Global Biotech Breakthroughs

CARsgen Therapeutics Holdings

Market Cap: HK$10.4b

An investment holding company, engages in discovering, developing, and commercializing chimeric antigen receptor T (CAR-T) cell therapies for the treatment of hematological malignancies, solid tumors, and autoimmune diseases in China.

Ascentage Pharma Group International

Market Cap: HK$28.2b

A clinical-stage biotechnology company, develops therapies for cancers, chronic hepatitis B virus (HBV), and age-related diseases in Mainland China.

Sichuan Kelun-Biotech Biopharmaceutical

Market Cap: HK$130.9b

A biopharmaceutical company, engages in the research and development, manufacturing, and commercialization of novel drugs in oncology, immunology, and other therapeutic areas in the People’s Republic of China and internationally.

Alnylam Pharmaceuticals

Market Cap: US$60.4b

Alnylam Pharmaceuticals, Inc. discovers, develops, and commercializes therapeutics based on ribonucleic acid interference.

Caris Life Sciences

Market Cap: US$8.4b

An artificial intelligence TechBio company, provides molecular profiling services in the United States and internationally.

RemeGen

Market Cap: HK$70.5b

A biopharmaceutical company, engages in the discovery, development, and commercialization of biologics for the treatment of autoimmune, oncology, and ophthalmic diseases with unmet medical needs in Mainland China and the United States.

Xbrane Biopharma

Market Cap: SEK 672.8m

A biotechnology company, engages in the development, manufacture, and sale of biosimilars.

Akeso

Market Cap: HK$128.8b

A biopharmaceutical company, engages in the research, development, manufacture, and commercialization of antibody drugs worldwide.

Mereo BioPharma Group

Market Cap: US$326.1m

A biopharmaceutical company, develops and commercializes therapeutics for the treatment of oncology and rare diseases in the United Kingdom, the United States, and internationally.

Cutia Therapeutics

Market Cap: HK$3.1b

An investment holding company, engages in the research, development, manufacture, and commercialization of scalp diseases and care products, and skin care products in the People’s Republic of China and Hong Kong.

Mesoblast

Market Cap: AU$3.5b

Engages in the development of regenerative medicine products in Australia, the United States, Singapore, and Switzerland.

Guard Therapeutics International

Market Cap: SEK 389.2m

A pharmaceutical company, identifies, develops, and commercializes therapies for the diagnosis and treatment of acute kidney injuries in Sweden.

Legend Biotech

Market Cap: US$6.0b

Through its subsidiaries, operates as a biopharmaceutical company that discovers, develops, manufactures, and commercializes novel cell therapies for oncology and other indications in the United States, China, and Europe.

Alterity Therapeutics

Market Cap: AU$108.8m

Engages in the research and development of therapeutic drugs to treat Alzheimer’s disease, Huntington disease, Parkinson’s disease, and other neurological disorders in Australia.

Soleno Therapeutics

Market Cap: US$3.1b

A clinical-stage biopharmaceutical company, focuses on the development and commercialization of novel therapeutics for the treatment of rare diseases.

Tenaya Therapeutics

Market Cap: US$260.8m

A clinical-stage biotechnology company, discovers, develops, and delivers therapies for heart disease in the United States.

Xspray Pharma

Market Cap: SEK 2.5b

A pharmaceutical company, engages in the development of protein kinase inhibitors for targeted cancer treatments in Sweden.

Beijing Luzhu Biotechnology

Market Cap: HK$4.8b

A biotechnology company, focuses on the research and development, production, and sale of human vaccines and therapeutic biologics to prevent and control infectious diseases, and treat cancer and autoimmune diseases in Mainland China.

Aldeyra Therapeutics

Market Cap: US$319.4m

A biotechnology company, discovers and develops therapies designed to treat immune-mediated and metabolic diseases.

ARS Pharmaceuticals

Market Cap: US$1.0b

A biopharmaceutical company, develops and commercializes treatments for severe allergic reactions.

OS Therapies

Market Cap: US$63.0m

A clinical stage biopharmaceutical company, focuses on the identification, development, and commercialization of treatments for osteosarcoma and other solid tumors in the United States.

Achieve Life Sciences

Market Cap: US$163.0m

A late-stage pharmaceutical company, develops and commercializes cytisinicline for nicotine independence in Canada, the United States, and the United Kingdom.

Capricor Therapeutics

Market Cap: US$364.4m

A clinical-stage biotechnology company, engages in the development of transformative cell and exosome-based therapeutics for treating duchenne muscular dystrophy (DMD) and other diseases with unmet medical needs in the United States.

Madrigal Pharmaceuticals

Market Cap: US$10.0b

A biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States.

Vanda Pharmaceuticals

Market Cap: US$304.9m

A biopharmaceutical company, focuses on the development and commercialization of therapies to address high unmet medical needs worldwide.

RenovoRx

Market Cap: US$46.5m

A clinical-stage biopharmaceutical company, engages in the developing of targeted combination therapies to enhance therapeutic outcomes for cancer patients undergoing treatment.

Dizal (Jiangsu) Pharmaceutical

Market Cap: CN¥33.3b

Dizal (Jiangsu) Pharmaceutical Co., Ltd. discovers, develops, and commercializes medicines in the areas of cancer and immunological diseases.

Immutep

Market Cap: AU$403.7m

A biotechnology company, engages in developing novel Lymphocyte Activation Gene-3 related immunotherapies for cancer and autoimmune diseases in Australia.

Arcutis Biotherapeutics

Market Cap: US$2.5b

A biopharmaceutical company, focuses on developing and commercializing treatments for dermatological diseases.

Syndax Pharmaceuticals

Market Cap: US$1.3b

A commercial-stage biopharmaceutical company, develops therapies for the treatment of cancer.

Aelis Farma

Market Cap: €15.7m

A clinical-stage biopharmaceutical company, focuses on discovering and developing drug candidates for the treatment of central nervous system disorders in France.

Lipigon Pharmaceuticals

Market Cap: SEK 87.6m

Develops drugs for lipid related diseases in Sweden.

AC Immune

Market Cap: US$394.8m

A clinical stage biopharmaceutical company, discovers, designs, and develops medicines, and therapeutic and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding.

GNI Group

Market Cap: JP¥134.6b

Engages in the research, development, manufacture, and sale of pharmaceutical drugs in Japan and internationally.

Cynata Therapeutics

Market Cap: AU$53.4m

Engages in the development and commercialization of proprietary induced pluripotent stem cell and mesenchymal stem cell technology under the Cymerus brand for human therapeutic use in Australia.

Kuros Biosciences

Market Cap: CHF 1.1b

Engages in the commercialization and development of biologic technologies for musculoskeletal care in the United States of America, the European Union, and internationally.