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Jazz Pharmaceuticals

Ziihera And Zanidatamab Approvals Will Expand Oncology And Rare Disease Markets

AN
Consensus Narrative from 18 Analysts
Published
28 Aug 24
Updated
26 Mar 25
Share
AnalystConsensusTarget's Fair Value
US$193.58
35.4% undervalued intrinsic discount
26 Mar
US$124.99
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1Y
6.3%
7D
-7.6%

Author's Valuation

US$193.6

35.4% undervalued intrinsic discount

Analyst Price Target Fair Value

Key Takeaways

  • New product launches and successful trials in oncology suggest potential revenue boosts and market expansion, impacting future earnings positively.
  • Strategic diversification and robust financial flexibility support sustainable growth and improved margins, with significant opportunities in high-growth segments.
  • Risks from generic competition and strategic uncertainties may impact revenue streams, operational effectiveness, and investor confidence at Jazz Pharmaceuticals.

Catalysts

About Jazz Pharmaceuticals
    Jazz Pharmaceuticals plc identifies, develops, and commercializes pharmaceutical products in the United States, Europe, and internationally.
What are the underlying business or industry changes driving this perspective?
  • The approval and launch of new products such as Ziihera and upcoming regulatory submissions like the sNDA for Zepzelca offer potential revenue growth through expansion into new market segments, such as treating HER2-positive biliary tract cancer and extensive-stage small cell lung cancer. This is expected to impact revenue positively.
  • Clinical trial progress, specifically the positive results from the Phase III Zepzelca trial and the anticipated data from the HERIZON-GEA-01 Phase III trial, suggest potential label expansions and increased market share in oncology, likely boosting future revenue and earnings.
  • Strategic focus on diversifying commercial and pipeline portfolios through neuroscience, oncology, and rare disease assets indicates potential for sustainable long-term revenue growth and increased operational efficiency, positively affecting net margins.
  • The estimated $2 billion peak sales potential for zanidatamab, if successful in further trials and approvals (e.g., breast cancer), signifies a significant opportunity for earnings growth and top-line extension.
  • Strong cash flow and financial flexibility allow for strategic M&A and internal investments in high-growth segments, potentially improving earnings per share (EPS) through increased scale and elimination of lower-margin components.

Jazz Pharmaceuticals Earnings and Revenue Growth

Jazz Pharmaceuticals Future Earnings and Revenue Growth

Assumptions

How have these above catalysts been quantified?
  • Analysts are assuming Jazz Pharmaceuticals's revenue will grow by 4.9% annually over the next 3 years.
  • Analysts assume that profit margins will increase from 13.8% today to 15.4% in 3 years time.
  • Analysts expect earnings to reach $724.3 million (and earnings per share of $12.29) by about March 2028, up from $560.1 million today. However, there is a considerable amount of disagreement amongst the analysts with the most bullish expecting $986 million in earnings, and the most bearish expecting $276 million.
  • In order for the above numbers to justify the analysts price target, the company would need to trade at a PE ratio of 17.6x on those 2028 earnings, up from 14.7x today. This future PE is greater than the current PE for the US Pharmaceuticals industry at 17.0x.
  • Analysts expect the number of shares outstanding to decline by 3.66% per year for the next 3 years.
  • To value all of this in today's terms, we will use a discount rate of 6.85%, as per the Simply Wall St company report.

Jazz Pharmaceuticals Future Earnings Per Share Growth

Jazz Pharmaceuticals Future Earnings Per Share Growth

Risks

What could happen that would invalidate this narrative?
  • Jazz Pharmaceuticals faces risks from generic competition, as the release of true generic Xyrem could rapidly erode revenues from high-sodium oxybate products, impacting overall revenue and potentially affecting Xywav sales.
  • Changes to pediatric oncology treatment protocols have temporarily affected Rylaze revenue, highlighting potential vulnerabilities in revenue due to external treatment guideline shifts impacting demand.
  • The delay in the data readout timeline for the zanidatamab Phase III GEA trial could impact speed to market and anticipated revenue growth from this potential new indication, leading to uncertainty around future earnings.
  • With the impending CEO transition, there could be potential strategic and execution risks that may affect investor confidence and the company’s continued operational effectiveness, impacting share price and valuation.
  • The uncertain impact of a potential early generic entry for high-sodium oxybate products on Jazz’s sleep franchise could lead to increased revenue erosion and pressure on profit margins, depending on payer dynamics and market responses.

Valuation

How have all the factors above been brought together to estimate a fair value?
  • The analysts have a consensus price target of $193.579 for Jazz Pharmaceuticals based on their expectations of its future earnings growth, profit margins and other risk factors. However, there is a degree of disagreement amongst analysts, with the most bullish reporting a price target of $230.0, and the most bearish reporting a price target of just $150.0.
  • In order for you to agree with the analyst's consensus, you'd need to believe that by 2028, revenues will be $4.7 billion, earnings will come to $724.3 million, and it would be trading on a PE ratio of 17.6x, assuming you use a discount rate of 6.9%.
  • Given the current share price of $135.25, the analyst price target of $193.58 is 30.1% higher.
  • We always encourage you to reach your own conclusions though. So sense check these analyst numbers against your own assumptions and expectations based on your understanding of the business and what you believe is probable.

How well do narratives help inform your perspective?

Disclaimer

Warren A.I. is a tool utilizing a Large Language Model (LLM) that ingests data on consensus price targets, forecasted revenue and earnings figures, as well as the transcripts of earnings calls to produce qualitative analysis. The narratives produced by Warren A.I. are general in nature and are based solely on analyst data and publicly-available material published by the respective companies. These scenarios are not indicative of the company's future performance and are exploratory in nature. Simply Wall St has no position in the company(s) mentioned. Simply Wall St may provide the securities issuer or related entities with website advertising services for a fee, on an arm's length basis. These relationships have no impact on the way we conduct our business, the content we host, or how our content is served to users. The price targets and estimates used are consensus data, and do not constitute a recommendation to buy or sell any stock, and they do not take account of your objectives, or your financial situation. Note that Warren A.I.'s analysis may not factor in the latest price-sensitive company announcements or qualitative material.

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