quantity, as well as overall economics. By replacing phosphoramidite chemistry with enzymatic methods, Codexis' proprietary ECO Synthesis(TM)technology is specifically engineered to overcome these difficulties to enable scalable and sustainable manufacturing. Annuncio • May 06
Codexis, Inc. Provides Revenue Guidance for the Year 2023 Codexis, Inc. provided revenue guidance for the year 2023. For the year, the company expects total revenue guidance range of $63 million to $68 million. Reported Earnings • May 05
First quarter 2023 earnings released: US$0.34 loss per share (vs US$0.13 loss in 1Q 2022) First quarter 2023 results: US$0.34 loss per share (further deteriorated from US$0.13 loss in 1Q 2022). Revenue: US$13.0m (down 63% from 1Q 2022). Net loss: US$22.6m (loss widened 171% from 1Q 2022). Revenue is forecast to grow 20% p.a. on average during the next 3 years, compared to a 16% growth forecast for the Life Sciences industry in the United Kingdom. Recent Insider Transactions • Mar 12
Chief Operating Officer recently sold US$77k worth of stock On the 8th of March, Kevin Norrett sold around 17k shares on-market at roughly US$4.58 per share. This transaction amounted to 16% of their direct individual holding at the time of the trade. This was the largest sale by an insider in the last 3 months. This was Kevin's only on-market trade for the last 12 months. Reported Earnings • Feb 24
Full year 2022 earnings released: US$0.51 loss per share (vs US$0.33 loss in FY 2021) Full year 2022 results: US$0.51 loss per share (further deteriorated from US$0.33 loss in FY 2021). Revenue: US$138.6m (up 32% from FY 2021). Net loss: US$33.6m (loss widened 58% from FY 2021). Revenue is forecast to grow 12% p.a. on average during the next 3 years, compared to a 18% growth forecast for the Life Sciences industry in the United Kingdom. Annuncio • Feb 10
Codexis, Inc. to Report Q4, 2022 Results on Feb 23, 2023 Codexis, Inc. announced that they will report Q4, 2022 results at 4:00 PM, US Eastern Standard Time on Feb 23, 2023 Annuncio • Jan 24
Codexis, Inc. Announces Appointment of Sri Ryali as Chief Financial Officer Codexis, Inc. announced the appointment of Sri Ryali as Chief Financial Officer effective immediately. Mr. Ryali brings 20 years of finance and commercial experience in life sciences to Codexis. In this role, Mr. Ryali will lead all aspects of the Company’s financial operations and will report directly to Dr. Stephen Dilly, President and Chief Executive Officer of Codexis. Most recently, Mr. Ryali served as the Chief Financial Officer of Eiger BioPharmaceuticals, Inc., a publicly traded, commercial-stage company, where he was responsible for finance, investor relations and other general and administrative functions during a period when the company initiated multiple late-stage clinical trials and launched its first commercial product in the United States and Europe. Prior to Eiger BioPharmaceuticals, Mr. Ryali held roles of increasing responsibility at Aimmune Therapeutics, Inc., most recently serving as Vice President of Finance. Prior to this, he was Senior Director, Financial Planning and Analysis at Jazz Pharmaceuticals, plc. and held a series of different finance-related positions of increasing responsibility at Onyx Pharmaceuticals, Inc. and Amgen Inc. Mr. Ryali earned a B.A. from the University of California, Los Angeles, with a double major in Economics and Microbiology, Immunology and Molecular Genetics and an M.B.A. from the UCLA Anderson School of Management. Board Change • Nov 16
High number of new directors There are 5 new directors who have joined the board in the last 3 years. Director Rahul Singhvi was the last director to join the board, commencing their role in 2022. The company’s lack of board continuity is considered a risk according to the Simply Wall St Risk Model. Reported Earnings • Nov 05
Third quarter 2022 earnings released: US$0.15 loss per share (vs US$0.035 profit in 3Q 2021) Third quarter 2022 results: US$0.15 loss per share (down from US$0.035 profit in 3Q 2021). Revenue: US$34.5m (down 6.3% from 3Q 2021). Net loss: US$9.99m (down US$12.2m from profit in 3Q 2021). Revenue is forecast to grow 10% p.a. on average during the next 3 years, compared to a 18% growth forecast for the Life Sciences industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 16% per year but the company’s share price has fallen by 22% per year, which means it is performing significantly worse than earnings. Board Change • Nov 02
High number of new directors There are 5 new directors who have joined the board in the last 3 years. Director Rahul Singhvi was the last director to join the board, commencing their role in 2022. The company’s lack of board continuity is considered a risk according to the Simply Wall St Risk Model. Reported Earnings • Aug 05
Second quarter 2022 earnings released: US$0.04 loss per share (vs US$0.066 loss in 2Q 2021) Second quarter 2022 results: US$0.04 loss per share (up from US$0.066 loss in 2Q 2021). Revenue: US$38.4m (up 51% from 2Q 2021). Net loss: US$2.64m (loss narrowed 38% from 2Q 2021). Over the next year, revenue is expected to shrink by 6.1% compared to a 25% growth forecast for the industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 11% per year but the company’s share price has fallen by 20% per year, which means it is performing significantly worse than earnings. Buying Opportunity • Jul 15
Now 39% undervalued after recent price drop Over the last 90 days, the stock is down 62%. The fair value is estimated to be US$11.46, however this is not to be taken as a buy recommendation but rather should be used as a guide only. Revenue has grown by 22% over the last 3 years. Earnings per share has declined by 16%. For the next 3 years, revenue is forecast to grow by 19% per annum. Earnings is also forecast to grow by 58% per annum over the same time period. Reported Earnings • May 07
First quarter 2022 earnings released: US$0.13 loss per share (vs US$0.14 loss in 1Q 2021) First quarter 2022 results: US$0.13 loss per share (up from US$0.14 loss in 1Q 2021). Revenue: US$35.3m (up 96% from 1Q 2021). Net loss: US$8.36m (loss narrowed 7.9% from 1Q 2021). Over the next year, revenue is forecast to grow 32%, compared to a 11% growth forecast for the industry in the United Kingdom. Over the last 3 years on average, earnings per share has fallen by 16% per year and the company’s share price has also fallen by 16% per year. Buying Opportunity • Apr 28
Now 21% undervalued after recent price drop Over the last 90 days, the stock is down 40%. The fair value is estimated to be US$15.06, however this is not to be taken as a buy recommendation but rather should be used as a guide only. Revenue has grown by 17% over the last 3 years. Earnings per share has declined by 19%. For the next 3 years, revenue is forecast to grow by 19% per annum. Earnings is also forecast to grow by 48% per annum over the same time period. Breakeven Date Change • Apr 27
No longer forecast to breakeven The 8 analysts covering Codexis no longer expect the company to break even during the foreseeable future. The company was expected to make a profit of US$2.57m in 2024. New consensus forecast suggests the company will make a loss of US$6.74m in 2024.