Analysts Weigh In on Lantheus Holdings Amid Pylarify Challenges and Lowered Growth Forecasts

Key Takeaways

• Alzheimer's and prostate cancer imaging expansions, plus new product launches, are expected to drive strong revenue growth and diversify the company's portfolio.
  
• Strategic acquisitions and industry tailwinds position the company for sustained margin improvement and growth across radiopharmaceutical and neuroimaging markets.
  
• Heavy dependence on a single product amid intensifying competition, pricing pressure, and limited diversification threatens revenue growth and earnings stability despite ongoing acquisition efforts.

Catalysts

Develops, manufactures, and commercializes diagnostic and therapeutic products that assist clinicians in diagnosis and treatment of heart, cancer, and other diseases worldwide.

• The expansion of Lantheus's Alzheimer's disease imaging franchise-including the recent FDA label expansion for Neuraceq and late-stage tau-targeted radiodiagnostic MK-6240-positions the company to capture accelerating demand driven by broader adoption of amyloid-targeted therapies and increased focus on early diagnosis. This is likely to drive strong revenue growth as the U.S. PET imaging market for Alzheimer's is expected to exceed $1.5 billion by 2030.
  
• The development, anticipated approval, and launch of the new high-yield PYLARIFY formulation are expected to deliver meaningful gross margin improvement and restore revenue growth for the prostate cancer imaging franchise, by expanding supply, improving geographic access, and resetting reimbursement dynamics with potential 340B price resets and three years of transitional pass-through status.
  
• Multiple new product launches within the next 18 months-including the new F-18 PSMA PET, MK-6240, OCTEVY, and PNT2003-are set to diversify the revenue base, mitigate concentration risk, and open additional growth channels in oncology and neuroendocrine tumor imaging, supporting both top-line and future earnings expansion.
  
• Recent acquisitions (Evergreen and Life Molecular Imaging) enhance Lantheus's manufacturing capabilities, broaden its product portfolio, and provide an immediate and scalable entry into high-growth radiopharmaceutical and neuroimaging markets, which should support both revenue growth and longer-term operating margin improvements.
  
• Long-term demand tailwinds from an aging population, increased incidence of chronic diseases, and the structural shift toward early diagnosis and personalized medicine underpin sustainable volume growth for Lantheus's radiopharmaceuticals in both core and emerging markets, positively impacting revenues and offering upside to valuation if the stock is currently discounted.

Lantheus Holdings Future Earnings and Revenue Growth

Assumptions

• Analysts are assuming Lantheus Holdings's revenue will grow by 5.7% annually over the next 3 years.
• Analysts assume that profit margins will increase from 17.8% today to 23.4% in 3 years time.
• Analysts expect earnings to reach $419.8 million (and earnings per share of $5.75) by about September 2028, up from $271.0 million today. However, there is a considerable amount of disagreement amongst the analysts with the most bullish expecting $472.3 million in earnings, and the most bearish expecting $259.8 million.
• In order for the above numbers to justify the analysts price target, the company would need to trade at a PE ratio of 16.8x on those 2028 earnings, up from 13.8x today. This future PE is lower than the current PE for the US Medical Equipment industry at 29.7x.
• Analysts expect the number of shares outstanding to decline by 2.2% per year for the next 3 years.
• To value all of this in today's terms, we will use a discount rate of 7.75%, as per the Simply Wall St company report.

Lantheus Holdings Future Earnings Per Share Growth

Risks

• Intensifying price competition in the PSMA PET imaging market, especially from F-18 competitors, has resulted in Lantheus accepting lower prices, renegotiating contracts, and walking away from certain volumes, leading to ongoing net price compression and posing a risk to revenue and net margins.
  
• Continued over-reliance on PYLARIFY as the primary revenue driver, combined with signs of market share loss and the likelihood of flat or negative PYLARIFY growth in 2026, creates vulnerability to further competitive disruption or reimbursement changes, negatively impacting long-term earnings stability.
  
• Slow growth within large institutional customers and failure to fully penetrate the broader, high-growth PET imaging market-where competitors are gaining-limits Lantheus' ability to offset pricing and contract pressures, constraining overall revenue growth prospects.
  
• Strategic acquisitions and diversification efforts (e.g., Evergreen, LMI/Neuraceq) provide new growth drivers but are expected to deliver only low-single-digit EPS accretion in the near term, and integration/dilution risks remain, potentially weighing on aggregate net margin improvement and earnings growth.
  
• Best-price resets, 340B program exposure, and future regulatory changes (e.g., TPT/ASP dynamics) create reimbursement headwinds that may further erode pricing power and profitability, especially if new entrants or competing modalities accelerate adoption, impacting both revenue and net margins.

Valuation

• The analysts have a consensus price target of $89.5 for Lantheus Holdings based on their expectations of its future earnings growth, profit margins and other risk factors. However, there is a degree of disagreement amongst analysts, with the most bullish reporting a price target of $130.0, and the most bearish reporting a price target of just $63.0.
• In order for you to agree with the analyst's consensus, you'd need to believe that by 2028, revenues will be $1.8 billion, earnings will come to $419.8 million, and it would be trading on a PE ratio of 16.8x, assuming you use a discount rate of 7.8%.
• Given the current share price of $55.07, the analyst price target of $89.5 is 38.5% higher.
• We always encourage you to reach your own conclusions though. So sense check these analyst numbers against your own assumptions and expectations based on your understanding of the business and what you believe is probable.