Stock Analysis

A Fresh Look at Neurocrine Biosciences (NBIX) Valuation Following New Narrative Review on VMAT2 Therapies

Neurocrine Biosciences (NBIX) has drawn fresh attention following the release of a detailed peer-reviewed narrative review on its FDA-approved VMAT2 inhibitors, notably INGREZZA. The publication examines over ten years of clinical research, comparing distinct therapy profiles and outcomes.

See our latest analysis for Neurocrine Biosciences.

Momentum has been building for Neurocrine Biosciences, with the latest peer-reviewed research and management changes drawing interest. The 1-year total shareholder return stands at 20.05%, which signals confidence in its long-term prospects. Recent weeks have brought a notable 10.24% share price return over 30 days.

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While recent momentum and analyst price targets suggest optimism, the question remains whether the current valuation leaves room for further upside, or if the market has already accounted for Neurocrine’s future growth potential. Could this present a favorable opportunity, or is everything already reflected in the current price?

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Most Popular Narrative: 37.8% Undervalued

According to the most closely followed narrative by kapirey, Neurocrine Biosciences' estimated fair value stands significantly above its last close of $152.16. This indicates a strong disconnect that has investors talking. There is ongoing debate around bold growth projections and how these could shape future returns.

Neurocrine continues to focus on treatments for neurological, neuroendocrine, and neuropsychiatric disorders. Their portfolio includes FDA-approved drugs like Ingrezza and Orilissa, and they are advancing multiple compounds in mid- to late-stage clinical trials.

Read the complete narrative.

Explore the factors behind this notable valuation gap. What market dynamics and aggressive assumptions about future product launches, revenue, and margins are driving such a significant potential upside? Discover how this narrative’s perspective differs from conventional analyst estimates. Many investors are seeking the insights that set this viewpoint apart.

Result: Fair Value of $244.8 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, regulatory setbacks or unmet expectations for pipeline drug launches could quickly challenge the current optimism surrounding Neurocrine’s valuation narrative.

Find out about the key risks to this Neurocrine Biosciences narrative.

Another View: What Do Market Ratios Say?

Shifting from fair value estimates to market ratios, Neurocrine Biosciences trades at a price-to-earnings ratio of 35.4x. That is significantly higher than both industry peers (17.2x) and the sector average (19.1x), and also well above the fair ratio of 25.5x our models suggest the market could move towards. This raises questions about whether investors are paying too much for future growth, or if the optimism is truly justified. Could this premium signal additional risk for buyers at current levels?

See what the numbers say about this price — find out in our valuation breakdown.

NasdaqGS:NBIX PE Ratio as at Nov 2025
NasdaqGS:NBIX PE Ratio as at Nov 2025

Build Your Own Neurocrine Biosciences Narrative

You’re encouraged to dive into the numbers and craft your own take on Neurocrine Biosciences’ outlook. Draw fresh insights in just a few minutes with Do it your way.

A good starting point is our analysis highlighting 3 key rewards investors are optimistic about regarding Neurocrine Biosciences.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Valuation is complex, but we're here to simplify it.

Discover if Neurocrine Biosciences might be undervalued or overvalued with our detailed analysis, featuring fair value estimates, potential risks, dividends, insider trades, and its financial condition.

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Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

About NasdaqGS:NBIX

Neurocrine Biosciences

Neurocrine Biosciences, Inc. discovers, develops, and markets pharmaceuticals for neurological, neuroendocrine, and neuropsychiatric disorders in the United States and internationally.

Flawless balance sheet with reasonable growth potential.

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